The Effects of Long-Term Magnesium Creatine Chelate Supplementation on Repeated Sprint Ability (RAST) in Elite Soccer Players
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Aim: The aim of the study was to evaluate the effects of 16 weeks of a low dose of magnesium creatine chelate supplementation on repeated sprint ability test (RAST) results in elite soccer players. Materials: Twenty well-trained soccer players participated in the study. The players were divided randomly into two groups: the supplemented group (SG = 10) and placebo group (PG = 10). Out of the 20 subjects selected for the study, 16 (SG = 8, PG = 8) completed the entire experiment. The SG ingested a single dose of 5500 mg of magnesium creatine chelate (MgCr-C), in 4 capsules per day, which was 0.07 g/kg/d. The PG received an identical 4 capsules containing corn starch. Before and after the study, the RAST was performed. In the RAST, total time (TT), first and sixth 35 m sprint length (s), average power (AP) and max power (MP) were measured. Additionally, before and after the test, lactate LA (mmol/L) and acid–base equilibrium pH (-log(H+)), bicarbonates HCO3− (mmol/L) were evaluated. Also, in serum at rest, creatinine (mg/dL) concentration was measured. Results: After the study, significantly better results in TT, AP and MP were observed in the SG. No significant changes in the RAST results were observed in the PG. After the study, significant changes in the first 35 m sprint, as well as the sixth 35 m sprint results were registered in the SG, while insignificant changes occurred in the PG. A significantly higher creatinine concentration was observed. Also, a higher post-RAST concentration of LA, HCO3− and lower values of pH were observed in April, May and June compared with baseline values. Conclusions: The long timeframe, i.e., 16 weeks, of the low dose of magnesium creatine chelate supplementation improved the RAST results in the SG. Despite the long period of MgCr-C supplementation, in the end of the study, the creatinine level in the SG reached higher but still reference values.
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Creatinine levels significantly increased throughout training with MgCr-C compared to placebo, and this increase was higher than reported in long-term CrM studies during training in hot and humid environments.
“creatinine levels were also significantly increased throughout training with MgCr-C (0.83 to 1.87 mmol/L) compared to placebo (0.92 to 0.82 mmol/L), which is higher than reported in other long-term CrM studies during training in hot and humid environments that administered 5–10 g/day of CrM for 21 months in well-trained athletes [144].”
From Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review (2022) · cites this paper as [191]
The Results report that creatinine rose significantly from 0.83 at baseline to 1.87 after four weeks of MgCr-C, while it did not change significantly in the placebo group. The increase did not continue throughout training: creatinine fell to 1.38 by week 16. The Results give the placebo endpoint as 0.85, not 0.82, and the Discussion gives the creatinine unit as mg/dL, not mmol/L. Our copy does not support the claimed comparison with CrM studies conducted in hot and humid environments. (LLM, conf=0.91)
Experimental — accuracy not yet measured5.5 g/day of MgCr-C supplementation during 16 weeks of soccer training improved repeated sprint ability performance compared to placebo, but the study did not compare MgCr-C to CrM and performance changes were consistent with other CrM studies.
“Zajac et al. [191] reported that 5.5 g/day of MgCr-C supplementation during 16 weeks of soccer training improved repeated sprint ability performance compared to placebo.”
From Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review (2022) · cites this paper as [191]
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Cites
Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D. G., Kleiner, S. M., Almada, A. L., & Lopez, H. L. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0173-z · Cited by 854 · cited 2× · see citing works
“The majority of available data comes from typical Cr supplementation regimens, which include a loading phase of 20–25 g/d for 5–7 days followed by a maintenance phase of 3–5 g/d for several weeks [2,3].”
