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Gene therapy boom continues

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The involvement of immune system in intervertebral disc herniation and degeneration

Ye, F., Lyu, F., Wang, H., & Zheng, Z. (2022) · JOR Spine · doi:10.1002/jsp2.1196 · Cited by 145 · see citing works

Applications of Hyaluronic Acid in Ophthalmology and Contact Lenses

Chang, W.-H., Liu, P., Lin, M.-H., Lu, C.-J., Chou, H.-Y., Nian, C.-Y., Jiang, Y.-T., & Hsu, Y. (2021) · Molecules · doi:10.3390/molecules26092485 · Cited by 116 · see citing works

Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective

Rehman, M., Tahir, N., Sohail, M. F., Qadri, M. U., Duarte, S. O. D., Brandão, P., Esteves, T., Javed, I., & Fonte, P. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16111376 · Cited by 104 · see citing works

Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery

Grijalvo, S., Puras, G., Sesma, J. Z., Sainz-Ramos, M., Qtaish, N. A., López-Méndez, T. B., Mashal, M., Attia, N., Díaz, D. D., Pons, R., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020050 · Cited by 95 · see citing works

Nose-to-brain drug delivery approach: a key to easily accessing the brain for the treatment of Alzheimer's disease

Alexander, A., & Saraf, S. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.241458 · Cited by 77 · see citing works

How Far Are Non-Viral Vectors to Come of Age and Reach Clinical Translation in Gene Therapy?

Sainz-Ramos, M., Gallego, I., Villate-Beitia, I., Sesma, J. Z., Maldonado, I., Puras, G., & Pedraz, J. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147545 · Cited by 59 · see citing works

Current developments of gene therapy in human diseases

Liu, F., Li, R., Zhu, Z., Yang, Y., & Lu, F. (2024) · MedComm · doi:10.1002/mco2.645 · Cited by 43 · see citing works

Scaffold-Mediated Gene Delivery for Osteochondral Repair

Madry, H., Venkatesan, J. K., Carballo-Pedrares, N., Rey‐Rico, A., & Cucchiarini, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100930 · Cited by 35 · see citing works

Next generation therapeutics for retinal neurodegenerative diseases

Appell, M. B., Pejavar, J., Pasupathy, A., Rompicharla, S. V. K., Abbasi, S., Malmberg, K., Kolodziejski, P., & Ensign, L. M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.063 · Cited by 32 · see citing works

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar, R. Y., Fakhr, Z. A., Abbasgholinejad, E., & Doroudian, M. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300275 · Cited by 30 · see citing works

Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy

Alvarez-Rivera, F., Rey‐Rico, A., Venkatesan, J. K., Díaz-Gómez, L. A., Cucchiarini, M., Concheiro, Á., & Alvarez‐Lorenzo, C. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040335 · Cited by 30 · see citing works

Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Zakharova, L. Y., Maganova, F., Sinyashin, K. O., Gaynanova, G. A., Mirgorodskaya, A. B., Vasilieva, E. A., & Sinyashin, O. G. (2023) · Russian Journal of General Chemistry · doi:10.1134/s1070363223070253 · Cited by 28 · see citing works

Nanodiamond integration into niosomes as an emerging and efficient gene therapy nanoplatform for central nervous system diseases

AL Qtaish, N., Gallego, I., Paredes, A. J., Villate-Beitia, I., Soto-Sánchez, C., Martínez-Navarrete, G., Sainz-Ramos, M., Lopez-Mendez, T. B., Fernández, E., Puras, G., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02182 · Cited by 29 · see citing works

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

Chiş, A. A., Dobrea, C. M., Rus, L. L., Frum, A., Morgovan, C., Butucă, A., Totan, M., Juncan, A. M., Gligor, F. G., & Arseniu, A. M. (2021) · Molecules · doi:10.3390/molecules26195976 · Cited by 27 · see citing works

Optical-Property-Enhancing Novel Near-Infrared Active Niosome Nanoformulation for Deep-Tissue Bioimaging

Bishnoi, S., Rehman, S., Dutta, S. B., De, S. K., Chakraborty, A., Nayak, D., & Gupta, S. (2021) · ACS Omega · doi:10.1021/acsomega.1c02632 · Cited by 25 · see citing works

Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging

Gallego, I., Villate-Beitia, I., del Burgo, L. S., Puras, G., & Pedraz, J. L. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000418 · Cited by 25 · see citing works

Recent Developments in Gene Therapy for Neovascular Age-Related Macular Degeneration: A Review

