Impact of Environmental Factors on the Regulation of Cyanotoxin Production

Boopathi, Thangavelu; Ki, Jang-Seu

doi:10.3390/toxins6071951

Cited by 167Aquatic Ecosystems and Phytoplankton DynamicsBiocrusts and Microbial EcologyMicrobial Natural Products and Biosynthesis

Impact of Environmental Factors on the Regulation of Cyanotoxin Production

Open access

Boopathi, Thangavelu, Ki, Jang-Seu·2014·Toxins

DOI 10.3390/toxins6071951PMC PMC4113735

Open this paper in CoChat — free account

Abstract

Cyanobacteria are capable of thriving in almost all environments. Recent changes in climatic conditions due to increased human activities favor the occurrence and severity of harmful cyanobacterial bloom all over the world. Knowledge of the regulation of cyanotoxins by the various environmental factors is essential for effective management of toxic cyanobacterial bloom. In recent years, progress in the field of molecular mechanisms involved in cyanotoxin production has paved the way for assessing the role of various factors on the cyanotoxin production. In this review, we present an overview of the influence of various environmental factors on the production of major group of cyanotoxins, including microcystins, nodularin, cylindrospermopsin, anatoxins and saxitoxins.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/toxins6071951

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Synthesis of microcystins and other metabolites by M. aeruginosa is greatly induced and influenced by light intensity, temperature, pH, and nutrients, such as carbon, nitrogen, and phosphorus.
“Synthesis of microcystins and other metabolites by M. aeruginosa is greatly induced and influenced by light intensity, temperature, pH, and nutrients, such as carbon, nitrogen, and phosphorus [155].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [155]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Blooms like it hot
Paerl, H. W., & Huisman, J. (2008) · Science · doi:10.1126/science.1155398 · Cited by 2,854 · see citing works
Toxic Cyanobacteria in Water
Bartram, J., & Chorus, I. (1999) · CRC Press eBooks · doi:10.1201/9781482295061 · Cited by 2,581 · see citing works
The rise of harmful cyanobacteria blooms: the potential roles of eutrophication and climate change
O’Neil, J. M., Davis, T. W., Burford, M. A., & Gobler, C. J. (2012) · Harmful Algae · doi:10.1016/j.hal.2011.10.027 · Cited by 2,225 · see citing works
Harmful Cyanobacterial Blooms: Causes, Consequences, and Controls
Paerl, H. W., & Otten, T. G. (2013) · Microbial Ecology · doi:10.1007/s00248-012-0159-y · Cited by 1,908 · see citing works
Climate change: Links to global expansion of harmful cyanobacteria
Paerl, H. W., & Paul, V. J. (2011) · Water Research · doi:10.1016/j.watres.2011.08.002 · Cited by 1,728 · see citing works
Toxic Cyanobacteria in Water
(1999) · Taylor & Francis eBooks · doi:10.4324/9780203478073 · Cited by 1,556 · see citing works
The ecology of cyanobacteria: their diversity in time and space.
Whitton, B. A., & Potts, M. (2000) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46855-7 · Cited by 1,429 · see citing works
Liver Failure and Death after Exposure to Microcystins at a Hemodialysis Center in Brazil
Jochimsen, E. M., Carmichael, W. W., An, J., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381304 · Cited by 1,112 · see citing works
The Toxins of Cyanobacteria
Carmichael, W. W. (1994) · Scientific American · doi:10.1038/scientificamerican0194-78 · Cited by 1,100 · see citing works
Health Effects of Toxin-Producing Cyanobacteria: “The CyanoHABs”
Carmichael, W. W. (2001) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/20018091095087 · Cited by 991 · see citing works
Warmer climates boost cyanobacterial dominance in shallow lakes
Kosten, S., Huszar, V. L. M., Bécares, E., Costa, L. S., van Donk, E., Hansson, L., Jeppesen, E., Kruk, C., Lacerot, G., Mazzeo, N., et al. (2011) · Global Change Biology · doi:10.1111/j.1365-2486.2011.02488.x · Cited by 909 · see citing works
Neurotoxic Alkaloids: Saxitoxin and Its Analogs
Wiese, M., D’Agostino, P. M., Mihali, T. K., Moffitt, M. C., & Neilan, B. A. (2010) · Marine Drugs · doi:10.3390/md8072185 · Cited by 773 · see citing works
Nitrogen Control in Cyanobacteria
Herrero, A., Muro-Pastor, A. M., & Flores, E. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.2.411-425.2001 · Cited by 735 · see citing works
Toxins of cyanobacteria
van Apeldoorn, M. E., van Egmond, H. P., Speijers, G. J. A., & Bakker, G. J. I. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600185 · Cited by 732 · see citing works
Cyanobacterial Harmful Algal Blooms: State of the Science and Research Needs
Hudnell, H. K. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-75865-7 · Cited by 671 · see citing works
Cylindrospermopsin: a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii
Ohtani, I. I., Moore, R. E., & Runnegar, M. T. C. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00046a067 · Cited by 629 · see citing works
On the Chemistry, Toxicology and Genetics of the Cyanobacterial Toxins, Microcystin, Nodularin, Saxitoxin and Cylindrospermopsin
Pearson, L. A., Mihali, T. K., Moffitt, M. C., et al. (2010) · Marine Drugs · doi:10.3390/md8051650 · Cited by 570 · see citing works
Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin
Fischer, W. J., Altheimer, S., Cattori, V., et al. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.08.012 · Cited by 520 · see citing works
The Cyanobacterial Hepatotoxin Microcystin Binds to Proteins and Increases the Fitness of Microcystis under Oxidative Stress Conditions
Zilliges, Y., Kehr, J., Meißner, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017615 · Cited by 467 · see citing works
Light and the Transcriptional Response of the Microcystin Biosynthesis Gene Cluster
Kaebernick, M., Neilan, B. A., Börner, T., & Dittmann, E. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.8.3387-3392.2000 · Cited by 394 · see citing works
Biosynthetic Intermediate Analysis and Functional Homology Reveal a Saxitoxin Gene Cluster in Cyanobacteria
Kellmann, R., Mihali, T. K., Jeon, Y. J., Pickford, R., Pomati, F., & Neilan, B. A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00353-08 · Cited by 391 · see citing works
