Cited by 1,048Infectious Encephalopathies and EncephalitisLong-Term Effects of COVID-19Respiratory viral infections research

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Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

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Desforges, Marc, Le Coupanec, Alain, Dubeau, Philippe, Bourgouin, Andréanne, Lajoie, Louise, Dubé, Mathieu, Talbot, Pierre J.·2019·Viruses

DOI 10.3390/v12010014PMC PMC7020001

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Abstract

Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). Respiratory viruses can also exacerbate asthma and lead to various types of respiratory distress syndromes. Furthermore, as they can adapt fast and cross the species barrier, some of these pathogens, like influenza A and SARS-CoV, have occasionally caused epidemics or pandemics, and were associated with more serious clinical diseases and even mortality. For a few decades now, data reported in the scientific literature has also demonstrated that several respiratory viruses have neuroinvasive capacities, since they can spread from the respiratory tract to the central nervous system (CNS). Viruses infecting human CNS cells could then cause different types of encephalopathy, including encephalitis, and long-term neurological diseases. Like other well-recognized neuroinvasive human viruses, respiratory viruses may damage the CNS as a result of misdirected host immune responses that could be associated with autoimmunity in susceptible individuals (virus-induced neuro-immunopathology) and/or viral replication, which directly causes damage to CNS cells (virus-induced neuropathology). The etiological agent of several neurological disorders remains unidentified. Opportunistic human respiratory pathogens could be associated with the triggering or the exacerbation of these disorders whose etiology remains poorly understood. Herein, we present a global portrait of some of the most prevalent or emerging human respiratory viruses that have been associated with possible pathogenic processes in CNS infection, with a special emphasis on human coronaviruses.

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Tg, K., Erdman, D. D., Cs, G., Zaki, Peret, T. C. T., Emery, S. L., Tong, S., Urbani, C., Comer, J. A., Lim, W., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030781 · Cited by 4,353
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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
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Guan, Y., Zheng, B., He, Y., Liu, X. L., Zhuang, Z. X., Cheung, C. L., Luo, S., Li, P. H., Zhang, L., Guan, Y., et al. (2003) · Science · doi:10.1126/science.1087139 · Cited by 2,404

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Neurological associations of COVID-19
Ellul, M. A., Benjamin, L., Singh, B., Lant, S., Michael, B. D., Easton, A., Kneen, R., Defres, S., Sejvar, J., & Solomon, T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30221-0 · Cited by 2,156
Nervous system involvement after infection with COVID-19 and other coronaviruses
Wu, Y., Xu, X., Chen, Z., Duan, J., Hashimoto, K., Yang, L., Liu, C., & Yang, C. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.03.031 · Cited by 2,046
Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors
Mazza, M. G., De Lorenzo, R., Conte, C., Poletti, S., Vai, B., Bollettini, I., Melloni, E. M. T., Furlan, R., Ciceri, F., Rovere-Querini, P., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.037 · Cited by 1,804
COVID‐19 diagnosis and management: a comprehensive review
Pascarella, G., Strumia, A., Piliego, C., Bruno, F., BUONO, R. D., Costa, F., Scarlata, S., & Agrò, F. E. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13091 · Cited by 1,435
Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
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Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms
Troyer, E. A., Kohn, J. N., & Hong, S. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.027 · Cited by 964
Central nervous system manifestations of COVID-19: A systematic review
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Raony, Í., de Figueiredo, C. S., Pandolfo, P., Giestal-de-Araujo, E., Oliveira-Silva Bomfim, P., & Savino, W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01170 · Cited by 185
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Benameur, K., Agarwal, A., Auld, S. C., Butters, M. P., Webster, A. S., Ozturk, T. T., Howell, J. C., Bassit, L., Velasquez, A., Schinazi, R. F., et al. (2020) · Emerging infectious diseases · doi:10.3201/eid2609.202122 · Cited by 171
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Acharya, A., Kevadiya, B. D., Gendelman, H. E., & Byrareddy, S. N. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09924-9 · Cited by 97
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Bon, S. D. L., Pisarski, N., Verbeke, J., Prunier, L., Cavelier, G., Thill, M., Rodriguez, A., Dequanter, D., Lechien, J. R., Bon, O. L., et al. (2020) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-020-06267-2 · Cited by 101

Authors: Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J.
Affiliations: Institut National de la Recherche Scientifique (CA)
Laboratory of Neuroimmunovirology, Institut national de la recherche scientifique (INRS)-Institut Armand-Frappier, Université du Québec, Laval, QC H7V 1B7, Canada
Université de Sherbrooke (CA)
Corresponding author: Desforges, Marc
Talbot, Pierre J.
ORCID: Desforges, Marc
Dubeau, Philippe
Talbot, Pierre J.
Venue: Viruses
Publisher: MDPI AG
Published: 2019-12-20
Volume: 12
Issue: 1
Pages: 14
ISSN: 1999-4915 (ISSN-L)
DOI: 10.3390/v12010014
PMC: PMC7020001
OpenAlex: W2995936855
Cited by: 1,048
References: 341
Citations by year: 2026: 16 · 2025: 32 · 2024: 59 · 2023: 101 · 2022: 200 · 2021: 323 · 2020: 314 · 2019: 3
FWCI: 29.51
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Viruses (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
EspaceINRS (National Institute for Scientific Research (Canada)) (submittedVersion)
HAL (submittedVersion)
Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
Funders: Canadian Institutes of Health Research (MT-9203)
Topics: Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords: human coronaviruses, respiratory viruses, central nervous system infection, encephalitis, neuropathology, opportunistic pathogens, emerging respiratory viruses, influenza A virus, SARS-CoV, autoimmunity, neurological disorders
MeSH terms: Animals, Central Nervous System, Humans, Nervous System Diseases, Respiratory Tract Infections, Virus Replication, Coronavirus, Coronavirus Infections, Encephalitis, Viral, Central Nervous System Viral Diseases

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Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

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