BackgroundEffects of creatine supplementation on body composition, strength, and sprint performance
KREIDER, R. B., FERREIRA, M., WILSON, M., GRINDSTAFF, P., PLISK, S., REINARDY, J., CANTLER, E., & ALMADA, A. L. (1998) · Medicine &amp Science in Sports &amp Exercise · doi:10.1097/00005768-199801000-00011 · Cited by 430 · see citing works
Creatine Supplementation and Exercise Performance: Recent Findings
Bemben, M. G., & Lamont, H. S. (2005) · Sports Medicine · doi:10.2165/00007256-200535020-00002 · Cited by 270 · see citing works
Effect of creatine and weight training on muscle creatine and performance in vegetarians
BURKE, D. G., CHILIBECK, P. D., PARISE, G., CANDOW, D. G., MAHONEY, D., & TARNOPOLSKY, M. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000093614.17517.79 · Cited by 224 · see citing works
Analysis of the efficacy, safety, and regulatory status of novel forms of creatine
Jäger, R., Purpura, M., Shao, A., Inoue, T., & Kreider, R. B. (2011) · Amino Acids · doi:10.1007/s00726-011-0874-6 · Cited by 181 · see citing works
Ramírez-Campillo, R., González-Jurado, J. A., Martínez, C., Nakamura, F. Y., Peñailillo, L., Meylan, C. M. P., Caniuqueo, A., Cañas-Jamet, R., Moran, J., Alonso-Martínez, A. M., et al. (2016) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2015.10.005 · Cited by 118 · see citing works
Cox, G., Mujika, I., Tumilty, D., & Burke, L. (2002) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.12.1.33 · Cited by 110 · see citing works
Butts, J., Jacobs, B., & Silvis, M. (2018) · Sports Health: A Multidisciplinary Approach · doi:10.1177/1941738117737248 · Cited by 100 · see citing works
Spillane, M., Schoch, R., Cooke, M., Harvey, T., Greenwood, M., Kreider, R., & Willoughby, D. S. (2009) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-6-6 · Cited by 95 · see citing works
Mielgo-Ayuso, J., Calleja-Gonzalez, J., Marqués-Jiménez, D., Caballero-García, A., Córdova, A., & Fernández-Lázaro, D. (2019) · Nutrients · doi:10.3390/nu11040757 · Cited by 91 · see citing works
Creatine monohydrate supplementation on lower-limb muscle power in Brazilian elite soccer players
Claudino, J. G., Mezêncio, B., Amaral, S., Zanetti, V., Benatti, F., Roschel, H., Gualano, B., Amadio, A. C., & Serrão, J. C. (2014) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-11-32 · Cited by 78 · see citing works
Creatine supplementation in young soccer players
Ostojic, S. M. (2004) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.14.1.95 · Cited by 72 · see citing works
Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain
Rawson, E. S., Stec, M. J., Frederickson, S. J., & Miles, M. P. (2011) · Nutrition · doi:10.1016/j.nut.2010.04.001 · Cited by 58 · see citing works
Michalczyk, M. M., Gołaś, A., Maszczyk, A., Kaczka, P., & Zając, A. (2020) · Nutrients · doi:10.3390/nu12051311 · Cited by 39 · see citing works
Self-citationCrisafulli, D. L., Buddhadev, H. H., Brilla, L. R., Chalmers, G. R., Suprak, D. N., & San Juan, J. G. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0226-y · Cited by 30 · see citing works
Flagged first, then by citations
Research works printed but not linked: 26
- [3]Kreider R.B. Jung Y.P. Creatine supplementation in exercise, sport, and medicine J. Exerc. Nutr. Biochem. 2011 15 53 69 10.5717/jenb.2011.15.2.53 · DOI · Paper page
