Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 32

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Athletes Can Benefit from Increased Intake of EPA and DHA—Evaluating the Evidence

Tomczyk, Maja, Heileson, Jeffery L., Babiarz, Mirosław, Calder, Philip C.·2023·Nutrients

Abstract

Fatty fish, which include mackerel, herring, salmon and sardines, and certain species of algae (e.g., Schizochytrium sp., Crytthecodiniumcohnii and Phaeodactylumtricornutum) are the only naturally rich sources of the omega-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA and DHA are the most biologically active members of the n-3 PUFA family. Limited dietary sources and fluctuating content of EPA and DHA in fish raise concerns about the status of EPA and DHA among athletes, as confirmed in a number of studies. The beneficial effects of EPA and DHA include controlling inflammation, supporting nervous system function, maintaining muscle mass after injury and improving training adaptation. Due to their inadequate intake and beneficial health-promoting effects, athletes might wish to consider using supplements that provide EPA and DHA. Here, we provide an overview of the effects of EPA and DHA that are relevant to athletes and discuss the pros and cons of supplements as a source of EPA and DHA for athletes.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/nu15234925

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 14 references

Research works printed but not linked: 117

  1. Baker, 2016, Metabolism and functional effects of plant-derived omega-3 fatty acids in humans, Prog. Lipid Res., 64, 30, 10.1016/j.plipres.2016.07.002 · DOI · Paper page
  2. Emken, 1999, Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic, and linolenic acids by male subjects, Lipids, 34, 785, 10.1007/s11745-999-0424-2 · DOI
  3. Salem, 1999, In vivo conversion of linoleic acid to arachidonic acid in human adults, Prostaglandins Leukot. Essent. Fat. Acids, 60, 407, 10.1016/S0952-3278(99)80021-0 · DOI
  4. Hussein, 2005, Long-chain conversion of [13C]linoleic acid and α-linolenic acid in response to marked changes in their dietary intake in men, J. Lipid Res., 46, 269, 10.1194/jlr.M400225-JLR200 · DOI · Paper page
  5. Pawlosky, 2001, Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans, J. Lipid Res., 42, 1257, 10.1016/S0022-2275(20)31576-5 · DOI · Paper page
  6. Harris, 2004, The Omega-3 Index: A new risk factor for death from coronary heart disease?, Prev. Med., 39, 212, 10.1016/j.ypmed.2004.02.030 · DOI · Paper page
  7. Kemper, 2014, Low omega-3 index in 106 German elite winter endurance athletes: A pilot study, Int. J. Sport Nutr. Exerc. Metab., 24, 559564
  8. Craddock, 2022, A cross-sectional comparison of the whole blood fatty acid profile and omega-3 index of male vegan and omnivorous endurance athletes, J. Am. Nutr. Assoc., 41, 333
  9. Anzalone, 2019, The omega-3 index in National Collegiate Athletic Association division I collegiate football athletes, J. Athl. Train., 54, 7, 10.4085/1062-6050-387-18 · DOI
  10. Lust, 2023, The dose-response effect of docosahexaenoic acid on the omega-3 index in American football athletes, Med. Sci. Sports Exerc., 55, 865, 10.1249/MSS.0000000000003117 · DOI
  11. Davis, 2021, Evaluation of omega-3 status in professional basketball players, J. Strength Cond. Res., 35, 1794, 10.1519/JSC.0000000000004023 · DOI
  12. Kunces, 2021, Molecular deficits relevant to concussion are prevalent in top-ranked football players entering the national football league draft, J. Strength Cond. Res., 35, 339, 10.1519/JSC.0000000000004131 · DOI
  13. Armstrong, A., Anzalone, A.J., Pethick, W., Murray, H., Dahlquist, D.T., Askow, A.T., Heileson, J.L., Hillyer, L.M., Ma, D.W.L., and Oliver, J.M. (2021). An evaluation of omega-3 status and intake in Canadian elite rugby 7s players. Nutrients, 13. · DOI
