Carbohydrate Immune Adjuvants in Subunit Vaccines

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400 · see citing works

Regulation of Adaptive Immunity by the Innate Immune System

Iwasaki, A., & Medzhitov, R. M. (2010) · Science · doi:10.1126/science.1183021 · Cited by 2,139 · see citing works

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

† (2015) · The Lancet · doi:10.1016/s0140-6736(15)60721-8 · Cited by 1,535 · see citing works

Key roles of adjuvants in modern vaccines

Reed, S. G., Orr, M. T., & Fox, C. B. (2013) · Nature Medicine · doi:10.1038/nm.3409 · Cited by 1,435 · see citing works

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., & Simon, J. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20001858 · Cited by 1,378 · see citing works

The ins and outs of MHC class II-mediated antigen processing and presentation

Roche, P. A., & Furuta, K. (2015) · Nature reviews. Immunology · doi:10.1038/nri3818 · Cited by 1,207 · see citing works

The immune geography of IgA induction and function

Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047 · see citing works

Hyaluronic acid (hyaluronan): A review

Necas, J., Bartosikova, L., Brauner, P., & Kolar, J. (2008) · Veterinární medicína · doi:10.17221/1930-vetmed · Cited by 998 · see citing works

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

Rogers, N. C., Slack, E. M. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L. J., Brown, G. D., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.004 · Cited by 897 · see citing works

Hyaluronic Acid in the Third Millennium

Fallacara, A., Baldini, E., Manfredini, S., & Vertuani, S. (2018) · Polymers · doi:10.3390/polym10070701 · Cited by 877 · see citing works

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

Goodridge, H. S., Reyes, C. N., Becker, C. A., Katsumoto, T. R., Ma, J., Wolf, A. J., Bose, N., Chan, A. S. H., Magee, A. S., Danielson, M. E., et al. (2011) · Nature · doi:10.1038/nature10071 · Cited by 871 · see citing works

Glycoprotein-D–Adjuvant Vaccine to Prevent Genital Herpes

Stanberry, L. R., Spruance, S. L., Cunningham, A. L., Bernstein, D. I., Mindel, A., Sacks, S. L., Tyring, S. K., Aoki, F. Y., Slaoui, M., Denis, M., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011915 · Cited by 791 · see citing works

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

Netea, M. G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27114 · Cited by 754 · see citing works

Activation of Natural Killer T Cells by α-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein

Fujii, S., Shimizu, K., Smith, C., Bonifaz, L. C., & Steinman, R. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030324 · Cited by 712 · see citing works

Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses

Morein, B., Sundquist, B. G., Höglund, S., Dalsgaard, K., & Osterhaus, A. D. M. E. (1984) · Nature · doi:10.1038/308457a0 · Cited by 708 · see citing works

Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination

Yang, R., Xu, J., Xu, L., Sun, X., Chen, Q., Zhao, Y., Peng, R., & Liu, Z. (2018) · ACS Nano · doi:10.1021/acsnano.7b09041 · Cited by 702 · see citing works

Current views on fungal chitin/chitosan, human chitinases, food preservation, glucans, pectins and inulin: A tribute to Henri Braconnot, precursor of the carbohydrate polymers science, on the chitin bicentennial

Muzzarelli, R. A. A., Boudrant, J., Meyer, D., Manno, N., DeMarchis, M., & Paoletti, M. G. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.09.063 · Cited by 694 · see citing works

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial.

Bache, E. B., Agnandji, S. T., Lell, B., Fernandes, J. F., Abossolo, B. P., Kabwende, A. L., Adégnika, A. A., Mordmüller, B. G., Kremsner, P. G., Loembé, M. M., et al. (2015) · The Lancet · doi:10.15496/publikation-6508 · Cited by 651 · see citing works

Peptide-based synthetic vaccines

Skwarczynski, M., & Toth, I. (2016) · Chemical Science · doi:10.1039/c5sc03892h · Cited by 596 · see citing works

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

Casella, C. R., & Mitchell, T. C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8228-6 · Cited by 563 · see citing works

Vaccine delivery using nanoparticles

Gregory, A. E., Titball, R. W., & Williamson, D. E. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00013 · Cited by 562 · see citing works

Semisynthetic resorbable materials from hyaluronan esterification

Campoccia, D. (1998) · Biomaterials · doi:10.1016/s0142-9612(98)00042-8 · Cited by 529 · see citing works

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

Didierlaurent, A. M., Laupèze, B., Pasquale, A. D., Hergli, N., Collignon, C., & Garçon, N. (2016) · Expert Review of Vaccines · doi:10.1080/14760584.2016.1213632 · Cited by 521 · see citing works

Dectin-2 Is a Pattern Recognition Receptor for Fungi That Couples with the Fc Receptor γ Chain to Induce Innate Immune Responses

Sato, K., Yang, X.-L., Yudate, T., Chung, J., Wu, J., Luby‐Phelps, K., Kimberly, R. P., Underhill, D. M., Cruz, P. D., & Ariizumi, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606542200 · Cited by 458 · see citing works

Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice

Vila, A., Sánchez, A., Janes, K. A., Behrens, I., Kissel, T., Jato, J. L. V., & Alonso, M. J. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2003.09.006 · Cited by 449 · see citing works

Tuberculosis Subunit Vaccination Provides Long-Term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells

Lindenstrøm, T., Agger, E. M., Korsholm, K. S., Darrah, P. A., Aagaard, C., Seder, R. A., Rosenkrands, I., & Andersen, P. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801592 · Cited by 422 · see citing works

C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805177106 · Cited by 421 · see citing works

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

Burgdorf, S., Scholz, C. W., Kautz, A., Tampé, R., & Kurts, C. (2008) · Nature Immunology · doi:10.1038/ni.1601 · Cited by 404 · see citing works

The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose

McGreal, E. P., Rosas, M., Brown, G. D., ZAMZE, S. E., Wong, S. Y. C., Gordon, S., Martínez‐Pomares, L., & Taylor, P. R. (2006) · Glycobiology · doi:10.1093/glycob/cwj077 · Cited by 380 · see citing works

The C‐type lectin DC‐SIGN (CD209) is an antigen‐uptake receptor for Candida albicans on dendritic cells

Cambi, A., Gijzen, K., de Vries, I. J. M., Torensma, R., Joosten, B., Adema, G. J., Netea, M. G., Kullberg, B. J., Romani, L. R., & Figdor, C. G. (2003) · European Journal of Immunology · doi:10.1002/immu.200310029 · Cited by 375 · see citing works

Aluminium adjuvants—in retrospect and prospect

Lindblad, E. B. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.03.032 · Cited by 363 · see citing works

Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6·4 years

‡ (2009) · The Lancet · doi:10.1016/s0140-6736(09)61567-1 · Cited by 352 · see citing works

Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6′-dibehenate)—A novel adjuvant inducing both strong CMI and antibody responses

Davidsen, J. R., Rosenkrands, I., Christensen, D., Vangala, A., Kirby, D. J., Perrie, Y., Agger, E. M., & Andersen, P. L. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.10.011 · Cited by 341 · see citing works

C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection

Zhu, L., Zhao, X.-Q., Jiang, C., You, Y., Chen, X., Jiang, Y.-Y., Jia, X., & Lin, X. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.017 · Cited by 340 · see citing works

Polymer-Based Nanomaterials and Applications for Vaccines and Drugs

Han, J., Zhao, D., Li, D., Wang, X., Jin, Z., & Zhao, K. (2018) · Polymers · doi:10.3390/polym10010031 · Cited by 327 · see citing works

Recent Advances in Subunit Vaccine Carriers

Vartak, A., & Sucheck, S. J. (2016) · Vaccines · doi:10.3390/vaccines4020012 · Cited by 325 · see citing works

Trimethyl chitosan and its applications in drug delivery

Mourya, V. K., & Inamdar, N. (2008) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-008-3659-z · Cited by 317 · see citing works

Candida albicansPhospholipomannan Is Sensed through Toll‐Like Receptors

Jouault, T., Ibata‐Ombetta, S., Takeuchi, O., Trinel, P. A., Sacchetti, P., Lefèbvre, P., Akira, S., & Poulain, D. (2003) · The Journal of Infectious Diseases · doi:10.1086/375784 · Cited by 310 · see citing works

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

Maisonneuve, C., Bertholet, S., Philpott, D. J., & Gregorio, E. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400478111 · Cited by 303 · see citing works

Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine

Shi, G., Zhang, C., Xu, R., Niu, J., Song, H., Zhang, X.-Y., Wang, W., Wang, Y., Li, C., Wei, X., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.047 · Cited by 301 · see citing works

Mannose-targeted systems for the delivery of therapeutics

Irache, J. M., Salman, H. H., Gamazo, C., & Espuelas, S. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.6.703 · Cited by 295 · see citing works

Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants

Oda, K., Matsuda, H., Murakami, T., Katayama, S., Ohgitani, T., & Yoshikawa, M. (2000) · Biological Chemistry · doi:10.1515/bc.2000.009 · Cited by 291 · see citing works

Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity

Marciani, D. J. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02864-2 · Cited by 290 · see citing works

Particulate vaccines: on the quest for optimal delivery and immune response

Temmerman, M. D., Rejman, J., Demeester, J., Irvine, D. J., Gander, B. A., & Smedt, S. C. D. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.04.006 · Cited by 288 · see citing works

Sterically Hindered Analogs of Thyroxine

Kharasch, N., & Saha, N. N. (1958) · Science · doi:10.1126/science.127.3301.756-a · Cited by 262 · see citing works

Taking toll: lipid A mimetics as adjuvants and immunomodulators

Persing, D. H., Coler, R. N., Lacy, M. J., Johnson, D. A., Baldridge, J. R., Hershberg, R. M., & Reed, S. G. (2002) · Trends in Microbiology · doi:10.1016/s0966-842x(02)02426-5 · Cited by 260 · see citing works

Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models

Zhang, X., Qi, C., Guo, Y., Zhou, W., & Zhang, Y. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.04.097 · Cited by 254 · see citing works

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

van Dissel, J. T., Joosten, S. A., Hoff, S. T., Soonawala, D., Prins, C., Hokey, D. A., O’Dee, D. M., Graves, A. J., Thierry-Carstensen, B., Andreasen, L. V., et al. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.10.036 · Cited by 245 · see citing works

Polysaccharides as vaccine adjuvants

Sun, B., Yu, S., Zhao, D., Guo, S., Wang, X., & Zhao, K. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.07.040 · Cited by 243 · see citing works

Structural requirements for high affinity binding of complex ligands by the macrophage mannose receptor.

