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Living with Food Hypersensitivity as an Adolescent Impairs Health Related Quality of Life Irrespective of Disease Severity: Results from a Population-Based Birth Cohort

Jonsson, Marina, Ekström, Sandra, Protudjer, Jennifer L. P., Bergström, Anna, Kull, Inger·2021·Nutrients
DOI 10.3390/nu13072357PMC PMC8308910
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Abstract

Food hypersensitivity (FHS) refers to food-related symptoms, with or without concurrent Immunoglobulin E (IgE) antibodies related to food(s). It remains unclear how different FHS phenotypes affect health-related quality of life (HRQoL). We examined self-reported HRQoL (with the generic instrument EQ-5D (dimensions and a Visual Analogue Scale (VAS), range 0–100) in association with phenotypes of FHS, and food-specific symptoms among adolescents (n = 2990) from a population-based birth cohort. Overall, 22% of the adolescents had FHS. Compared to adolescents without FHS, those with FHS reported more problems in the dimensions of pain/discomfort (p < 0.001), and anxiety/depression (p = 0.007). Females with FHS reported more problems than males in these dimensions (p < 0.001). Different FHS phenotypes (IgE-sensitization, allergic co-morbidity, and severity of symptoms) were not associated with differences in HRQoL. EQ-VAS scores were lowest for adolescents with symptoms for wheat vs. no wheat, median 80 vs. 89, p = 0.04) and milk vs. no milk (median 85 vs. 90, p = 0.03). Physician-diagnosed lactose intolerance median EQ-VAS was 80 vs. 90, p = 0.03 and also associated with more problems in the dimension of anxious/depression. In conclusion, FHS is associated with lower HRQoL in adolescence, irrespective of phenotypes, but differentially affects females vs. males, and those with vs. without symptoms for milk or wheat.

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Figure 1 The distribution of symptoms of different food items among adolescents with food hypersensitivity. Common foods: milk, egg, fish and wheat. Nuts and peanuts: peanut, hazelnut, almond, walnut/pecan, cashew/pistachio, Brazil nuts. Other foods: Shellfish, soy, sesame seed, apple/pear, peach/nectarine/plum/cherry, kiwi, banana and raw carrot.
Figure 1 The distribution of symptoms of different food items among adolescents with food hypersensitivity. Common foods: milk, egg, fish and wheat. Nuts and peanuts: peanut, hazelnut, almond, walnut/pecan, cashew/pistachio, Brazil nuts. Other foods: Shellfish, soy, sesame seed, apple/pear, peach/nectarine/plum/cherry, kiwi, banana and raw carrot.CC BY · PubMed Central
Figure 2 Median EQ VAS and Interquartile Range (IQR) in relation to FHS with specific symptoms to milk and wheat.
Figure 2 Median EQ VAS and Interquartile Range (IQR) in relation to FHS with specific symptoms to milk and wheat.CC BY · PubMed Central

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Research works printed but not linked: 52

