The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Human Antimicrobial Peptides as Therapeutics for Viral Infections
Open accessAbstract
Successful in vivo infection following pathogen entry requires the evasion and subversion of multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune pathways upregulated during infection by multiple pathogens, in multiple organs in vivo. In humans, there are many classes of AMPs exhibiting broad antimicrobial activities, with defensins and the human cathelicidin LL-37 being the best studied examples. Whereas historically the efficacy and therapeutic potential of AMPs against bacterial infection has been the primary focus of research, recent studies have begun to elucidate the antiviral properties of AMPs as well as their role in regulation of inflammation and chemoattraction. AMPs as therapeutic tools seem especially promising against emerging infectious viral pathogens for which no approved vaccines or treatments are currently available, such as dengue virus (DENV) and Zika virus (ZIKV). In this review, we summarize recent studies elucidating the efficacy and diverse mechanisms of action of various classes of AMPs against multiple viral pathogens, as well as the potential use of human AMPs in novel antiviral therapeutic strategies.
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Defensins in innate antiviral immunity
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V ENEZUELAN E QUINE E NCEPHALITIS
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Antiviral properties of lactoferrin--a natural immunity molecule
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“Consequently, high levels of hepcidin result in inhibition of iron uptake and sequestration of blood iron in macrophages, whereas low levels of hepcidin result in excessive uptake and toxic accumulation of dietary iron [137, 138] .”
BackgroundInteractions of α-, β-, and θ-Defensins with Influenza A Virus and Surfactant Protein D
Doss, M., White, M. R., Tecle, T., Gantz, D., Crouch, E. C., Jung, G., Ruchala, P., Waring, A. J., Lehrer, R. I., & Hartshorn, K. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804049 · Cited by 138
Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections
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BackgroundResultInfluential
Cited by
Antimicrobial peptides: mechanism of action, activity and clinical potential
Zhang, Q.-Y., Yan, Z.-B., Meng, Y.-M., Hong, X.-Y., Shao, G., Ma, J.-J., Cheng, X.-R., Liu, J., Kang, J., & Fu, C.-Y. (2021) · Military Medical Research · doi:10.1186/s40779-021-00343-2 · Cited by 1,065
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
Antimicrobial Peptides: An Update on Classifications and Databases
Bin Hafeez, A., Jiang, X., Bergen, P. J., & Zhu, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111691 · Cited by 341
Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications
Talapko, J., Meštrović, T., Juzbašić, M., Tomas, M., Erić, S., Horvat Aleksijević, L., Bekić, S., Schwarz, D., Matić, S., Neuberg, M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11101417 · Cited by 281
Metadata
- Authors
- Ahmed, A., Siman-Tov, G., Hall, G., Bhalla, N., & Narayanan, A.
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2019-08-01
- Volume
- 11
- Issue
- 8
- Pages
- 704
- ISSN
- 1999-4915 (ISSN-L)
- OpenAlex
- W2965044151
- Cited by
- 220
- References
- 9
- FWCI
- 22.26
- Type
- journal article
- Language
- en
- Open access
- gold
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