High-Fat Diet Augments Myocardial Inflammation and Cardiac Dysfunction in Arrhythmogenic Cardiomyopathy
Open accessAbstract
Arrhythmogenic cardiomyopathy (ACM) is a familial heart disease characterized by cardiac dysfunction, arrhythmias, and myocardial inflammation. Exercise and stress can influence the disease’s progression. Thus, an investigation of whether a high-fat diet (HFD) contributes to ACM pathogenesis is warranted. In a robust ACM mouse model, 8-week-old Desmoglein-2 mutant (Dsg2mut/mut) mice were fed either an HFD or rodent chow for 8 weeks. Chow-fed wildtype (WT) mice served as controls. Echo- and electrocardiography images pre- and post-dietary intervention were obtained, and the lipid burden, inflammatory markers, and myocardial fibrosis were assessed at the study endpoint. HFD-fed Dsg2mut/mut mice showed numerous P-wave perturbations, reduced R-amplitude, left ventricle (LV) remodeling, and reduced ejection fraction (%LVEF). Notable elevations in plasma high-density lipoprotein (HDL) were observed, which correlated with the %LVEF. The myocardial inflammatory adipokines, adiponectin (AdipoQ) and fibroblast growth factor-1, were substantially elevated in HFD-fed Dsg2mut/mut mice, albeit no compounding effect was observed in cardiac fibrosis. The HFD not only potentiated cardiac dysfunction but additionally promoted adverse cardiac remodeling. Further investigation is warranted, particularly given elevated AdipoQ levels and the positive correlation of HDL with the %LVEF, which may suggest a protective effect. Altogether, the HFD worsened some, but not all, disease phenotypes in Dsg2mut/mut mice. Notwithstanding, diet may be a modifiable environmental factor in ACM disease progression.
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Multiple pro-inflammatory cytokines and chemokines are upregulated early in ACM pathogenesis.
“Multiple pro-inflammatory cytokines and chemokines have been shown to be upregulated early in ACM pathogenesis.”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [35]
The Introduction reports increased inflammatory cytokine and chemokine levels in ACM, and Results §3.3 identifies elevated inflammatory markers in Dsg2-mutant mice. But the measurements were made at 16 weeks, after cardiac dysfunction had developed; the paper does not establish that these markers are upregulated early in ACM pathogenesis. (LLM, conf=0.87)
Experimental — accuracy not yet measuredHigh-fat diet exposure in Dsg2mut/mut mice dramatically elevates myocardial levels of adiponectin (AdipoQ) and fibroblast growth factor 1 (FGF1).
“high-fat diet (HFD) exposure in Dsg2mut/mut mice dramatically elevates myocardial levels of adiponectin (AdipoQ) and fibroblast growth factor 1 (FGF1) [35].”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [35]
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Cites
Obesity and cardiovascular disease: a scientific statement from the American Heart Association
Powell-Wiley, T. M., Poirier, P., Burke, L. E., Després, J.-P., Gordon-Larsen, P., Lavie, C. J., Lear, S. A., Ndumele, C. E., Neeland, I. J., Sanders, P., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000973 · Cited by 3,691 · see citing works
Role of C-Reactive Protein at Sites of Inflammation and Infection
Sproston, N. R., & Ashworth, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00754 · Cited by 3,053 · see citing works
McKenna, W. J., Thiene, G., Nava, A. K., Fontaliran, F., Blomström‐Lundqvist, C., Fontaine, G. H., & Camerini, F. (1994) · Heart · doi:10.1136/hrt.71.3.215 · Cited by 1,649 · see citing works
Right Ventricular Dysplasia: A Report of 24 Adult Cases
Marcus, F. I., Fontaine, G. H., Guiraudon, G., Frank, R., Laurenceau, J. L., Malergue, C., & Grosgogeat, Y. (1982) · Circulation · doi:10.1161/01.cir.65.2.384 · Cited by 1,603 · see citing works
Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association
Sacks, F. M., Lichtenstein, A. H., Wu, J. H. Y., Appel, L. J., Creager, M. A., Kris-Etherton, P. M., Miller, M., Rimm, E. B., Rudel, L. L., Robinson, J. G., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000510 · Cited by 1,386 · see citing works
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
Elumalai, A., & Jain, S. K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061321 · Cited by 1,172 · see citing works