Finocchio, L., Zeppieri, M., Gabai, A., Toneatto, G., Spadea, L., & Salati, C. (2023) · Biomedicines · doi:10.3390/biomedicines11123221 · Cited by 28 · see citing works

Niosomes-based gene delivery systems for effective transfection of human mesenchymal stem cells

Carballo-Pedrares, N., Kattar, A., Concheiro, Á., Alvarez‐Lorenzo, C., & Rey‐Rico, A. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112307 · Cited by 23 · see citing works

Chondrogenic Differentiation of Human Mesenchymal Stem Cells via SOX9 Delivery in Cationic Niosomes

Carballo-Pedrares, N., Sanjurjo‐Rodríguez, C., Señarís, J., Díaz‐Prado, S., & Rey‐Rico, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112327 · Cited by 20 · see citing works

Stability of polymeric cationic niosomes and their plasmid DNA-based complexes as gene delivery carriers

Mashal, M., Attia, N., Grijalvo, S., Eritja, R., Puras, G., & Pedraz, J. L. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2219420 · Cited by 19 · see citing works

Chemical Modifications in Nucleic Acids for Therapeutic and Diagnostic Applications

Fàbrega, C., Aviñó, A. M., & Eritja, R. (2021) · The Chemical Record · doi:10.1002/tcr.202100270 · Cited by 18 · see citing works

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Chen, S., Zhang, H., Wang, Z., Zhu, D., Li, Y., Zhang, Y., Wang, D., Chen, S.-W., Liu, H., & Kang, X. (2025) · Cell Proliferation · doi:10.1111/cpr.70068 · Cited by 15 · see citing works

Current Designs of Polymeric Platforms Towards the Delivery of Nucleic Acids Inside the Cells with Focus on Polyethylenimine

de Oliveira, F. A., Albuquerque, L. J. C., Delecourt, G., Bennevault, V., Guégan, P., & Giacomelli, F. C. (2021) · Current Gene Therapy · doi:10.2174/1566523221666210705130238 · Cited by 15 · see citing works

A Comprehensive Review on Niosomes as a Strategy in Targeted Drug Delivery: Pharmaceutical, and Herbal Cosmetic Applications

Saharawat, S., & Verma, S. (2024) · Current Drug Delivery · doi:10.2174/0115672018269199231121055548 · Cited by 15 · see citing works

Efficient Gene Delivery Based on Guanidyl‐Nucleic Acid Molecular Interactions

Wang, D., Song, J., Wang, J., Zhang, Z., Shen, Q. X., Wang, J., Guo, H., Wang, R., Xie, C., Lu, W., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202004783 · Cited by 14 · see citing works

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

Kattar, A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1953466 · Cited by 14 · see citing works

Sphingolipid extracts enhance gene delivery of cationic lipid vesicles into retina and brain

Qtaish, N. A., Gallego, I., Villate-Beitia, I., Sainz-Ramos, M., Martı́nez, G., Soto‐Sánchez, C., Fernández, E., Gálvez‐Martín, P., López-Méndez, T. B., Puras, G., et al. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.09.011 · Cited by 13 · see citing works

Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies

Eş, İ., Thakur, A., Khaneghah, A. M., Foged, C., & de la Torre, L. G. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2024.108342 · Cited by 13 · see citing works

Drug Encapsulation: Review of Niosomes for Promoting Antimicrobial Activity

do Nascimento, T., Garófalo, D. D. A., Monteiro, M. S. D. S. D. B., Santos‐Oliveira, R., Matos, A. P. D. S., & Ricci‐Júnior, E. (2022) · Journal of Nanoparticle Research · doi:10.1007/s11051-022-05637-7 · Cited by 11 · see citing works

Correlation between Biophysical Properties of Niosomes Elaborated with Chloroquine and Different Tensioactives and Their Transfection Efficiency

Sainz-Ramos, M., Villate-Beitia, I., Gallego, I., Qtaish, N. A., Menéndez, M., Lagartera, L., Grijalvo, S., Eritja, R., Puras, G., & Pedraz, J. L. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111787 · Cited by 10 · see citing works

Photosensitive Poly-l-lysine/Heparin Interpolyelectrolyte Complexes for Delivery of Genetic Drugs

Korzhikov-Vlakh, V. A., Katernuk, I., Pilipenko, I., Lavrentieva, A. V., Guryanov, I., Sharoyko, V. V., Manshina, A., & Tennikova, T. B. (2020) · Polymers · doi:10.3390/polym12051077 · Cited by 10 · see citing works