  14. 2012, Altered plasma and erythrocyte phospholipid fatty acid profile in elite female water polo and football players, Appl. Physiol. Nutr. Metab., 37, 40, 10.1139/h11-125 · DOI
  15. Esteve, 2011, DHA-rich fish oil improves complex reaction time in female elite soccer players, J. Sports Sci. Med., 10, 301
  16. Oliver, 2016, Effect of docosahexaenoic acid on a biomarker of head trauma in American Football, Med. Sci. Sports Exerc., 48, 974, 10.1249/MSS.0000000000000875 · DOI · Paper page
  17. Heileson, 2023, The effect of fish oil supplementation on resistance training-induced adaptations, J. Int. Soc. Sports Nutr., 20, 2174704, 10.1080/15502783.2023.2174704 · DOI
  18. You, 2010, Dietary fish oil inhibits the early stage of recovery of atrophied soleus muscle in rats via Akt-p70s6k signaling and PGF2α, J. Nutr. Biochem., 21, 929, 10.1016/j.jnutbio.2009.07.007 · DOI · Paper page
  19. McGlory, 2019, Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women, FASEB J., 33, 4586, 10.1096/fj.201801857RRR · DOI
  20. Tomczyk, 2023, Effects of 12 wk of omega-3 fatty acid supplementation in long-distance runners, Med. Sci. Sports Exerc., 55, 216, 10.1249/MSS.0000000000003038 · DOI
  21. Tsuchiya, 2016, Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint range of motion after eccentric contractions: A randomized, double-blind, placebo-controlled, parallel-group trial, Eur. J. Appl. Physiol., 116, 216
  22. Calder, 2012, Mechanisms of action of (n-3) fatty acids, J. Nutr., 142, 592S, 10.3945/jn.111.155259 · DOI · Paper page
  23. Deckelbaum, 2006, n-3 fatty acids and gene expression, Am. J. Clin. Nutr., 83, 1520S, 10.1093/ajcn/83.6.1520S · DOI · Paper page
  24. Calder, 2020, N-3 PUFA and inflammation: From membrane to nucleus and from bench to bedside, Proc. Nutr. Soc., 79, 404, 10.1017/S0029665120007077 · DOI
  25. Christiansen, 2015, Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases, Br. J. Nutr., 113, 1677, 10.1017/S000711451500118X · DOI
  26. Moniri, 2016, Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders, Biochem. Pharmacol., 110–111, 1, 10.1016/j.bcp.2016.01.021 · DOI
  27. Im, 2016, Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages, Eur. J. Pharmacol., 785, 36, 10.1016/j.ejphar.2015.03.094 · DOI
  28. Weatherill, 2005, Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4, J. Immunol., 174, 5390, 10.4049/jimmunol.174.9.5390 · DOI · Paper page
  29. Wong, 2009, Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner, J. Biol. Chem., 284, 27384, 10.1074/jbc.M109.044065 · DOI · Paper page
  30. Gani, 2008, Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor α, J. Mol. Graph. Model., 27, 217, 10.1016/j.jmgm.2008.04.008 · DOI
  31. Allred, 2008, PPARγ1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells, J. Nutr., 138, 250, 10.1093/jn/138.2.250 · DOI
  32. Genolet, 2004, PPARs as drug targets to modulate inflammatory responses?, Curr. Drug Targets Inflamm. Allergy, 3, 361, 10.2174/1568010042634578 · DOI
  33. Dyall, 2022, Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions, Prog. Lipid Res., 86, 101165, 10.1016/j.plipres.2022.101165 · DOI · Paper page
  34. Panigrahy, 2021, Resolution of inflammation: An organizing principle in biology and medicine, Pharmacol. Ther., 227, 107879, 10.1016/j.pharmthera.2021.107879 · DOI · Paper page
  35. Chiang, 2020, Specialized pro-resolving mediator network: An update on production and actions, Essays Biochem., 64, 443, 10.1042/EBC20200018 · DOI · Paper page
  36. Calder, 2009, Inflammatory disease processes and interactions with nutrition, Br. J. Nutr., 101, S1, 10.1017/S0007114509377867 · DOI · Paper page
  37. Calder, 2013, A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies, Br. J. Nutr., 109, S1, 10.1017/S0007114512005119 · DOI · Paper page
  38. Calder, 2017, Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition, Ageing Res. Rev., 40, 95, 10.1016/j.arr.2017.09.001 · DOI · Paper page
  39. Minihane, 2015, Low-grade inflammation, diet composition and health: Current research evidence and its translation, Br. J. Nutr., 114, 999, 10.1017/S0007114515002093 · DOI · Paper page