Microcystin Biosynthesis in Planktothrix : Genes, Evolution, and Manipulation
Christiansen, G., Fastner, J., Erhard, M., Börner, T., & Dittmann, E. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.2.564-572.2003 · Cited by 374 · see citing works
HUMAN HEALTH ASPECTS
Bartram, J., & Chorus, I. (1999) · CRC Press eBooks · doi:10.1201/9781482295061-10 · Cited by 347 · see citing works
Cyanobacterial toxins: Modes of actions, fate in aquatic and soil ecosystems, phytotoxicity and bioaccumulation in agricultural crops
Corbel, S., Mougin, C., & Bouaı̈cha, N. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.07.056 · Cited by 345 · see citing works
Environmental conditions that influence toxin biosynthesis in cyanobacteria
Neilan, B. A., Pearson, L. A., Muenchhoff, J., Moffitt, M. C., & Dittmann, E. (2012) · Environmental Microbiology · doi:10.1111/j.1462-2920.2012.02729.x · Cited by 342 · see citing works
Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method
Harada, K., Ohtani, I. I., Iwamoto, K., Suzuki, M., Watanabe, M. F., Watanabe, M., & Terao, K. (1994) · Toxicon · doi:10.1016/0041-0101(94)90023-x · Cited by 337 · see citing works
The cyanotoxin-microcystins: current overview
Rastogi, R. P., Sinha, R. P., & Incharoensakdi, A. (2014) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-014-9334-6 · Cited by 336 · see citing works
Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems
Briand, J., Jacquet, S., Bernard, C., & Humbert, J. F. (2003) · Veterinary Research · doi:10.1051/vetres:2003019 · Cited by 331 · see citing works
Ecological and molecular investigations of cyanotoxin production
Kaebernick, M., & Neilan, B. A. (2001) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2001.tb00782.x · Cited by 323 · see citing works
IDENTIFICATION OF CYLINDROSPERMOPSIN IN APHANIZOMENON OVALISPORUM (CYANOPHYCEAE) ISOLATED FROM LAKE KINNERET, ISRAEL1
Banker, R., Carmeli, S., Hadas, O., et al. (1997) · Journal of Phycology · doi:10.1111/j.0022-3646.1997.00613.x · Cited by 317 · see citing works
Identification of anatoxin-A in benthic cyanobacteria (blue-green algae) and in associated dog poisonings at Loch Insh, Scotland
Edwards, C., Beattie, K. A., Scrimgeour, C. M., & Codd, G. A. (1992) · Toxicon · doi:10.1016/0041-0101(92)90432-5 · Cited by 315 · see citing works
Growth, nitrogen fixation, and nodularin production by two baltic sea cyanobacteria
Lehtimaki, J., Moisander, P. H., Sivonen, K., & Kononen, K. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.5.1647-1656.1997 · Cited by 308 · see citing works
Is the future blue-green? A review of the current model predictions of how climate change could affect pelagic freshwater cyanobacteria
Elliott, J. A. (2011) · Water Research · doi:10.1016/j.watres.2011.12.018 · Cited by 303 · see citing works
Cellular Microcystin Content in N-Limited Microcystis aeruginosa Can Be Predicted from Growth Rate
Long, B. M., Jones, G. J., & Orr, P. T. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.1.278-283.2001 · Cited by 302 · see citing works
Characterization of the Gene Cluster Responsible for Cylindrospermopsin Biosynthesis
Mihali, T. K., Kellmann, R., Muenchhoff, J., Barrow, K. D., & Neilan, B. A. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01988-07 · Cited by 300 · see citing works
Pathological and Biochemical Characterization of Microcystin-Induced Hepatopancreas and Kidney Damage in Carp (Cyprinus carpio)
Fischer, W. J., & Dietrich, D. R. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8861 · Cited by 296 · see citing works
PALM ISLAND MYSTERY DISEASE
Byth, S. (1980) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1980.tb131814.x · Cited by 285 · see citing works
Toxicology and Risk Assessment of Freshwater Cyanobacterial (Blue-Green Algal) Toxins in Water
Duy, T. N., Lam, P. K. S., Shaw, G. R., & Connell, D. (2000) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-1-4757-6429-1_3 · Cited by 283 · see citing works
Identification of genes implicated in toxin production in the cyanobacterium Cylindrospermopsis raciborskii
Schembri, M. A., Neilan, B. A., & Saint, C. P. (2001) · Environmental Toxicology · doi:10.1002/tox.1051 · Cited by 280 · see citing works
Characterization of the Nodularin Synthetase Gene Cluster and Proposed Theory of the Evolution of Cyanobacterial Hepatotoxins
Moffitt, M. C., & Neilan, B. A. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6353-6362.2004 · Cited by 273 · see citing works
Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes
Runnegar, M. T. C., Kong, S., Zhong, Y.-Z., et al. (1995) · Biochemical Pharmacology · doi:10.1016/s0006-2952(94)00466-8 · Cited by 268 · see citing works
Genes Coding for Hepatotoxic Heptapeptides (Microcystins) in the Cyanobacterium Anabaena Strain 90
Rouhiainen, L., Vakkilainen, T., Siemer, B. L., et al. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.2.686-692.2004 · Cited by 266 · see citing works
Cylindrospermopsin‐induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes
Froscio, S. M., Humpage, A. R., Burcham, P. C., & Falconer, I. R. (2003) · Environmental Toxicology · doi:10.1002/tox.10121 · Cited by 256 · see citing works
Toxin-producing cyanobacteria in freshwater: A review of the problems, impact on drinking water safety, and efforts for protecting public health
Cheung, M. Y., Liang, S., & Lee, J. (2013) · The Journal of Microbiology · doi:10.1007/s12275-013-2549-3 · Cited by 243 · see citing works
FIRST REPORT OF THE CYANOTOXINS CYLINDROSPERMOPSIN AND DEOXYCYLINDROSPERMOPSIN FROM RAPHIDIOPSIS CURVATA (CYANOBACTERIA)
Li, R., Carmichael, W. W., Brittain, S. M., et al. (2001) · Journal of Phycology · doi:10.1046/j.1529-8817.2001.01075.x · Cited by 237 · see citing works
The ecological stoichiometry of toxins produced by harmful cyanobacteria: an experimental test of the carbon‐nutrient balance hypothesis
de Waal, D. B. V., Verspagen, J. M. H., Lürling, M., et al. (2009) · Ecology Letters · doi:10.1111/j.1461-0248.2009.01383.x · Cited by 233 · see citing works
Climate Change and Eutrophication Induced Shifts in Northern Summer Plankton Communities
