Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

mRNA vaccines — a new era in vaccinology

Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667

Direct Gene Transfer into Mouse Muscle in Vivo

Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173 · cited 2×

Liposome: classification, preparation, and applications

Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., Samiei, M., Kouhi, M., & Nejati‐Koshki, K. (2013) · Nanoscale Research Letters · doi:10.1186/1556-276x-8-102 · Cited by 3,648

Mechanisms of type-I- and type-II-interferon-mediated signalling

Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,631

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474

Toxicity of cationic lipids and cationic polymers in gene delivery

Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.014 · Cited by 2,286

The alphaviruses: gene expression, replication, and evolution.

Strauss, J. H., & Strauss, E. G. (1994) · Microbiological Reviews · doi:10.1128/mmbr.58.3.491-562.1994 · Cited by 2,221

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., & Weissman, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.200 · Cited by 1,930

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Kranz, L. M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K. C., Meng, M., Fritz, D., Vascotto, F., Hefesha, H., et al. (2016) · Nature · doi:10.1038/nature18300 · Cited by 1,819

Stimuli-responsive nanocarriers for targeted mRNA therapeutics: a paradigm shift in mRNA delivery for biomedical applications

Yadav, N., Debnath, N., & Das, S. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-02040-2 · Cited by 11

Deciphering the regulatory landscape of enhancer RNAs in health and disease

Wang, Q., ten Dijke, P., & Fan, C. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02436-z · Cited by 15

Novel Lipid Nanoparticle (LNP) Delivery Systems Enabling the Advancement of RNA Therapeutics

Zhang, H., Han, S., Zhang, X., Ma, J., Jin, L., Wang, Y., Ma, Y., Ma, T., Yu, F., & Song, G. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505340 · Cited by 15

Recent advances in polymeric and lipid stimuli-responsive nanocarriers for cell-based cancer immunotherapy

Gharatape, A., Amanzadi, B., Mohamadi, F., Rafieian, M., & Majidi, R. F. (2024) · Nanomedicine · doi:10.1080/17435889.2024.2416377 · Cited by 13

Technological breakthroughs and advancements in the application of mRNA vaccines: a comprehensive exploration and future prospects

Wei, Z., Zhang, S., Wang, X., Xue, Y., Dang, S., & Zhai, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1524317 · Cited by 16

Lipid Nanoparticles for mRNA Delivery in Cancer Immunotherapy

Alshehry, Y., Liu, X., Li, W., Wang, Q., Cole, J., & Zhu, G. (2025) · The AAPS Journal · doi:10.1208/s12248-025-01051-8 · Cited by 13

Incorporation of cellular membrane protein extracts into lipid nanoparticles enhances their cellular uptake and mRNA delivery efficiency

Rodríguez, D. A., Lefebvre, G. P. R., Yang, Q., Barendrecht, A. D., Seinen, C. W., Schiffelers, R. M., & Vader, P. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113676 · Cited by 11

Enzymatic Modification of the 5’ Cap with Photocleavable ONB‐Derivatives Using GlaTgs V34A

Klöcker, N., Anhäuser, L., & Rentmeister, A. (2022) · ChemBioChem · doi:10.1002/cbic.202200522 · Cited by 11

RNA Vaccines: Yeast as a Novel Antigen Vehicle

Silva, A. J. D., de Sousa, M. M. G., de Macêdo, L. S., Franca-Neto, P. L., de Moura, I. A., Espinoza, B. C. F., Invenção, M. D. C. V., de Pinho, S. S., da Gama, M. A. T. M., & de Freitas, A. C. (2023) · Vaccines · doi:10.3390/vaccines11081334 · Cited by 12

Recent advancements in cancer vaccines: A systematic review

Srivastava, S., Singh, D., Verma, S. K., Pandey, M., Sharma, A., Pandey, H., & Mishra, A. (2023) · Vacunas (English Edition) · doi:10.1016/j.vacun.2023.10.005 · Cited by 15

RNA Vaccines against Infectious Diseases: Vital Progress with Room for Improvement

Abdelzaher, H. M., Gabr, A. S., Saleh, B. M., Gawad, R. M. A., Nour, A. A., & Abdelnaser, A. (2021) · Vaccines · doi:10.3390/vaccines9111211 · Cited by 12

