Defensins in innate antiviral immunity

Innate immune recognition

Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works

Chemokines

Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,859 · see citing works

Defensins: antimicrobial peptides of innate immunity

Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066 · see citing works

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809 · see citing works

Defensins. Natural peptide antibiotics of human neutrophils.

Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S. L., Daher, K. A., Bainton, D. F., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112120 · Cited by 1,416 · see citing works

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder, J., Bartels, J., Christophers, E., & Schröder, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,309 · see citing works

Mammalian defensins in the antimicrobial immune response

Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,196 · see citing works

Antibacterial peptides: basic facts and emerging concepts

Boman, H. G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01228.x · Cited by 1,163 · see citing works

The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility

Gonzalez, E., Kulkarni, H. R., Bolivar, H., Mangano, A. M., Sanchez, R., Catano, G., Nibbs, R. J. B., Freedman, B. I., Quinones, M. P., Bamshad, M. J., et al. (2005) · Science · doi:10.1126/science.1101160 · Cited by 1,127 · see citing works

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

Lehrer, R. I., Lichtenstein, A. K., & Ganz, T. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.000541 · Cited by 1,000 · see citing works

Cathelicidins, multifunctional peptides of the innate immunity

Zanetti, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403147 · Cited by 988 · see citing works

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

Biragyn, A., Ruffini, P. A., Leifer, C. A., Klyushnenkova, E., Shakhov, A., Chertov, O., Shirakawa, A., Farber, J. M., Segal, D. M., Oppenheim, J. J., et al. (2002) · Science · doi:10.1126/science.1075565 · Cited by 904 · see citing works

The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations

Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., & Gudmundsson, G. H. (2000) · Blood · doi:10.1182/blood.v96.9.3086 · Cited by 758 · see citing works

A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins

Tang, Y., Yuan, J. J., Ösapay, G., Ősapay, K., Tran, D., Miller, C. J., Ouellette, A. J., & Selsted, M. E. (1999) · Science · doi:10.1126/science.286.5439.498 · Cited by 698 · see citing works

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense

Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572 · see citing works

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

Chertov, O., Michiel, D. F., Xu, L., Wang, J., Tani, K., Murphy, W. J., Longo, D. L., Taub, D. D., & Oppenheim, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2935 · Cited by 548 · see citing works

Direct inactivation of viruses by human granulocyte defensins

Daher, K. A., Selsted, M. E., & Lehrer, R. I. (1986) · Journal of Virology · doi:10.1128/jvi.60.3.1068-1074.1986 · Cited by 535 · see citing works

Primary structures of three human neutrophil defensins.

Selsted, M. E., Harwig, S. S. L., Ganz, T., Schilling, J., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112121 · Cited by 534 · see citing works

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.9 · Cited by 501 · see citing works

Monocyte-chemotactic activity of defensins from human neutrophils.

Territo, M., Ganz, T., Selsted, M. E., & Lehrer, R. I. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114394 · Cited by 489 · see citing works

Discovery of five conserved β-defensin gene clusters using a computational search strategy

Schutte, B. C., Mitros, J., Bartlett, J. A., Walters, J. D., Jia, H. P., Welsh, M. J., Casavant, T. L., & McCray, P. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042692699 · Cited by 488 · see citing works

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

Conejo-Garcia, J. R., Krause, A., Schulz, S., Rodríguez-Jiménez, F. J., Klüver, E., Adermann, K., Forssmann, U., Frimpong‐Boateng, A., Bals, R., & Forssmann, W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0865fje · Cited by 469 · see citing works

Primate defensins

Lehrer, R. I. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro976 · Cited by 455 · see citing works

Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3

Wu, Z., Hoover, D. M., Yang, D., Boulègue, C., Santamaria, F., Oppenheim, J. J., Lubkowski, J. T., & Lu, W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533186100 · Cited by 439 · see citing works

