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Cited by 155Phytochemicals and Antioxidant ActivitiesEssential Oils and Antimicrobial ActivityAntimicrobial agents and applications

The DOI matches its Crossref record; 228 of the 230 references it cites were found in a registry or an index, and 2 are not checked yet.

Antimicrobial Activities of Natural Bioactive Polyphenols

Open access
Mandal, Manas Kumar, Domb, Abraham J.·2024·Pharmaceutics
DOI 10.3390/pharmaceutics16060718PMC PMC11206801
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Abstract

Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety of biological functions in the natural environment. These uses include polyphenols in food, beauty products, dietary supplements, and medicinal products and have grown rapidly during the past 20 years. Antimicrobial polyphenols are described together with their sources, classes, and subclasses. Polyphenols are found in different sources, such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples of benefits are antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, and antimicrobe properties. From these sources, different classes of polyphenols are helpful for the growth of internal functional systems of the human body, providing healthy fats, vitamins, and minerals, lowering the risk of cardiovascular diseases, improving brain health, and rebooting our cellular microbiome health by mitochondrial uncoupling. Among the various health benefits of polyphenols (curcumin, naringenin, quercetin, catechin, etc.) primarily different antimicrobial activities are discussed along with possible future applications. For polyphenols and antimicrobial agents to be proven safe, adverse health impacts must be substantiated by reliable scientific research as well as in vitro and in vivo clinical data. Future research may be influenced by this evaluation.

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Research works printed but not linked: 6

  1. Tijjani, H., Zangoma, M.H., Mohammed, Z.S., Obidola, S.M., Egbuna, C., and Abdulai, S.I. (2020). Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations, Springer.
  2. Ravindran, R., Swamy, M.K., and Jaganathan, R. (2019). Natural Bio-Active Compounds: Volume 2: Chemistry, Pharmacology and Health Care Practices, Springer.
  3. Nabavi, S.M., and Silva, A.S. (2022). Antioxidants Effects in Health, Elsevier.
  4. Manzoor, A., Dar, I.H., Bhat, S.A., and Ahmad, S. (2020). Functional Food Products and Sustainable Health, Springer.
  5. Schmidt, T.M. (2019). Encyclopedia of Microbiology, Academic Press. [4th ed.].
  6. Aulakh, 2019, Bioactive phytoconstituents of pteridophytes–a review, Indian Fern. J., 36, 37

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Metadata

Authors
Mandal, M. K., & Domb, A. J.
Affiliations
Hebrew University of Jerusalem (IL)
Corresponding author
Domb, Abraham J.
ORCID
Domb, Abraham J.
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2024-05-27
Volume
16
Issue
6
Pages
718
ISSN
1999-4923 (ISSN-L)
DOI
10.3390/pharmaceutics16060718
PMC
PMC11206801
OpenAlex
W4399042628
Cited by
141
References
230
Citations by year
2026: 66 · 2025: 64 · 2024: 11
FWCI
5.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Hebrew University of Jerusalem
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Keywords
polyphenols, antimicrobial activity, plant secondary metabolites, curcumin, naringenin, quercetin, catechins, olive oil, dark chocolate, berries, green tea, functional foods, food safety

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