Circular mRNA encoded PROTAC (RiboPROTAC) as a new platform for the degradation of intracellular therapeutic targetsPreprint

Yang, J., Sun, J., Zhu, J., Du, Y., Tan, Y., Wei, L., Zhao, Y., Hou, Q., Zhang, Y., Sun, Z., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.22.489232 · Cited by 11

Construction of a Chikungunya Virus, Replicon, and Helper Plasmids for Transfection of Mammalian Cells

Colunga-Saucedo, M., Rubio-Hernández, E. I., Coronado-Ipiña, M. Á., Rosales‐Mendoza, S., Castillo, C. G., & Comas‐García, M. (2022) · Viruses · doi:10.3390/v15010132 · Cited by 10

Recent Advances in Biomaterials for mRNA Delivery to Immune Cells

Isaac, I., Bhatia, M., & Bhattacharya, C. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00734 · Cited by 10

Applications of microfluidics in mRNA vaccine development: A review

Fardoost, A., Karimi, K., Govindaraju, H., Jamali, P., & Javanmard, M. (2024) · Biomicrofluidics · doi:10.1063/5.0228447 · Cited by 12

Fluorinated polyethyleneimine vectors with serum resistance and adjuvant effect to deliver LMP2 mRNA vaccine for nasopharyngeal carcinoma therapy

Yang, S., Chen, R., Wu, Y., Song, X., Peng, X., & Chen, M. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.022 · Cited by 10

Biomimetic Nanoparticle Based Targeted mRNA Vaccine Delivery as a Novel Therapy for Glioblastoma Multiforme

Ahmed, T., & Alam, K. T. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03065-z · Cited by 10

Transfection Technologies for Next-Generation Therapies

Simkhada, D., Teo, S. H. C., Deorkar, N., & Vemuri, M. C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14155515 · Cited by 9

Promising Cancer Vaccine for Glioblastoma Therapy: A Focus on mRNA Vaccine

Barati, S., Ghoflchi, S., Hosseinzadeh, P., Pouramini, S., Hosseini, H., & Jalili‐Nik, M. (2025) · Cancer Medicine · doi:10.1002/cam4.71187 · Cited by 11

Medicinal Mushrooms and Their Use to Strengthen Respiratory Health during and Post-COVID-19 Pandemic

Booi, H.-N., Lee, M.-K., Fung, S. Y., Ng, S. T., Tan, C.-S., Lim, K., Roberts, R. E., & Ting, K. (2022) · International journal of medicinal mushrooms · doi:10.1615/intjmedmushrooms.2022045068 · Cited by 11

mRNA PROTACs: engineering PROTACs for high‐efficiency targeted protein degradation

Xue, X., Zhang, C., Li, X., Wang, J., Zhang, H., Feng, Y., Xu, N., Li, H., Tan, C., Jiang, Y., et al. (2024) · MedComm · doi:10.1002/mco2.478 · Cited by 9

Advantages and disadvantages of RNA therapeutics

Huy, B. L., Phuong, H. B. T., & Xuan, H. L. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.12.016 · Cited by 10

Identifying Key Drivers of Efficient B Cell Responses: On the Role of T Help, Antigen-Organization, and Toll-like Receptor Stimulation for Generating a Neutralizing Anti-Dengue Virus Response

Sobczak, J. M., Barkovska, I., Baļķe, I., Rothen, D. A., Mohsen, M. O., Skrastiņa, D., Ogrina, A., Martina, B. E. E., Jansons, J., Bogans, J., et al. (2024) · Vaccines · doi:10.3390/vaccines12060661 · Cited by 9

Systematic evaluation of the induction of efficient neutralizing antibodies by recombinant multicomponent subunit vaccines against monkeypox virus

Tan, M. J. A., Zhang, R., Shen, T., Li, A., Hou, X., Zhang, Y., Wang, T., Zhang, B., Sun, P., Gong, X., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.126384 · Cited by 9

Development of non-viral targeted RNA delivery vehicles – a key factor in success of therapeutic RNA

Choudry, M. W., Riaz, R., Raza, M. H., Nawaz, P., Ahmad, B. M., Jahan, N., Rafique, S., Afzal, S., Amin, I., & Shahid, M. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2416241 · Cited by 10