- [5]Baker J.S. McCormick M.C. Robergs R.A. Interaction among Skeletal Muscle Metabolic Energy Systems during Intense Exercise J. Nutr. Metab. 2010 210 10.1155/2010/905612 PMC3005844 21188163 · DOI
- [8]Kreider R.B. Melton C. Rasmussen C.J. Greenwood M. Lancaster S. Cantler E.C. Milnor P. Almada A.L. Long-term Creatine Supplementation Does Not Significantly Affect Clinical Markers of Health in Athletes Mol. Cell Biochem. 2003 244 95 104 10.1023/A:1022469320296 12701816 · DOI · Paper page
- [10]Van Loon L.J. Murphy R. Oosterlaar A.M. Cameron-Smith D. Hargreaves M. Wagenmakers A.J. Snow R. Creatine Supplementation Increases Glycogen Storage but Not GLUT-4 Expression in Human Skeletal Muscle Clin. Sci. (Lond.) 2004 106 99 106 10.1042/CS20030116 14507259 · DOI
- [12]Yáñez-Silva A. Buzzachera C.F. Piçarro I.D. Januario R.S. Herreira L.H. McAnulty S.R. Utter A.C. Souza-Junior T.P. Effect of Low Dose, Short-Term Creatine Supplementation on Muscle Power Output in Elite Youth Soccer Players J. Int. Soc. Sports Nutr. 2017 14 5 10.1186/s12970-017-0162-2 28190980 PMC5296953 · DOI · Paper page
- [15]Castagna C. Manzi V. Impellizzeri F. Weston M. Alvarez J.C.B. Relationship between Endurance Field Tests and Match Performance in Young Soccer Players J. Strength Cond. Res. 2010 24 3227 3233 10.1519/JSC.0b013e3181e72709 21068683 · DOI
- [16]Reilly T. Bangsbo J. Franks A. Anthropometric and physiological predispositions for elite soccer J. Sports Sci. 2000 18 669 683 10.1080/02640410050120050 11043893 · DOI
- [18]Andrzejewski M. Chmura J. Pluta B. Strzelczyk R. Kasprzak A. Analysis of Sprinting Activities of Professional Soccer Players J. Strength Cond. Res. 2013 27 2134 2140 10.1519/JSC.0b013e318279423e 23168374 · DOI
- [19]Gaitanos G.C. Williams C. Boobis L.H. Brooks S. Human Muscle Metabolism during Intermittent Maximal Exercise J. Appl. Physiol. 1993 75 712 719 10.1152/jappl.1993.75.2.712 8226473 · DOI · Paper page
- [20]Biwer C.J. Jensen R.L. Schmidt W.D. Watts P.B. The Effect of Creatine on Treadmill Running with High-Intensity Intervals J. Strength Cond. Res. 2003 17 439 445 12930167
- [22]Aedma M. Timpmann S. Lätt E. Ööpik V. Short-term creatine supplementation has no impact on upper-body anaerobic power in trained wrestlers J. Int. Soc. Sports Nutr. 2015 12 45 10.1186/s12970-015-0107-6 26664350 PMC4673838 · DOI
- [24]Mujika I. Padilla S. Ibañez J. Izquierdo M. Gorostiaga E. Creatine Supplementation and Sprint Performance in Soccer Players Med. Sci. Sports Exerc. 2000 32 518 525 10.1097/00005768-200002000-00039 10694141 · DOI
- [27]Brilla L.R. Giroux M.S. Taylor A. Knutzen K.M. Magnesium-creatine supplementation effects on body water Met. Clin. Exper. 2003 53 1136 1140 10.1016/S0026-0495(03)00188-4 14506619 · DOI · Paper page
- [30]Baxmann A.C. Ahmed M.S. Heliberg I.P. Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystain C Clin. J. Am. Soc. Nephrol. 2008 3 348 354 10.2215/CJN.02870707 18235143 PMC2390952 · DOI
- [31]Velema M.S. Ronde W. Elevated plasma creatinine due to creatine ethyl ester use Neth. J. Med. 2011 69 79 81 21411845
- [32]Kreider R.B. Stout J.R. Greenwood M. Campbell B. Spano M. Ziegenfuss T. Lopez H. Landis J. Antonio J. International Society of Sports Nutrition Position Stand: Creatine Supplementation and Exercise J. Int. Soc. Sports Nutr. 2007 4 6 17908288 PMC2048496
