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Energy Drinks and Sports Performance, Cardiovascular Risk, and Genetic Associations; Future Prospects

Gutiérrez-Hellín, Jorge, Varillas-Delgado, David·2021·Nutrients
DOI 10.3390/nu13030715
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Abstract

The consumption of energy drinks (e.g., containing caffeine and taurine) has increased over the last decade among adolescents and athletes to enhance their cognitive level and improve intellectual and athletic performance. Numerous studies have shown that drinking moderate doses of such drinks produces beneficial effects, as they considerably boost the sporting performance of elite athletes in various sports, including both endurance and explosive events. However, apart from their ergogenic effects, the regular consumption of energy drinks also increases blood pressure and consequently incites problems such as hypertension, tachycardia, and nervousness, all of which can lead to cardiovascular disorders. A potential positive correlation between genetics and the moderate consumption of energy drinks and athletic performance has recently been reported; notwithstanding, a better understanding of the genetic variants involved in metabolism is a key area for future research to optimize the dose of energy drink consumed and obtain the maximal ergogenic effect in elite sports. The aim of this literature review, therefore, is to present the results of recent studies, classifying them according to the differences in the associations between energy drinks and: (i) Athletic performance; (ii) cardiovascular risk factors while practicing sports; and (iii) genetic associations and future prospects between the consumption of energy drinks and performance.

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Research works printed but not linked: 99

  1. Ali, 2015, Energy drinks and their adverse health effects: A systematic review of the current evidence, Postgrad. Med., 127, 308, 10.1080/00325481.2015.1001712 · DOI
  2. Kumar, 2015, Perceptions about energy drinks are associated with energy drink intake among U.S. youth, Am. J. Health Promot., 29, 238, 10.4278/ajhp.130820-QUAN-435 · DOI
  3. Higgins, 2018, Energy Drinks: A Contemporary Issues Paper, Curr. Sports Med. Rep., 17, 65, 10.1249/JSR.0000000000000454 · DOI
  4. Porrini, 2016, Ergogenic Aids and Supplements, Front. Horm. Res., 47, 128, 10.1159/000445176 · DOI
  5. Bishop, 2010, Dietary supplements and team-sport performance, Sports Med., 40, 995, 10.2165/11536870-000000000-00000 · DOI
  6. McDowall, 2007, Supplement use by Young Athletes, J. Sports Sci. Med., 6, 337
  7. Astorino, 2010, Efficacy of acute caffeine ingestion for short-term high-intensity exercise performance: A systematic review, J. Strength Cond. Res., 24, 257, 10.1519/JSC.0b013e3181c1f88a · DOI · Paper page
  8. McLellan, 2012, Do energy drinks contain active components other than caffeine?, Nutr. Rev., 70, 730, 10.1111/j.1753-4887.2012.00525.x · DOI
  9. Gwacham, 2012, Acute effects of a caffeine-taurine energy drink on repeated sprint performance of American college football players, Int. J. Sport Nutr. Exerc. Metab., 22, 109, 10.1123/ijsnem.22.2.109 · DOI
  10. Lara, 2014, Caffeine-containing energy drink improves physical performance in female soccer players, Amino Acids, 46, 1385, 10.1007/s00726-014-1709-z · DOI
  11. Astorino, 2012, Effects of red bull energy drink on repeated sprint performance in women athletes, Amino Acids, 42, 1803, 10.1007/s00726-011-0900-8 · DOI
  12. Prins, 2016, Energy Drinks Improve Five-Kilometer Running Performance in Recreational Endurance Runners, J. Strength Cond. Res., 30, 2979, 10.1519/JSC.0000000000001391 · DOI · Paper page