Resistin, an Adipokine with Potent Proinflammatory Properties
Bokarewa, M. I., Nagaev, I., Dahlberg, L., Smith, U., & Tarkowski, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5789 · Cited by 1,037 · see citing works
Corrado, D., Basso, C., Thiene, G., McKenna, W. J., Davies, M. J., Fontaliran, F., Nava, A., Silvestri, F., Blomstrom-Lundqvist, C., Wlodarska, E. K., et al. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00332-x · Cited by 978 · see citing works
Arrhythmogenic Right Ventricular Cardiomyopathy
Corrado, D., Link, M. S., & Calkins, H. G. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1509267 · Cited by 739 · see citing works
Madsen, C. M., Varbo, A., & Nordestgaard, B. G. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx163 · Cited by 715 · see citing works
Trends in Dietary Carbohydrate, Protein, and Fat Intake and Diet Quality Among US Adults, 1999-2016
Shan, Z., Rehm, C. D., Rogers, G. T., Ruan, M., Wang, D. D., Hu, F. B., Mozaffarian, D., Zhang, F. F., & Bhupathiraju, S. N. (2019) · JAMA · doi:10.1001/jama.2019.13771 · Cited by 558 · see citing works
Inflammatory Links Between High Fat Diets and Diseases
Duan, Y., Zeng, L., Zheng, C., Song, B., Li, F., Kong, X., & Xu, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02649 · Cited by 495 · see citing works
A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis
Brandsma, E. T., Kloosterhuis, N., Koster, M. H., Dekker, D., Gijbels, M. J., van der Velden, S., Ríos-Morales, M., van Faassen, M. H. J. R., Loreti, M. G., de Bruin, A., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.313234 · Cited by 376 · see citing works
Ali, K. M., Wonnerth, A., Huber, K., & Wojta, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02081.x · Cited by 296 · see citing works
Molecular mechanisms of arrhythmogenic cardiomyopathy
Austin, K. M., Trembley, M. A., Chandler, S. F., Sanders, S. P., Saffitz, J. E., Abrams, D. J., & Pu, W. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0200-7 · Cited by 265 · see citing works
Use of high-fat diets to study rodent obesity as a model of human obesity
Speakman, J. R. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0363-7 · Cited by 261 · see citing works
Saturated fats and cardiovascular health: Current evidence and controversies
Maki, K. C., Dicklin, M. R., & Kirkpatrick, C. F. (2021) · Journal of clinical lipidology · doi:10.1016/j.jacl.2021.09.049 · Cited by 218 · see citing works
Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy
Chelko, S. P., Asimaki, A., Lowenthal, J., Bueno-Beti, C., Bedja, D., Scalco, A., Amat-Alarcon, N., Andersen, P., Judge, D. P., Tung, L., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.040676 · Cited by 192 · see citing works
Self-citationCentral role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy
Chelko, S. P., Asimaki, A., Andersen, P., Bedja, D., Amat-Alarcon, N., DeMazumder, D., Jasti, R., MacRae, C. A., Leber, R., Kleber, A. G., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.85923 · Cited by 180 · see citing works
Self-citationFractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes
Shah, R. D., Hinkle, C. C., Ferguson, J. F., Mehta, N. N., Li, M., Qu, L., Lu, Y., Putt, M., Ahima, R. S., & Reilly, M. P. (2011) · Diabetes · doi:10.2337/db10-0956 · Cited by 169 · see citing works
Evolving Diagnostic Criteria for Arrhythmogenic Cardiomyopathy
Corrado, D., Zorzi, A., Cipriani, A., Bauce, B., Bariani, R., Beffagna, G., Lazzari, M. D., Migliore, F., Pilichou, K., Rampazzo, A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021987 · Cited by 166 · see citing works
Lipidomic Analysis of Serum from High Fat Diet Induced Obese Mice
Eisinger, K., Liebisch, G., Schmitz, G., Aslanidis, C., Krautbauer, S., & Buechler, C. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022991 · Cited by 151 · see citing works
Hirata, A., Sugiyama, D., Watanabe, M., Tamakoshi, A., Iso, H., Kotani, K., Kiyama, M., Yamada, M., Ishikawa, S., Murakami, Y., et al. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.01.014 · Cited by 148 · see citing works
Gordon, S. M., Li, H., Zhu, X., SHAH, A. S., Lu, L. J., & Davidson, W. S. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00213 · Cited by 143 · see citing works
