The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments
Open accessAbstract
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.
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Cites
Gaudana, R., Ananthula, H. K., Parenky, A., & Mitra, A. K. (2010) · The AAPS Journal · doi:10.1208/s12248-010-9183-3 · Cited by 1,406
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y.-Y., Cone, R., & Hanes, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608611104 · Cited by 1,050
Challenges and obstacles of ocular pharmacokinetics and drug delivery
Urtti, A. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.027 · Cited by 1,003
Alginate Oligosaccharides: Production, Biological Activities, and Potential Applications
Liu, J., Yang, S., Li, X., Yan, Q., Reaney, M. J. T., & Jiang, Z. (2019) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12494 · Cited by 311
Mendes, A. C., Sevilla Moreno, J., Hanif, M., E.L. Douglas, T., Chen, M., & Chronakis, I. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082266 · Cited by 55
Cited by
Harugade, A., Sherje, A. P., & Pethe, A. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105634 · Cited by 474
Fan, X., Jiang, K., Geng, F., Lu, W., & Wei, G. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114864 · Cited by 33
Metadata
- Authors
- Zamboulis, A., Nanaki, S., Michailidou, G., Koumentakou, I., Lazaridou, M., Ainali, N. M., Xanthopoulou, E., & Bikiaris, D. N.
- Venue
- Polymers
- Publisher
- MDPI AG
- Published
- 2020-07-08
- Volume
- 12
- Issue
- 7
- Pages
- 1519
- ISSN
- 2073-4360 (ISSN-L)
- OpenAlex
- W3041459602
- Cited by
- 187
- References
- 5
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zamboulis, A., Nanaki, S., Michailidou, G., Koumentakou, I., Lazaridou, M., Ainali, N. M., Xanthopoulou, E., & Bikiaris, D. N. (2020). Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments. Polymers. https://doi.org/10.3390/polym12071519
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