  13. Salinero, 2014, Enhancing physical performance in male volleyball players with a caffeine-containing energy drink, Int. J. Sports Physiol. Perform., 9, 1013, 10.1123/ijspp.2013-0448 · DOI
  14. Muñoz, A., López-Samanes, Á., Aguilar-Navarro, M., Varillas-Delgado, D., Rivilla-García, J., Moreno-Pérez, V., and Del Coso, J. (2020). Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players. Genes, 11. · DOI
  15. Grasser, 2016, Energy Drinks and Their Impact on the Cardiovascular System: Potential Mechanisms, Adv. Nutr., 7, 950, 10.3945/an.116.012526 · DOI
  16. Basrai, 2019, Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomized Controlled Trial, J. Nutr., 149, 441, 10.1093/jn/nxy303 · DOI · Paper page
  17. Wolk, 2012, Toxicity of energy drinks, Curr. Opin. Pediatr., 24, 243, 10.1097/MOP.0b013e3283506827 · DOI
  18. Chrysant, 2015, Cardiovascular complications from consumption of high energy drinks: Recent evidence, J. Hum. Hypertens., 29, 71, 10.1038/jhh.2014.47 · DOI
  19. Pickering, 2019, Caffeine and Exercise: What Next?, Sports Med., 49, 1007, 10.1007/s40279-019-01101-0 · DOI · Paper page
  20. Guest, 2019, Sport Nutrigenomics: Personalized Nutrition for Athletic Performance, Front. Nutr., 6, 8, 10.3389/fnut.2019.00008 · DOI
  21. Pickering, 2018, Are the Current Guidelines on Caffeine Use in Sport Optimal for Everyone? Inter-individual Variation in Caffeine Ergogenicity, and a Move Towards Personalised Sports Nutrition, Sports Med., 48, 7, 10.1007/s40279-017-0776-1 · DOI
  22. Grgic, 2020, CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance, J. Int. Soc. Sports Nutr., 17, 21, 10.1186/s12970-020-00349-6 · DOI · Paper page
  23. Puente, C., Abián-Vicén, J., Del Coso, J., Lara, B., and Salinero, J.J. (2018). The CYP1A2 -163C>A polymorphism does not alter the effects of caffeine on basketball performance. PLoS ONE, 13. · DOI
  24. Grgic, J., Pickering, C., Del Coso, J., Schoenfeld, B.J., and Mikulic, P. (2020). CYP1A2 genotype and acute ergogenic effects of caffeine intake on exercise performance: A systematic review. Eur. J. Nutr. · DOI
  25. Mottram, 2008, Athletes’ knowledge and views on OTC medication, Int. J. Sports Med., 29, 851, 10.1055/s-2008-1038403 · DOI
  26. Wickham, 2018, Administration of Caffeine in Alternate Forms, Sports Med., 48, 79, 10.1007/s40279-017-0848-2 · DOI
  27. Campbell, 2013, International Society of Sports Nutrition position stand: Energy drinks, J. Int. Soc. Sports Nutr., 10, 1, 10.1186/1550-2783-10-1 · DOI
  28. Pasman, 1995, The effect of different dosages of caffeine on endurance performance time, Int. J. Sports Med., 16, 225, 10.1055/s-2007-972996 · DOI · Paper page
  29. Polito, 2019, Caffeine and resistance exercise: The effects of two caffeine doses and the influence of individual perception of caffeine, Eur. J. Sport Sci., 19, 1342, 10.1080/17461391.2019.1596166 · DOI
  30. Jenkins, 2008, Ergogenic effects of low doses of caffeine on cycling performance, Int. J. Sport Nutr. Exerc. Metab., 18, 328, 10.1123/ijsnem.18.3.328 · DOI
  31. Bruce, 2000, Enhancement of 2000-m rowing performance after caffeine ingestion, Med. Sci. Sports Exerc., 32, 1958, 10.1097/00005768-200011000-00021 · DOI
  32. Rivers, 1907, The action of caffeine on the capacity for muscular work, J. Physiol., 36, 33, 10.1113/jphysiol.1907.sp001215 · DOI
  33. Killen, 2013, Effects of caffeine on session ratings of perceived exertion, Eur. J. Appl. Physiol., 113, 721, 10.1007/s00421-012-2480-z · DOI
  34. Vicente-Salar, N., Santos-Sánchez, G., and Roche, E. (2020). Nutritional Ergogenic Aids in Racquet Sports: A Systematic Review. Nutrients, 12. · DOI
  35. Steele, 1990, The effects of taurine on Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ sensitivity of chemically skinned rat heart, J. Physiol., 422, 499, 10.1113/jphysiol.1990.sp017997 · DOI
  36. Stapleton, 1997, Taurine and human nutrition, Clin. Nutr., 16, 103, 10.1016/S0261-5614(97)80234-8 · DOI
