The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Spontaneous mirror symmetry breaking in heterocatalytically coupled enantioselective replicators
Open accessAbstract
Hypercycles proposed as a chemical basis for the selection of biological replicators may lead to homochirality when fed from achiral resources.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Models for enantioselective hypercyclic replicators replace Frank inhibition with mutual cross-catalytic processes.
“Models for enantioselective hypercyclic replicators were recently disclosed in which the inhibition reaction in the Frank model has been replaced by mutual cross-catalytic processes occurring between families of coupled replicators.350,351”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [350]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
The Hypercycle: A principle of natural self-organization
Eigen, M., & Schuster, P. M. (1979) · Cited by 1,906
A principle of natural self-organization: Part A: Emergence of the hypercycle
Eigen, M., & Schuster, P. (1977) · Naturwissenschaften · doi:10.1007/bf00450633 · Cited by 1,752
Prebiotic chemistry and the origin of the RNA world.
Leslie E., O. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490460765 · Cited by 1,124
Eigen, M., & Schuster, P. (1979) · doi:10.1007/978-3-642-67247-7 · Cited by 949
On spontaneous asymmetric synthesis
Frank, F. C. (1953) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(53)90082-1 · Cited by 905
Enantiomeric Excesses in Meteoritic Amino Acids
Cronin, J. R., & Pizzarello, S. (1997) · Science · doi:10.1126/science.275.5302.951 · Cited by 889
Viedma, C. (2005) · Physical Review Letters · doi:10.1103/physrevlett.94.065504 · Cited by 818
Autocatalytic sets of proteins
Kauffman, S. A. (1986) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(86)80047-9 · Cited by 741
Lee, D. H., Granja, J. R., Martinez, J. A., Severin, K., & Ghadiri, M. R. (1996) · Nature · doi:10.1038/382525a0 · Cited by 677
Eigen, M., McCaskill, J., & Schuster, P. (1988) · The Journal of Physical Chemistry · doi:10.1021/j100335a010 · Cited by 670
A Self‐Replicating Hexadeoxynucleotide
von Kiedrowski, G. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198609322 · Cited by 583
Comets and the Formation of Biochemical Compounds on the Primitive Earth
ORÓ, J. (1961) · Nature · doi:10.1038/190389a0 · Cited by 541
The case for an ancestral genetic system involving simple analogues of the nucleotides.
Joyce, G. F., Schwartz, A. W., Miller, S. L., & Orgel, L. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.13.4398 · Cited by 387
Detecting autocatalytic, self-sustaining sets in chemical reaction systems
Hordijk, W., & Steel, M. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2003.11.020 · Cited by 251
Mirror symmetry breaking at the molecular level.
Avetisov, V, & Goldanskii, V (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11435 · Cited by 206
The origin of replicators and reproducers
Szathmáry, E. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1912 · Cited by 200
Chiral Symmetry Breaking in Nonequilibrium Systems
Kondepudi, D. K., & Nelson, G. W. (1983) · Physical Review Letters · doi:10.1103/physrevlett.50.1023 · Cited by 190
A cross-chiral RNA polymerase ribozyme
Sczepanski, J. T., & Joyce, G. F. (2014) · Nature · doi:10.1038/nature13900 · Cited by 186
Soai, K., Kawasaki, T., & Matsumoto, A. (2014) · Accounts of Chemical Research · doi:10.1021/ar5003208 · Cited by 181
Plasson, R., Brandenburg, A., Jullien, L., & Bersini, H. (2011) · The Journal of Physical Chemistry A · doi:10.1021/jp110079p · Cited by 106
(2009) · Choice Reviews Online · doi:10.5860/choice.46-5620 · Cited by 75
Re-Examination of Reversibility in Reaction Models for the Spontaneous Emergence of Homochirality
Blackmond, D. G., & Matar, O. K. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp7118586 · Cited by 70
Sensitivity of chemical chiral systems to weak asymmetric factors
Аветисов, В. А., Kuz'min, V. V., & Anikin, S. A. (1987) · Chemical Physics · doi:10.1016/0301-0104(87)80160-x · Cited by 39
Sensitivity of branch selection in nonequilibrium systems
Kondepudi, D. K., Prigogine, I., & Nelson, G. (1985) · Physics Letters A · doi:10.1016/0375-9601(85)90795-9 · Cited by 37
Flagged first, then by citations
Cited by
Sorted by citations
Wang, L., Yin, L., Zhang, W., Zhu, X., & Fujiki, M. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b07626 · Cited by 210
