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Antimicrobial Activities of Natural Bioactive Polyphenols
Open accessAbstract
Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety of biological functions in the natural environment. These uses include polyphenols in food, beauty products, dietary supplements, and medicinal products and have grown rapidly during the past 20 years. Antimicrobial polyphenols are described together with their sources, classes, and subclasses. Polyphenols are found in different sources, such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples of benefits are antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, and antimicrobe properties. From these sources, different classes of polyphenols are helpful for the growth of internal functional systems of the human body, providing healthy fats, vitamins, and minerals, lowering the risk of cardiovascular diseases, improving brain health, and rebooting our cellular microbiome health by mitochondrial uncoupling. Among the various health benefits of polyphenols (curcumin, naringenin, quercetin, catechin, etc.) primarily different antimicrobial activities are discussed along with possible future applications. For polyphenols and antimicrobial agents to be proven safe, adverse health impacts must be substantiated by reliable scientific research as well as in vitro and in vivo clinical data. Future research may be influenced by this evaluation.
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“Additionally, phenolics can inactivate vital microbial enzymes by binding to their active sites or altering enzyme conformation, thereby inhibiting metabolic pathways essential for microbial growth and survival (Mandal & Domb, 2024).”
From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Mandal & Domb, 2024
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“Phenolic compounds exert antimicrobial effects through a diverse array of mechanisms that target key structural and functional components of microbial cells.”
From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Mandal & Domb, 2024
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Metadata
- Authors
- Mandal, M. K., & Domb, A. J.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Domb, Abraham J.
- ORCID
- Domb, Abraham J.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2024-05-27
- Volume
- 16
- Issue
- 6
- Pages
- 718
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC11206801
- OpenAlex
- W4399042628
- Cited by
- 141
- References
- 230
- Citations by year
- 2026: 66 · 2025: 64 · 2024: 11
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Hebrew University of Jerusalem
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- polyphenols, antimicrobial activity, plant secondary metabolites, curcumin, naringenin, quercetin, catechins, olive oil, dark chocolate, berries, green tea, functional foods, food safety
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