Current status of xenotransplantation from an immunobiological standpoint

Ko, J., Lee, G. S., Kim, H. W., Kang, M., Kim, H. J., & Park, C. (2025) · Clinical Transplantation and Research · doi:10.4285/ctr.24.0065 · Cited by 10

EBV Vaccines in the Prevention and Treatment of Nasopharyngeal Carcinoma

Zhang, W., Wang, C., Meng, Y., He, L., & Dong, M. (2025) · Vaccines · doi:10.3390/vaccines13050478 · Cited by 10

Exosome-based therapies and biomarkers in stroke: Current advances and future directions

Poondla, N., Babaeizad, A., Sheykhhasan, M., Barry, C. J., Manoochehri, H., Tanzadehpanah, H., Mahaki, H., & Al-Musawi, S. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115286 · Cited by 11

mRNA-Based Therapeutics: Advances in Drug Delivery, Comparative Innovations, and Biomedical Applications

Joshi, R., Sharma, S., Kapoor, D. U., Prajapati, B. G., Huanbutta, K., & Sriamornsak, P. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00774 · Cited by 10

mRNA therapeutics: Molecular mechanisms, delivery platforms, regulatory frameworks, and equitable global access

Ikrar, T., Muchsin, W., & Sophian, A. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115019 · Cited by 10

An Appraisal of the Current Scenario in Vaccine Research for COVID-19

Chong, W. C., Chellappan, D. K., Shukla, S. D., Peterson, G. M., Patel, R. P., Jha, N. K., Eri, R. D., Dua, K., Tambuwala, M. M., & Shastri, M. D. (2021) · Viruses · doi:10.3390/v13071397 · Cited by 9

The mRNA Vaccine Heralds a New Era in Vaccinology

Shinde, K., Bendre, S., Kale, N., & Gilda, S. (2022) · Asian Journal of Pharmacy and Technology · doi:10.52711/2231-5713.2022.00042 · Cited by 9

Delivery of gene editing therapeutics

Kevadiya, B. D., Islam, F. S., Deol, P., Zaman, L. A., Mosselhy, D. A., Ashaduzzaman, M., Bajwa, N., Routhu, N. K., Singh, P. A., Dawre, S., et al. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102711 · Cited by 9

Developing Vaccines in Pancreatic Adenocarcinoma: Trials and Tribulations

Phan, T. X., Fan, D., & Melstrom, L. G. (2024) · Current Oncology · doi:10.3390/curroncol31090361 · Cited by 9

The Road Ahead in Pancreatic Cancer: Emerging Trends and Therapeutic Prospects

Do, C. T. P., Prochnau, J. Y., Domínguez, A. M., Wang, P., & Rao, M. K. (2024) · Biomedicines · doi:10.3390/biomedicines12091979 · Cited by 9

mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic

Chen, P., Shi, X., He, W., Zhong, G., Tang, Y., Wang, H., & Zhang, P. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2040330 · Cited by 10

Nurturing Deep Tech to Solve Social Problems: Learning from COVID-19 mRNA Vaccine Development

Okuyama, R. (2022) · Pathogens · doi:10.3390/pathogens11121469 · Cited by 11

Enhancement of SARS-CoV-2 mRNA Vaccine Efficacy through the Application of TMSB10 UTR for Superior Antigen Presentation and Immune Activation

Ding, X., Zhou, Y., He, J., Zhao, J., & Li, J. (2024) · Vaccines · doi:10.3390/vaccines12040432 · Cited by 8

In Situ Tumor-Infiltrating Lymphocyte Therapy by Local Delivery of an mRNA Encoding Membrane-Anchored Anti-CD3 Single-Chain Variable Fragment

Yoon, J., Fagan, E., Jeong, M., & Park, J. (2024) · ACS Nano · doi:10.1021/acsnano.4c03518 · Cited by 8

Replicon RNA vaccines: design, delivery, and immunogenicity in infectious diseases and cancer

Tang, L., Que, H., Wei, Y., Yang, T., Tong, A., & Wei, X. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01694-2 · Cited by 11

Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis

Borhan, B., Murray, A. M., Saei, A. A., Ghaffari, B., Jackson, J. E., Mohammed, N., Mitchell, M. J., Vali, H., Whitehead, K. A., & Mahmoudi, M. (2026) · Nature Communications · doi:10.1038/s41467-026-74240-4 · Cited by 11

Current Perspectives and Future Prospects of mRNA Vaccines against Viral Diseases: A Brief Review.