Suikkanen, S., Pulina, S., Engström‐Öst, J., Lehtiniemi, M., Lehtinen, S., & Brutemark, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066475 · Cited by 221 · see citing works
Anatoxin-a Synthetase Gene Cluster of the Cyanobacterium Anabaena sp. Strain 37 and Molecular Methods To Detect Potential Producers
Ylinen, A., Känä, S., Wang, H., Rouhiainen, L., Wahlsten, M., Rizzi, E., Berg, K. A., Gugger, M. F., & Sivonen, K. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06022-11 · Cited by 215 · see citing works
Cylindrospermopsin Genotoxicity and Cytotoxicity: Role Of Cytochrome P-450 and Oxidative Stress
Humpage, A. R., Fontaine, F. R., Froscio, S. M., et al. (2005) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390590925465 · Cited by 213 · see citing works
First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand
Wood, S. A., Selwood, A. I., Rueckert, A., et al. (2007) · Toxicon · doi:10.1016/j.toxicon.2007.03.025 · Cited by 212 · see citing works
Reversal in competitive dominance of a toxic versus non-toxic cyanobacterium in response to rising CO2
de Waal, D. B. V., Verspagen, J. M. H., Finke, J. F., Vournazou, V., Immers, A. K., Kardinaal, W. E. A., Tonk, L., Becker, S., van Donk, E., Visser, P., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2011.28 · Cited by 211 · see citing works
Increased incidence of Cylindrospermopsis raciborskii in temperate zones – Is climate change responsible?
Sinha, R. K., Pearson, L. A., Davis, T. W., Burford, M. A., Orr, P. T., & Neilan, B. A. (2011) · Water Research · doi:10.1016/j.watres.2011.12.019 · Cited by 204 · see citing works
Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin-a
Osswald, J., Rellán, S., Gago-Martı́nez, A., & Vasconcelos, V. M. (2007) · Environment International · doi:10.1016/j.envint.2007.06.003 · Cited by 197 · see citing works
The Fossil Record: Tracing the Roots of the Cyanobacterial Lineage
Schopf, J. W. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46855-7_2 · Cited by 194 · see citing works
Deoxycylindrospermopsin, an analog of cylindrospermopsin fromCylindrospermopsis raciborskii
Norris, R. L. G., Eaglesham, G. K., Pierens, G., Shaw, G. R., Smith, M. J., Chiswell, R. K., Seawright, A. A., & Moore, M. R. (1999) · Environmental Toxicology · doi:10.1002/(sici)1522-7278(199902)14:1 · Cited by 188 · see citing works
The Microcystin Composition of the Cyanobacterium Planktothrix agardhii Changes toward a More Toxic Variant with Increasing Light Intensity
Tonk, L., Visser, P., Christiansen, G., et al. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.9.5177-5181.2005 · Cited by 183 · see citing works
Cylindrospermopsin: A Decade of Progress on Bioaccumulation Research
Kinnear, S. H. W. (2010) · Marine Drugs · doi:10.3390/md8030542 · Cited by 183 · see citing works
Varied Diazotrophies, Morphologies, and Toxicities of Genetically Similar Isolates of Cylindrospermopsis raciborskii (Nostocales, Cyanophyceae) from Northern Australia
Saker, M. L., & Neilan, B. A. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.4.1839-1845.2001 · Cited by 182 · see citing works
Characterisation of the paralytic shellfish toxin biosynthesis gene clusters in Anabaena circinalis AWQC131C and Aphanizomenon sp. NH-5
Mihali, T. K., Kellmann, R., & Neilan, B. A. (2009) · BMC Biochemistry · doi:10.1186/1471-2091-10-8 · Cited by 178 · see citing works
Iron availability affects mcyD expression and microcystin‐LR synthesis in Microcystis aeruginosa PCC7806
Sevilla, E., Martín-Luna, B., Vela, L., Bes, M. T., Fillat, M. F., & Peleato, M. L. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01663.x · Cited by 177 · see citing works
Uracil Moiety is Required for Toxicity of the Cyanobacterial Hepatotoxin Cylindrospermopsin
Banker, R., Carmeli, S., Werman, M. J., Teltsch, B., Porat, R., & Sukenik, A. (2001) · Journal of Toxicology and Environmental Health · doi:10.1080/009841001459432 · Cited by 177 · see citing works
Anatoxin-a concentration inAnabaena andAphanizomenon under different environmental conditions and comparison of growth by toxic and non-toxicAnabaena-strains — a laboratory study
Rapala, J., Sivonen, K., Luukkainen, R., & Niemelä, S. I. (1993) · Journal of Applied Phycology · doi:10.1007/bf02184637 · Cited by 177 · see citing works
Detection of an anatoxin-a(s)-like anticholinesterase in natural blooms and cultures of cyanobacteria/blue-green algae from danish lakes and in the stomach contents of poisoned birds
Henriksen, P., Carmichael, W. W., An, J., & Moestrup, Ø. (1997) · Toxicon · doi:10.1016/s0041-0101(96)00190-0 · Cited by 174 · see citing works
Toxin Production by Microcystis aeruginosa as a Function of Light in Continuous Cultures and Its Ecological Significance
Utkilen, H., & Gjølme, N. (1992) · Applied and Environmental Microbiology · doi:10.1128/aem.58.4.1321-1325.1992 · Cited by 172 · see citing works
Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis
Kaasalainen, U., Fewer, D. P., Jokela, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200279109 · Cited by 172 · see citing works
Enslavement in the Water Body by Toxic Aphanizomenon ovalisporum, Inducing Alkaline Phosphatase in Phytoplanktons
Bar‐Yosef, Y., Sukenik, A., Hadas, O., Viner‐Mozzini, Y., & Kaplan, A. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.032 · Cited by 172 · see citing works
Nitrogen availability increases the toxin quota of a harmful cyanobacterium, Microcystis aeruginosa
Horst, G. P., Sarnelle, O., White, J. D., et al. (2014) · Water Research · doi:10.1016/j.watres.2014.01.063 · Cited by 171 · see citing works
First observation of cylindrospermopsin in Anabaena lapponica isolated from the boreal environment (Finland)
Spoof, L., Berg, K. A., Rapala, J., et al. (2006) · Environmental Toxicology · doi:10.1002/tox.20216 · Cited by 170 · see citing works
The Role of Glutathione in the Toxicity of a Novel Cyanobacterial Alkaloid Cylindrospermopsin in Cultured Rat Hepatocytes
Runnegar, M. T. C., Kong, S., Zhong, Y., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1694 · Cited by 169 · see citing works
Allelopathy in freshwater cyanobacteria
Leão, P. N., Vasconcelos, T., & Vasconcelos, V. M. (2009) · Critical Reviews in Microbiology · doi:10.3109/10408410902823705 · Cited by 162 · see citing works