Exploiting niosomes as efficient non-viral vectors for enhanced gene transfer to human mesenchymal stem cells

López-Seijas, J., Iglesias-Fente, A., Miranda-Balbuena, D., & Rey‐Rico, A. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106766 · Cited by 9 · see citing works

Nanovesicular Drug Delivery Systems for Rare Ocular Diseases: Advances, Challenges, and Future Directions

Sultana, S., Yusuf, M., & Sharma, V. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03159-8 · Cited by 9 · see citing works

Development of new non-viral systems for genetic modification of senescent cells

López-Seijas, J., Miranda-Balbuena, D., Iglesias-Fente, A., Sacristán-Santos, M., Carballo-Pedrares, N., Arufe, M. C., Rey‐Rico, A., & Fafián‐Labora, J. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.03.010 · Cited by 9 · see citing works

Non-Viral Delivery Systems to Transport Nucleic Acids for Inherited Retinal Disorders

Jony, M. J. H., Joshi, A., Dash, A. K., & Shukla, S. (2025) · Pharmaceuticals · doi:10.3390/ph18010087 · Cited by 10 · see citing works

Elegant, Flexible Vesicular Nanocarriers for the Efficient Skin Delivery of Topically Applied Drugs

Albalawi, W. I., Alharbi, S., Alanazi, F., Alahmadi, H., Alghamdi, M., Soliman, G. M., & Safwat, M. A. (2021) · Current Nanoscience · doi:10.2174/1573413718666211230111538 · Cited by 8 · see citing works

Intravitreal CBD-loaded niosomes enhance retinal neuroprotection in ischemic injury

da Silva, C. N., Dourado, L. F. N., Agata, B. L., Fernandes, M. A. S., Dias, M. F., & Fialho, S. L. (2025) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2025.114705 · Cited by 6 · see citing works

Long-term biophysical stability of nanodiamonds combined with lipid nanocarriers for non-viral gene delivery to the retina

Qtaish, N. A., Villate-Beitia, I., Gallego, I., Martı́nez, G., Soto‐Sánchez, C., Sainz-Ramos, M., López-Méndez, T. B., Paredes, A. J., Chichón, F. J., Zamarreño, N., et al. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122968 · Cited by 6 · see citing works

Evaluation and Optimization of Poly-d-Lysine as a Non-Natural Cationic Polypeptide for Gene Transfer in Neuroblastoma Cells

Sánchez-Martos, M. Á., Martı́nez, G., Bernabeu-Zornoza, A., Humphreys, L., & Fernández, E. (2021) · Nanomaterials · doi:10.3390/nano11071756 · Cited by 5 · see citing works

A Comprehensive Review on Recent Advances and Patents of Niosomes

Saharawat, S., & Verma, S. (2023) · Recent Patents on Nanotechnology · doi:10.2174/0118722105259776231002071218 · Cited by 4 · see citing works

Characteristics and Applications of Peptide Nucleic Acid in the Treatment of Infectious Diseases and the Effect of Antimicrobial Photodynamic Therapy on Treatment Effectiveness

Javanmard, Z., Pourhajibagher, M., & Bahador, A. (2023) · Infectious Disorders - Drug Targets · doi:10.2174/1871526523666230724120957 · Cited by 3 · see citing works

Development and evaluation of niosomes containing amphotericin B and clove oil for the improvement of antifungal and antiparasitic therapies

do Nascimento, T., Cardoso, V. D. S., Santos‐Oliveira, R., Barreto-Vieira, D. F., Vermelho, A. B., & Ricci‐Júnior, E. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107243 · Cited by 2 · see citing works

Nanovesicles for intravenous drug delivery

Gülteki̇n, H. E., Öner, E., İlhan, M., & Karpuz, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91865-7.00018-3 · Cited by 2 · see citing works

FORMULATION AND CARACTERIZATION OF QUERCETIN NIOSOME WITH CONCENTRATION VARIATIONS OF SPAN 20 SURFACTANT

Bhagawan, W. S., Annisa, R., & Maulidya, A. F. (2021) · Journal of Pharmaceutical Sciences and Community · doi:10.24071/jpsc.002839 · Cited by 1 · see citing works

Natural medicines, plants ingredients, foods, and essential oils nano-formulations: A new paradigm in nanotechnical developments

Al‐Saffar, A. Z., Mohammed, H. A., Khan, R. A., Sulaiman, G. M., Hadi, N. A., Ismaeel, F. E., Mostafa, E. M., Khashan, K. S., & Ismail, A. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107822 · Cited by 1 · see citing works

