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Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives

Open access
Dong, Chanjuan, Lv, Yonggang·2016·Polymers

Abstract

Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to tissues. Collagen can be extracted and purified from a variety of sources and offers low immunogenicity, a porous structure, good permeability, biocompatibility and biodegradability. Collagen scaffolds have been widely used in tissue engineering due to these excellent properties. However, the poor mechanical property of collagen scaffolds limits their applications to some extent. To overcome this shortcoming, collagen scaffolds can be cross-linked by chemical or physical methods or modified with natural/synthetic polymers or inorganic materials. Biochemical factors can also be introduced to the scaffold to further improve its biological activity. This review will summarize the structure and biological characteristics of collagen and introduce the preparation methods and modification strategies of collagen scaffolds. The typical application of a collagen scaffold in tissue engineering (including nerve, bone, cartilage, tendon, ligament, blood vessel and skin) will be further provided. The prospects and challenges about their future research and application will also be pointed out.

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Crossref · 10.3390/polym8020042

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Metadata

Authors
Dong, C., & Lv, Y.
Venue
Polymers
Publisher
MDPI AG
Published
2016-02-04
Volume
8
Issue
2
Pages
42
ISSN
2073-4360 (ISSN-L)
OpenAlex
W2265225559
Cited by
851
References
2
FWCI
15.29
Type
journal article
Language
en
Open access
gold

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