7-Epicylindrospermopsin, a Toxic Minor Metabolite of the Cyanobacterium Aphanizomenon ovalisporum from Lake Kinneret, Israel
Banker, R., Teltsch, B., Sukenik, A., et al. (2000) · Journal of Natural Products · doi:10.1021/np990498m · Cited by 157 · see citing works
Iron uptake and toxin synthesis in the bloom‐forming Microcystis aeruginosa under iron limitation
Alexova, R., Fujii, M., Birch, D., Cheng, J., Waite, T. D., Ferrari, B. C., & Neilan, B. A. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2010.02412.x · Cited by 155 · see citing works
Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue‐green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin
Falconer, I. R., & Humpage, A. R. (2001) · Environmental Toxicology · doi:10.1002/tox.1024 · Cited by 154 · see citing works
The relationships between nutrients, cyanobacterial toxins and the microbial community in Taihu (Lake Tai), China
Wilhelm, S. W., Farnsley, S. E., LeCleir, G. R., et al. (2010) · Harmful Algae · doi:10.1016/j.hal.2010.10.001 · Cited by 154 · see citing works
Assessment of Environmental Conditions That Favor Hepatotoxic and Neurotoxic Anabaena spp. Strains Cultured under Light Limitation at Different Temperatures
Rapala, J., & Sivonen, K. (1998) · Microbial Ecology · doi:10.1007/s002489900105 · Cited by 152 · see citing works
Nitrogen Forms Influence Microcystin Concentration and Composition via Changes in Cyanobacterial Community Structure
Monchamp, M., Pick, F. R., Beisner, B. E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085573 · Cited by 151 · see citing works
Evidence that Biosynthesis of the Neurotoxic Alkaloids Anatoxin-a and Homoanatoxin-a in the Cyanobacterium Oscillatoria PCC 6506 Occurs on a Modular Polyketide Synthase Initiated by l -Proline
Méjean, A., Mann, S., Maldiney, T., et al. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9024353 · Cited by 149 · see citing works
Multiple Alternate Transcripts Direct the Biosynthesis of Microcystin, a Cyanobacterial
Kaebernick, M., Dittmann, E., Börner, T., & Neilan, B. A. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.2.449-455.2002 · Cited by 149 · see citing works
Saxitoxin Is a Gating Modifier of hERG K+ Channels
Wang, J., Salata, J. J., & Bennett, P. B. (2003) · The Journal of General Physiology · doi:10.1085/jgp.200308812 · Cited by 144 · see citing works
Comparative Metagenomics of Toxic Freshwater Cyanobacteria Bloom Communities on Two Continents
Steffen, M. M., Li, Z., Effler, T. C., Hauser, L., Boyer, G. L., & Wilhelm, S. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044002 · Cited by 140 · see citing works
Medium N:P Ratios and Specific Growth Rate ComodulateMicrocystin and Protein Content in Microcystis aeruginosa PCC7806 and M. aeruginosa UV027
Downing, T. G., Sember, C. S., Gehringer, M. M., et al. (2005) · Microbial Ecology · doi:10.1007/s00248-004-0054-2 · Cited by 138 · see citing works
Saxitoxin Blocks L-Type ICa
Su, Z. G., Sheets, M. F., Ishida, H., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.056564 · Cited by 138 · see citing works
State of the art on cyanotoxins in water and their behaviour towards chlorine
Merel, S., Clément, M., & Thomas, O. (2009) · Toxicon · doi:10.1016/j.toxicon.2009.10.028 · Cited by 132 · see citing works
Biosynthesis of Cylindrospermopsin and 7-Epicylindrospermopsin in Oscillatoria sp. Strain PCC 6506: Identification of the cyr Gene Cluster and Toxin Analysis
Mazmouz, R., Chapuis‐Hugon, F., Mann, S., Pichon, V., Méjean, A., & Ploux, O. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00717-10 · Cited by 132 · see citing works
Microcystin content of Microcystis aeruginosa is modulated by nitrogen uptake rate relative to specific growth rate or carbon fixation rate
Downing, T. G., Meyer, C., Gehringer, M. M., et al. (2005) · Environmental Toxicology · doi:10.1002/tox.20106 · Cited by 131 · see citing works
The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos
Zeng, C., Sun, H. C., Xie, P., Wang, J., Zhang, G., Chen, N., Yan, W., & Li, G. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.01.021 · Cited by 125 · see citing works
Green algal extracellular products regulate antialgal toxin production in a cyanobacterium
Kearns, K. D., & Hunter, M. D. (2000) · Environmental Microbiology · doi:10.1046/j.1462-2920.2000.00104.x · Cited by 124 · see citing works
Unveiling Distribution Patterns of Freshwater Phytoplankton by a Next Generation Sequencing Based Approach
Eiler, A., Drakare, S., Bertilsson, S., Pernthaler, J., Peura, S., Rofner, C., Šimek, K., Yang, Y., Znachor, P., & Lindström, E. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053516 · Cited by 123 · see citing works
In Vitro Hepatotoxicity of the Cyanobacterial Alkaloid Cylindrospermopsin and Related Synthetic Analogues
Runnegar, M. T. C., Xie, C., Snider, B. B., et al. (2002) · Toxicological Sciences · doi:10.1093/toxsci/67.1.81 · Cited by 122 · see citing works
TWO MORPHOLOGICAL FORMS OF CYLINDROSPERMOPSIS RACIBORSKII (CYANOBACTERIA) ISOLATED FROM SOLOMON DAM, PALM ISLAND, QUEENSLAND
Saker, M. L., Neilan, B. A., & GRIFFITHS, D. J. (1999) · Journal of Phycology · doi:10.1046/j.1529-8817.1999.3530599.x · Cited by 121 · see citing works
Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate
Zhao, M., Jiang, Y., He, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001556107 · Cited by 121 · see citing works
Comparative genomics analysis of NtcA regulons in cyanobacteria: regulation of nitrogen assimilation and its coupling to photosynthesis
Su, Z. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki817 · Cited by 120 · see citing works
Cylindrospermopsin is not degraded by co-occurring natural bacterial communities during a 40-day study
Wörmer, L., Cirés, S., Carrasco, D., & Quesada, A. (2007) · Harmful Algae · doi:10.1016/j.hal.2007.07.004 · Cited by 119 · see citing works
Microcystin production revisited: conjugate formation makes a major contribution
Meißner, S., Fastner, J., & Dittmann, E. (2012) · Environmental Microbiology · doi:10.1111/1462-2920.12072 · Cited by 118 · see citing works