Preparation and Characterization of Niosomes for Bacteriophage Delivery

George, A. H., Jelínek, P., Benešík, M., Košiarčiková, S., Mikšátko, J., Pečurlić, I., Moša, M., & Šoóš, M. (2025) · Small Science · doi:10.1002/smsc.202500530 · Cited by 1 · see citing works

Recent advances in lipid and biomimetic nanocarriers for nucleic acid delivery in glioblastoma

Xu, C., He, Z., & Li, J. (2026) · Discover Oncology · doi:10.1007/s12672-026-04991-5 · Cited by 1 · see citing works

Hydrogels as biologics/gene delivery systems

Rey‐Rico, A., Carballo-Pedrares, N., Venkatesan, J. K., Madry, H., & Cucchiarini, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823948-3.00034-8 · Cited by 1 · see citing works

A novel gene delivery approach to face cystic fibrosis by non-viral vectors based on niocarbosomes

Maldonado, I., Gallego, I., Enríquez, L., Iturrospe, A., Arbe, A., Mashal, M., Attia, N., Puras, G., & Pedraz, J. L. (2025) · Surfaces and Interfaces · doi:10.1016/j.surfin.2025.106639 · Cited by 1 · see citing works

Potential anti-osteoclastic and anti-inflammatory effects of metformin-encapsulated hyaluronic acid-decorated niosome nanoparticles: possible application for effective treatment of rheumatoid arthritisPreprint

Hatem, S. J., Al-Tu’ma, F. J., & Mukheef, M. A. (2024) · Research Square · doi:10.21203/rs.3.rs-4767562/v1 · Cited by 1 · see citing works

ABSTRACTS (BY NUMBER)

Vaithilingam, V., Reys, L. L., Sthijns, M. M. J. P. E., Rademakers, T., de Vries, R. H. W., Mohammed, S. G., Bont, D. D., Jetten, M., de Koning, E. J. P., Mourad, N. I., et al. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.29025.abstracts

Niosomes

Fabiano, M. G., Forte, J., Hanieh, P. N., Rinaldi, F., Marianecci, C., & Carafa, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-59478-6_3

A multidimensional approach to retinal dystrophies: Bridging advanced therapeutics, nutrition, and personalized care

Goyal, S., & Vanita, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-43986-5.00042-4

Discoradicular conflict: vicious circles of the inflammatory model

Kovalev, M. A., Sherman, M. A., Муравьев, С. В., Зурабиевна, К. Г., & Дмитриевич, Ш. И. (2026) · Perm Medical Journal · doi:10.17816/pmj43334-49

Innovative niosome screening for efficient gene delivery in senescent primary umbilical cord stroma-derived MSCs

Iglesias-Fente, A., López-Seijas, J., Arufe, M. C., Fafián‐Labora, J., & Rey‐Rico, A. (2026) · Drug Delivery · doi:10.1080/10717544.2026.2726650

The role of the cationic and helper lipids on niosomes for gene delivery applications: transfection of retina and brain as a main goal.

Hernández, E. O. (2016) · Communities in ADDI (Universidad del Pais Vasco)

Non-viral vectors based on cationic niosomes as efficient gene delivery vehicles to central nervous system cells into the brain

Mashal, M., Attia, N., Soto‐Sánchez, C., Martı́nez, G., Fernández, E., Puras, G., & Pedraz, J. L. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.09.038 · Cited by 36 · see citing works

The influence of the polar head-group of synthetic cationic lipids on the transfection efficiency mediated by niosomes in rat retina and brain

Ojeda, E., Puras, G., Agirre, M., Sesma, J. Z., Grijalvo, S., Eritja, R., Martı́nez, G., Soto‐Sánchez, C., Díaz‐Tahoces, A., Avilés‐Trigueros, M., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.017 · Cited by 74 · see citing works

Design, elaboration, characterization and evaluation of niosome formulations for gene delivery to retina and brain

Ahmed Mashal, M. A. (2020) · Communities in ADDI (Universidad del Pais Vasco)

Polysorbate 20 non-ionic surfactant enhances retinal gene delivery efficiency of cationic niosomes after intravitreal and subretinal administration

Villate-Beitia, I., Gallego, I., Martínez-Navarrete, G., Zárate, J., López-Méndez, T., Soto-Sánchez, C., Santos-Vizcaíno, E., Puras, G., Fernández, E., & Pedraz, J. L. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.07.035 · Cited by 42 · see citing works