  40. Meijerink, 2013, N-acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids—From fishy endocannabinoids to potential leads, Br. J. Pharmacol., 169, 772, 10.1111/bph.12030 · DOI
  41. Wainwright, 2013, Endocannabinoid system as a potential mechanism for n-3 long-chain polyunsaturated fatty acid mediated cardiovascular protection, Proc. Nutr. Soc., 72, 460, 10.1017/S0029665113003406 · DOI
  42. Dyall, 2017, Interplay between n-3 and n-6 long-chain polyunsaturated fatty acids and the endocannabinoid system in brain protection and repair, Lipids, 52, 885, 10.1007/s11745-017-4292-8 · DOI
  43. Kim, 2018, N-docosahexaenoylethanolamine: A neurotrophic and neuroprotective metabolite of docosahexaenoic acid, Mol. Asp. Med., 64, 34, 10.1016/j.mam.2018.03.004 · DOI
  44. Witkamp, 2019, The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation, Prostaglandins Other Lipid Mediat., 144, 106351, 10.1016/j.prostaglandins.2019.106351 · DOI
  45. Mallick, 2019, Docosahexaenoic acid,22:6n-3: Its roles in the structure and function of the brain, Int. J. Dev. Neurosci., 79, 21, 10.1016/j.ijdevneu.2019.10.004 · DOI
  46. Calder, 2016, Docosahexaenoic acid, Ann. Nutr. Metab., 69, S7, 10.1159/000448262 · DOI
  47. Calder, 2017, Omega-3: The good oil, Nutr. Bull., 42, 132, 10.1111/nbu.12261 · DOI
  48. Aidos, 2002, Seasonal changes in crude and lipid composition of herring fillets, byproducts, and respective produced oils, J. Agric. Food Chem., 50, 4589, 10.1021/jf0115995 · DOI
  49. Hooks, M.P., Madigan, S.M., Woodside, J.V., and Nugent, A.P. (2023). Dietary intake, biological status, and barriers towards omega-3 intake in elite level (tier 4), female athletes: Pilot study. Nutrients, 15. · DOI
  50. Bogard, 2019, Will fish be part of future healthy and sustainable diets?, Lancet Planet. Health, 3, e159, 10.1016/S2542-5196(19)30018-X · DOI
  51. Chang, 2020, Optimization of cultivation conditions for efficient production of carotenoid-rich DHA oil by Schizochytrium sp. S31, Process Biochem., 94, 190, 10.1016/j.procbio.2020.04.007 · DOI
  52. Zeb, 2019, Microwave-assisted three-liquid-phase salting-out extraction of docosahexaenoic acid (DHA)-rich oil from cultivation broths of Schizochytrium limacinium SR21, Food Bioprod. Process., 118, 237, 10.1016/j.fbp.2019.09.008 · DOI
  53. European Food Safety Authority (2010). Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids and cholesterol. EFSA J., 8, 1461. · DOI
  54. Vannice, 2014, Position of the academy of nutrition and dietetics: Dietary fatty acids for healthy adults, J. Acad. Nutr. Diet., 114, 136, 10.1016/j.jand.2013.11.001 · DOI · Paper page
  55. Simopoulos, 2000, Workshop statement on the essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids, Prostagland Leukot Essent Fatty Acids, 63, 119, 10.1054/plef.2000.0176 · DOI · Paper page
  56. Jackson, 2019, Association of reported fish intake and supplementation status with the omega-3 index, Prostaglandins Leukot. Essent. Fat. Acids, 142, 4, 10.1016/j.plefa.2019.01.002 · DOI
  57. Block, 2008, Determinants of blood cell omega-3 fatty acid content, Open Biomark. J., 1, 1, 10.2174/1875318300801010001 · DOI
  58. Dempsey, 2023, The influence of dietary and supplemental omega-3 fatty acids on the omega-3 index: A scoping review, Front. Nutr., 10, 1072653, 10.3389/fnut.2023.1072653 · DOI
  59. Black, 2018, Adding omega-3 fatty acids to a protein-based supplement during pre-season training results in reduced muscle soreness and the better maintenance of explosive power in professional Rugby Union players, Eur. J. Sport Sci., 18, 1357, 10.1080/17461391.2018.1491626 · DOI
  60. Theadom, 2020, Incidence of sports-related traumatic brain injury of all severities: A systematic review, Neuroepidemiology, 54, 1516, 10.1159/000505424 · DOI