Taylor, M. E., & Drickamer, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54164-8 · Cited by 238 · see citing works

Liposomal malaria vaccine in humans: a safe and potent adjuvant strategy.

Fries, L. F., Gordon, D. M., Richards, R. L., Egan, J. E., Hollingdale, M. R., Gross, M. S., Silverman, C., & Alving, C. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.358 · Cited by 228 · see citing works

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Wilson, D. S., Hirosue, S., Raczy, M. M., Bonilla-Ramírez, L., Jeanbart, L., Wang, R., Kwissa, M., Franetich, J., Broggi, M. A. S., Diaceri, G., et al. (2019) · Nature Materials · doi:10.1038/s41563-018-0256-5 · Cited by 222 · see citing works

Galectin-3 Induces Death of Candida Species Expressing Specific β-1,2-Linked Mannans

Kohatsu, L., Hsu, D. K., Jegalian, A. G., Liu, F., & Baum, L. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4718 · Cited by 221 · see citing works

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

Vandepapelière, P., Horsmans, Y., Moris, P., Mechelen, M. V., Janssens, M., Koutsoukos, M., Belle, P. V., Clément, F., Hanon, E., Wettendorff, M. A., et al. (2008) · Vaccine · doi:10.1016/j.vaccine.2007.12.038 · Cited by 218 · see citing works

Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

Ragupathi, G., Gardner, J. R., Livingston, P. O., & Gin, D. Y. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.18 · Cited by 207 · see citing works

New hepatitis B vaccine formulated with an improved adjuvant system

Kundi, M. (2007) · Expert Review of Vaccines · doi:10.1586/14760584.6.2.133 · Cited by 194 · see citing works

Innate Sensing of Chitin and Chitosan

Bueter, C. L., Specht, C. A., & Levitz, S. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003080 · Cited by 192 · see citing works

Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination

Slütter, B., Plapied, L., Fievez, V., Alonso, M. J., Rieux, A. D., Schneider, Y., van Riet, E., Jiskoot, W., & Véronique Préat, A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.05.011 · Cited by 192 · see citing works

Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery

Chong, C. S. W., Cao, M., Wong, W. W., Fischer, K. P., Addison, W. R., Kwon, G. S., Tyrrell, D. L., & Samuel, J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.014 · Cited by 191 · see citing works

Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses.

Apostolopoulos, V., Pietersz, G. A., Loveland, B. E., Sandrin, M. S., & McKenzie, I. F. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10128 · Cited by 189 · see citing works

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

Alloatti, A., Kotsias, F., Pauwels, A.-M., Carpier, J.-M., Jouve, M. J., Timmerman, E., Pace, L., Vargas, P., Maurin, M., Gehrmann, U., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.006 · Cited by 189 · see citing works

α-Galactosylceramide Can Act As a Nasal Vaccine Adjuvant Inducing Protective Immune Responses against Viral Infection and Tumor

Ko, S., Ko, H., Chang, W., Park, S., Kweon, M., & Kang, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3309 · Cited by 182 · see citing works

Low Molecular Weight Hyaluronic Acid Increases the Self-Defense of Skin Epithelium by Induction of β-Defensin 2 via TLR2 and TLR4

Gariboldi, S., Palazzo, M., Zanobbio, L., Selleri, S., Sommariva, M., Sfondrini, L., Cavicchini, S., Balsari, A., & Rumio, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.2103 · Cited by 176 · see citing works

Targeted antigen delivery to dendritic cell via functionalized alginate nanoparticles for cancer immunotherapy

Zhang, C., Shi, G., Zhang, J., Song, H., Niu, J., Shi, S., Huang, P., Wang, Y., Wang, W., Li, C., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.020 · Cited by 172 · see citing works

Saponin: Properties, Methods of Evaluation and Applications

Moghimipour, E., & Handali, S. (2014) · Annual Research & Review in Biology · doi:10.9734/arrb/2015/11674 · Cited by 170 · see citing works

Targeted Drug Delivery : Concepts and Design

Jain, S., & Devarajan, P. V. (2014) · Advances in delivery science and technology · doi:10.1007/978-3-319-11355-5 · Cited by 168 · see citing works

N,N,N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicine

Kulkarni, A. D., Patel, H., Surana, S. J., Vanjari, Y. H., Belgamwar, V. S., & Pardeshi, C. V. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.10.041 · Cited by 166 · see citing works

Potential targets for next generation antimicrobial glycoconjugate vaccines

Micoli, F., Costantino, P., & Adamo, R. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy011 · Cited by 165 · see citing works

Syk‐dependent ERK activation regulates IL‐2 and IL‐10 production by DC stimulated with zymosan

Slack, E. M. C., Robinson, M. J., Hernanz‐Falcón, P., Brown, G. D., Williams, D. L., Schweighoffer, E., Tybulewicz, V. L. J., & Sousa, C. R. E. (2007) · European Journal of Immunology · doi:10.1002/eji.200636830 · Cited by 160 · see citing works

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses

Christensen, D., Mortensen, R. J., Rosenkrands, I., Dietrich, J., & Andersen, P. L. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.28 · Cited by 160 · see citing works

Cationic liposome–hyaluronic acid hybrid nanoparticles for intranasal vaccination with subunit antigens