Toxicological comparison of diverseCylindrospermopsis raciborskiistrains: Evidence of liver damage caused by a FrenchC. raciborskiistrain
Bernard, C., Harvey, M., Briand, J., et al. (2003) · Environmental Toxicology · doi:10.1002/tox.10112 · Cited by 115 · see citing works
The Languages Spoken in the Water Body (or the Biological Role of Cyanobacterial Toxins)
Kaplan, A., Harel, M., Kaplan‐Levy, R. N., et al. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00138 · Cited by 107 · see citing works
NtcA from Microcystis aeruginosa PCC 7806 Is Autoregulatory and Binds to the Microcystin Promoter
Ginn, H. P., Pearson, L. A., & Neilan, B. A. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.01862-09 · Cited by 99 · see citing works
Nodularin, a cyanobacterial toxin, is synthesized in planta by symbiotic Nostoc sp.
Gehringer, M. M., Adler, L., Roberts, A. A., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.25 · Cited by 98 · see citing works
Temperature-related changes in polar cyanobacterial mat diversity and toxin production
Kleinteich, J., Wood, S. A., Küpper, F. C., Camacho, A., Quesada, A., Frickey, T., & Dietrich, D. R. (2012) · Nature Climate Change · doi:10.1038/nclimate1418 · Cited by 96 · see citing works
Cylindrospermopsis raciborskii dominates under very low and high nitrogen-to-phosphorus ratios
Chislock, M. F., Sharp, K. L., & Wilson, A. E. (2013) · Water Research · doi:10.1016/j.watres.2013.11.022 · Cited by 95 · see citing works
Persistence and degradation of cyanobacterial paralytic shellfish poisons (PSPs) in freshwaters
Jones, G. J., & Negri, A. P. (1997) · Water Research · doi:10.1016/s0043-1354(96)00134-0 · Cited by 94 · see citing works
Neurotoxins in axenic oscillatorian cyanobacteria: coexistence of anatoxin-a and homoanatoxin-a determined by ligand-binding assay and GC/MS
Aráoz, R., Nghiêm, H. O., Rippka, R., Palibroda, N., de Marsac, N. T., & Herdman, M. (2005) · Microbiology · doi:10.1099/mic.0.27660-0 · Cited by 93 · see citing works
The effect of temperature on growth and production of paralytic shellfish poisoning toxins by the cyanobacterium Cylindrospermopsis raciborskii C10
Castro, D., Vera, D., Lagos, N., et al. (2004) · Toxicon · doi:10.1016/j.toxicon.2004.06.005 · Cited by 92 · see citing works
Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve.
Strichartz, G. R. (1984) · The Journal of General Physiology · doi:10.1085/jgp.84.2.281 · Cited by 90 · see citing works
Transcription of the Anabaena sp. strain PCC 7120 ntcA gene: multiple transcripts and NtcA binding
Ramasubramanian, T. S., Wei, T. F., Oldham, A., et al. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.3.922-926.1996 · Cited by 89 · see citing works
Insights into the Physiology and Ecology of the Brackish-Water-Adapted Cyanobacterium Nodularia spumigena CCY9414 Based on a Genome-Transcriptome Analysis
Voß, B., Bolhuis, H., Fewer, D. P., Kopf, M., Möke, F., Haas, F. B., El‐Shehawy, R. M., Hayes, P. K., Bergman, B., Sivonen, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060224 · Cited by 87 · see citing works
The cylindrospermopsin gene cluster of Aphanizomenon sp. strain 10E6: organization and recombination
Stüken, A., & Jakobsen, K. S. (2010) · Microbiology · doi:10.1099/mic.0.036988-0 · Cited by 84 · see citing works
Nutrient-related changes in the toxicity of field blooms of the cyanobacterium,Cylindrospermopsis raciborskii
Burford, M. A., Davis, T. W., Orr, P. T., et al. (2014) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12341 · Cited by 83 · see citing works
PRODUCTION OF PARALYTIC SHELLFISH TOXINS BY APHANIZOMENON SP. LMECYA 31 (CYANOBACTERIA)1
Dias, E. M., Pereira, P., & Franca, S. (2002) · Journal of Phycology · doi:10.1046/j.1529-8817.2002.01146.x · Cited by 82 · see citing works
Effects of light intensity on cylindrospermopsin production in the cyanobacterial HAB speciesCylindrospermopsis raciborskii
Dyble, J., Tester, P., & Litaker, R. (2006) · African Journal of Marine Science · doi:10.2989/18142320609504168 · Cited by 81 · see citing works
BIOCHEMICAL CHARACTERIZATION OF PARALYTIC SHELLFISH TOXIN BIOSYNTHESIS IN VITRO1
Kellmann, R., & Neilan, B. A. (2007) · Journal of Phycology · doi:10.1111/j.1529-8817.2007.00351.x · Cited by 80 · see citing works
Microcystin-LR synthesis as response to nitrogen: transcriptional analysis of the mcyD gene in Microcystis aeruginosa PCC7806
Sevilla, E., Martín-Luna, B., Vela, L., et al. (2010) · Ecotoxicology · doi:10.1007/s10646-010-0500-5 · Cited by 80 · see citing works
Comparative genomics of Cylindrospermopsis raciborskii strains with differential toxicities
Sinha, R. K., Pearson, L. A., Davis, T. W., Muenchhoff, J., Pratama, R., Jex, A. R., Burford, M. A., & Neilan, B. A. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-83 · Cited by 80 · see citing works
Effects of light intensity and light quality on growth and circadian rhythm of saxitoxins production in Cylindrospermopsis raciborskii (Cyanobacteria)
Carneiro, R. L., dos Santos, M. E. V., Pacheco, A. B. F., et al. (2009) · Journal of Plankton Research · doi:10.1093/plankt/fbp006 · Cited by 77 · see citing works
Species composition and cyanotoxin production in periphyton mats from three lakes of varying trophic status
Wood, S. A., Kuhajek, J., de Winton, M. D., et al. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01217.x · Cited by 72 · see citing works
Characterization of nodularin variants in Nodularia spumigena from the Baltic Sea using liquid chromatography/mass spectrometry/mass spectrometry
Mazur‐Marzec, H., Meriluoto, J. A. O., Pliński, M., et al. (2006) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2558 · Cited by 72 · see citing works
Reassessment of the toxin profile of Cylindrospermopsis raciborskii T3 and function of putative sulfotransferases in synthesis of sulfated and sulfonated PSP toxins
Soto-Liebe, K., Murillo, A. A., Krock, B., et al. (2010) · Toxicon · doi:10.1016/j.toxicon.2010.07.022 · Cited by 70 · see citing works
Interactions between intracellular Na+ levels and saxitoxin production in Cylindrospermopsis raciborskii T3
Pomati, F., Rossetti, C., Manarolla, G., et al. (2004) · Microbiology · doi:10.1099/mic.0.26350-0 · Cited by 69 · see citing works