Paneth cell trypsin is the processing enzyme for human defensin-5

Ghosh, D., Porter, E. M., Shen, B., Lee, S. K., Wilk, D. J., Drazba, J. A., Yadav, S. P., Crabb, J. W., Ganz, T., & Bevins, C. L. (2002) · Nature Immunology · doi:10.1038/ni797 · Cited by 428 · see citing works

Human epithelial β-defensins 2 and 3 inhibit HIV-1 replication

Quiñones‐Mateu, M. E., Lederman, M. M., Feng, Z., Chakraborty, B., Weber, J., Rangel, H. R., Marotta, M. L., Mirza, M., Jiang, B., Kiser, P. K., et al. (2003) · AIDS · doi:10.1097/00002030-200311070-00001 · Cited by 424 · see citing works

Identification of a novel, multifunctional *-defensin (human *-defensin 3) with specific antimicrobial activity

Conejo-Garcia, J. R., Jaumann, F., Schulz, S., Krause, A., Rodríguez-Jiménez, J., Forssmann, U., Adermann, K., Klüver, E., Vogelmeier, C. F., Becker, D., et al. (2001) · Cell and Tissue Research · doi:10.1007/s004410100433 · Cited by 408 · see citing works

Extensive Normal Copy Number Variation of a β-Defensin Antimicrobial-Gene Cluster

Hollox, E. J., Armour, J. A. L., & Barber, J. C. K. (2003) · The American Journal of Human Genetics · doi:10.1086/378157 · Cited by 354 · see citing works

Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production

Chalifour, A., Jeannin, P., Gauchat, J., Blaecke, A., Malissard, M., Nguyen, T. N., Thiéblemont, N., & Delneste, Y. (2004) · Blood · doi:10.1182/blood-2003-08-2820 · Cited by 351 · see citing works

Distinct Strains of Propionibacterium acnes Induce Selective Human β-Defensin-2 and Interleukin-8 Expression in Human Keratinocytes Through Toll-Like Receptors

Nagy, I., Pivarcsi, A., Koreck, A., Széll, M., Urbán, E. Z., & Kemény, L. V. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23705.x · Cited by 336 · see citing works

Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.

Quayle, A. J., Porter, E. M., Nussbaum, A. A., Wang, Y. M., Brabec, C., Yip, K., & Mok, S. C. (1998) · Europe PMC (PubMed Central) · Cited by 315 · see citing works

HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels

Gonzalez, E., Rovin, B. H., Sen, L., Cooke, G. E., Dhanda, R., Mummidi, S., Kulkarni, H. R., Bamshad, M. J., Telles, V., Anderson, S. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202357499 · Cited by 302 · see citing works

Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1

Cole, A. M., Hong, T., Boo, L. M., Nguyen, T. X., Zhao, C., Bristol, G., Zack, J. A., Waring, A. J., Yang, O. O., & Lehrer, R. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052706399 · Cited by 298 · see citing works

Selective Killing of Vaccinia Virus by LL-37: Implications for Eczema Vaccinatum

Howell, M. D., Jones, J. F., Kisich, K. O., Streib, J. E., Gallo, R. L., & Leung, D. Y. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1763 · Cited by 291 · see citing works

Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37)

Yang, D., Chertov, O., & Oppenheim, J. J. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.5.691 · Cited by 278 · see citing works

Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins

Leikina, E., Delanoë‐Ayari, H., Melikov, K., et al. (2005) · Nature Immunology · doi:10.1038/ni1248 · Cited by 266 · see citing works

Innate Immunity in the Human Female Reproductive Tract: Antiviral Response of Uterine Epithelial Cells to the TLR3 Agonist Poly(I:C)

Schaefer, T. M., Fahey, J. V., Wright, J. A., & Wira, C. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.992 · Cited by 265 · see citing works

θ Defensins Protect Cells from Infection by Herpes Simplex Virus by Inhibiting Viral Adhesion and Entry

Yasin, B., Wang, W., Pang, M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.10.5147-5156.2004 · Cited by 254 · see citing works

Expression of β‐defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells

Duits, L. A., Ravensbergen, B., Rademaker, M., Hiemstra, P. S., & Nibbering, P. H. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01430.x · Cited by 249 · see citing works