Fan, Y., Sahdev, P., Ochyl, L. J., Akerberg, J. J., & Moon, J. J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.04.010 · Cited by 159 · see citing works

Carbohydrate-based immune adjuvants

Petrovsky, N., & Cooper, P. D. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.30 · Cited by 157 · see citing works

Differential functional effects of biomaterials on dendritic cell maturation

Park, J., & Babensee, J. E. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.006 · Cited by 156 · see citing works

Vaccination Strategies to Promote Mucosal Antibody Responses

Chen, K., & Cerutti, A. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.013 · Cited by 155 · see citing works

Applications of synthetic carbohydrates to chemical biology

Lepenies, B., Yin, J., & Seeberger, P. H. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.02.016 · Cited by 152 · see citing works

Intranasal and oral vaccination with protein-based antigens: advantages, challenges and formulation strategies

Wang, S., Liu, H., Zhang, X., & Qian, F. (2015) · Protein & Cell · doi:10.1007/s13238-015-0164-2 · Cited by 152 · see citing works

β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination

Smet, R. D., Demoor, T., Verschuere, S., Dullaers, M., Ostroff, G. R., Leclercq, G., Allais, L., Pilette, C., Dierendonck, M., Geest, B. G. D., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.09.007 · Cited by 151 · see citing works

Targeted delivery of chitosan nanoparticles to Peyer’s patch using M cell-homing peptide selected by phage display technique

Yoo, M. K., Kang, S., Choi, J.-H., Park, I., Na, H. S., Lee, H., Kim, E.-B., Lee, N.-K., Nah, J., Choi, Y.-J., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.059 · Cited by 150 · see citing works

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

den Brok, M. H., Büll, C., Wassink, M., de Graaf, A. M., Wagenaars, J. A. L., Minderman, M., Thakur, M., Amigorena, S., Rijke, E., Schrier, C. C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13324 · Cited by 142 · see citing works

Defending the mucosa: adjuvant and carrier formulations for mucosal immunity

Lawson, L. B., Norton, E. B., & Clements, J. D. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.03.009 · Cited by 140 · see citing works

Antigenic Targeting of the Human Mannose Receptor Induces Tumor Immunity

He, L.-Z., Crocker, A., Lee, J., Mendoza-Ramírez, J.-L., Wang, X.-T., Vitale, L. A., O’Neill, T. J., Petromilli, C., Zhang, H., Lopez, J., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6259 · Cited by 139 · see citing works

Mannose and Mannose‐6‐Phosphate Receptor–Targeted Drug Delivery Systems and Their Application in Cancer Therapy

Vedove, E. D., Costabile, G., & Merkel, O. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701398 · Cited by 137 · see citing works

Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration

Baldridge, J. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00572-1 · Cited by 136 · see citing works

A novel bioadhesive intranasal delivery system for inactivated influenza vaccines

Singh, M., Briones, M., & O’Hagan, D. T. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00330-8 · Cited by 135 · see citing works

Pathogens target DC‐SIGN to influence their fate DC‐SIGN functions as a pathogen receptor with broad specificity

Geijtenbeek, T. B. H., & van Kooyk, Y. (2003) · Apmis · doi:10.1034/j.1600-0463.2003.11107803.x · Cited by 127 · see citing works

Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration

Porporatto, C., Bianco, I. D., & Correa, S. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0904541 · Cited by 126 · see citing works

C-type lectin Mincle is an activating receptor for pathogenic fungus

Yamasaki, S. (2009) · Medical Entomology and Zoology · Cited by 124 · see citing works

Biological activities of derivatized d-glucans: A review

Kagimura, F. Y., da Cunha, M. A. A., Barbosa, A. M., Dekker, R. F. H., & Malfatti, C. R. M. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.09.008 · Cited by 122 · see citing works

Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines

Alving, C. R., Rao, M., Steers, N. J., Matyas, G. R., & Mayorov, A. V. (2012) · Expert Review of Vaccines · doi:10.1586/erv.12.35 · Cited by 122 · see citing works

Selection of adjuvants for vaccines targeting specific pathogens

Sarkar, I., Garg, R., & den Hurk, S. V. D. L. (2019) · Expert Review of Vaccines · doi:10.1080/14760584.2019.1604231 · Cited by 122 · see citing works

Co-delivery of antigen and dual agonists by programmed mannose-targeted cationic lipid-hybrid polymersomes for enhanced vaccination

Zhu, D., Hu, C., Fan, F., Qin, Y., Huang, C., Zhang, Z., Lu, L., Wang, H., Sun, H., Leng, X., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.03.012 · Cited by 118 · see citing works

Hyaluronic Acid-Modified Cationic Lipid–PLGA Hybrid Nanoparticles as a Nanovaccine Induce Robust Humoral and Cellular Immune Responses

Liu, L., Cao, F., Liu, X., Wang, H., Zhang, C., Sun, H., Wang, C., Leng, X., Song, C. X., Kong, D., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01135 · Cited by 117 · see citing works

Novel application of trimethyl chitosan as an adjuvant in vaccine delivery

Malik, A., Gupta, M. K., Gupta, V., Gogoi, H., & Bhatnagar, R. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s165876 · Cited by 112 · see citing works

Chitosan-based mucosal adjuvants: Sunrise on the ocean

Xia, Y., Fan, Q., Hao, D., Wu, J., Ma, G., & Su, Z. G. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.07.101 · Cited by 111 · see citing works

Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination

Verheul, R. J., Slütter, B., Bal, S. M., Bouwstra, J. A., Jiskoot, W., & Hennink, W. E. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.014 · Cited by 110 · see citing works

Bilayer Properties of Lipid A from Various Gram-Negative Bacteria

Kim, S., Patel, D. S., Park, S., Slusky, J. S. G., Klauda, J. B., Widmalm, G., & Im, W. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.09.001 · Cited by 110 · see citing works

Immunocorrelates of CAF family adjuvants

Pedersen, G. K., Andersen, P. L., & Christensen, D. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.003 · Cited by 107 · see citing works

Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21

Welsby, I., Detienne, S., N’Kuli, F., Thomas, S., Wouters, S., Bechtold, V., Wit, D. D., Gineste, R., Reinheckel, T., Elouahabi, A., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00663 · Cited by 105 · see citing works

Chitosan-based delivery systems for mucosal vaccines

Jabbal‐Gill, I., Watts, P., & Smith, A. M. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.697455 · Cited by 104 · see citing works

Role of TLR1 and TLR6 in the host defense against disseminated candidiasis

Netea, M. G., van de Veerdonk, F. L., Verschueren, I., van der Meer, J. W. M., & Kullberg, B. J. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00353.x · Cited by 102 · see citing works

Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis

Fernández‐Tejada, A., Tan, D. S., & Gin, D. Y. (2016) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00242 · Cited by 102 · see citing works

Eudragit® L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery

Xu, B., Zhang, W., Chen, Y., Xu, Y., Wang, B., & Zong, L. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.02.016 · Cited by 100 · see citing works

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus

Nevagi, R. J., Khalil, Z. G., Hussein, W. M., Powell, J. L., Batzloff, M. R., Capon, R. J., Good, M. F., Skwarczyński, M., & Tóth, I. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.037 · Cited by 99 · see citing works

Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: Adjuvant- and site-dependent immunogenicity in mice

Bal, S. M., Slütter, B., Verheul, R. J., Bouwstra, J. A., & Jiskoot, W. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.10.003 · Cited by 98 · see citing works

Army Liposome Formulation (ALF) family of vaccine adjuvants

Alving, C. R., Peachman, K. K., Matyas, G. R., Rao, M., & Beck, Z. (2020) · Expert Review of Vaccines · doi:10.1080/14760584.2020.1745636 · Cited by 98 · see citing works

Adjuvants in the Driver’s Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators

Bergmann‐Leitner, E. S., & Leitner, W. W. (2014) · Vaccines · doi:10.3390/vaccines2020252 · Cited by 97 · see citing works

Chemical Modification of Chitosan for Efficient Vaccine Delivery

Xing, L., Fan, Y., Zhou, T., Gong, J., Cui, L.-H., Cho, K., Choi, Y., Jiang, H., & Cho, C. (2018) · Molecules · doi:10.3390/molecules23020229 · Cited by 94 · see citing works

Immunity by formulation design: Induction of high CD8+ T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method

Nordly, P., Rose, F., Christensen, D., Nielsen, H. M., Andersen, P. L., Agger, E. M., & Foged, C. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.021 · Cited by 93 · see citing works

Mannan Mucin-1 Peptide Immunization: Influence of Cyclophosphamide and the Route of Injection

Karanikas, V., Thynne, G., Mitchell, P., Ong, C.-S., Gunawardana, D. H., Blum, R., Pearson, J. M., Lodding, J., Pietersz, G. A., Broadbent, R., et al. (2001) · Journal of Immunotherapy · doi:10.1097/00002371-200103000-00012 · Cited by 93 · see citing works

Polymers for subunit vaccine delivery

Nevagi, R. J., Skwarczyński, M., & Tóth, I. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.03.009 · Cited by 93 · see citing works

Chitosan-based particulate systems for the delivery of mucosal vaccines against infectious diseases

Singh, B., Maharjan, S., Cho, K., Cui, L., Park, I., Choi, Y., & Cho, C. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.10.101 · Cited by 92 · see citing works

Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents

Mosaiab, T., Farr, D. C., Kiefel, M. J., & Houston, T. A. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.09.002 · Cited by 92 · see citing works

Safety, tolerability and immunogenicity of new formulations of the Plasmodium falciparum malaria peptide vaccine SPf66 combined with the immunological adjuvant QS-21

Kashala, O., Amador, R., Valero-Bernal, M. V., Moreno, A., Barbosa, A., Nickel, B., Daubenberger, C., Guzmán, F., Pluschke, G., & Patarroyo, M. E. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00115-9 · Cited by 91 · see citing works

Polyelectrolyte-Based Platforms for the Delivery of Peptides and Proteins

Zhao, L., Skwarczyński, M., & Tóth, I. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01135 · Cited by 90 · see citing works

Dissolving Microneedle Delivery of Nanoparticle-Encapsulated Antigen Elicits Efficient Cross-Priming and Th1 Immune Responses by Murine Langerhans Cells

Zaric, M., Lyubomska, O., Poux, C., Hanna, M. L., McCrudden, M., MALISSEN, B., Ingram, R. J., Power, U. F., Scott, C. J., Donnelly, R. F., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.415 · Cited by 87 · see citing works

Non-invasive mucosal vaccine delivery: advantages, challenges and the future

Skwarczyński, M., & Tóth, I. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1731468 · Cited by 87 · see citing works

Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid a (MPL) adjuvant against toxoplasma chronic infection in mice

Golkar, M., Shokrgozar, M.-A., Rafati, S., Musset, K., Assmar, M., Sadaie, R., Cesbron-Delauw, M.-F., & Mercier, C. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.02.057 · Cited by 86 · see citing works

Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory

Wang, C., Liu, P., Zhuang, Y., Li, P., Jiang, B.-L., Pan, H., Liu, L., Cai, L., & Ma, Y. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.07.081 · Cited by 85 · see citing works

Intranasal Delivery of Nanoparticle-Based Vaccines

Marasini, N., Skwarczyński, M., & Tóth, I. (2017) · Therapeutic Delivery · doi:10.4155/tde-2016-0068 · Cited by 82 · see citing works

MPL nano-liposomal vaccine containing P5 HER2/neu-derived peptide pulsed PADRE as an effective vaccine in a mice TUBO model of breast cancer

Zamani, P., Navashenaq, J. G., Nikpoor, A. R., Hatamipour, M., Oskuee, R. K., Badiee, A., & Jaafari, M. R. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.019 · Cited by 82 · see citing works

A comparative study of cationic liposome and niosome-based adjuvant systems for protein subunit vaccines: characterisation, environmental scanning electron microscopy and immunisation studies in mice

Vangala, A., Kirby, D. J., Rosenkrands, I., Agger, E. M., Andersen, P. L., & Perrie, Y. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.6.0009 · Cited by 81 · see citing works

Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls

Vendelė, I., Willment, J. A., Silva, L. M., Palma, A. S., Chai, W., Liu, Y., Feizi, T., Spyrou, M., Stappers, M. H. T., Brown, G. D., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1007927 · Cited by 80 · see citing works

Immune effects of β-glucan are determined by combined effects on Dectin-1, TLR2, 4 and 5

Kanjan, P., Sahasrabudhe, N. M., de Haan, B. J., & de Vos, P. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.07.061 · Cited by 79 · see citing works

Potential of glucans as vaccine adjuvants: A review of the α-glucans case

Moreno-Mendieta, S. A., Guillén, D., Hernández‐Pando, R., Sánchez, S., & Rodrı́guez-Sanoja, R. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.02.030 · Cited by 77 · see citing works

Triggering Intracellular Receptors for Vaccine Adjuvantation

Gutjahr, A., Tiraby, G., Pérouzel, É., Verrier, B., & Paul, S. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.07.001 · Cited by 73 · see citing works

Plasmid DNA vaccines: where are we now?

Ghaffarifar, F. (2018) · Drugs of today · doi:10.1358/dot.2018.54.5.2807864 · Cited by 73 · see citing works

Immunogenicity and Protective Capacity of a Virosomal Respiratory Syncytial Virus Vaccine Adjuvanted with Monophosphoryl Lipid A in Mice

Kamphuis, T., Meijerhof, T., Stegmann, T., Lederhofer, J., Wilschut, J., & de Haan, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036812 · Cited by 72 · see citing works

MPLA incorporation into DC-targeting glycoliposomes favours anti-tumour T cell responses

Boks, M. A., Ambrosini, M., Bruijns, S. C. M., Kalay, H., van Bloois, L., Storm, G., García-Vallejo, J. J., & van Kooyk, Y. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.033 · Cited by 69 · see citing works

Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor

Xue, M., Hu, S. X., Lü, Y., Zhang, Y., Jiang, X., An, S., Guo, Y., Zhou, X., Hou, H., & Jiang, C. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.08.056 · Cited by 68 · see citing works

Polymer nanoparticles for cross-presentation of exogenous antigens and enhanced cytotoxic T-lymphocyte immune response

Lim, Y. T., Song, C., & Noh, Y. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s110796 · Cited by 67 · see citing works

Are chitosan natural polymers suitable as adjuvant/delivery system for anti-tuberculosis vaccines?

Khademi, F., Taheri, R. A., Avarvand, A. Y., Vaez, H., Momtazi‐Borojeni, A. A., & Soleimanpour, S. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.05.035 · Cited by 67 · see citing works

P5 HER2/neu-derived peptide conjugated to liposomes containing MPL adjuvant as an effective prophylactic vaccine formulation for breast cancer

Shariat, S., Badiee, A., Jalali, S. A., Mansourian, M., Yazdani, M., Mortazavi, S. A., & Jaafari, M. R. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.09.016 · Cited by 66 · see citing works

Induction of dendritic cell maturation by β-glucan isolated from Sparassis crispa

Kim, H. S., Kim, J. Y., Ryu, H. S., Park, H.-G., Kim, Y. O., Kang, J. S., Kim, H. M., Hong, J. T., Kim, Y., & Han, S. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.07.012 · Cited by 65 · see citing works

The adjuvant effect of a non‐toxic mutant of heat‐labile enterotoxin of Escherichia coli for the induction of measles virus‐specific CTL responses after intranasal co‐immunization with a synthetic peptide

Partidos, C. D., Pizza, M., Rappuoli, R., & Steward, M. W. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-790.x · Cited by 63 · see citing works

Structure–function relationship of the saponins from the roots of Platycodon grandiflorum for hemolytic and adjuvant activity

Sun, H., Chen, L., Wang, J., Wang, K., & Zhou, J. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.08.018 · Cited by 62 · see citing works