  61. Lemme, 2020, Incidence of combat sport-related mild traumatic brain injuries presenting to the emergency department from 2012 to 2016, Clin. J. Sport Med. Off. J. Can. Acad. Sport Med., 30, 585, 10.1097/JSM.0000000000000633 · DOI
  62. Langlois, 2006, The epidemiology and impact of traumatic brain injury: A brief overview, J. Head Trauma Rehabil., 21, 375, 10.1097/00001199-200609000-00001 · DOI · Paper page
  63. Zhu, 2018, Docosahexaenoic acid (DHA) provides neuroprotection in traumatic brain injury models via activating Nrf2-ARE signaling, Inflammation, 41, 1182, 10.1007/s10753-018-0765-z · DOI
  64. Zhu, 2020, Docosahexaenoic acid protects traumatic brain injury by regulating NOX2 generation via Nrf2 signaling pathway, Neurochem. Res., 45, 1839, 10.1007/s11064-020-03078-z · DOI
  65. Lust, 2020, Sports-related concussions and subconcussive impacts in athletes: Incidence, diagnosis, and the emerging role of EPA and DHA, Appl. Physiol. Nutr. Metab., 45, s886, 10.1139/apnm-2019-0555 · DOI · Paper page
  66. Patch, 2021, The more, the better: High-dose omega-3 fatty acids improve behavioural and molecular outcomes in preclinical models in mild brain injury, Curr. Neurol. Neurosci. Rep., 21, 45, 10.1007/s11910-021-01132-z · DOI
  67. Heileson, 2021, The effect of omega-3 fatty acids on a biomarker of head trauma in NCAA football athletes: A multi-site, non-randomized study, J. Int. Soc. Sports Nutr., 18, 65, 10.1186/s12970-021-00461-1 · DOI
  68. Mullins, V.A., Graham, S., Cummings, D., Wood, A., Ovando, V., Skulas-Ray, A.C., Polian, D., Wang, Y., Hernandez, G.D., and Lopez, C.M. (2022). Effects of fish oil on biomarkers of axonal injury and inflammation in American football players: A placebo-controlled randomized controlled trial. Nutrients, 14. · DOI
  69. Raikes, 2022, Effects of docosahexaenoic acid and eicosapentaoic acid supplementation on white matter integrity after repetitive sub-concussive head impacts during American football: Exploratory neuroimaging findings from a pilot RCT, Front. Neurol., 13, 891531, 10.3389/fneur.2022.891531 · DOI
  70. Miller, 2022, A pilot randomized controlled trial of docosahexaenoic acid for the treatment of sport-related concussion in adolescents, Clin. Pediatr., 61, 785, 10.1177/00099228221101726 · DOI · Paper page
  71. Bostock, 2017, Omega-3 fatty acids and vitamin D in immobilisation: Part A—Modulation of appendicular mass content, composition and structure, J. Nutr. Health Aging, 21, 51, 10.1007/s12603-016-0710-5 · DOI
  72. Owens, 2019, Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions?, Eur. J. Sport Sci., 19, 71, 10.1080/17461391.2018.1505957 · DOI · Paper page
  73. Heileson, 2020, The effect of fish oil supplementation on the promotion and preservation of lean body mass, strength, and recovery from physiological stress in young, healthy adults: A systematic review, Nutr. Rev., 78, 1001, 10.1093/nutrit/nuaa034 · DOI
  74. Harty, 2019, Nutritional and supplementation strategies to prevent and attenuate exercise-induced muscle damage: A brief review, Sports Med. Open, 5, 1, 10.1186/s40798-018-0176-6 · DOI
  75. Tartibian, 2009, The effects of ingestion of omega-3 fatty acids on perceived pain and external symptoms of delayed onset muscle soreness in untrained men, Clin. J. Sport Med., 19, 115, 10.1097/JSM.0b013e31819b51b3 · DOI
  76. Ramos-Campo, D.J., Ávila-Gandía, V., López-Román, F.J., Miñarro, J., Contreras, C., Soto-Méndez, F., Pedrol JC, D., and Luque-Rubia, A.J. (2020). Supplementation of re-esterified docosahexaenoic and eicosapentaenoic acids reduce inflammatory and muscle damage markers after exercise in endurance athletes: A randomized, controlled crossover trial. Nutrients, 12. · DOI
  77. Tsuchiya, 2019, Supplementation of eicosapentaenoic acid-rich fish oil attenuates muscle stiffness after eccentric contractions of human elbow flexors, J. Int. Soc. Sports Nutr., 16, 19, 10.1186/s12970-019-0283-x · DOI