Differential Regulation of β-Defensin Expression in Human Skin by Microbial Stimuli

Sørensen, O. E., Thapa, D. R., Rosenthal, A., Liu, L., Roberts, A. A., & Ganz, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4870 · Cited by 243 · see citing works

Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes

Ganz, T. (1987) · Infection and Immunity · doi:10.1128/iai.55.3.568-571.1987 · Cited by 241 · see citing works

The role of Toll-like receptors in the host response to viruses

Bowie, A., & Haga, I. R. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2004.11.007 · Cited by 239 · see citing works

Human α-defensins block papillomavirus infection

Buck, C. B., Day, P. M., Thompson, C. D., Lubkowski, J. T., Lu, W., Lowy, D. R., & Schiller, J. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508033103 · Cited by 238 · see citing works

Antimicrobial factors in the cervical mucus plug

Hein, M., Valore, E. V., Helmig, R. B., Uldbjerg, N., & Ganz, T. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.123034 · Cited by 237 · see citing works

Human β-Defensins Suppress Human Immunodeficiency Virus Infection: Potential Role in Mucosal Protection

Sun, L., Finnegan, C. M., Kish-Catalone, T. M., Blumenthal, R. P., Garzino‐Demo, P., Maggiore, G. M. L. T., Berrone, S., Kleinman, C. S., Wu, Z., Abdelwahab, S. F., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.14318-14329.2005 · Cited by 235 · see citing works

Identification of Multiple Novel Epididymis-Specific β-Defensin Isoforms in Humans and Mice

Yamaguchi, Y., Nagase, T., Makita, R., Fukuhara, S., Tomita, T., Tominaga, T., Kurihara, H., & Ouchi, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2516 · Cited by 228 · see citing works

Dual role of α-defensin-1 in anti–HIV-1 innate immunity

Chang, T. L.-Y., Vargas, J., DelPortillo, A., & Klotman, M. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21948 · Cited by 225 · see citing works

Purification and Characterization of Human Neutrophil Peptide 4, a Novel Member of the Defensin Family

WILDE, C. G., Griffith, J. E., Marra, M. N., Snable, J. L., & Scott, R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60449-1 · Cited by 224 · see citing works

Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis

FAHLGREN, A., Hammarström, S., Danielsson, A., & HAMMARSTRÖM, M.-L. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02035.x · Cited by 209 · see citing works

Homodimeric θ-Defensins from Rhesus macaqueLeukocytes

Tran, D., Tran, P. A., Tang, Y., Yuan, J. J., Cole, T., & Selsted, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109117200 · Cited by 198 · see citing works

Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils

Robinson, W. E., McDougall, B. R., Tran, D., & Selsted, M. E. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.1.94 · Cited by 197 · see citing works

Activity of α- and θ-Defensins against Primary Isolates of HIV-1

Wang, W., Owen, S. M., Rudolph, D. L., Cole, A. M., Hong, T., Waring, A. J., Lal, R. B., & Lehrer, R. I. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.515 · Cited by 195 · see citing works

Retrocyclin, an Antiretroviral θ-Defensin, Is a Lectin

Wang, W., Cole, A. M., Hong, T., Waring, A. J., & Lehrer, R. I. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4708 · Cited by 190 · see citing works

Copy number polymorphism and expression level variation of the human α-defensin genes DEFA1 and DEFA3

Aldred, P. M. R., Hollox, E. J., & Armour, J. A. L. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi209 · Cited by 186 · see citing works

Genotype–phenotype correlation in cystic fibrosis: The role of modifier genes

Salvatore, F., Scudiero, O., & Castaldo, G. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10461 · Cited by 185 · see citing works

Evolution of primate θ-defensins: a serpentine path to a sweet tooth

Nguyen, T. X., Cole, A. M., & Lehrer, R. I. (2003) · Peptides · doi:10.1016/j.peptides.2003.07.023 · Cited by 178 · see citing works