THE TOXIC CYANOBACTERIUM NOSTOC SP. STRAIN 152 PRODUCES HIGHEST AMOUNTS OF MICROCYSTIN AND NOSTOPHYCIN UNDER STRESS CONDITIONS1
Kurmayer, R. (2011) · Journal of Phycology · doi:10.1111/j.1529-8817.2010.00931.x · Cited by 68 · see citing works
Evaluation of quantitative real-time PCR to characterise spatial and temporal variations in cyanobacteria, Cylindrospermopsis raciborskii (Woloszynska) Seenaya et Subba Raju and cylindrospermopsin concentrations in three subtropical Australian reservoirs
Orr, P. T., Rasmussen, J. P., Burford, M. A., et al. (2010) · Harmful Algae · doi:10.1016/j.hal.2010.09.006 · Cited by 68 · see citing works
Identification of a Polyketide Synthase Coding Sequence Specific for Anatoxin-a-Producing Oscillatoria Cyanobacteria
Cadel-Six, S., Iteman, I., Peyraud-Thomas, C., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02478-08 · Cited by 68 · see citing works
Alteration of cylindrospermopsin production in sulfate- or phosphate-starved cyanobacteriumAphanizomenon ovalisporum
Bácsi, I., Vasas, G., SurÃ¡nyi, G., et al. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00282.x · Cited by 67 · see citing works
A novel prokaryotic l ‐arginine:glycine amidinotransferase is involved in cylindrospermopsin biosynthesis
Muenchhoff, J., Siddiqui, K. S., Poljak, A., et al. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07788.x · Cited by 64 · see citing works
Comparative Protein Expression in Different Strains of the Bloom-forming Cyanobacterium Microcystis aeruginosa
Alexova, R., Haynes, P. A., Ferrari, B. C., & Neilan, B. A. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.003749 · Cited by 64 · see citing works
Determination of anatoxin-a stability under certain abiotic factors
Kamiński, A., Bober, B., Lechowski, Z., & Białçzyk, J. (2013) · Harmful Algae · doi:10.1016/j.hal.2013.05.014 · Cited by 63 · see citing works
Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)
Tsuchiya, S., Cho, Y., Konoki, K., et al. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00071d · Cited by 61 · see citing works
Relationship between photosynthetic processes and microcystin in Microcystis aeruginosa grown under different photon irradiances
Deblois, C. P., & Juneau, P. (2009) · Harmful Algae · doi:10.1016/j.hal.2009.07.001 · Cited by 61 · see citing works
Evaluation of quantitative real-time PCR to characterise spatial and temporal variations in cyanobacteria, Cylindrospermopsis raciborskii (Woloszynska) Seenaya et Subba Raju and cylindrospermopsin concentrations in three subtropical Australian reservoirs
Orr, P. T., Rasmussen, J. P., Burford, M. A., et al. (2009) · Harmful Algae · doi:10.1016/j.hal.2009.11.001 · Cited by 61 · see citing works
Genetic and morphologic characterization of four putative cylindrospermopsin producing species of the cyanobacterial genera Anabaena and Aphanizomenon
Stüken, A., Campbell, R. J., Quesada, A., et al. (2009) · Journal of Plankton Research · doi:10.1093/plankt/fbp011 · Cited by 59 · see citing works
Molecular Basis and Phylogenetic Implications of Deoxycylindrospermopsin Biosynthesis in the Cyanobacterium Raphidiopsis curvata
Jiang, Y., Xiao, P., Yu, G., et al. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.07321-11 · Cited by 58 · see citing works
Allelopathic activity of cyanobacteria on green microalgae at low cell densities
Leão, P. N., Vasconcelos, T., & Vasconcelos, V. M. (2009) · European Journal of Phycology · doi:10.1080/09670260802652156 · Cited by 58 · see citing works
Microcystin production by Microcystis aeruginosa: Direct regulation by multiple environmental factors
Jähnichen, S., Long, B. M., & Petzoldt, T. (2011) · Harmful Algae · doi:10.1016/j.hal.2011.09.002 · Cited by 56 · see citing works
Climate change and regulation of hepatotoxin production in Cyanobacteria
Gehringer, M. M., & Wannicke, N. (2014) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12291 · Cited by 56 · see citing works
An AbrB‐like protein might be involved in the regulation of cylindrospermopsin production by Aphanizomenon ovalisporum
Shalev‐Malul, G., Lieman‐Hurwitz, J., Viner‐Mozzini, Y., et al. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01519.x · Cited by 56 · see citing works
Investigating the production and release of cylindrospermopsin and deoxy-cylindrospermopsin by Cylindrospermopsis raciborskii over a natural growth cycle
Davis, T. W., Orr, P. T., Boyer, G. L., & Burford, M. A. (2013) · Harmful Algae · doi:10.1016/j.hal.2013.09.007 · Cited by 55 · see citing works
Two laboratory case studies on the oral toxicity to calves of the freshwater cyanophyte (blue-green alga) Anabaena flos-aquae NRC-44-1.
Carmichael, W. W., Gorham, P. R., & Biggs, D. F. (1977) · PubMed · Cited by 55 · see citing works
Cylindrospermopsin in Water Supply Reservoirs in Brazil Determined by Immunochemical and Molecular Methods
Bittencourt‐Oliveira, M. D. C., dos Santos, V. P., Kujbida, P. D. S., et al. (2011) · Journal of Water Resource and Protection · doi:10.4236/jwarp.2011.36044 · Cited by 52 · see citing works
The cyanobacterial toxin, cylindrospermopsin, induces fetal toxicity in the mouse after exposure late in gestation
Rogers, E. H., ZEHR, R. D. J., Gage, M. I., Humpage, A. R., Falconer, I. R., Marr, M. C., & Chernoff, N. (2007) · Toxicon · doi:10.1016/j.toxicon.2006.12.009 · Cited by 49 · see citing works
Chlorination for degrading saxitoxins (paralytic shellfish poisons) in water
Nicholson, B. C., Shaw, G. R., Morrall, J., et al. (2003) · Environmental Technology · doi:10.1080/09593330309385678 · Cited by 49 · see citing works
NUTRITIONAL REQUIREMENTS OF HAEMATOCOCCUS PLUVIALIS AND RELATED SPECIES1
Pringsheim, E. G. (1966) · Journal of Phycology · doi:10.1111/j.1529-8817.1966.tb04584.x · Cited by 49 · see citing works
A GROWTH ADVANTAGE FOR MICROCYSTIN PRODUCTION BY MICROCYSTIS PCC7806 UNDER HIGH LIGHT 1
Phelan, R. R., & Downing, T. G. (2011) · Journal of Phycology · doi:10.1111/j.1529-8817.2011.01056.x · Cited by 47 · see citing works
2-oxoglutarate enhances NtcA binding activity to promoter regions of the microcystin synthesis gene cluster
Kuniyoshi, T. M., González, A., López-Gomollón, S., et al. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.10.034 · Cited by 47 · see citing works
