The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recent Advances in Subunit Vaccine Carriers
Open accessAbstract
The lower immunogenicity of synthetic subunit antigens, compared to live attenuated vaccines, is being addressed with improved vaccine carriers. Recent reports indicate that the physio-chemical properties of these carriers can be altered to achieve optimal antigen presentation, endosomal escape, particle bio-distribution, and cellular trafficking. The carriers can be modified with various antigens and ligands for dendritic cells targeting. They can also be modified with adjuvants, either covalently or entrapped in the matrix, to improve cellular and humoral immune responses against the antigen. As a result, these multi-functional carrier systems are being explored for use in active immunotherapy against cancer and infectious diseases. Advancing technology, improved analytical methods, and use of computational methodology have also contributed to the development of subunit vaccine carriers. This review details recent breakthroughs in the design of nano-particulate vaccine carriers, including liposomes, polymeric nanoparticles, and inorganic nanoparticles.
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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
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Liposomes in drug delivery: Progress and limitations
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Cited by
Application of built-in adjuvants for epitope-based vaccines
Lei, Y., Zhao, F., Shao, J., Li, Y., Li, S., Chang, H., & Zhang, Y. (2019) · PeerJ · doi:10.7717/peerj.6185 · Cited by 115
Advances in Toxoplasma gondii vaccines: current strategies and challenges for vaccine development
Chu, K.-B., & Quan, F.-S. (2021) · Vaccines · doi:10.3390/vaccines9050413 · Cited by 92
Axial pharmaceutical properties of liposome in cancer therapy: Recent advances and perspectives
Kiaie, S. H., Mojarad-Jabali, S., Khaleseh, F., Allahyari, S., Taheri, E., Zakeri-Milani, P., & Valizadeh, H. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119269 · Cited by 87
Chen, G., Li, X., Sun, M., Zhou, Y., Yin, M., Zhao, B., & Li, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669010 · Cited by 49
Carbohydrate Immune Adjuvants in Subunit Vaccines
Bashiri, S., Koirala, P., Toth, I., & Skwarczynski, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100965 · Cited by 45
Metadata
- Authors
- Vartak, A., & Sucheck, S.
- Venue
- Vaccines
- Publisher
- MDPI AG
- Published
- 2016-04-19
- Volume
- 4
- Issue
- 2
- Pages
- 12
- ISSN
- 2076-393X (ISSN-L)
- OpenAlex
- W2339647820
- Cited by
- 323
- References
- 4
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- gold
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