  78. Corder, 2016, Effects of short-term docosahexaenoic acid supplementation on markers of inflammation after eccentric strength exercise in women, J. Sports Sci. Med., 15, 176
  79. Jouris, 2011, The effect of omega-3 fatty acid supplementation on the inflammatory response to eccentric strength exercise, J. Sports Sci. Med., 10, 432
  80. Lembke, 2014, Influence of omega-3 (N3) index on performance and wellbeing in young adults after heavy eccentric exercise, J. Sports Sci. Med., 13, 151
  81. van Dusseldorp, T.A., Escobar, K.A., Johnson, K.E., Stratton, M.T., Moriarty, T., Kerksick, C.M., Mangine, G.T., Holmes, A.J., Lee, M., and Endito, M.R. (2020). Impact of varying dosages of fish oil on recovery and soreness following eccentric exercise. Nutrients, 12. · DOI
  82. Philpott, 2018, Adding fish oil to whey protein, leucine, and carbohydrate over a six-week supplementation period attenuates muscle soreness following eccentric exercise in competitive soccer players, Int. J. Sport Nutr. Exerc. Metab., 28, 26, 10.1123/ijsnem.2017-0161 · DOI
  83. Kyriakidou, 2021, The effect of omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage, J. Int. Soc. Sports Nutr., 18, 9, 10.1186/s12970-020-00405-1 · DOI
  84. Anthony, R., MaCartney, M.J., Heileson, J.L., McLennan, P.L., and Peoples, G.E. (Nutr. Res. Rev., 2023). A review and evaluation of study design considerations for omega-3 fatty acid supplementation trials in physically trained participants, Nutr. Res. Rev., in press. · DOI
  85. Philpott, 2019, Influence of fish oil-derived n-3 fatty acid supplementation on changes in body composition and muscle strength during short-term weight loss in resistance-trained men, Front. Nutr., 6, 102, 10.3389/fnut.2019.00102 · DOI
  86. Raastad, 1997, Omega-3 fatty acid supplementation does not improve maximal aerobic power, anaerobic threshold and running performance in well-trained soccer players, Scand. J. Med. Sci. Sports, 7, 25, 10.1111/j.1600-0838.1997.tb00113.x · DOI · Paper page
  87. Mizia, 2015, Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes, Eur. J. Sport Sci., 15, 305, 10.1080/17461391.2014.949310 · DOI
  88. Thielecke, F., and Blannin, A. (2020). Omega-3 fatty acids for sport performance—Are they equally beneficial for athletes and amateurs? A narrative review. Nutrients, 12. · DOI
  89. Browning, 2012, Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish, Am. J. Clin. Nutr., 96, 748, 10.3945/ajcn.112.041343 · DOI · Paper page
  90. Villani, A.M., Crotty, M., Cleland, L.G., James, M.J., Fraser, R.J., Cobiac, L., and Miller, M.D. (2013). Fish oil administration in older adults: Is there potential for adverse events? A systematic review of the literature. BMC Geriatr., 13. · DOI
  91. Dyerberg, 1979, Haemostatic function and platelet polyunsaturated fatty acids in Eskimos, Lancet, 8140, 433, 10.1016/S0140-6736(79)91490-9 · DOI · Paper page
  92. Bang, 1976, The composition of food consumed by Greenland Eskimos, Acta Medica Scand., 200, 69, 10.1111/j.0954-6820.1976.tb08198.x · DOI · Paper page
  93. Wachira, 2014, n-3 fatty acids affect haemostasis but do not increase the risk of bleeding: Clinical observations and mechanistic insights, Br. J. Nutr., 111, 1652, 10.1017/S000711451300425X · DOI · Paper page
  94. Jeansen, 2018, Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition, Clin. Nutr., 37, 948, 10.1016/j.clnu.2017.03.027 · DOI
  95. Akintoye, 2018, Fish oil and perioperative bleeding, Circ. Cardiovasc. Qual. Outcomes, 11, e004584, 10.1161/CIRCOUTCOMES.118.004584 · DOI
  96. Jairoun, A.A., Shahwan, M., and Zyoud, S.H. (2020). Fish oil supplements, oxidative status, and compliance behaviour: Regulatory challenges and opportunities. PLoS ONE, 15. · DOI
  97. EFSA (2012). Scientific opinion on the tolerable upper intake level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA). EFSA J., 10, 2815. · DOI · Paper page
  98. Lien, 2009, Toxicology and safety of DHA, Prostaglandins Leukot. Essent. Fat. Acids, 81, 125, 10.1016/j.plefa.2009.05.004 · DOI