Salvador, A. M., Nevers, T. A., Velázquez, F., Aronovitz, M. J., Wang, B., Abadía‐Molina, A. C., Jaffe, I. Z., Karas, R. H., Blanton, R. M., & Alcaide, P. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.003126 · Cited by 140 · see citing works
Trimarco, V., Izzo, R., Morisco, C., Mone, P., Manzi, M. V., Falco, A., Pacella, D., Gallo, P., Lembo, M., Santulli, G., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19912 · Cited by 130 · see citing works
Reduced Endoglin Activity Limits Cardiac Fibrosis and Improves Survival in Heart Failure
Kapur, N. K., Wilson, S., Yunis, A., Qiao, X., Mackey, E., Paruchuri, V., Baker, C., Aronovitz, M. J., Karumanchi, S. A., Letarte, M., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.080002 · Cited by 122 · see citing works
Systemic inflammation as a novel QT-prolonging risk factor in patients with torsades de pointes
Lazzerini, P. E., Pasini, F. L., Bertolozzi, I., Morozzi, G., Lorenzini, S., Simpatico, A., Selvi, E., Bacarelli, M. R., Finizola, F., Vanni, F., et al. (2017) · Heart · doi:10.1136/heartjnl-2016-311079 · Cited by 119 · see citing works
Endoglin: Beyond the Endothelium
Schoonderwoerd, M. J. A., Goumans, M., & Hawinkels, L. J. A. C. (2020) · Biomolecules · doi:10.3390/biom10020289 · Cited by 119 · see citing works
Lazzerini, P. E., Abbate, A., Boutjdir, M., & Capecchi, P. L. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.12.004 · Cited by 118 · see citing works
Triglycerides and risk for coronary artery disease
McBride, P. E. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-008-0060-9 · Cited by 116 · see citing works
Phu, T. A., Ng, M., Vu, N. K., Bouchareychas, L., & Raffaı̈, R. L. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.03.008 · Cited by 104 · see citing works
Gillers, B. S., Chiplunkar, A. R., Aly, H., Valenta, T., Basler, K., Christoffels, V. M., Efimov, I. R., Boukens, B. J., & Rentschler, S. (2014) · Circulation Research · doi:10.1161/circresaha.116.304731 · Cited by 101 · see citing works
Cho, G.-S., Lee, D. I., Tampakakis, E., Murphy, S. A., Andersen, P., Uosaki, H., Chelko, S. P., Chakir, K., Hong, I., Seo, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.040 · Cited by 100 · see citing works
Self-citationChelko, S. P., Keceli, G., Carpi, A., Doti, N., Agrimi, J., Asimaki, A., Beti, C. B., Miyamoto, M., Amat-Codina, N., Bedja, D., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf0891 · Cited by 92 · see citing works
Self-citationIs a High HDL-Cholesterol Level Always Beneficial?
Franczyk, B., Rysz, J., Ławiński, J., Rysz-Górzyńska, M., & Gluba-Brzózka, A. (2021) · Biomedicines · doi:10.3390/biomedicines9091083 · Cited by 92 · see citing works
Inflammatory cytokines and cardiac arrhythmias: the lesson from COVID-19
Lazzerini, P. E., Pasini, F. L., Boutjdir, M., & Capecchi, P. L. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00714-3 · Cited by 90 · see citing works
Novel insights on the role of VCAM-1 and ICAM-1: Potential biomarkers for cardiovascular diseases
Kaur, R., Singh, V., Kumari, P., Singh, R. J., Chopra, H., & Emran, T. B. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.104802 · Cited by 87 · see citing works
Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis
Merchant, A. T., Kelemen, L. E., de Koning, L., Lonn, E., Vuksan, V., Jacobs, R., Davis, B. C., Teo, K. K., Yusuf, S., & Anand, S. S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.168 · Cited by 80 · see citing works
Role of CD93 in Health and Disease
Tossetta, G., Piani, F., Borghi, C., & Marzioni, D. (2023) · Cells · doi:10.3390/cells12131778 · Cited by 80 · see citing works
Syed, F. M., Diwan, A., & Hahn, H. S. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.05.001 · Cited by 75 · see citing works
Bosman, L. P., Cadrin‐Tourigny, J., Bourfiss, M., Ghasabeh, M. A., Sharma, A., Tichnell, C., Roudijk, R. W., Murray, B. A., Tandri, H. S., Khairy, P., et al. (2020) · EP Europace · doi:10.1093/europace/euaa039 · Cited by 72 · see citing works
James, C. A., Tichnell, C., Murray, B., Daly, A., Sears, S. F., & Calkins, H. (2012) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.111.960898 · Cited by 72 · see citing works
Arrhythmogenic Cardiomyopathy in 2018–2019: ARVC/ALVC or Both?