Vasavi, K., Poloju, D., Puvvala, B., Madineni, K., Balaji, S. N., Sheela, C. M. P., Manchikanti, S. S. C., & Moon, S. M. (2022) · PubMed Central · doi:10.22088/ijmcm.bums.11.3.260 · Cited by 12

COVID-19 mRNA Vaccine Degradation Prediction Using LR and LGBM Algorithms

Soon, H. I., Abdullah, A. A., Harun, N. H., & Kanaya, S. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1997/1/012005 · Cited by 8

Lessons learned from COVID-19 pandemic: Vaccine platform is a key player

Alhashemi, S. H., Ahmadi, F., & Dehshahri, A. (2022) · Process Biochemistry · doi:10.1016/j.procbio.2022.12.002 · Cited by 11

mRNA—From COVID-19 Treatment to Cancer Immunotherapy

Kŕause, W. (2023) · Biomedicines · doi:10.3390/biomedicines11020308 · Cited by 8

Unleashing the potential of mRNA : Overcoming delivery challenges with nanoparticles

Chen, Q., Huo, K.-G., Ji, S., Pang, S., Sun, T., Niu, Y., Jiang, Z., Zhang, P., Han, S., & Li, J. (2024) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10713 · Cited by 8

On‐Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles

Zilberzwige‐Tal, S., Levin, A., Ezra, A., Elia, U., Finkelstein‐Zuta, G., Kreiser, T., Gershon, L., Goldsmith, M., Kon, E., Navon, Y., et al. (2025) · Small · doi:10.1002/smll.202500114 · Cited by 7

Gold Nanoparticle–mRNA Conjugates Encapsulated in Lipid Nanoparticles for Coordinated Codelivery of Multiple mRNAs

Hwang, D., Park, S. A., Kim, J. H., Lee, S.-Y., Lee, J., Kim, H. S., Kim, K., Lee, S., Oh, T. J., Lee, J., et al. (2025) · ACS Omega · doi:10.1021/acsomega.5c02145 · Cited by 7

Harnessing the Potential of mRNA Vaccines Against Infectious Diseases

Rezk, N., & McClean, S. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70212 · Cited by 10

mRNA-LNP vaccines: rational design, delivery optimization, and clinical translation

Jiang, S., & Lu, Z. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01972a · Cited by 10

Rewriting Tumor Entry Rules: Microfluidic Polyplexes and Tumor-Penetrating Strategies—A Literature Review

Volovăț, S. R., Augustin, I. G., Volovat, C. D., Ingrid, T. V., Ostafe, M. R., Panaite, D. I., Burlacu, A. I., & Volovăț, C. C. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18010084 · Cited by 8

Advanced strategies for the diagnosis, treatment, and vaccination of monkeypox

Wang, W., Gao, Q., Li, Y., Guo, H., Zheng, J., Fu, Y., & Liao, Y. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03876-z · Cited by 8

Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency

Miliotou, Α. N., Foltopoulou, P. F., Ingendoh‐Tsakmakidis, A., Tsiftsoglou, A. S., Vizirianakis, I. S., Pappas, I. S., & Papadopoulou, L. C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010286 · Cited by 7

Biomaterial‐Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury

McGuire, T. K., Stasiewicz, M., Woods, I., Dervan, A. G., & O’Brien, F. J. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300030 · Cited by 8

Current status of vaccine immunotherapy for gastrointestinal cancers

Suzuki, N., Shindo, Y., Nakajima, M., Tsunedomi, R., & Nagano, H. (2023) · Surgery Today · doi:10.1007/s00595-023-02773-y · Cited by 7

Innovative translational platforms for rapid developing clinical vaccines against COVID‐19 and other infectious disease

Wang, N., & Wang, T. (2024) · Biotechnology Journal · doi:10.1002/biot.202300658 · Cited by 11

Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines

Meldgaard, T. S., Blengio, F., Maffione, D., Sammicheli, C., Tavarini, S., Nuti, S., Kratzer, R., Medini, D., Siena, E., & Bertholet, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.757151 · Cited by 7

Comparison of Physicochemical Properties of LipoParticles as mRNA Carrier Prepared by Automated Microfluidic System and Bulk Method