  37. Spriet, 2015, Taurine and skeletal muscle function, Curr. Opin. Clin. Nutr. Metab. Care, 18, 96, 10.1097/MCO.0000000000000135 · DOI
  38. Hamilton, 2006, The effect of taurine depletion on the contractile properties and fatigue in fast-twitch skeletal muscle of the mouse, Amino Acids, 31, 273, 10.1007/s00726-006-0291-4 · DOI
  39. Huxtable, 1992, Physiological actions of taurine, Physiol. Rev., 72, 101, 10.1152/physrev.1992.72.1.101 · DOI · Paper page
  40. Waldron, 2018, The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis, Sports Med., 48, 1247, 10.1007/s40279-018-0896-2 · DOI
  41. Huxtable, 1974, Taurine concentrations in congestive heart failure, Science, 184, 1187, 10.1126/science.184.4142.1187 · DOI
  42. Hoyte, 2013, The use of energy drinks, dietary supplements, and prescription medications by United States college students to enhance athletic performance, J. Community Health, 38, 575, 10.1007/s10900-013-9653-5 · DOI · Paper page
  43. Quinlivan, 2015, The effects of Red Bull energy drink compared with caffeine on cycling time-trial performance, Int. J. Sports Physiol. Perform., 10, 897, 10.1123/ijspp.2014-0481 · DOI
  44. Cureton, 2007, Caffeinated sports drink: Ergogenic effects and possible mechanisms, Int. J. Sport Nutr. Exerc. Metab., 17, 35, 10.1123/ijsnem.17.1.35 · DOI
  45. Kovacs, 1998, Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance, J. Appl. Physiol. (1985), 85, 709, 10.1152/jappl.1998.85.2.709 · DOI · Paper page
  46. Portillo, 2013, Caffeine-containing energy drink improves sprint performance during an international rugby sevens competition, Amino Acids, 44, 1511, 10.1007/s00726-013-1473-5 · DOI
  47. Portillo, 2016, Caffeinated Energy Drinks Improve High-Speed Running in Elite Field Hockey Players, Int. J. Sport Nutr. Exerc. Metab., 26, 26, 10.1123/ijsnem.2015-0128 · DOI
  48. Salinero, 2015, Caffeinated energy drinks improve volleyball performance in elite female players, Med. Sci. Sports Exerc., 47, 850, 10.1249/MSS.0000000000000455 · DOI
  49. Lara, 2015, Acute consumption of a caffeinated energy drink enhances aspects of performance in sprint swimmers, Br. J. Nutr., 114, 908, 10.1017/S0007114515002573 · DOI
  50. Abian, 2015, The ingestion of a caffeinated energy drink improves jump performance and activity patterns in elite badminton players, J. Sports Sci., 33, 1042, 10.1080/02640414.2014.981849 · DOI
  51. Areces, 2015, Enhancing physical performance in elite junior tennis players with a caffeinated energy drink, Int. J. Sports Physiol. Perform., 10, 305, 10.1123/ijspp.2014-0103 · DOI
  52. Rahnama, 2010, The effectiveness of two energy drinks on selected indices of maximal cardiorespiratory fitness and blood lactate levels in male athletes, J. Res. Med. Sci., 15, 127
  53. Ganio, 2010, Effect of various carbohydrate-electrolyte fluids on cycling performance and maximal voluntary contraction, Int. J. Sport Nutr. Exerc. Metab., 20, 104, 10.1123/ijsnem.20.2.104 · DOI · Paper page
  54. Robinson, 2012, The effect of energy drinks on cortisol levels, cognition and mood during a fire-fighting exercise, Psychopharmacology, 219, 83, 10.1007/s00213-011-2379-0 · DOI
  55. Ratamess, 2007, Effects of an amino acid/creatine energy supplement on the acute hormonal response to resistance exercise, Int. J. Sport Nutr. Exerc. Metab., 17, 608, 10.1123/ijsnem.17.6.608 · DOI
  56. Chtourou, H., Trabelsi, K., Ammar, A., Shephard, R.J., and Bragazzi, N.L. (2019). Acute Effects of an “Energy Drink” on Short-Term Maximal Performance, Reaction Times, Psychological and Physiological Parameters: Insights from a Randomized Double-Blind, Placebo-Controlled, Counterbalanced Crossover Trial. Nutrients, 11. · DOI