Biopolymer‐based Carriers for DNA Vaccine Design

Franck, C. O., Fanslau, L., Bistrović, A., Tyagi, P., & Fruk, L. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202010282 · Cited by 62 · see citing works

Development of a self-assembling protein nanoparticle vaccine targeting Plasmodium falciparum Circumsporozoite Protein delivered in three Army Liposome Formulation adjuvants

Seth, L., Ferlez, K. M. B., Kaba, S. A., Musser, D. M., Emadi, S., Matyas, G. R., Beck, Z., Alving, C. R., Burkhard, P., & Lanar, D. E. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.02.040 · Cited by 61 · see citing works

Enhanced gene delivery efficiency of cationic liposomes coated with PEGylated hyaluronic acid for anti P-glycoprotein siRNA: A potential candidate for overcoming multi-drug resistance

Ran, R., Liu, Y., Gao, H., Kuang, Q., Zhang, Q., Tang, J., Huang, K. J., Chen, X., Zhang, Z., & He, Q. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.11.012 · Cited by 60 · see citing works

Pollinex®Quattro: a novel and well–tolerated, ultra short–course allergy vaccine

Patel, P. M., & Salapatek, A. M. (2006) · Expert Review of Vaccines · doi:10.1586/14760584.5.5.617 · Cited by 60 · see citing works

Double Adjuvanting Strategy for Peptide-Based Vaccines: Trimethyl Chitosan Nanoparticles for Lipopeptide Delivery

Marasini, N., Giddam, A. K., Khalil, Z. G., Hussein, W. M., Capon, R. J., Batzloff, M. R., Good, M. F., Tóth, I., & Skwarczyński, M. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0291 · Cited by 59 · see citing works

The safety and tolerability of an HIV-1 DNA prime–protein boost vaccine (DP6-001) in healthy adult volunteers

Kennedy, J. S., Co, M. D. T., Green, S., Longtine, K. J., Longtine, J., O'Neill, M. A., Adams, J. P., Rothman, A. L., Yu, Q., Johnson-Leva, R., et al. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.05.090 · Cited by 58 · see citing works

A Synthetic MUC1 Anticancer Vaccine Containing Mannose Ligands for Targeting Macrophages and Dendritic Cells

Glaffig, M., Stergiou, N., Hartmann, S., Schmitt, E., & Kunz, H. (2017) · ChemMedChem · doi:10.1002/cmdc.201700646 · Cited by 58 · see citing works

Biodegradable polymers for modern vaccine development

Bose, R. J., Kim, M., Chang, J. H., Paulmurugan, R., Moon, J. J., Koh, W., Lee, S.-H., & Park, H. (2019) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2019.04.044 · Cited by 58 · see citing works

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu, R., Ghica, M. V., Dinu‐Pîrvu, C., Anuța, V., Lupuliasa, D., & Popa, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145016 · Cited by 57 · see citing works

Nasal vaccination with r4M2e.HSP70c antigen encapsulated into N-trimethyl chitosan (TMC) nanoparticulate systems: Preparation and immunogenicity in a mouse model

Dabaghian, M., Latifi, A. M., Tebianian, M., Najminejad, H., & Ebrahimi, S. M. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.02.072 · Cited by 56 · see citing works

Zymosan enhances the mucosal adjuvant activity of poly(I:C) in a nasal influenza vaccine

Ainai, A., Ichinohe, T., Tamura, S., Kurata, T., Sata, T., Tashiro, M., & Hasegawa, H. (2010) · Journal of Medical Virology · doi:10.1002/jmv.21694 · Cited by 55 · see citing works

Incorporation of the TLR4 Agonist Monophosphoryl Lipid A Into the Bilayer of DDA/TDB Liposomes: Physico-Chemical Characterization and Induction of CD8+ T-Cell Responses In Vivo

Nordly, P., Agger, E. M., Andersen, P. L., Nielsen, H. M., & Foged, C. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0301-9 · Cited by 55 · see citing works

Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine

Patil, H. P., Murugappan, S., ter Veer, W., Meijerhof, T., de Haan, A., Frijlink, H. W., Wilschut, J., Hinrichs, W. L. J., & Huckriede, A. L. W. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.013 · Cited by 55 · see citing works

Adjuvant synergy: The effects of nasal coadministration of adjuvants

Moschos, S. A., Bramwell, V., Somavarapu, S., & Alpar, H. O. (2004) · Immunology and Cell Biology · doi:10.1111/j.0818-9641.2004.01280.x · Cited by 55 · see citing works

Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands

Braganza, C. D., Teunissen, T., Timmer, M. S. M., & Stocker, B. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01940 · Cited by 54 · see citing works

Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci

Krug, L. M., Ragupathi, G., Hood, C., George, C. M., Hong, F., Shen, R., Abrey, L. E., Jennings, H. J., Kris, M. G., & Livingston, P. O. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1083-6 · Cited by 53 · see citing works

Role of sugars in surface microbe–host interactions and immune reaction modulation

Lloyd, D. H., Viac, J., Werling, D., Rème, C. A., & Gatto, H. (2007) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2007.00594.x · Cited by 53 · see citing works

On the Composition of Zymosan

Carlo, F. J. D., & Fiore, J. V. (1958) · Science · doi:10.1126/science.127.3301.756.b · Cited by 53 · see citing works