Amino acid availability determines the ratio of microcystin variants in the cyanobacterium Planktothrix agardhii
Tonk, L., de Waal, D. B. V., Slot, P. C., et al. (2008) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00541.x · Cited by 46 · see citing works
Expression of the nodularin synthetase genes in the Baltic Sea bloom-former cyanobacterium Nodularia spumigena strain AV1
Jonasson, S., Vintila, S., Sivonen, K., et al. (2008) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00499.x · Cited by 44 · see citing works
RELEASE OF CARBOHYDRATES AND PROTEINS BY A SUBTROPICAL STRAIN OF RAPHIDIOPSIS BROOKII (CYANOBACTERIA) ABLE TO PRODUCE SAXITOXIN AT THREE NITRATE CONCENTRATIONS1
Yunes, J. S., Rocha, S. D. L., Giroldo, D., et al. (2009) · Journal of Phycology · doi:10.1111/j.1529-8817.2009.00673.x · Cited by 44 · see citing works
UVB Radiation as a Potential Selective Factor Favoring Microcystin Producing Bloom Forming Cyanobacteria
Ding, Y., Song, L., & Sedmak, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073919 · Cited by 44 · see citing works
Cylindrospermopsin Accumulation and Release by the Benthic Cyanobacterium Oscillatoria sp. PCC 6506 under Different Light Conditions and Growth Phases
Bormans, M., Lengronne, M., Brient, L., et al. (2013) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-013-1144-y · Cited by 44 · see citing works
Assessment of cylindrospermopsin toxin in an arid Saudi lake containing dense cyanobacterial bloom
Mohamed, Z. A., & Al-Shehri, A. M. (2012) · Environmental Monitoring and Assessment · doi:10.1007/s10661-012-2696-8 · Cited by 43 · see citing works
Cloning and characterisation of ahypgene cluster in the filamentous cyanobacteriumNostocsp. strain PCC 73102
Hansel, A., Axelsson, R., Lindberg, P., et al. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10733.x · Cited by 41 · see citing works
Ammonium ions inhibit nitrogen fixation but do not affect heterocyst frequency in the bloom-forming cyanobacterium Nodularia spumigena strain AV1
Vintila, S., & El‐Shehawy, R. M. (2007) · Microbiology · doi:10.1099/mic.0.2007/007849-0 · Cited by 41 · see citing works
An active photosynthetic electron transfer chain required for mcyD transcription and microcystin synthesis in Microcystis aeruginosa PCC7806
Sevilla, E., Martín-Luna, B., Bes, M. T., Fillat, M. F., & Peleato, M. L. (2011) · Ecotoxicology · doi:10.1007/s10646-011-0842-7 · Cited by 40 · see citing works
Climatic forcing and primary productivity in a subalpine lake: Interannual variability as a natural experiment
Park, S., Brett, M. T., Müller-Solger, A. B., et al. (2004) · Limnology and Oceanography · doi:10.4319/lo.2004.49.2.0614 · Cited by 40 · see citing works
The genetics and genomics of cyanobacterial toxicity
Neilan, B. A., Pearson, L. A., Moffitt, M., et al. (2008) · Springer eBooks · doi:10.1007/978-0-387-75865-7_17 · Cited by 37 · see citing works
The effect of pyrogallic acid on growth, oxidative stress, and gene expression in Cylindrospermopsis raciborskii (Cyanobacteria)
Wu, Z., Shi, J., & Yang, S. (2012) · Ecotoxicology · doi:10.1007/s10646-012-1023-z · Cited by 37 · see citing works
Detection of Anatoxin-a and Three Analogs in Anabaena spp. Cultures: New Fluorescence Polarization Assay and Toxin Profile by LC-MS/MS
Sanchez, J., Otero, P., Alfonso, A., et al. (2014) · Toxins · doi:10.3390/toxins6020402 · Cited by 34 · see citing works
In vivo activity of the nitrogen control transcription factor NtcA is subjected to metabolic regulation in Synechococcus sp. strain PCC 7942
Luque, I. (2004) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2004.05.018 · Cited by 32 · see citing works
A highly sensitive analytical method for the neurotoxin anatoxin-a, using GC-ECD, and first application to laboratory cultures
Bumke‐Vogt, C., Mailahn, W., Rotard, W., et al. (1996) · Phycologia · doi:10.2216/i0031-8884-35-6s-51.1 · Cited by 32 · see citing works
Transcription Activation by NtcA in the Absence of Consensus NtcA-Binding Sites in an Anabaena Heterocyst Differentiation Gene Promoter
Camargo, S., Valladares, A., Flores, E., & Antonia Herrero, B. (2012) · Journal of Bacteriology · doi:10.1128/jb.05994-11 · Cited by 29 · see citing works
In vivo activity of the nitrogen control transcription factor NtcA is subjected to metabolic regulation inSynechococcussp. strain PCC 7942
Luque, I., Vázquez-Bermúdez, M. F., Paz-Yepes, J., Flores, E., & Antonia Herrero, B. (2004) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2004.tb09625.x · Cited by 27 · see citing works
Lichen species identity and diversity of cyanobacterial toxins in symbiosis
Kaasalainen, U., Fewer, D. P., Jokela, J., et al. (2013) · New Phytologist · doi:10.1111/nph.12215 · Cited by 25 · see citing works
Growth characteristics and toxin production in batch cultures of Anabaena flos-aquae: effects of culture media and duration
Gupta, N., Bhaskar, A. S. B., & Rao, P. V. L. (2002) · World Journal of Microbiology and Biotechnology · doi:10.1023/a:1013937317014 · Cited by 23 · see citing works
Optimization of 2D-PAGE protocols for proteomic analysis of two nonaxenic toxin-producing freshwater cyanobacteria:Cylindrospermopsis raciborskiiandRaphidiopsissp.
Plominsky, Á. M., Soto-Liebe, K., & Vásquez, M. (2009) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2009.02665.x · Cited by 15 · see citing works
Isolation of Microcystins from the Cyanobacterium Planktothrix rubescens Strain No80
Niedermeyer, T. H. J., Schmieder, P., & Kurmayer, R. (2014) · Natural Products and Bioprospecting · doi:10.1007/s13659-013-0001-3 · Cited by 11 · see citing works
PII signaling proteins of cyanobacteria and green algae. New features of conserved proteins
Ermilova, E., & Forchhammer, K. (2013) · Russian Journal of Plant Physiology · doi:10.1134/s1021443713040055 · Cited by 4 · see citing works
The genetics and genomics of cyanobacterial toxicity
Hudnell, H. K., Kellmann, R., Neilan, B. A., et al. (2015) · Cited by 4 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[2]Knoll A.H. Cyanobacteria and Earth History The Cyanobacteria: Molecular Biology, Genomics, and Evolution Herrero A. Flores E. Caister Academic Press Norfolk, UK 2008 484