  57. Jacobson, 2018, Effect of Energy Drink Consumption on Power and Velocity of Selected Sport Performance Activities, J. Strength Cond. Res., 32, 1613, 10.1519/JSC.0000000000002026 · DOI
  58. Thomas, C.J., Rothschild, J., Earnest, C.P., and Blaisdell, A. (2019). The Effects of Energy Drink Consumption on Cognitive and Physical Performance in Elite League of Legends Players. Sports, 7. · DOI
  59. 2005, Consumption of an “energy drink” does not improve aerobic performance in male athletes, Int. J. Appl. Sports Sci., 17, 26
  60. Agnol, 2009, Efeitos fisiológicos agudos da taurina contida em uma bebida energética em indivíduos fisicamente ativos, Revista Brasileira Med. Esporte, 15, 123, 10.1590/S1517-86922009000200008 · DOI
  61. Kammerer, 2014, Effects of energy drink major bioactive compounds on the performance of young adults in fitness and cognitive tests: A randomized controlled trial, J. Int. Soc. Sports Nutr., 11, 44, 10.1186/s12970-014-0044-9 · DOI
  62. Pettitt, 2013, Do the noncaffeine ingredients of energy drinks affect metabolic responses to heavy exercise?, J. Strength Cond. Res., 27, 1994, 10.1519/JSC.0b013e3182736e31 · DOI
  63. Hoffman, 2009, Examination of a pre-exercise, high energy supplement on exercise performance, J. Int. Soc. Sports Nutr., 6, 2, 10.1186/1550-2783-6-2 · DOI
  64. Goel, 2014, Effect of red bull energy drink on auditory reaction time and maximal voluntary contraction, Indian J. Physiol. Pharmacol., 58, 17
  65. Petit, 2012, Energy drinks: An unknown risk, Rev. Prat., 62, 673
  66. Holmgren, 2004, Caffeine fatalities—four case reports, Forensic Sci. Int., 139, 71, 10.1016/j.forsciint.2003.09.019 · DOI
  67. Kerrigan, 2005, Fatal caffeine overdose: Two case reports, Forensic Sci. Int., 153, 67, 10.1016/j.forsciint.2005.04.016 · DOI
  68. Rudolph, 2010, A case of fatal caffeine poisoning, Acta Anaesthesiol. Scand., 54, 521, 10.1111/j.1399-6576.2009.02201.x · DOI
  69. Sepkowitz, 2013, Energy drinks and caffeine-related adverse effects, JAMA, 309, 243, 10.1001/jama.2012.173526 · DOI
  70. Dhar, 2005, Cardiovascular toxicities of performance-enhancing substances in sports, Mayo Clin. Proc., 80, 1307, 10.4065/80.10.1307 · DOI · Paper page
  71. Williams, 2008, The effect of ephedra and caffeine on maximal strength and power in resistance-trained athletes, J. Strength Cond. Res., 22, 464, 10.1519/JSC.0b013e3181660320 · DOI
  72. Haller, 2004, Enhanced stimulant and metabolic effects of combined ephedrine and caffeine, Clin. Pharmacol. Ther., 75, 259, 10.1016/j.clpt.2003.11.375 · DOI
  73. Fenster, 1998, Rate of caffeine metabolism and risk of spontaneous abortion, Am. J. Epidemiol., 147, 503, 10.1093/oxfordjournals.aje.a009477 · DOI
  74. Adam, 2005, A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans, Proc. Natl. Acad. Sci. USA, 102, 15676, 10.1073/pnas.0505414102 · DOI · Paper page
  75. Erblang, M., Drogou, C., Gomez-Merino, D., Metlaine, A., Boland, A., Deleuze, J.F., Thomas, C., Sauvet, F., and Chennaoui, M. (2019). The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep. Genes, 10. · DOI
  76. Iio, 2012, The effects of oral taurine administration on behavior and hippocampal signal transduction in rats, Amino Acids, 43, 2037, 10.1007/s00726-012-1282-2 · DOI
  77. Horvath, 2016, The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice, Amino Acids, 48, 2635, 10.1007/s00726-016-2292-2 · DOI
  78. Salinero, J.J., Lara, B., Ruiz-Vicente, D., Areces, F., Puente-Torres, C., Gallo-Salazar, C., Pascual, T., and Del Coso, J. (2017). CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study. Nutrients, 9. · DOI
  79. Pataky, 2016, Caffeine and 3-km cycling performance: Effects of mouth rinsing, genotype, and time of day, Scand. J. Med. Sci. Sports, 26, 613, 10.1111/sms.12501 · DOI
  80. Spineli, H., Pinto, M.P., Dos Santos, B.P., Lima-Silva, A.E., Bertuzzi, R., Gitaí, D.L.G., and de Araujo, G.G. (2020). Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes. Scand. J. Med. Sci. Sports. · DOI · Paper page
  81. Glaister, M., Chopra, K., Pereira De Sena, A., Sternbach, C., Morina, L., and Mavrommatis, Y. (2020). Caffeine, exercise physiology, and time-trial performance: No effect of ADORA2A or CYP1A2 genotypes. Appl. Physiol. Nutr. Metab. · DOI
  82. Davenport, 2020, A Randomised, Placebo-Controlled, Crossover Study Investigating the Optimal Timing of a Caffeine-Containing Supplement for Exercise Performance, Sports Med. Open, 6, 17, 10.1186/s40798-020-00246-x · DOI
  83. Higgins, 2010, Energy beverages: Content and safety, Mayo Clin. Proc., 85, 1033, 10.4065/mcp.2010.0381 · DOI · Paper page
  84. Benowitz, 1990, Clinical pharmacology of caffeine, Annu Rev. Med., 41, 277, 10.1146/annurev.me.41.020190.001425 · DOI · Paper page
  85. Davis, 2003, Central nervous system effects of caffeine and adenosine on fatigue, Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R399, 10.1152/ajpregu.00386.2002 · DOI · Paper page
  86. Bazzucchi, 2011, Caffeine improves neuromuscular function during maximal dynamic exercise, Muscle Nerve, 43, 839, 10.1002/mus.21995 · DOI
  87. McPherson, 1991, The brain ryanodine receptor: A caffeine-sensitive calcium release channel, Neuron, 7, 17, 10.1016/0896-6273(91)90070-G · DOI · Paper page
  88. 2018, Effects of p-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise, Med. Sci. Sports Exerc., 50, 1899, 10.1249/MSS.0000000000001653 · DOI
  89. Portillo, 2017, Effects of Caffeine Ingestion on Skill Performance During an International Female Rugby Sevens Competition, J. Strength Cond. Res., 31, 3351, 10.1519/JSC.0000000000001763 · DOI
  90. Curran, 2017, Taurine, caffeine, and energy drinks: Reviewing the risks to the adolescent brain, Birth Defects Res., 109, 1640, 10.1002/bdr2.1177 · DOI
  91. Ortega, 2013, Neuromuscular responses to incremental caffeine doses: Performance and side effects, Med. Sci. Sports Exerc., 45, 2184, 10.1249/MSS.0b013e31829a6672 · DOI
  92. Nowak, D., Gośliński, M., and Nowatkowska, K. (2018). The Effect of Acute Consumption of Energy Drinks on Blood Pressure, Heart Rate and Blood Glucose in the Group of Young Adults. Int. J. Environ. Res. Public Health, 15. · DOI
  93. Hajsadeghi, 2016, Effects of energy drinks on blood pressure, heart rate, and electrocardiographic parameters: An experimental study on healthy young adults, Anatol. J. Cardiol., 16, 94
  94. Grgic, J., Pickering, C., Bishop, D.J., Del Coso, J., Schoenfeld, B.J., Tinsley, G.M., and Pedisic, Z. (2020). ADOR2A C Allele Carriers Exhibit Ergogenic Responses to Caffeine Supplementation. Nutrients, 12. · DOI
  95. Martins, 2020, Caffeine and Exercise Performance: Possible Directions for Definitive Findings, Front. Sports Act. Living, 2, 574854, 10.3389/fspor.2020.574854 · DOI
  96. Pickering, 2019, Caffeine, CYP1A2 genotype, and sports performance: Is timing important?, Ir. J. Med. Sci., 188, 349, 10.1007/s11845-018-1811-4 · DOI
  97. Ahmetov, 2016, Genes and Athletic Performance: An Update, Med. Sport Sci., 61, 41, 10.1159/000445240 · DOI
  98. Joyner, M.J. (2019). Genetic Approaches for Sports Performance: How Far Away Are We?. Sports Med. · DOI
  99. 2019, Liver-Metabolizing Genes and Their Relationship to the Performance of Elite Spanish Male Endurance Athletes; a Prospective Transversal Study, Sports Med. Open, 5, 50, 10.1186/s40798-019-0227-7 · DOI

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Metadata

Authors
Gutiérrez-Hellín, J., & Varillas-Delgado, D.
Venue
Nutrients
Publisher
MDPI AG
Published
2021-02-24
Volume
13
Issue
3
Pages
715
ISSN
2072-6643
DOI
10.3390/nu13030715
Cited by
67
References
34
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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