Ayad, C., Yavuz, A., Salvi, J.-P., Libeau, P., Exposito, J., Ginet, V., Monge, C., Verrier, B., & Arruda, D. C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061297 · Cited by 7

mRNA Delivery and Storage by Co-Assembling Nanostructures with Designer Oligopeptides

Feng, R., Chang, A. C. Y., Ni, R., Li, C. Y., & Chau, Y. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00397 · Cited by 7

mRNA as a medicine in nephrology: the future is now

Granata, S., Stallone, G., & Zaza, G. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad196 · Cited by 7

Good Manufacturing Practices and Upscaling of mRNA Vaccine Production

Stamoula, Ε., Vavilis, T., Dardalas, I., & Papazisis, G. (2024) · Wiley eBooks · doi:10.1002/9783527838394.ch6 · Cited by 7

Enhanced Pulmonary and Splenic mRNA Delivery Using DOTAP-Incorporated Poly(β-Amino Ester)-Lipid Nanoparticles

Gao, Y., Zhang, L., Wang, Z., Bai, H., Wu, C., Shuai, Q., & Yan, Y. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.4c01445 · Cited by 6

Hierarchically porous carnosine-Zn microspheres

Chen, Y., Zilberzwige‐Tal, S., Rosenmann, N. D., Oktawiec, J., Nensel, A. K., Ma, Q., Lichtenstein, S., Gazit, E., & Gianneschi, N. C. (2025) · Matter · doi:10.1016/j.matt.2025.102108 · Cited by 6

State of the art in CAR-based therapy: In vivo CAR production as a revolution in cell-based cancer treatment

Esmaeilzadeh, A., Hadiloo, K., Yaghoubi, S., Makoui, M. H., & Mostanadi, P. (2025) · Cellular Oncology · doi:10.1007/s13402-025-01056-7 · Cited by 7

Recent Developments of RNA Vaccines and Therapeutics: Reagents, Formulations, and Characterization

Tomeh, M. A., Smith, R. K., & Watkinson, A. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00670 · Cited by 8

Hepatocyte-specific partial cellular reprogramming via selective OSK mRNA lipid nanoparticle attenuates liver fibrosis

Zhang, C., Bai, Y., Yin, Q., Li, J., Huang, K., & Qiu, M. R. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114569 · Cited by 6

Nucleic Acid Vaccines Encoding Proteins and Virus-like Particles for HIV Prevention

Tarrés-Freixas, F., Clotet, B., Carrillo, J., & Blanco, J. (2024) · Vaccines · doi:10.3390/vaccines12030298 · Cited by 6

Unlocking the potential of nanocarrier-mediated mRNA delivery across diverse biomedical frontiers: A comprehensive review

Pawar, S., Pingale, P., Garkal, A., Osmani, R. A. M., Gajbhiye, K. R., Kulkarni, M., Pardeshi, K., Mehta, T. A., & Rajput, A. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131139 · Cited by 6

Recent strategies for enhanced delivery of mRNA to the lungs

Heiser, B. J., Veyssi, A., & Ghosh, D. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2485669 · Cited by 7

Exploration of hybrid deep learning algorithms for covid-19 mrna vaccine degradation prediction system

Soon, H. I., Abdullah, A. A., Mashor, ‪. Y., Mohamed‐Hussein, Z., Mohamed, Z., & Ang, W. C. (2022) · International Journal of Advances in Intelligent Informatics · doi:10.26555/ijain.v8i3.950 · Cited by 6

Medicinal Mushrooms for Respiratory Health

Booi, H.-N., Lee, M.-K., Ting, K., & Fung, S. Y. (2023) · Springer eBooks · doi:10.1007/978-981-19-9550-7_2 · Cited by 7

mRNA-Based Nanomedicine: A New Strategy for Treating Infectious Diseases and Beyond

Prakash, S. (2023) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-023-00849-1 · Cited by 6

Multifunctional nanocarrier-mediated delivery for targeting and treating skin cancer

Mongia, P. R., Singh, M. A., Sahu, K. K., Yadav, D. K., Joshi, R., Kaurav, M., Minz, S., Raj, R., & Gupta, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95303-0.00013-7 · Cited by 6

