CoChat
Sign Up
Cited by 1,048Infectious Encephalopathies and EncephalitisLong-Term Effects of COVID-19Respiratory viral infections research

The DOI matches its Crossref record; 342 of the 342 references it cites were found in a registry or an index.

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

Open access
Desforges, Marc, Le Coupanec, Alain, Dubeau, Philippe, Bourgouin, Andréanne, Lajoie, Louise, Dubé, Mathieu, Talbot, Pierre J.·2019·Viruses
DOI 10.3390/v12010014PMC PMC7020001
Open this paper in CoChat — free accountOpen PDF

Abstract

Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). Respiratory viruses can also exacerbate asthma and lead to various types of respiratory distress syndromes. Furthermore, as they can adapt fast and cross the species barrier, some of these pathogens, like influenza A and SARS-CoV, have occasionally caused epidemics or pandemics, and were associated with more serious clinical diseases and even mortality. For a few decades now, data reported in the scientific literature has also demonstrated that several respiratory viruses have neuroinvasive capacities, since they can spread from the respiratory tract to the central nervous system (CNS). Viruses infecting human CNS cells could then cause different types of encephalopathy, including encephalitis, and long-term neurological diseases. Like other well-recognized neuroinvasive human viruses, respiratory viruses may damage the CNS as a result of misdirected host immune responses that could be associated with autoimmunity in susceptible individuals (virus-induced neuro-immunopathology) and/or viral replication, which directly causes damage to CNS cells (virus-induced neuropathology). The etiological agent of several neurological disorders remains unidentified. Opportunistic human respiratory pathogens could be associated with the triggering or the exacerbation of these disorders whose etiology remains poorly understood. Herein, we present a global portrait of some of the most prevalent or emerging human respiratory viruses that have been associated with possible pathogenic processes in CNS infection, with a special emphasis on human coronaviruses.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/v12010014

Cites

342 of 342 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 341 references

Cited by

Sorted by citations

Items 801–900 of 999

Related

See all

Metadata

Authors
Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J.
Affiliations
  • Institut National de la Recherche Scientifique (CA)
  • Laboratory of Neuroimmunovirology, Institut national de la recherche scientifique (INRS)-Institut Armand-Frappier, Université du Québec, Laval, QC H7V 1B7, Canada
  • Université de Sherbrooke (CA)
Corresponding author
  • Desforges, Marc
  • Talbot, Pierre J.
ORCID
Venue
Viruses
Publisher
MDPI AG
Published
2019-12-20
Volume
12
Issue
1
Pages
14
ISSN
1999-4915 (ISSN-L)
DOI
10.3390/v12010014
PMC
PMC7020001
OpenAlex
W2995936855
Cited by
1,048
References
341
Citations by year
2026: 16 · 2025: 32 · 2024: 59 · 2023: 101 · 2022: 200 · 2021: 323 · 2020: 314 · 2019: 3
FWCI
29.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Viruses (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • EspaceINRS (National Institute for Scientific Research (Canada)) (submittedVersion)
  • HAL (submittedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
Funders
Canadian Institutes of Health Research (MT-9203)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
human coronaviruses, respiratory viruses, central nervous system infection, encephalitis, neuropathology, opportunistic pathogens, emerging respiratory viruses, influenza A virus, SARS-CoV, autoimmunity, neurological disorders
MeSH terms
Animals, Central Nervous System, Humans, Nervous System Diseases, Respiratory Tract Infections, Virus Replication, Coronavirus, Coronavirus Infections, Encephalitis, Viral, Central Nervous System Viral Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review