Antimicrobial Peptides from Amphibian Skin Potently Inhibit Human Immunodeficiency Virus Infection and Transfer of Virus from Dendritic Cells to T Cells

VanCompernolle, S. E., Taylor, R. J., Oswald-Richter, K. A., Jiang, J., Youree, B. E., Bowie, J. H., Tyler, M. J., Conlon, J. M., Wade, D. C., Aiken, C., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.18.11598-11606.2005 · Cited by 163 · see citing works

Human α-defensin 1 (HNP-1) inhibits adenoviral infection in vitro

Bastian, A., & Schäfer, H. J. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00282-8 · Cited by 161 · see citing works

Host defense function of the airway epithelium in health and disease: clinical background

Message, S. D., & Johnston, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703315 · Cited by 159 · see citing works

Direct Cytotoxicity of Polymorphonuclear Leukocyte Granule Proteins to Human Lung-derived Cells and Endothelial Cells

Okrent, D. G., Lichtenstein, A. K., & Ganz, T. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.179 · Cited by 158 · see citing works

α-Defensins in the gastrointestinal tract

Cunliffe, R. (2003) · Molecular Immunology · doi:10.1016/s0161-5890(03)00157-3 · Cited by 157 · see citing works

Human Rhinovirus Infection Induces Airway Epithelial Cell Production of Human β-Defensin 2 Both In Vitro and In Vivo

Proud, D., Sanders, S. P., & Wiehler, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4637 · Cited by 154 · see citing works

The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro

Lorin, C., Saïdi, H., Belaïd, A., Zaïri, A., Baleux, F., Hocini, H., Bélec, L., Hani, K., & Tangy, F. (2005) · Virology · doi:10.1016/j.virol.2005.02.002 · Cited by 151 · see citing works

Critical Role of Lipid Composition in Membrane Permeabilization by Rabbit Neutrophil Defensins

Hristova, K. A., Selsted, M. E., & White, S. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24224 · Cited by 149 · see citing works

Microbial compounds induce the expression of pro-inflammatory cytokines, chemokines and human β-defensin-2 in vaginal epithelial cells

Pivarcsi, A., Nagy, I., Koreck, A., Kis, K., Kenderessy, A. S., Széll, M., DOBOZY, A., & Kemény, L. V. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.03.016 · Cited by 146 · see citing works

α-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors

Mackewicz, C. E., Yuan, J. J., Tran, P. A., et al. (2003) · AIDS · doi:10.1097/00002030-200309260-00001 · Cited by 144 · see citing works

Influence of Host Genetic Variation on Susceptibility to HIV Type 1 Infection

Kaslow, R. A., Dorak, T., & Tang, J. (2005) · The Journal of Infectious Diseases · doi:10.1086/425269 · Cited by 140 · see citing works

The θ-Defensin, Retrocyclin, Inhibits HIV-1 Entry

Münk, C., Wei, G., Yang, O. O., et al. (2003) · AIDS Research and Human Retroviruses · doi:10.1089/088922203322493049 · Cited by 138 · see citing works

Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production

Watering, S. V., Mannesse-Lazeroms, S. P. G., Dijkman, J. H., & Hiemstra, P. S. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.62.2.217 · Cited by 136 · see citing works

Rhinovirus increases human β-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells

Duits, L. A., Nibbering, P. H., Strijen, E., Vos, J. B., Mannesse-Lazeroms, S. P. G., Sterkenburg, M. A. J. A., & Hiemstra, P. S. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00106-8 · Cited by 135 · see citing works

Lymphoid Follicles Are Sites of Heightened Human Immunodeficiency Virus Type 1 (HIV-1) Replication and Reduced Antiretroviral Effector Mechanisms

Folkvord, J. M., Armon, C., & Connick, E. (2005) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2005.21.363 · Cited by 134 · see citing works

Host Determinants in HIV Infection and Disease: Part 2: Genetic Factors and Implications for Antiretroviral Therapeutics*

Hogan, C., & Hammer, S. M. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-10-200105150-00012 · Cited by 133 · see citing works