  99. U.S. Food and Drug Administration (2019). Qualified Health Claims: Letters of Enforcement Discretion.
  100. Mozaffarian, 2006, Fish intake, contaminants, and human health evaluating the risks and the benefits, JAMA, 296, 1885, 10.1001/jama.296.15.1885 · DOI · Paper page
  101. Fischer, 1985, Long-term effects of dietary marine ω-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans, J. Clin. Investig., 76, 1626, 10.1172/JCI112147 · DOI · Paper page
  102. Blonk, 1990, Dose-response effects of fish-oil supplementation in healthy volunteers, Am. J. Clin. Nutr., 52, 120, 10.1093/ajcn/52.1.120 · DOI
  103. Harris, 1991, Effects of four doses of n-3 fatty acids given to hyperlipidemic patients for six months, J. Am. Coll. Nutr., 10, 220, 10.1080/07315724.1991.10718148 · DOI
  104. Rees, 2006, Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: A comparison of young and older men, Am. J. Clin. Nutr., 83, 331, 10.1093/ajcn/83.2.331 · DOI · Paper page
  105. Faber, 2011, Supplementation with a fish oil-enriched, high-protein medical food leads to rapid incorporation of EPA into white blood cells and modulates immune responses within one week in healthy men and women, J. Nutr., 141, 964, 10.3945/jn.110.132985 · DOI
  106. Yaqoob, 2000, Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions, Eur. J. Clin. Investig., 30, 260, 10.1046/j.1365-2362.2000.00623.x · DOI · Paper page
  107. Katan, 1997, Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: An 18-month controlled study, J. Lipid Res., 38, 2012, 10.1016/S0022-2275(20)37132-7 · DOI · Paper page
  108. Marsen, 1992, Pharmacokinetics of omega-3-fatty acids during ingestion of fish oil preparations, Prostaglandins Leukot. Essent. Fat. Acids, 46, 191, 10.1016/0952-3278(92)90069-U · DOI
  109. West, 2016, Lipid structure does not modify incorporation of EPA and DHA into blood lipids in healthy adults: A randomised-controlled trial, Br. J. Nutr., 116, 788, 10.1017/S0007114516002713 · DOI
  110. Colette, 1987, Enteral absorption in man of eicosapentaenoic acid in different chemical forms, Lipids, 22, 711, 10.1007/BF02533970 · DOI
  111. Schuchardt, 2011, Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial, Prostaglandins Leukot. Essent. Fat. Acids, 85, 381, 10.1016/j.plefa.2011.07.006 · DOI
  112. Qin, 2017, A novel self-micro-emulsifying delivery system (SMEDS) formulation significantly improves the fasting absorption of EPA and DHA from a single dose of an omega-3 ethyl ester concentrate, Lipids Health Dis., 16, 204, 10.1186/s12944-017-0589-0 · DOI
  113. West, 2018, A novel self-micro-emulsifying delivery system enhances enrichment of eicosapentaenoic acid and docosahexaenoic acid after single and repeated dosing in healthy adults in a randomized trial, J. Nutr., 148, 1704, 10.1093/jn/nxy127 · DOI
  114. Fisk, 2021, A novel n-3 glyceride mixture enhances enrichment of EPA and DHA after single dosing in healthy older adults: Results from a double-blind crossover trial, Br. J. Nutr., 126, 244, 10.1017/S0007114520004031 · DOI
  115. Kagan, 2013, Acute appearance of fatty acids in human plasma—A comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males, Lipids Health Dis., 12, 102, 10.1186/1476-511X-12-102 · DOI
  116. Schuchardt, 2013, Bioavailability of long-chain omega-3 fatty acids, Prostaglandins Leukot. Essent. Fat. Acids, 89, 18, 10.1016/j.plefa.2013.03.010 · DOI · Paper page
  117. Innes, J.K., and Calder, P.C. (2018). The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiometabolic risk factors: A systematic review. Int. J. Mol. Sci., 19. · DOI

Metadata

Authors
Tomczyk, M., Heileson, J. L., Babiarz, M., & Calder, P. C.
Venue
Nutrients
Publisher
MDPI AG
Published
2023-11-26
Volume
15
Issue
23
Pages
4925
ISSN
2072-6643
Cited by
32
References
14
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Athletes Can Benefit from Increased Intake of EPA and DHA—Evaluating the Evidence. https://app.cochat.ai/papers/10.3390/nu15234925
The paper
Tomczyk, M., Heileson, J. L., Babiarz, M., & Calder, P. C. (2023). Athletes Can Benefit from Increased Intake of EPA and DHA—Evaluating the Evidence. Nutrients. https://doi.org/10.3390/nu15234925

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.