Cited by 159Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsNonmelanoma Skin Cancer Studies

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Current Challenges and Opportunities of Photodynamic Therapy against Cancer

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Huis in ‘t Veld, Ruben V., Heuts, Jeroen, Ma, Sen, Cruz, Luis J., Ossendorp, Ferry A., Jager, Martine J.·2023·Pharmaceutics

DOI 10.3390/pharmaceutics15020330PMC PMC9965442

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Abstract

BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are generated that ultimately induce cell death and disruption of the tumor area. Moreover, PDT can result in damage to the tumor vasculature and induce the release and/or exposure of damage-associated molecular patterns (DAMPs) that may initiate an antitumor immune response. However, there are currently several challenges of PDT that limit its widespread application for certain indications in the clinic. METHODS: A literature study was conducted to comprehensively discuss these challenges and to identify opportunities for improvement. RESULTS: The most notable challenges of PDT and opportunities to improve them have been identified and discussed. CONCLUSIONS: The recent efforts to improve the current challenges of PDT are promising, most notably those that focus on enhancing immune responses initiated by the treatment. The application of these improvements has the potential to enhance the antitumor efficacy of PDT, thereby broadening its potential application in the clinic.

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Authors: Huis in ‘t Veld, R. V., Heuts, J., Ma, S., Cruz, L. J., Ossendorp, F. A., & Jager, M. J.
Affiliations: Department of Ophthalmology, Leiden University Medical Centre (LUMC), 2333 ZA Leiden, Zuid-Holland, The Netherlands
Leiden University Medical Center (NL)
ORCID: Heuts, Jeroen
Ma, Sen
Cruz, Luis J.
Ossendorp, Ferry A.
Jager, Martine J.
Venue: Pharmaceutics
Publisher: MDPI AG
Published: 2023-01-18
Volume: 15
Issue: 2
Pages: 330
ISSN: 1999-4923 (ISSN-L)
DOI: 10.3390/pharmaceutics15020330
PMC: PMC9965442
OpenAlex: W4317425740
Cited by: 159
References: 338
Citations by year: 2026: 35 · 2025: 50 · 2024: 48 · 2023: 26
FWCI: 7.36
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Pharmaceutics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Health-Holland (LSHM19061)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Keywords: photodynamic therapy, cancer therapy, reactive oxygen species, cancer cell death, damage-associated molecular patterns, antitumor immunity, immunotherapy

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