θ-Defensins Prevent HIV-1 Env-mediated Fusion by Binding gp41 and Blocking 6-Helix Bundle Formation

Gallo, S. A., Wang, W., Rawat, S. S., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602422200 · Cited by 133 · see citing works

A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children

Braida, L., Boniotto, M., Pontillo, A., Tovo, P., Amoroso, A., & Crovella, S. (2004) · AIDS · doi:10.1097/01.aids.0000131363.82951.fb · Cited by 132 · see citing works

Functional Analysis of the α-Defensin Disulfide Array in Mouse Cryptdin-4

Maemoto, A., Qu, X., Rosengren, K. J., Tanabe, H., Henschen-Edman, A. H., Craik, D. J., & Ouellette, A. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406154200 · Cited by 124 · see citing works

Defensins inhibit HIV replication in vitro

Nakashima, H., Yamamoto, N., Masuda, M., & Fujii, N. (1993) · AIDS · doi:10.1097/00002030-199308000-00019 · Cited by 117 · see citing works

Circular minidefensins and posttranslational generation of molecular diversity

Leonovа, L. E., Kokryakov, V. N., Gm, A., et al. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.3.461 · Cited by 113 · see citing works

NP-1, a Rabbit α-Defensin, Prevents the Entry and Intercellular Spread of Herpes Simplex Virus Type 2

Sinha, S., Cheshenko, N., Lehrer, R. I., et al. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.2.494-500.2003 · Cited by 113 · see citing works

Detection of human defensin 5 in reproductive tissues

Svinarich, D. M., Wolf, N. A., Gómez, R., Gonik, B., & Romero, R. J. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70517-9 · Cited by 112 · see citing works

Distinct Defensin Profiles inNeisseria gonorrhoeaeandChlamydia trachomatisUrethritis Reveal Novel Epithelial Cell-Neutrophil Interactions

Porter, E. M., Yang, H., Yavagal, S., Preza, G. C., Murillo, O., Lima, H., Greene, S. J., Mahoozi, L., Klein-Patel, M. E., Diamond, G., et al. (2005) · Infection and Immunity · doi:10.1128/iai.73.8.4823-4833.2005 · Cited by 107 · see citing works

レトロサイクリン HIV‐1のT‐及びM‐親和性株による感染から細胞を保護する霊長類ペプチド

Cole, A., Hong, T., M, B. L., Nguyen, T. T. V., Zhao, C., Bristol, G., Zack, J. A., Yang, O. O., & Lehrer, R. I. (2002) · Cited by 106 · see citing works

CAF-Mediated Human Immunodeficiency Virus (HIV) Type 1 Transcriptional Inhibition Is Distinct from α-Defensin-1 HIV Inhibition

Chang, T. L.-Y., François, F., Mosoian, A., & Klotman, M. E. (2003) · Journal of Virology · doi:10.1128/jvi.77.12.6777-6784.2003 · Cited by 105 · see citing works

Genetic Variants of Human β-Defensin-1 and Chronic Obstructive Pulmonary Disease

Matsushita, I., Hasegawa, K., Nakata, K., Yasuda, K., Tokunaga, K., & Keicho, N. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6395 · Cited by 101 · see citing works

Defensins – innate immunity at the epithelial frontier

Fellermann, K., & Stange, E. F. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200107000-00003 · Cited by 101 · see citing works

Abundant human β-defensin-1 expression in milk and mammary gland epithelium

Jia, H. P., Starner, T. D., Ackermann, M. R., Kirby, P., Tack, B. F., & McCray, P. B. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.109375 · Cited by 99 · see citing works

Human neutrophil α‐defensin 4 inhibits HIV‐1 infection in vitro

Wu, Z., Cocchi, F., Gentles, D., Ericksen, B., Lubkowski, J. T., DeVico, A. L., Lehrer, R. I., & Lu, W. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.062 · Cited by 98 · see citing works

Identification and quantification of innate immune system mediators in human breast milk.