Bennett, R. G., Haqqani, H. M., Berruezo, A., Bella, P. E. D., Marchlinski, F. E., Hsu, C., & Kumar, S. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.10.013 · Cited by 67 · see citing works
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease
Nakagawa, N., Barron, L., Gomez, I. G., Johnson, B. G., Roach, A. M., Kameoka, S., Jack, R. M., Lupher, M. L., Gharib, S. A., & Duffield, J. S. (2016) · JCI Insight · doi:10.1172/jci.insight.87446 · Cited by 59 · see citing works
Crosstalk between the CX3CL1/CX3CR1 Axis and Inflammatory Signaling Pathways in Tissue Injury
Zhuang, Q., Ou, J., Zhang, S., & Ming, Y. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190305165722 · Cited by 57 · see citing works
Acidic and basic fibroblast growth factors involved in cardiac angiogenesis following infarction
Zhao, T., Zhao, W., Chen, Y., Ahokas, R. A., & Sun, Y. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.07.024 · Cited by 56 · see citing works
The arrhythmogenic right ventricle. Dysplasia versus cardiomyopathy
Fontaine, G., Fontaliran, F., Rosas Andrade, F., Velasquez, E., Tonet, J., Jouven, X., Fujioka, Y., & Frank, R. (1995) · Heart and Vessels · doi:10.1007/bf01744901 · Cited by 55 · see citing works
Cerrone, M., Marrón-Liñares, G. M., van Opbergen, C. J. M., Costa, S., Bourfiss, M., Pérez-Hernández, M., Schlamp, F., Sanchis-Gomar, F., Malkani, K., Drenkova, K., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehab772 · Cited by 51 · see citing works
Hussain, S. M., Robb, C. E., Tonkin, A. M., Lacaze, P. A., Chong, T. T. ‐., Beilin, L. J., Yu, C., Watts, G. F., Ryan, J. L., Ernst, M. E., et al. (2023) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2023.100963 · Cited by 50 · see citing works
Stanciulescu, L. A., Scafa‐Udriște, A., & Dorobanţu, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076669 · Cited by 43 · see citing works
Hawthorne, R. N., Blazeski, A., Lowenthal, J., Kannan, S., Teuben, R., DiSilvestre, D., Morrissette-McAlmon, J., Saffitz, J. E., Boheler, K. R., James, C. A., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143061 · Cited by 41 · see citing works
Self-citationMattesi, G., Cipriani, A., Bauce, B., Rigato, I., Zorzi, A., & Corrado, D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102212 · Cited by 40 · see citing works
Adiponectin: a pleiotropic hormone with multifaceted roles
Shklyaev, S. S., Melnichenko, G. A., Volevodz, N. N., Falaleeva, N. A., Ivanov, S. A., Kaprin, A. D., & Mokrysheva, N. G. (2021) · Problems of Endocrinology · doi:10.14341/probl12827 · Cited by 40 · see citing works
Border, W. L., Sachdeva, R., Stratton, K. L., Armenian, S. H., Bhat, A. H., Cox, D. E., Leger, K. J., Leisenring, W. M., Meacham, L. R., Sadak, K. T., et al. (2020) · JACC CardioOncology · doi:10.1016/j.jaccao.2020.02.016 · Cited by 37 · see citing works
Diagnostic Criteria, Genetics, and Molecular Basis of Arrhythmogenic Cardiomyopathy
Basso, C., Pilichou, K., Bauce, B., Corrado, D., & Thiene, G. (2018) · Heart Failure Clinics · doi:10.1016/j.hfc.2018.01.002 · Cited by 36 · see citing works
Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review
Piani, F., Tossetta, G., Cara‐Fuentes, G., Agnoletti, D., Marzioni, D., & Borghi, C. (2023) · Biomolecules · doi:10.3390/biom13060910 · Cited by 35 · see citing works
The association of coagulation and atrial fibrillation: a systematic review and meta-analysis
Tilly, M. J., Geurts, S., Pezzullo, A. M., Bramer, W. M., de Groot, N. M. S., Kavousi, M., & de Maat, M. P. M. (2022) · EP Europace · doi:10.1093/europace/euac130 · Cited by 33 · see citing works
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy
Sommariva, E., Stadiotti, I., Casella, M., Catto, V., Russo, A. D., Carbucicchio, C., Arnaboldi, L., Metrio, S. D., Milano, G., Scopece, A., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114365 · Cited by 33 · see citing works