  1. Nwaru, 2014, Prevalence of common food allergies in Europe: A systematic review and meta-analysis, Allergy, 69, 992, 10.1111/all.12423 · DOI
  2. Deschildre, 2017, Food allergy phenotypes: The key to personalized therapy, Clin. Exp. Allergy, 47, 1125, 10.1111/cea.12984 · DOI
  3. Sicherer, 2018, Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management, J. Allergy Clin. Immunol., 141, 41, 10.1016/j.jaci.2017.11.003 · DOI
  4. Venter, 2019, EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis, Allergy, 74, 1429, 10.1111/all.13764 · DOI
  5. Tuck, C.J., Biesiekierski, J.R., Schmid-Grendelmeier, P., and Pohl, D. (2019). Food Intolerances. Nutrients, 11. · DOI
  6. Ballardini, 2012, Development and comorbidity of eczema, asthma and rhinitis to age 12: Data from the BAMSE birth cohort, Allergy, 67, 537, 10.1111/j.1398-9995.2012.02786.x · DOI
  7. Pereira, 2005, Prevalence of sensitization to food allergens, reported adverse reaction to foods, food avoidance, and food hypersensitivity among teenagers, J. Allergy Clin. Immunol., 116, 884, 10.1016/j.jaci.2005.05.047 · DOI
  8. Rona, 2007, The prevalence of food allergy: A meta-analysis, J. Allergy Clin. Immunol., 120, 638, 10.1016/j.jaci.2007.05.026 · DOI
  9. Savage, 2015, Food allergy: Epidemiology and natural history, Immunol. Allergy Clin. N. Am., 35, 45, 10.1016/j.iac.2014.09.004 · DOI
  10. Roehr, 2004, Food allergy and non-allergic food hypersensitivity in children and adolescents, Clin. Exp. Allergy, 34, 1534, 10.1111/j.1365-2222.2004.02080.x · DOI
  11. Protudjer, J.L., Vetander, M., Kull, I., Hedlin, G., van Hage, M., Wickman, M., and Bergstrom, A. (2016). Food-Related Symptoms and Food Allergy in Swedish Children from Early Life to Adolescence. PLoS ONE, 11. · DOI
  12. Boyce, 2010, NIAD-sponsored expert panel. Guidelines for the diagnoses and management of food allergy in United States: Summary of NIAID-sponsered expert panel report, J. Allergy Clin. Immunol., 126, 1105, 10.1016/j.jaci.2010.10.008 · DOI
  13. Iweala, 2018, Food Allergy, Curr. Gastroenterol. Rep., 20, 17, 10.1007/s11894-018-0624-y · DOI
  14. Begen, 2018, Eating out with a food allergy in the UK: Change in the eating out practices of consumers with food allergy following introduction of allergen information legislation, Clin. Exp., 48, 317
  15. Begen, F.M., Barnett, J., Barber, M., Payne, R., Gowland, M.H., and Lucas, J.S. (2017). Parents’ and caregivers’ experiences and behaviours when eating out with children with a food hypersensitivity. BMC Public Health, 18. · DOI
  16. Clarke, 2017, Food-induced anaphylaxis to a known food allergen in children often occurs despite adult supervision, Pediatric Allergy Immunol., 28, 715, 10.1111/pai.12770 · DOI
  17. Miles, 2020, When and how pediatric anaphylaxis cases reach the emergency department: Findings from the Cross-Canada Anaphylaxis Registry, J. Allergy Clin. Immunol. Pract., 8, 1406, 10.1016/j.jaip.2019.10.009 · DOI
  18. Lagercrantz, 2017, “Healthcare seems to vary a lot”: A focus group study among parents of children with severe allergy, J. Asthma, 54, 1, 10.1080/02770903.2016.1258079 · DOI
  19. Michaud, 2004, The adolescent with a chronic condition. Part II: Healthcare provision, Arch. Dis. Child., 89, 943, 10.1136/adc.2003.045377 · DOI
  20. Jonsson, 2017, Experiences of Daily Life Among Adolescents with Asthma—A Struggle with Ambivalence, J. Pediatric Nurs., 35, 23, 10.1016/j.pedn.2017.02.005 · DOI
  21. Greenhawt, 2014, Food allergy quality of life, Ann. Allergy Asthma Immunol., 113, 506, 10.1016/j.anai.2014.06.027 · DOI
  22. Haraldstad, K., Kvarme, L.G., Christophersen, K.A., and Helseth, S. (2019). Associations between self-efficacy, bullying and health-related quality of life in a school sample of adolescents: A cross-sectional study. BMC Public Health, 19. · DOI · Paper page
  23. Jonsson, 2016, Asthma during adolescence impairs health-related quality of life, J. Allergy Clin. Immunol. Pract., 4, 144, 10.1016/j.jaip.2015.07.020 · DOI
  24. Covaciu, 2013, Childhood allergies affect health-related quality of life, J. Asthma, 50, 522, 10.3109/02770903.2013.789057 · DOI
  25. Marklund, 2006, Health-related quality of life in food hypersensitive schoolchildren and their families: Parents’ perceptions, Health Qual. Life Outcomes, 4, 48, 10.1186/1477-7525-4-48 · DOI · Paper page
  26. Avery, 2003, Assessment of quality of life in children with peanut allergy, Pediatric Allergy Immunol., 14, 378, 10.1034/j.1399-3038.2003.00072.x · DOI
  27. DunnGalvin, 2008, Development and validation of the self-administered Food Allergy Quality of Life Questionnaire for adolescents, J. Allergy Clin. Immunol., 122, 139, 10.1016/j.jaci.2008.05.008 · DOI
  28. Protudjer, 2016, Impaired health-related quality of life in adolescents with allergy to staple foods, Clin. Transl. Allergy, 6, 37, 10.1186/s13601-016-0128-5 · DOI
  29. Thornqvist, 2019, Health-related quality of life worsens by school age amongst children with food allergy, Clin. Transl. Allergy, 9, 10, 10.1186/s13601-019-0244-0 · DOI
  30. Cavkaytar, 2018, Factors Affecting Food Allergy-Related Quality of Life From Parents’ Perception in Turkish Children, Allergy Asthma Immunol. Res., 10, 379, 10.4168/aair.2018.10.4.379 · DOI