Armogida, S. A., Yannaras, N. M., Melton, A. L., et al. (2005) · PubMed · Cited by 94 · see citing works

Structure of a novel human granulocyte peptide with anti-ACTH activity

Singh, A., Bateman, A., Zhu, Q., et al. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81118-5 · Cited by 92 · see citing works

RC-101, a Retrocyclin-1 Analogue with Enhanced Activity against Primary HIV Type 1 Isolates

Owen, S. M., Rudolph, D. L., Wang, W., Cole, A. M., Waring, A. J., Lal, R. B., & Lehrer, R. I. (2004) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2004.20.1157 · Cited by 92 · see citing works

Human α-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor–related protein/α2-macroglobulin receptor

Nassar, T., Akkawi, S., Bar‐Shavit, R., et al. (2002) · Blood · doi:10.1182/blood-2002-04-1080 · Cited by 88 · see citing works

Defensin Modulates Tissue-type Plasminogen Activator and Plasminogen Binding to Fibrin and Endothelial Cells

Higazi, A. A., Ganz, T., Kariko, K., & Cines, D. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17650 · Cited by 87 · see citing works

Association of defensin β-1 gene polymorphisms with asthma

Levy, H., Raby, B. A., Lake, S. L., Tantisira, K. G., Kwiatkowski, D. J., Lazarus, R. M., Silverman, E. K., Richter, B. G., Klimecki, W. T., Vercelli, D., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.11.013 · Cited by 83 · see citing works

Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils

Charp, P. A., Rice, W. G., Raynor, R. L., Reimund, E., Kinkade, J. M., Ganz, T., Selsted, M. E., Lehrer, R. I., & Kuo, J. F. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90187-6 · Cited by 83 · see citing works

Enhanced Surfactant Protein and Defensin mRNA Levels and Reduced Viral Replication during Parainfluenza Virus Type 3 Pneumonia in Neonatal Lambs

Grubor, B., Gallup, J. M., Meyerholz, D. K., Crouch, E. C., Evans, R. B., Brogden, K. A., Lehmkuhl, H. D., & Ackermann, M. R. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.3.599-607.2004 · Cited by 82 · see citing works

Defensins: natural anti-HIV peptides.

Chang, T. L.-Y., & Klotman, M. E. (2004) · PubMed · Cited by 71 · see citing works

Alpha-defensins in the prevention of HIV transmission among breastfed infants.

Kuhn, L., Trabattoni, D., Kankasa, C., et al. (2005) · PubMed · Cited by 71 · see citing works

Antibacterial activities and conformations of synthetic α‐defensin HNP‐1 and analogs with one, two and three disulfide bridges

Mandal, M., & Nagaraj, R. (2002) · Journal of Peptide Research · doi:10.1034/j.1399-3011.2002.01945.x · Cited by 71 · see citing works

Human α Defensin in HIV-Exposed But Uninfected Individuals

Trabattoni, D., Caputo, S. L., Maffeis, G., Vichi, F., Biasin, M., Pierotti, P., Fasano, F. R., Saresella, M., Franchini, M., Ferrante, P., et al. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200404150-00003 · Cited by 70 · see citing works

Inheritance of Unequal Numbers of the Genes Encoding the Human Neutrophil Defensins HP-1 and HP-3

Mars, W. M., Patmasiriwat, P., Maity, T., Huff, V., Weil, M. M., & Saunders, G. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30371 · Cited by 68 · see citing works

Defensins and cathelicidins: Neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis

Kougias, P., Chai, H., Lin, P. H., Yao, Q., Lumsden, A. B., & Chen, C. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00332.x · Cited by 65 · see citing works

Polymorphisms of the humanβ-defensin-1gene

Dörk, T., & Stuhrmann, M. (1998) · Molecular and Cellular Probes · doi:10.1006/mcpr.1998.0165 · Cited by 58 · see citing works

Epithelial Cell-Derived Antibacterial Peptides Human β-Defensins and Cathelicidin: Multifunctional Activities on Mast Cells

Niyonsaba, F., Hirata, M., Ogawa, H., et al. (2003) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010033484115 · Cited by 58 · see citing works

The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis.