Buhse, T., Cruz, J.-M., Noble-Terán, M. E., Hochberg, D., Ribó, J. M., Crusats, J., & Micheau, J.-C. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00819 · Cited by 189
Self-citationPossible chemical and physical scenarios towards biological homochirality
Sallembien, Q., Bouteiller, L., Crassous, J., & Raynal, M. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01179k · Cited by 186
Exploring the emergence of complexity using synthetic replicators
Kosikova, T., & Philp, D. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00123a · Cited by 96
Sang, Y., Yang, D., Duan, P., & Liu, M. (2019) · Chemical Science · doi:10.1039/c8sc04687e · Cited by 88
Spontaneous mirror symmetry breaking and origin of biological homochirality
Ribó, J. M., Hochberg, D., Crusats, J., El-Hachemi, Z., & Moyano, A. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0699 · Cited by 68
Self-citationThe protometabolic nature of prebiotic chemistry
Nogal, N., Sanz-Sánchez, M., Vela-Gallego, S., Ruiz-Mirazo, K., & de la Escosura, A. (2023) · Chemical Society Reviews · doi:10.1039/d3cs00594a · Cited by 61
In Situ Mass Spectrometric and Kinetic Investigations of Soai's Asymmetric Autocatalysis
Trapp, O., Lamour, S., Maier, F., Siegle, A. F., Zawatzky, K., & Straub, B. F. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202003260 · Cited by 60
Stoichiometric network analysis of spontaneous mirror symmetry breaking in chemical reactions
Hochberg, D., Bourdon-García, R. D., Ágreda, J. A., & Ribó, J. M. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp02159c · Cited by 34
Self-citationChemical Basis of Biological Homochirality during the Abiotic Evolution Stages on Earth
Ribó, J., & Hochberg, D. (2019) · Symmetry · doi:10.3390/sym11060814 · Cited by 30
Self-citationKosikova, T., & Philp, D. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b06270 · Cited by 28
A Quantification of the Soai Reaction
Noble‐Terán, M. E., Cruz, J., Micheau, J., & Buhse, T. (2018) · ChemCatChem · doi:10.1002/cctc.201701554 · Cited by 27
Arlegui, A., Soler, B., Galindo, A., Arteaga, O., Canillas, A., Ribó, J. M., El-Hachemi, Z., Crusats, J., & Moyano, A. (2019) · Chemical Communications · doi:10.1039/c9cc05946f · Cited by 27
Self-citationChirality: The Backbone of Chemistry as a Natural Science
Ribó, J. M. (2020) · Symmetry · doi:10.3390/sym12121982 · Cited by 27
Self-citationEntropic Analysis of Mirror Symmetry Breaking in Chiral Hypercycles
Hochberg, D., & Ribó, J. M. (2019) · Life · doi:10.3390/life9010028 · Cited by 23
Self-citationRibó, J. M., & Hochberg, D. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/d0cp02280b · Cited by 21
Self-citationBistability and Bifurcation in Minimal Self‐Replication and Nonenzymatic Catalytic Networks
Wagner, N., Mukherjee, R., Maity, I., Peacock-López, E., & Ashkenasy, G. (2017) · ChemPhysChem · doi:10.1002/cphc.201601293 · Cited by 20
Mechanically Induced Homochirality in Nucleated Enantioselective Polymerization
Blanco, C., Stich, M., & Hochberg, D. (2017) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b10705 · Cited by 20
Self-citationLi, C., Sang, Y., Jin, X., Duan, P., & Liu, M. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202206332 · Cited by 19
A robust transition to homochirality in complex chemical reaction networks
Laurent, G., Gaspard, P., & Lacoste, D. (2022) · Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rspa.2021.0590 · Cited by 13
Gartzia‐Rivero, L., Ray, C., Sánchez‐Carnerero, E. M. M., Bañuelos, J., Moreno, F., Maroto, B. L., García‐Moreno, I., Infantes, L., Méndez, B., López‐Arbeloa, Í., et al. (2019) · Langmuir · doi:10.1021/acs.langmuir.9b00409 · Cited by 12
Programming Multistationarity in Chemical Replication Networks
Wagner, N., Mukherjee, R., Maity, I., Kraun, S., & Ashkenasy, G. (2019) · ChemSystemsChem · doi:10.1002/syst.201900048 · Cited by 11
Romero-Fernández, M. P., Babiano, R., & Cintas, P. (2018) · Chirality · doi:10.1002/chir.22805 · Cited by 10
An autocatalytic organic reaction network based on cross-catalysis
Hui, P., Branca, M., Limoges, B., & Mavré, F. (2021) · Chemical Communications · doi:10.1039/d1cc05121k · Cited by 10
Mauksch, M. (2022) · Physical Chemistry Chemical Physics · doi:10.1039/d2cp04285a · Cited by 10
Absolute Asymmetric Catalysis, from Concept to Experiment: A Narrative
Crusats, J., & Moyano, A. (2021) · Synlett · doi:10.1055/a-1536-4673 · Cited by 9
Self-citationChaotic oscillations, dissipation and mirror symmetry breaking in a chiral catalytic network
