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Vitamin C, Aging and Alzheimer’s Disease
Open accessAbstract
Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate genome integrity and stability, indicating a key role of targeted nutrition in healthy aging. Growing in vivo evidence supports the role of ascorbic acid in ameliorating factors linked to Alzheimer’s disease (AD) pathogenesis, although evidence in humans yielded equivocal results. The neuroprotective role of ascorbic acid not only relies on the general free radical trapping, but also on the suppression of pro-inflammatory genes, mitigating neuroinflammation, on the chelation of iron, copper, and zinc, and on the suppression of amyloid-beta peptide (Aβ) fibrillogenesis. Epidemiological evidence linking diet, one of the most important modifiable lifestyle factors, and risk of Alzheimer's disease is rapidly increasing. Thus, dietary interventions, as a way to epigenetically modulate the human genome, may play a role in the prevention of AD. The present review is aimed at providing an up to date overview of the main biological mechanisms that are associated with ascorbic acid supplementation/bioavailability in the process of aging and Alzheimer’s disease. In addition, we will address new fields of research and future directions.
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“In the brain, AA has been increasingly found to promote several beneficial effects on neurodegeneration by direct neuroprotection against OS [116].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [116]
In the citing paper
“Vitamin C or ascorbic acid (AA) is a powerful antioxidant that can have beneficial effects on delaying the aging process and age-related diseases thorough its action on redox oxidative and mitochondrial pathways, on the immune system, on inflamm-aging, on endothelial integrity, and on lipoprotein metabolism [114,115,116,117,118,119,120,121].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [116]
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“Extracellular amyloid plaques are also responsible for the hyperphosphorylation of the cytoskeletal Tau protein [67].”
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“A pro-oxidant or antioxidant effect of AA mainly relies on the concentration gradient and redox state of a cell [106].”
BackgroundProinflammatory Cytokines, Aging, and Age-Related Diseases
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“The conjugated aromatic ring of tyrosine residues is also a target for free-radical attack, and accumulation of dityrosine and 3-nitrotyrosine has also been reported in the AD brain [77].”
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BackgroundALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ
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Metadata
- Authors
- Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Monacelli, Fiammetta
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-06-27
- Volume
- 9
- Issue
- 7
- Pages
- 670
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5537785
- OpenAlex
- W2724874603
- Cited by
- 243
- References
- 148
- Citations by year
- 2026: 9 · 2025: 29 · 2024: 37 · 2023: 31 · 2022: 38 · 2021: 34 · 2020: 27 · 2019: 22 · 2018: 14 · 2017: 2
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin C, aging, Alzheimer's disease, accelerated senescence, inflammaging, immunosenescence, telomere shortening, oxidative stress, epigenetic regulation, neuroinflammation, dietary supplementation, lifespan extension, healthy aging
- MeSH terms
- Aging, Alzheimer Disease, Animals, Ascorbic Acid, Brain, Disease Models, Animal, Humans, Vascular Diseases, Randomized Controlled Trials as Topic, Oxidative Stress, Nutrigenomics, Epigenomics, Plaque, Amyloid, Observational Studies as Topic
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