Higazi, A. A., Nassar, T., Ganz, T., Rader, D. J., Udassin, R., Bdeir, K. H., Hiss, E., Sachais, B. S., Williams, K. J., Leitersdorf, E., et al. (2000) · PubMed · doi:10.1182/blood.v96.4.1393 · Cited by 57 · see citing works

Alpha-defensins inhibit HIV infection of macrophages through upregulation of CC-chemokines

Guo, C., Tan, N., Song, L., Douglas, S. D., & Ho, W. (2004) · AIDS · doi:10.1097/00002030-200405210-00020 · Cited by 47 · see citing works

Differential Effects on Human Immunodeficiency Virus Type 1 Replication by α-Defensins with Comparable Bactericidal Activities

Tanabe, H., Ouellette, A. J., Cocco, M. J., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.21.11622-11631.2004 · Cited by 46 · see citing works

The apoptosis of neutrophils is accelerated in respiratory syncytial virus (RSV)-induced bronchiolitis

Wang, S.-Z., Smith, P. K., Lovejoy, M., et al. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00681.x · Cited by 39 · see citing works

CC Chemokines Induce Neutrophils to Chemotaxis, Degranulation, and α-Defensin Release

Jan, M., Huang, Y.-H., Shieh, B., et al. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000188336.94090.14 · Cited by 38 · see citing works

Distribution of human β-defensin polymorphisms in various control and cystic fibrosis populations

Vankeerberghen, A., Scudiero, O., Boeck, K. D., et al. (2005) · Genomics · doi:10.1016/j.ygeno.2005.02.003 · Cited by 37 · see citing works

Adenovirus-Mediated Gene Therapy Enhances Parainfluenza Virus 3 Infection in Neonatal Lambs

Meyerholz, D. K., Grubor, B., Gallup, J. M., et al. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.10.4780-4787.2004 · Cited by 24 · see citing works

θ-Defensin pseudogenes in HIV-1-exposed, persistently seronegative female sex-workers from Thailand

YANG, C., Boone, L. A., Nguyen, T. T. T., et al. (2004) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2004.05.006 · Cited by 19 · see citing works

??-Defensins Released Into Stimulated CD8+ T-Cell Supernatants Are Likely Derived From Residual Granulocytes Within the Irradiated Allogeneic Peripheral Blood Mononuclear Cells Used as Feeders

Zaharatos, G. J., Tian, H., Lopez, P., et al. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200408150-00001 · Cited by 15 · see citing works

The airway epithelium: soldier in the fight against respiratory viruses

Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works

Interactions of α-, β-, and θ-Defensins with Influenza A Virus and Surfactant Protein D

Doss, M., White, M. R., Tecle, T., Gantz, D., Crouch, E. C., Jung, G., Ruchala, P., Waring, A. J., Lehrer, R. I., & Hartshorn, K. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804049 · Cited by 138 · see citing works

HUMAN DEFENSIN PEPTIDES WITH ANTIMICROBIAL PROPERTIES: AN OVERVIEW

Jha, L. L., Shah, D., & Ks, R. (2012)

Antimicrobial peptides in animals and their role in host defences

Brogden, K. A., Ackermann, M. R., McCray, P. B., & Tack, B. F. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(03)00180-8 · Cited by 458 · see citing works

Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells

van Wetering, S., Tjabringa, G. S., & Hiemstra, P. S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0604367 · Cited by 62 · see citing works

Epithelial antimicrobial peptides in host defense against infection

Bals, R. (2000) · Respiratory Research · doi:10.1186/rr25 · Cited by 499 · see citing works

The Spectrum of Antimicrobial Peptide Expression at the Ocular Surface

McIntosh, R. S., Cade, J. E., Al-Abed, M., Shanmuganathan, V., Gupta, R., Bhan, A., Tighe, P. J., & Dua, H. S. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0607 · Cited by 75 · see citing works