Chelko, S. P., Penna, V. R., Engel, M., Shiel, E. A., Centner, A. M., Farra, W., Cannon, E. N., Landim-Vieira, M., Schaible, N., Lavine, K., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172014 · Cited by 32 · see citing works
Self-citationNielsen, M. B., Çolak, Y., Benn, M., Mason, A. M., Burgess, S., & Nordestgaard, B. G. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad162 · Cited by 30 · see citing works
Agrimi, J., Scalco, A., Agafonova, J., Williams III, L., Pansari, N., Keceli, G., Jun, S., Wang, N., Mastorci, F., Tichnell, C., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123804 · Cited by 29 · see citing works
Self-citationRole of Endoglin in Fibrosis and Scleroderma
Maring, J. A., Trojanowska, M. E., & ten Dijke, P. (2012) · International review of cytology · doi:10.1016/b978-0-12-394308-8.00008-x · Cited by 28 · see citing works
Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy
Zhang, Z., Liu, X., Shen, Z., Quan, J., Lin, C., Li, X., & Hu, G. M. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1983071 · Cited by 27 · see citing works
Ewer, M. S., & Ewer, S. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.5091 · Cited by 22 · see citing works
Ueland, T., Nymo, S. H., Latini, R., McMurray, J. J. V., KJEKSHUS, J. K., Yndestad, A., Fucili, A., Grosu, A., Masson, S., Maggioni, A. P., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft031 · Cited by 21 · see citing works
Oxidized high-density lipoprotein associates with atrial fibrillation
Pagonas, N., Mueller, R., Weiland, L., Jänsch, M., Dammermann, W., Seibert, F. S., Hillmeister, P., Buschmann, I. R., Christ, M., Ritter, O., et al. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.11.024 · Cited by 17 · see citing works
Huang, Y., Ding, H., Song, T., Chen, Y., Wang, T., Tang, Y.-H., Barajas-Martínez, H., Huang, C.-X., & Hu, D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.716219 · Cited by 15 · see citing works
Guo, Y., Apostalakis, S., Blann, A. D., & Lip, G. Y. H. (2014) · Cerebrovascular Diseases · doi:10.1159/000365841 · Cited by 15 · see citing works
Trojanek, J. (2015) · PubMed · Cited by 13 · see citing works
Meng, X., Zhang, M., Hu, J.-K., Chen, X., Long, Y.-Q., Liu, H., Feng, X., Ji, F., & Peng, K. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.946524 · Cited by 12 · see citing works
AKT Mediates Adiponectin-Dependent Regulation of VSMC Phenotype
Cullen, A. E., Centner, A. M., Deitado, R., Ismaeel, A., Koutakis, P., Muller‐Delp, J. M., & Salazar, G. (2023) · Cells · doi:10.3390/cells12202493 · Cited by 11 · see citing works
Self-citationChanges in fractalkine in patients with ST-elevation myocardial infarction
Yao, K., Zhang, S., Lu, H., Hong, X., Qian, J., Sun, A., Zou, Y., & Ge, J. (2015) · Coronary Artery Disease · doi:10.1097/mca.0000000000000273 · Cited by 11 · see citing works
Day, S. M. (2012) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.962639 · Cited by 10 · see citing works
Endostatin and ST2 are predictors of pulmonary hypertension disease course in infants
Griffiths, M., Yang, J., Everett, A. D., Jennings, J. M., Freire, G., Williams, M. A., Nies, M., McGrath‐Morrow, S. A., & Collaco, J. M. (2020) · Journal of Perinatology · doi:10.1038/s41372-020-0671-8 · Cited by 10 · see citing works
Targeting arrhythmogenic macrophages: lessons learned from arrhythmogenic cardiomyopathy
Mesquita, T., & Cingolani, E. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180482 · Cited by 8 · see citing works
Landim-Vieira, M., Kahmini, A. R., Engel, M., Cannon, E. N., Amat-Alarcon, N., Judge, D. P., Pinto, J. R., & Chelko, S. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213909 · Cited by 7 · see citing works
Self-citationPhysical Exercise and Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Kaddoura, R., & Al-Tamimi, H. (2022) · Heart Views · doi:10.4103/heartviews.heartviews_70_22 · Cited by 6 · see citing works