Current Status of COVID‐19 (Pre)Clinical Vaccine Development

Ye, T., Zhong, Z., García‐Sastre, A., Schotsaert, M., & Geest, B. G. D. (2020) · Angewandte Chemie · doi:10.1002/ange.202008319 · Cited by 6

Lipid nanoparticle mediated mRNA delivery in cancer immunotherapy

Asthana, G. S., Bhattacharjee, S., Kumar, J., Sayyed, S., Jindal, A., Kumar, P., Chinchane, A., Bhattacharyya, A., Jaiswal, R., Kulkarni, S., et al. (2025) · Advances in immunology · doi:10.1016/bs.ai.2025.02.001 · Cited by 5

Amplifying STING activation by biomimetic manganese mRNA nanovaccines for local and systemic cancer immunotherapy

He, C., Shi, C., Fang, M., Chang, P., Hou, P., Zhang, Y., & Li, J. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113788 · Cited by 5

Selection of UTRs in mRNA-Based Gene Therapy and Vaccines

Volkhin, I. A., Paremskaia, A. I., Dashian, M. A., Smeshnova, D. S., Pavlov, R. E., Mityaeva, O. N., Volchkov, P. Y., & Deviatkin, A. A. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297924604659 · Cited by 7

Harnessing mRNA-encoded PcrV-targeting monoclonal antibodies for combating antibiotic-resistant P. aeruginosa infections

Wang, X., Gao, X., Liu, C., Yang, L., Li, L., Rcheulishvili, N., Wang, Z., Guo, J., Yang, C., Zheng, Y., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.09.025 · Cited by 5

Novel therapeutic approaches to cancer immunotherapy and mRNA vaccines technology: a review

Adebanjo, E. A., Bakare, K. M., Matthew, U. O., Fatai, L. O., & Oyekunle, D. O. T. (2025) · Holistic Integrative Oncology · doi:10.1007/s44178-025-00213-0 · Cited by 7

Simple ion-pairing reversed phase LC-UV method for the relative quantification of capping species in mRNA-based modalities

Maurer, J., Bouchard, D., Bousquier, A., Malburet, C., Cotte, J., & Guillarme, D. (2026) · Journal of Chromatography B · doi:10.1016/j.jchromb.2026.124922 · Cited by 5

Nanomaterial-enabled RNA therapeutics: bridging delivery barriers to clinical translation

Pandey, K., Jha, S., Chaliha, L. B., Gosai, H. B., & Patel, R. (2026) · Frontiers in Nanotechnology · doi:10.3389/fnano.2026.1860221 · Cited by 7

High-efficiency editing in hematopoietic stem cells and the HUDEP-2 cell line based on in vitro mRNA synthesis

Papaioannou, N. Y., Patsali, P., Naiisseh, B., Papasavva, P. L., Koniali, L., Kurita, R., Nakamura, Y., Christou, S., Sitarou, M., Mussolino, C., et al. (2023) · Frontiers in Genome Editing · doi:10.3389/fgeed.2023.1141618 · Cited by 5

Visible Light Conjugation with Triazolinediones as a Route to Degradable Poly(ethylene glycol)–Lipids for mRNA Lipid Nanoparticle Formulation

Golba, B., Soete, M., Zhong, Z., Sanders, N. N., Prez, F. D., Houck, H. A., & Geest, B. G. D. (2023) · Angewandte Chemie · doi:10.1002/ange.202301102 · Cited by 5

Targeting pediatric solid tumors in the new era of RNA therapeutics

Chaiyawat, P., Sangkhathat, S., Chiangjong, W., Wongtrakoongate, P., Hongeng, S., Pruksakorn, D., & Chutipongtanate, S. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104406 · Cited by 6

The Impact of Chemical Modifications on the Interferon-Inducing and Antiproliferative Activity of Short Double-Stranded Immunostimulating RNA

Bishani, A., Meschaninova, M. I., Аркадьевна, З. М., & Chernolovskaya, E. L. (2024) · Molecules · doi:10.3390/molecules29133225 · Cited by 5

Promising RNA-based therapies for viral infections, genetic disorders, and cancer

Musa, D. A., Raji, M. O., Sikiru, A. B., Aremu, H. K., & Aigboeghian, E. A. (2024) · Academia molecular biology and genomics. · doi:10.20935/acadmolbiogen7329 · Cited by 7