Sorted by citations

The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products
Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works

Analysis of cylindrospermopsin- and microcystin-producing genotypes and cyanotoxin concentrations in the Macau storage reservoir
Zhang, W., Lou, I., Ung, W. K., et al. (2014) · Hydrobiologia · doi:10.1007/s10750-013-1776-2 · Cited by 25 · see citing works
Analysis of Cylindrospermopsin- and Microcystin-Producing Genotypes and Cyanotoxin Concentrations in the Macau Storage Reservoir
Zhang, W., Lou, I., Ung, W. K., et al. (2016) · Springer eBooks · doi:10.1007/978-94-024-0933-8_6
Detection of Cyanotoxin-Producing Genes in a Eutrophic Reservoir (Billings Reservoir, São Paulo, Brazil)
Ribeiro, M. S. F., Tucci, A., Matarazzo, M., et al. (2020) · Water · doi:10.3390/w12030903 · Cited by 20 · see citing works
Identification of Microcystin, Nodularin Synthatase Gene Clusters in Toxic Cyanobacteria Using AntiSMASH Pipeline
Thajuddin, F., Rasheed, A. S., Thajuddin, N., et al. (2023) · Springer eBooks · doi:10.1007/978-981-99-4514-6_53
Snapshot of cyanobacterial toxins in Pakistani freshwater bodies
Batool, U., Tromas, N., Simon, D. F., et al. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-32744-w · Cited by 6 · see citing works

Authors: Boopathi, T., & Ki, J.-S.
Affiliations: Sangmyung University (KR)
Corresponding author: Ki, Jang-Seu
ORCID: Boopathi, Thangavelu
Ki, Jang-Seu
Venue: Toxins
Publisher: MDPI AG
Published: 2014-06-25
Volume: 6
Issue: 7
Pages: 1951-1978
ISSN: 2072-6651 (ISSN-L)
DOI: 10.3390/toxins6071951
PMC: PMC4113735
OpenAlex: W2090164609
Cited by: 167
References: 165
Citations by year: 2026: 8 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 8 · 2021: 21 · 2020: 22 · 2019: 16 · 2018: 18 · 2017: 8 · 2016: 18 · 2015: 12 · 2014: 2
FWCI: 1.27
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Toxins (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Biocrusts and Microbial Ecology
Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Keywords: cyanotoxins, cyanobacteria, harmful algal blooms, microcystins, nodularin, cylindrospermopsin, anatoxin, saxitoxin, environmental factors, toxin production regulation, climate change
MeSH terms: Cyanobacteria Toxins, Cyanobacteria, Alkaloids, Animals, Bacterial Toxins, Environment, Humans, Marine Toxins, Peptides, Cyclic, Saxitoxin, Tropanes, Uracil, Microcystins, Climate Change

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impact of Environmental Factors on the Regulation of Cyanotoxin Production

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks