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Cited by 111Antioxidant Activity and Oxidative StressInfant Nutrition and HealthBirth, Development, and Health

Health Effects of Carotenoids during Pregnancy and Lactation

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Zielińska, Monika, Wesołowska, Aleksandra, Pawlus, Beata, Hamułka, Jadwiga·2017·Nutrients
DOI 10.3390/nu9080838PMC PMC5579631
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Abstract

Adequate nutrition is particularly important during pregnancy since it is needed not only for maintaining the health of the mother, but also determines the course of pregnancy and its outcome, fetus development as well as the child’s health after birth and during the later period of life. Data coming from epidemiological and interventions studies support the observation that carotenoids intake provide positive health effects in adults and the elderly population. These health effects are the result of their antioxidant and anti-inflammatory properties. Recent studies have also demonstrated the significant role of carotenoids during pregnancy and infancy. Some studies indicate a correlation between carotenoid status and lower risk of pregnancy pathologies induced by intensified oxidative stress, but results of these investigations are equivocal. Carotenoids have been well studied in relation to their beneficial role in the prevention of preeclampsia. It is currently hypothesized that carotenoids can play an important role in the prevention of preterm birth and intrauterine growth restriction. Carotenoid status in the newborn depends on the nutritional status of the mother, but little is known about the transfer of carotenoids from the mother to the fetus. Carotenoids are among the few nutrients found in breast milk, in which the levels are determined by the mother’s diet. Nutritional status of the newborn directly depends on its diet. Both mix feeding and artificial feeding may cause depletion of carotenoids since infant formulas contain only trace amounts of these compounds. Carotenoids, particularly lutein and zeaxanthin play a significant role in the development of vision and nervous system (among others, they are important for the development of retina as well as energy metabolism and brain electrical activity). Furthermore, more scientific evidence is emerging on the role of carotenoids in the prevention of disorders affecting preterm infants, who are susceptible to oxidative stress, particularly retinopathy of prematurity.

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  • In smokers, high doses of beta-carotene were associated with a higher incidence of lung cancer and mortality rate.

    “Nevertheless, adverse health effects concerning carotenoids have been reported in smokers who had a higher incidence of lung cancer and mortality rate after high doses of beta-carotene [1,10,20,21,22].”

    From The Role of Vitamin A in Retinal Diseases (2022) · cites this paper as [20]

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Authors
Zielińska, M., Wesołowska, A., Pawlus, B., & Hamułka, J.
Affiliations
  • Department of Human Nutrition, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Science—SGGW, 159c Nowoursynowska St., 02-776 Warsaw, Poland
  • Laboratory of Human Milk and Lactation Research at Regional Human Milk Bank in Holy Hospital, Department of Neonatology, Medical University of Warsaw, 63A Zwirki i Wigury St., 02-091 Warsaw, Poland
  • Neonatal Unit, Holy Family Hospital in Warsaw, 25 Madalinskiego St., 02-544 Warsaw, Poland
  • Warsaw University of Life Sciences (PL)
Corresponding author
Hamułka, Jadwiga
ORCID
Hamułka, Jadwiga
Venue
Nutrients
Publisher
MDPI AG
Published
2017-08-04
Volume
9
Issue
8
Pages
838
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu9080838
PMC
PMC5579631
OpenAlex
W2742306073
Cited by
111
References
187
Citations by year
2026: 7 · 2025: 10 · 2024: 11 · 2023: 10 · 2022: 20 · 2021: 15 · 2020: 16 · 2019: 14 · 2018: 8
FWCI
1.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Polish Ministry of Science and Higher Education.
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
carotenoids, pregnancy, lactation, maternal nutrition, preeclampsia, preterm birth, fetal growth restriction, oxidative stress, breast milk, infant formula, lutein, zeaxanthin, retinopathy of prematurity, antioxidant activity, anti-inflammatory activity, fetal development
MeSH terms
Maternal Health, Animals, Carotenoids, Child Development, Female, Humans, Infant, Infant Nutritional Physiological Phenomena, Infant, Newborn, Lactation, Maternal-Fetal Exchange, Milk, Human, Nutritional Status, Pregnancy, Pregnancy Complications, Risk Factors, Oxidative Stress, Maternal Nutritional Physiological Phenomena, Recommended Dietary Allowances, Protective Factors

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