Potential therapeutic effects of curcumin on glycemic and lipid profile in uncomplicated type 2 diabetes—a meta-analysis of randomized controlled trial
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Diabetes mellitus is an important issue for public health, and it is growing in the world. In recent years, there has been a growing research interest on efficacy evidence of the curcumin use in the regulation of glycemia and lipidaemia. The molecular structure of curcumins allows to intercept reactive oxygen species (ROI) that are particularly harmful in chronic inflammation and tumorigenesis models. The aim of our study performed a systematic review and meta-analysis to evaluate the effect of curcumin on glycemic and lipid profile in subjects with uncomplicated type 2 diabetes. The papers included in the meta-analysis were sought in the MEDLINE, EMBASE, Scopus, Clinicaltrials.gov, Web of Science, and Cochrane Library databases as of October 2020. The sizes were pooled across studies in order to obtain an overall effect size. A random effects model was used to account for different sources of variation among studies. Cohen’s d, with 95% confidence interval (CI) was used as a measure of the effect size. Heterogeneity was assessed while using Q statistics. The ANOVA-Q test was used to value the differences among groups. Publication bias was analyzed and represented by a funnel plot. Curcumin treatment does not show a statistically significant reduction between treated and untreated patients. On the other hand, glycosylated hemoglobin, homeostasis model assessment (HOMA), and low-density lipoprotein (LDL) showed a statistically significant reduction in subjects that were treated with curcumin, respectively (p = 0.008, p < 0.001, p = 0.021). When considering HBA1c, the meta-regressions only showed statistical significance for gender (p = 0.034). Our meta-analysis seems to confirm the benefits on glucose metabolism, with results that appear to be more solid than those of lipid metabolism. However, further studies are needed in order to test the efficacy and safety of curcumin in uncomplicated type 2 diabetes.
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Others have found cardiometabolic improvement effects of anthocyanin, catechin, curcumin, flavanol, genistein, and quercetin.
“Others have also found cardiometabolic improvement effects of anthocyanin,32 catechin,33,34 curcumin,35 flavanol,36 genistein,37 and quercetin.38,39”
From Micronutrient Supplementation to Reduce Cardiovascular Risk (2022) · cites this paper as [35]
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BAZI BAHARATLARIN ANTİDİYABETİK ETKİLERİ;GENEL BAKIŞ
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- Authors
- Altobelli, E., Angeletti, P. M., Marziliano, C., Mastrodomenico, M., Giuliani, A. R., & Petrocelli, R.
- Affiliations
- University of L'Aquila (IT)
- Public Health Unit, ASREM, 86100 Campobasso, Italy
- Corresponding author
- Altobelli, Emma
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-01-27
- Volume
- 13
- Issue
- 2
- Pages
- 404
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7912109
- OpenAlex
- W3122741988
- Cited by
- 67
- References
- 43
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 10 · 2023: 18 · 2022: 14 · 2021: 6
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, public-domain)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
- Keywords
- curcumin, type 2 diabetes, glycemic control, lipid profile, HbA1c, HOMA, LDL cholesterol, glucose metabolism, lipid metabolism, reactive oxygen species, chronic inflammation
- MeSH terms
- Blood Glucose, Curcumin, Diabetes Mellitus, Type 2, Glycated Hemoglobin, Humans, Cholesterol, HDL, Cholesterol, LDL, Triglycerides, Randomized Controlled Trials as Topic
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