  31. Howe, 2014, What affects quality of life among caregivers of food-allergic children?, Ann. Allergy Asthma Immunol., 113, 69, 10.1016/j.anai.2014.04.016 · DOI
  32. Strinnholm, 2017, Health Related Quality of Life among schoolchildren aged 12–13 years in relation to food hypersensitivity phenotypes: A population-based study, Clin. Transl. Allergy, 7, 20, 10.1186/s13601-017-0156-9 · DOI
  33. Wickman, 2002, The BAMSE project: Presentation of a prospective longitudinal birth cohort study, Pediatric Allergy Immunol., 13, 11, 10.1034/j.1399-3038.13.s.15.10.x · DOI
  34. The EuroQol Group (1990). EuroQol—A new facility for the measurement of health-related quality of life. Health Policy, 16, 199–208. · DOI · Paper page
  35. Rabin, 2001, EQ-5D: A measure of health status from the EuroQol Group, Ann. Med., 33, 337, 10.3109/07853890109002087 · DOI · Paper page
  36. Dahlen, 2014, Factors associated with concordance between parental-reported use and dispensed asthma drugs in adolescents: Findings from the BAMSE birth cohort, Pharmacoepidemiol. Drug Saf., 23, 942, 10.1002/pds.3662 · DOI
  37. Finch, 2018, What is the evidence for the performance of generic preference-based measures? A systematic overview of reviews, Eur. J. Health Econ., 19, 557, 10.1007/s10198-017-0902-x · DOI
  38. Robles, L., and Priefer, R. (2020). Lactose Intolerance: What Your Breath Can Tell You. Diagnostics, 10. · DOI
  39. Ferro, 2016, Emotional and behavioral problems in adolescents and young adults with food allergy, Allergy, 71, 532, 10.1111/all.12829 · DOI
  40. Fong, 2017, Bullying and quality of life in children and adolescents with food allergy, J. Paediatr. Child Health, 53, 630, 10.1111/jpc.13570 · DOI
  41. DunnGalvin, 2010, Health-related quality of life of food allergic patients measured with generic and disease-specific questionnaires, Allergy, 65, 1031, 10.1111/j.1398-9995.2009.02304.x · DOI
  42. Verboom, 2014, Longitudinal associations between depressive problems, academic performance, and social functioning in adolescent boys and girls, Dev. Psychol., 50, 247, 10.1037/a0032547 · DOI · Paper page
  43. Hourihane, 2016, Health-related quality of life in food allergy: Impact, correlates, and predictors, Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 59, 841, 10.1007/s00103-016-2368-x · DOI
  44. Stukus, 2016, Leaving home: Helping teens with allergic conditions become independent, Ann. Allergy Asthma Immunol., 116, 388, 10.1016/j.anai.2016.03.026 · DOI
  45. Stensgaard, 2017, Quality of life in childhood, adolescence and adult food allergy: Patient and parent perspectives, Clin. Exp. Allergy, 47, 530, 10.1111/cea.12849 · DOI
  46. Venter, 2015, Health-related quality of life in children with perceived and diagnosed food hypersensitivity, Pediatric Allergy Immunol., 26, 126, 10.1111/pai.12337 · DOI
  47. Wassenberg, 2012, Parent perceived quality of life is age-dependent in children with food allergy, Pediatric Allergy Immunol., 23, 412, 10.1111/j.1399-3038.2012.01310.x · DOI
  48. Protudjer, 2019, Food allergy-related concerns during the transition to self-management, Allergy Asthma Clin. Immunol., 15, 54, 10.1186/s13223-019-0370-1 · DOI
  49. Hamshaw, 2019, Perceptions of Food Hypersensitivity Expertise on Social Media: Qualitative Study, Interact. J. Med. Res., 8, e10812, 10.2196/10812 · DOI
  50. Hart, 2004, The role of the Internet in patient-practitioner relationships: Findings from a qualitative research study, J. Med. Internet Res., 6, e36, 10.2196/jmir.6.3.e36 · DOI · Paper page
  51. Haahtela, 2017, The Finnish Allergy Programme 2008–2018 works, Eur. Respir. J., 49, 1700470, 10.1183/13993003.00470-2017 · DOI
  52. Quigley, 2017, Food Allergy in Patients Seeking Mental Health Care: What the Practicing Psychiatrist Should Know, Curr. Psychiatry Rep., 19, 99, 10.1007/s11920-017-0849-8 · DOI

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Metadata

Authors
Jonsson, M., Ekström, S., Protudjer, J. L. P., Bergström, A., & Kull, I.
Venue
Nutrients
Publisher
MDPI AG
Published
2021-07-09
Volume
13
Issue
7
Pages
2357
ISSN
2072-6643
DOI
10.3390/nu13072357
PMC
PMC8308910
Cited by
11
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • the Swedish Asthma and Allergy research foundation (F2017-0007)
  • the Swedish Research Council for Health, Working Life and Welfare (2010-00451, 2017-00526)
  • Swedish Heart-Lung Foundation (20180579)
  • the European Research Council (757919)

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CoChat. (2026). Citation check: Living with Food Hypersensitivity as an Adolescent Impairs Health Related Quality of Life Irrespective of Disease Severity: Results from a Population-Based Birth Cohort. https://app.cochat.ai/papers/10.3390/nu13072357
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Jonsson, M., Ekström, S., Protudjer, J. L. P., Bergström, A., & Kull, I. (2021). Living with Food Hypersensitivity as an Adolescent Impairs Health Related Quality of Life Irrespective of Disease Severity: Results from a Population-Based Birth Cohort. Nutrients. https://doi.org/10.3390/nu13072357