The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Whole Tumor Antigen Vaccines: Where Are We?
Open accessAbstract
With its vast amount of uncharacterized and characterized T cell epitopes available for activating CD4+ T helper and CD8+ cytotoxic lymphocytes simultaneously, whole tumor antigen represents an attractive alternative source of antigens as compared to tumor-derived peptides and full-length recombinant tumor proteins for dendritic cell (DC)-based immunotherapy. Unlike defined tumor-derived peptides and proteins, whole tumor lysate therapy is applicable to all patients regardless of their HLA type. DCs are essentially the master regulators of immune response, and are the most potent antigen-presenting cell population for priming and activating naïve T cells to target tumors. Because of these unique properties, numerous DC-based immunotherapies have been initiated in the clinics. In this review, we describe the different types of whole tumor antigens that we could use to pulse DCs ex vivo and in vivo. We also discuss the different routes of delivering whole tumor antigens to DCs in vivo and activating them with toll-like receptor agonists.
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Citations
Cites
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“One possible mechanism is via the recognition of HSP [27] and HMBG-1 [28] by scavenger receptor-A and TLR4 on DCs, and another mechanism is through interaction with uric acid which is the natural end product of the purine metabolic pathway of degraded cellular RNAs and DNAs [29,30].”
BackgroundGenes Expressed in Human Tumor Endothelium
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Molecular identification of a danger signal that alerts the immune system to dying cells
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A receptor for phosphatidylserine-specific clearance of apoptotic cells
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Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
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Cited by
Delivery technologies for cancer immunotherapy
Riley, R. S., June, C. H., Langer, R., & Mitchell, M. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0006-z · Cited by 2,607
Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer
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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Lu, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Canadas, I., Tian, Y., Niu, X., Wang, Y., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 373
Personalized Dendritic Cell Vaccines‐Recent Breakthroughs and Encouraging Clinical Results
Mastelic-Gavillet, B., Balint, K., Boudousquie, C., Gannon, P. O., & Kandalaft, L. E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00766 · Cited by 189
Self-citationHOCl and the Control of Oncogenesis
Bauer, G. (2018) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.11.005 · Cited by 58
Metadata
- Authors
- Chiang, C., Coukos, G., & Kandalaft, L.
- Venue
- Vaccines
- Publisher
- MDPI AG
- Published
- 2015-04-23
- Volume
- 3
- Issue
- 2
- Pages
- 344-372
- ISSN
- 2076-393X (ISSN-L)
- OpenAlex
- W2061662618
- Cited by
- 269
- References
- 122
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- gold
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