Hochberg, D., Torralba, A. S., & Morán, F. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/d0cp05109h · Cited by 7
Self-citationViedma deracemization mechanisms in self-assembly processes
Ribó, J. M., Hochberg, D., Buhse, T., & Micheau, J. C. (2024) · Physical Chemistry Chemical Physics · doi:10.1039/d4cp03910f · Cited by 5
Self-citationEntropic analysis of bistability and the general evolution criterion
Hochberg, D., & Ribó, J. M. (2021) · Physical Chemistry Chemical Physics · doi:10.1039/d1cp01236c · Cited by 5
Self-citationFormation of Multiple Supramolecular Helices for Spontaneous Resolution
Weng, P., Yan, X., & Jiang, Y. (2023) · ChemSystemsChem · doi:10.1002/syst.202200043 · Cited by 5
Asymmetry in Biological Homochirality
Hochberg, D. (2021) · MDPI eBooks · doi:10.3390/books978-3-0365-0442-1 · Cited by 4
Self-citationConditions for the origin of homochirality in primordial catalytic reaction networks
Gagnon, J.-S., & Hochberg, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-36852-4 · Cited by 4
Self-citationToxværd, S. (2023) · Symmetry · doi:10.3390/sym15010155 · Cited by 4
Ribó, J. M., Micheau, J. C., & Buhse, T. (2025) · ChemPhysChem · doi:10.1002/cphc.202500384 · Cited by 3
Self-citationBourdon-García, R. D., Ágreda, J. A., Burgos-Salcedo, J. D., Hochberg, D., Ribó, J. M., Bargueño, P., & Salamanca, A. F. E. (2022) · Physical Chemistry Chemical Physics · doi:10.1039/d2cp00538g · Cited by 3
Self-citationLi, C., Sang, Y., Jin, X., Duan, P., & Liu, M. (2022) · Angewandte Chemie · doi:10.1002/ange.202206332 · Cited by 3
Abiotic Emergence of Biological Homochirality
Ribó, J. M., Crusats, J., El‐Hachemi, Z., Hochberg, D., & Moyano, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812824-4.00016-2 · Cited by 3
Self-citationOrigin of homochirality in peptides: The first milestone at the origin of life
Toxværd, S. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105479 · Cited by 2
Does Pressure Break Mirror‐Image Symmetry? A Perspective and New Insights
Hochberg, D., & Cintas, P. (2020) · ChemPhysChem · doi:10.1002/cphc.201901115 · Cited by 2
Self-citationThe Coordinate Reaction Model: An Obstacle to Interpreting the Emergence of Chemical Complexity
Ribó, J. M., & Hochberg, D. (2021) · Chemistry - A European Journal · doi:10.1002/chem.202101562 · Cited by 2
Self-citationColwell, J. (2022) · Dynamics · doi:10.3390/dynamics2030016 · Cited by 2
Cross‐Catalysis and Weak Interactions: Keys to the Chiral Polarization of the Biosphere
Stovbun, S. V., Skoblin, А. А., & Zlenko, D. V. (2025) · Chirality · doi:10.1002/chir.70051 · Cited by 1
Managadze, G. G. (2022) · International Journal for Research in Applied Science and Engineering Technology · doi:10.22214/ijraset.2022.40049
(2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812212-9.16001-4
(2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839163685-00104
Diniz, P. C., Wattis, J. A. D., & da Costa, F. P. (2022) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-022-09631-w
Elucidation of Soai's Asymmetric Autocatalysis
Trapp, O. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166273-00239
Sallembien, Q. (2021) · theses.fr (ABES) · doi:10.70675/e8227832z1887z4770zb651zbdf3adf7a8d3
A Survey of the Battlefield for the Origin of Life
(2024) · Wiley eBooks · doi:10.1002/9781119901228.ch11
Hui, P., Pastor, A., Branca, M., Limoges, B., & Mavré, F. (2026) · ChemSystemsChem · doi:10.1002/syst.70042
Metadata
- Authors
- Ribó, J. M., Crusats, J., El-Hachemi, Z., Moyano, A., & Hochberg, D.
- Affiliations
- Institut de Ciències del Cosmos (ES)
- Department of Organic Chemistry
- Universitat de Barcelona (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Ribó, Josep M.
- Hochberg, David
- Venue
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 8
- Issue
- 1
- Pages
- 763-769
- ISSN
- 2041-6520 (ISSN-L)
- 2041-6539
- PMC
- PMC5299794
- OpenAlex
- W2520922898
- Cited by
- 50
- References
- 25
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 11 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 1 · 2017: 9
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Chemical Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- Funders
- Generalitat de Catalunya (2014SGR10)
- Ministerio de Economía y Competitividad (CTQ2013-47401-C2-1/2-P)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- origin of homochirality, origin of life
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review