- [33]Michalczyk M.M. Klonek G. Maszczyk A. Zajac A. The effects of a low calorie ketogenic diet on glycaemic control variables in hyperinsulinemic overweight/obese females Nutrients 2020 12 1854 10.3390/nu12061854 32580282 PMC7353458 · DOI
- [36]De Andrade V.L. Santiago P.R. Kalva Filho C.A. Campos E.Z. Papoti M. Reproducibility of Running Anaerobic Sprint Test for soccer players J. Sports Med. Phys. Fit. 2016 56 34 38 25373469
- [37]Rahimi R. Creatine Supplementation Decreases Oxidative DNA Damage and Lipid Peroxidation Induced by a Single Bout of Resistance Exercise J. Strength Cond. Res. 2011 25 3448 3455 10.1519/JSC.0b013e3182162f2b 22080314 · DOI · Paper page
- [38]Stone M.H. Sanborn K. Smith L.L. O’Bryant H.S. Hoke T. Utter A.C. Johnson R.L. Boros R. Hruby J. Pierce K.C. Effects of In-Season (5 Weeks) Creatine and Pyruvate Supplementation on Anaerobic Performance and Body Composition in American Football Players Int. J. Sport Nutr. 1999 9 146 165 10.1123/ijsn.9.2.146 10362452 · DOI · Paper page
- [39]Cancela P. Ohanian C. Cuitiño E. Hackney A.C. Creatine Supplementation Does Not Affect Clinical Health Markers in Football Players Br. J. Sports Med. 2008 42 731 735 10.1136/bjsm.2007.030700 18780799 · DOI · Paper page
- [40]Vega J. Huidobro J.P.E. Effects of Creatine Supplementation on Renal Function Rev. Med. Chil. 2019 147 628 633 10.4067/S0034-98872019000500628 31859895 · DOI · Paper page
- [41]Snow R.J. Murphy R.M. Creatine and the creatine transporter: A review Mol. Cell. Biochem. 2001 224 169 181 10.1023/A:1011908606819 11693194 · DOI
- [43]Williams J. Abt G. Kilding A.E. Effects of creatine monohydrate supplementation on simulated soccer performance Int. J. Sports Physiol. Perform. 2014 9 503 510 10.1123/ijspp.2013-0407 24434117 · DOI
- [45]Zagatto A.M. Beck W.R. Claudio A. Gobatto C.A. Validity of the running anaerobic sprint test for assessing anaerobic power and predicting short-distance performances J. Strength Cond. Res. 2009 23 1820 1827 10.1519/JSC.0b013e3181b3df32 19675478 · DOI
- [46]Ates O. Keskin B. Bayraktar B. The Effect of Acute Creatine Supplementation on Fatigue and Anaerobic Performance Cell. Eur. J. Sport Sci. Med. 2017 19 85 92 10.18276/cej.2017.3-08 · DOI
Cited by
Sorted by citations
Kreider, R. B., Jäger, R., & Purpura, M. (2022) · Nutrients · doi:10.3390/nu14051035 · Cited by 103 · see citing works
- Authors
- Zajac, A., Golas, A., Chycki, J., Halz, M., & Michalczyk, M. M.
- Affiliations
- Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Mikolowska 72a, 40-065 Katowice, Poland
- Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach (PL)
- Corresponding author
- Michalczyk, Małgorzata Magdalena
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-09-28
- Volume
- 12
- Issue
- 10
- Pages
- 2961
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7600931
- OpenAlex
- W3088899813
- Cited by
- 32
- References
- 15
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- dietary supplementation, repeated sprint ability, elite soccer players, creatine, creatinine, lactate, acid-base balance, bicarbonate, output power
- MeSH terms
- High-Intensity Interval Training, Adult, Chelating Agents, Creatine, Humans, Magnesium, Male, Soccer, Time Factors, Dietary Supplements, Athletic Performance, Young Adult
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