A capless hairpin-protected mRNA vaccine encoding the full-length Influenza A hemagglutinin protects mice against a lethal Influenza A infection

Solodushko, V., Kim, J. H., & Fouty, B. (2025) · Gene Therapy · doi:10.1038/s41434-025-00521-0 · Cited by 5

Challenges and opportunities in healthcare biotechnology

Bhatti, A., Rehman, A., & John, P. C. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90042-3.00014-1 · Cited by 7

Design and in silico analysis of mRNA vaccine construct against Salmonella

Imdad, M. J., Khan, M. N., Alam, H. S., Khan, A. B., Mirani, Z. A., Khan, A. U., & Ahmed, F. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2119280 · Cited by 5

mRNA Vaccines: a growing and complex IP landscape

Burrows, R., & Lambrix, E. (2022) · Vaccine Insights · doi:10.18609/vac.2022.029 · Cited by 5

Transitional Insight into the RNA-Based Oligonucleotides in Cancer Treatment

Tabasi, H., Mollazadeh, S., Fazeli, E., Abnus, K., Taghdisi, S. M., Ramezani, M., & Alibolandi, M. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04597-5 · Cited by 5

Future prospects in mRNA vaccine development

Mbatha, L. S., Akinyelu, J., Maiyo, F., & Kudanga, T. (2023) · Biomedical Materials · doi:10.1088/1748-605x/aceceb · Cited by 7

A computational study of cell membrane damage and intracellular delivery in a cross-slot microchannel

Lu, R., Yu, P., & Sui, Y. (2024) · Soft Matter · doi:10.1039/d4sm00047a · Cited by 5

Bioinformatics-Driven mRNA-Based Vaccine Design for Controlling Tinea Cruris Induced by Trichophyton rubrum

Elalouf, A., Maoz, H., & Yaniv‐Rosenfeld, A. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16080983 · Cited by 5

Development of COVID-19 mRNA Vaccine Degradation Prediction System

Soon, H. I., Abdullah, A. A., & Kanaya, S. (2021) · International Conference on Innovation and Intelligence for Informatics, Computing, and Technologies (3ICT) · doi:10.1109/3ict53449.2021.9582052 · Cited by 5

Viral vectors engineered for gene therapy

Lundstrom, K. H. (2023) · International review of cytology · doi:10.1016/bs.ircmb.2023.05.005 · Cited by 4

Engineering Universal Cancer Immunity: Non-Tumor-Specific mRNA Vaccines Trigger Epitope Spreading in Cold Tumors

Magoola, M., & Niazi, S. K. (2025) · Vaccines · doi:10.3390/vaccines13090970 · Cited by 7

CircRNA vaccine encoding a chimeric immunogen of B6 and M1 demonstrates robust immune responses against MPXV

Wu, J., Rou, W., Gao, Z., Ma, X., Ding, H., Zheng, T., Wang, L., Zhao, L., Yang, K., Li, X., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116432 · Cited by 4

PEG-free Lipid Nanoparticles for mRNA Delivery: Superhydrophilic Sulfoxide Polymer Coatings

Choy, O. T., Fletcher, N. L., Fu, C., Vu, M. N., Ediriweera, G. R., Humphries, J., Hu, M., Kent, S. J., Cai, R., Chen, C., et al. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c01899 · Cited by 5

mRNA delivery via non-viral carriers for biomedical applications

Shuai, Q., Zhu, F., Zhao, M., & Yan, Y. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121020 · Cited by 35

Nonviral targeted mRNA delivery: principles, progresses, and challenges

He, X., Li, G., Huang, L., Shi, H., Zhong, S., Zhao, S., Jiao, X., Xin, J., Yin, X., Liu, S., et al. (2025) · MedComm · doi:10.1002/mco2.70035 · Cited by 21

mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications

Wang, Y., Kumari, M., Chen, G., Hong, M.-H., Yuan, J. P., Tsai, J.-L., & Wu, H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00977-5 · Cited by 198

mRNA vaccines — a new era in vaccinology

Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667

Challenges and advances of the stability of mRNA delivery therapeutics

Zhai, J., Cote, T., & Chen, Y. (2024) · Nucleic Acid Insights · doi:10.18609/nai.2024.015 · Cited by 30