The Duality of Adiponectin: The Role of Sex in Atherosclerosis
Cullen, A. E., Centner, A. M., Deitado, R., Ukhanov, V., Ismaeel, A., Koutakis, P., Delp, J., & Salazar, G. (2023) · Cells · doi:10.3390/cells13010001 · Cited by 6 · see citing works
Self-citationAlehagen, U., Shamoun, L., & Wågsäter, D. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11555 · Cited by 6 · see citing works
Chen, F., Ye, Y., Wu, G., & Wu, M. (2023) · Cardiology · doi:10.1159/000535046 · Cited by 2 · see citing works
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Tomoaia, R., Beyer, R. S., Zdrenghea, D. T., Dădârlat‐Pop, A., Popescu, M. I., Cismaru, G. L., Guşetu, G., Bodisz, G., Chețan, M. I., & Pop, D. (2021) · Life · doi:10.3390/life11090968 · Cited by 1 · see citing works
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Gene-elusive arrhythmogenic cardiomyopathy: Roles of sports, inflammation, and beyond
Tramèr, L., Saguner, A. M., Beltrami, F. G., James, C. A., Calkins, H. G., & Duru, F. (2025) · Heart Rhythm · doi:10.1016/j.hrthm.2025.09.048 · Cited by 7 · see citing works
Wang, X., Wang, X., Zhuang, H., Lu, G., & Zhao, G. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178429 · Cited by 5 · see citing works
Shiel, E. A., Farra, W., Medarev, S. L., Ariyaratne, G. H. D. N., Cannon, E. N., Steiner, J. L., & Chelko, S. P. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00416.2025 · Cited by 5 · see citing works
Self-citationA Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease
Ariyaratne, G. H. D. N., Villatore, A., Peretto, G., & Chelko, S. P. (2026) · Cells · doi:10.3390/cells15100868 · Cited by 2 · see citing works
Self-citationElgrably, B., Rom, M., Alter, T., Kher, N., Haj, N., Saab, D., Tiwari, A., Levi, N., Saar, G., Karni-Ashkenazi, S., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114399 · Cited by 1 · see citing works
Desmoglein-2 deficiency drives mitochondrial morphological remodeling in cardiomyocytes
Gonçalves, A., Chen, E. Z., Rastegarpouyani, H., Fernandes, A. A., Alves, I. N., Sequeira, V., Kwon, C., Chelko, S. P., & Landim-Vieira, M. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2026 · Cited by 1 · see citing works
Self-citationGhasemi-Tarie, R., Esteghamati, A., Rakhshan, K., Esteghamati, S., & Keshavarz, M. (2026) · Biomedicines · doi:10.3390/biomedicines14071533
Pasini, N., Barocelli, F., Bettella, A., Ristagno, A., Santoro, M., Canu, E., Crocamo, A., Gurgoglione, F. L., Triglia, L. T., Russo, F., et al. (2026) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm51364
- Authors
- Centner, A. M., Shiel, E. A., Farra, W., Cannon, E. N., Landim-Vieira, M., Salazar, G., & Chelko, S. P.
- Affiliations
- Florida State University (US)
- Corresponding author
- Centner, Ann M.
- Chelko, Stephen P.
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2024-06-29
- Volume
- 16
- Issue
- 13
- Pages
- 2087
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC11243382
- OpenAlex
- W4400210913
- Cited by
- 8
- References
- 82
- Citations by year
- 2026: 4 · 2025: 4
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Heart Association Career Development Award (19CDA34760185, 204000-544-046752)
- FSU Research Foundation Award (19CDA34760185, 204000-544-046752)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- arrhythmogenic cardiomyopathy, high-fat diet, myocarditis, cardiac dysfunction, cardiac remodeling, ejection fraction, HDL cholesterol, adiponectin, fibroblast growth factor 1, myocardial fibrosis, cardiac arrhythmias
- MeSH terms
- Animals, Disease Models, Animal, Fibrosis, Inflammation, Male, Mice, Inbred C57BL, Cardiomyopathies, Myocarditis, Myocardium, Arrhythmogenic Right Ventricular Dysplasia, Ventricular Remodeling, Desmoglein 2, Mice, Adiponectin, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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