The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Improving the Endosomal Escape of Cell-Penetrating Peptides and Their Cargos: Strategies and Challenges
Open accessAbstract
Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells. In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis. However, they often remain trapped inside endocytic organelles and fail to reach the cytosolic space of cells efficiently. In this review, the evidence for CPP-mediated endosomal escape is discussed. In addition, several strategies that have been utilized to enhance the endosomal escape of CPP-cargos are described. The recent development of branched systems that display multiple copies of a CPP is presented. The use of viral or synthetic peptides that can disrupt the endosomal membrane upon activation by the low pH of endosomes is also discussed. Finally, we survey how CPPs labeled with chromophores can be used in combination with light to stimulate endosomal lysis. The mechanisms and challenges associated with these intracellular delivery methodologies are discussed.
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Cites
Synthesis of Proteins by Native Chemical Ligation
Dawson, P. E., Muir, T. W., Clark-Lewis, I., & Kent, S. B. H. (1994) · Science · doi:10.1126/science.7973629 · Cited by 4,131
Functions of Cell Surface Heparan Sulfate Proteoglycans
Bernfield, M., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J., & Zako, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.729 · Cited by 2,688
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
Schwarze, S. R., Ho, A., Vocero-Akbani, A., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,416
The third helix of the Antennapedia homeodomain translocates through biological membranes.
Derossi, D., Joliot, A. H., Chassaing, G., & Prochiantz, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34080-2 · Cited by 2,034
Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
Green, M., & Loewenstein, P. M. (1988) · Cell · doi:10.1016/0092-8674(88)90262-0 · Cited by 1,553
Richard, J. P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M. J., Chernomordik, L. V., & Lebleu, B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209548200 · Cited by 1,446
Tam, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5409 · Cited by 1,251 · cited 1×
“Notably, MCPPs share close structural resemblance with multiple antigenic peptides (MAPs) [105].”
BackgroundTat-mediated delivery of heterologous proteins into cells.
Fawell, S., Seery, J., Daikh, Y., Moore, C., Chen, L. L., Pepinsky, B., & Barsoum, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.664 · Cited by 1,225
Expressed protein ligation: A general method for protein engineering
Muir, T. W., Sondhi, D., & Cole, P. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6705 · Cited by 1,189
Cited by
Xie, J., Bi, Y., Zhang, H., Dong, S., Teng, L., Lee, R. J., & Yang, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00697 · Cited by 466
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines
Xiao, W., Jiang, W., Chen, Z., Huang, Y., Mao, J., Zheng, W., Hu, Y., & Shi, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02107-5 · Cited by 449
Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles
Selby, L. I., Cortez‐Jugo, C. M., Such, G. K., & Johnston, A. P. R. (2017) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1452 · Cited by 283
McCarthy, H. O., McCaffrey, J., McCrudden, C. M., Zholobenko, A., Ali, A. A., McBride, J. W., Massey, A. S., Pentlavalli, S., Chen, K.-H., Cole, G., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.048 · Cited by 216
Nabhan, J. F., Wood, K. M., Rao, V. P., Morin, J., Bhamidipaty, S., LaBranche, T. P., Gooch, R. L., Bozal, F., Bulawa, C. E., & Guild, B. C. (2016) · Scientific Reports · doi:10.1038/srep20019 · Cited by 140
Metadata
- Authors
- Erazo-Oliveras, A., Muthukrishnan, N., Baker, R., Wang, T.-Y., & Pellois, J.-P.
- Venue
- Pharmaceuticals
- Publisher
- MDPI AG
- Published
- 2012-11-01
- Volume
- 5
- Issue
- 11
- Pages
- 1177-1209
- ISSN
- 1424-8247 (ISSN-L)
- OpenAlex
- W2141506589
- Cited by
- 384
- References
- 163
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Erazo-Oliveras, A., Muthukrishnan, N., Baker, R., Wang, T.-Y., & Pellois, J.-P. (2012). Improving the Endosomal Escape of Cell-Penetrating Peptides and Their Cargos: Strategies and Challenges. Pharmaceuticals. https://doi.org/10.3390/ph5111177
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