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Cited by 30Origins and Evolution of LifeEvolution and Genetic DynamicsPhilosophy of Biology and Scientific Explanation

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Chemical Basis of Biological Homochirality during the Abiotic Evolution Stages on Earth

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Ribó, Josep, Hochberg, David·2019·Symmetry
DOI 10.3390/sym11060814
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Abstract

Spontaneous mirror symmetry breaking (SMSB), a phenomenon leading to non-equilibrium stationary states (NESS) that exhibits biases away from the racemic composition is discussed here in the framework of dissipative reaction networks. Such networks may lead to a metastable racemic non-equilibrium stationary state that transforms into one of two degenerate but stable enantiomeric NESSs. In such a bifurcation scenario, the type of the reaction network, as well the boundary conditions, are similar to those characterizing the currently accepted stages of emergence of replicators and autocatalytic systems. Simple asymmetric inductions by physical chiral forces during previous stages of chemical evolution, for example in astrophysical scenarios, must involve unavoidable racemization processes during the time scales associated with the different stages of chemical evolution. However, residual enantiomeric excesses of such asymmetric inductions suffice to drive the SMSB stochastic distribution of chiral signs into a deterministic distribution. According to these features, we propose that a basic model of the chiral machinery of proto-life would emerge during the formation of proto-cell systems by the convergence of the former enantioselective scenarios.

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  • Imposed boundary conditions for SMSB involve systems open to matter exchange or closed systems unable to equilibrate energy.

    “Imposed boundary conditions for SMSB involve ''either systems open to matter exchange, or closed systems unable to equilibrate energy with their surroundings''.301”

    From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [301]

  • These models support a scenario where combination of SMSB, self-replicators and their functions led to BH.

    “These models support a scenario in which the combination of SMSB, formation of the first (coupled) self-replicators and the emergence of their functions would have led to BH. 301”

    From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [301]

  • At the time between earth formation and the appearance of life, deracemization inevitably suffered from racemization, which may take place in days or less in a hot alkaline aqueous medium.

    “At that time, deracemization inevitably suffered from its nemesis, racemization, which may take place in days or less in a hot alkaline aqueous medium.35,301,[492][493][494]”

    From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [301]

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Metadata

Authors
Ribó, J., & Hochberg, D.
Affiliations
  • Universitat de Barcelona (ES)
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
Ribó, Josep
ORCID
Venue
Symmetry
Publisher
MDPI AG
Published
2019-06-20
Volume
11
Issue
6
Pages
814
ISSN
2073-8994 (ISSN-L)
DOI
10.3390/sym11060814
OpenAlex
W2949280085
Cited by
30
References
16
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 3 · 2020: 6
FWCI
2.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Symmetry (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministerio de Economía, Industria y Competitividad, Gobierno de España (CTQ2017-87864-C2-1P and –C2-2P)
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
Keywords
non-equilibrium stationary states, enantiomeric excess, racemization, asymmetric induction, enantioselectivity, origin of life, chemical evolution, autocatalytic systems, bifurcation

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