4th Meeting on novel adjuvants currently in/close to human clinical testing

Pink, J. R., & Kiény, M.-P. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.021 · Cited by 51 · see citing works

Modern lipid‐, carbohydrate‐, and peptide‐based delivery systems for peptide, vaccine, and gene products

Simerská, P., Moyle, P. M., & Tóth, I. (2009) · Medicinal Research Reviews · doi:10.1002/med.20191 · Cited by 50 · see citing works

Preparation and characterisation of quillaja saponin with less heterogeneity than Quil-A

Kamstrup, S., Martin, R. S., Doberti, A., Grande, H. J., & Dalsgaard, K. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00560-5 · Cited by 47 · see citing works

Lipids as Activators of Innate Immunity in Peptide Vaccine Delivery

Bartlett, S., Skwarczyński, M., & Tóth, I. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666181026100849 · Cited by 47 · see citing works

Chimeric Hemagglutinin-Based Influenza Virus Vaccines Induce Protective Stalk-Specific Humoral Immunity and Cellular Responses in Mice

Choi, A., Bouzya, B., Franco, K.-D. C., Stadlbauer, D., Rajabhathor, A., Rouxel, R. N., Mainil, R., der Wielen, M. V., Palese, P., García‐Sastre, A., et al. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1900022 · Cited by 47 · see citing works

Lipopeptide-Based Oral Vaccine Against Hookworm Infection

Bartlett, S., Eichenberger, R. M., Nevagi, R. J., Ghaffar, K. A., Marasini, N., Dai, Y., Loukas, A. C., Tóth, I., & Skwarczyński, M. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz528 · Cited by 47 · see citing works

Evaluation of an Intranasal Virosomal Vaccine against Respiratory Syncytial Virus in Mice: Effect of TLR2 and NOD2 Ligands on Induction of Systemic and Mucosal Immune Responses

Shafique, M. W., Meijerhof, T., Wilschut, J., & de Haan, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061287 · Cited by 46 · see citing works

A Novel Liposome-Based Adjuvant CAF01 for Induction of CD8+ Cytotoxic T-Lymphocytes (CTL) to HIV-1 Minimal CTL Peptides in HLA-A*0201 Transgenic Mice

Gram, G. J., Karlsson, I., Agger, E. M., Andersen, P. L., & Fomsgaard, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006950 · Cited by 45 · see citing works

Synthesis of High‐Mannose Oligosaccharide Analogues through Click Chemistry: True Functional Mimics of Their Natural Counterparts Against Lectins?

François‐Heude, M., Méndez‐Ardoy, A., Cendret, V., Lafite, P., Daniellou, R., Mellet, C. O., Fernández, J. M. G., Moreau, V., & Djedaïni‐Pilard, F. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201405481 · Cited by 43 · see citing works

Simultaneous Subcutaneous and Intranasal Administration of a CAF01-Adjuvanted Chlamydia Vaccine Elicits Elevated IgA and Protective Th1/Th17 Responses in the Genital Tract

Wern, J. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00569 · Cited by 43 · see citing works

Activated iNKT Cells Promote Memory CD8+ T Cell Differentiation during Viral Infection

Reilly, E. C., Thompson, E. A., Aspeslagh, S., Wands, J. R., Elewaut, D. S., & Brossay, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037991 · Cited by 42 · see citing works

Enhancement of humoral and cellular immune responses by monophosphoryl lipid A (MPLA) as an adjuvant to the rabies vaccine in BALB/c mice

Hu, X., Liu, R., & Zhu, N. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.05.006 · Cited by 42 · see citing works

Superparamagnetic Iron Oxide Nanoparticles Coated with Mannan for Macrophage Targeting

Yoo, M. K., Park, I. Y., Kim, I. Y., Park, I., Kwon, J., Jeong, H., Jeong, Y. Y., & Cho, C. S. (2008) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2008.1118 · Cited by 40 · see citing works

Protective Effect of Vaccine Promoted Neutralizing Antibodies against the Intracellular Pathogen Chlamydia trachomatis

Olsen, A. W., Lorenzen, E., Rosenkrands, I., Follmann, F., & Andersen, P. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01652 · Cited by 40 · see citing works

Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant

Torres, O. B., Matyas, G. R., Rao, M., Peachman, K. K., Jalah, R., Beck, Z., Michael, N. L., Rice, K. C., Jacobson, A. E., & Alving, C. R. (2017) · npj Vaccines · doi:10.1038/s41541-017-0013-9 · Cited by 38 · see citing works

α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

Sainz, V., Moura, L. I. F., Peres, C., Matos, A. I., Viana, A. S., Wagner, A. M., Ramirez, J. E. V., Barata, T. S., Gaspar, M. M., Brocchini, S., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.06.029 · Cited by 37 · see citing works

Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research

Mata, E., Salvador, A., Igartúa, M., Hernández, R. M., & Pedraz, J. L. (2013) · BioMed Research International · doi:10.1155/2013/282913 · Cited by 36 · see citing works

Chitosan/calcium phosphates nanosheet as a vaccine carrier for effective cross-presentation of exogenous antigens

Pei, M., Liang, J., Zhang, C., Wang, X., Zhang, C., Ma, G., & Sun, H. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115172 · Cited by 35 · see citing works

Oxidised mannan as a novel adjuvant inducing mucosal IgA production

Stambas, J., Pietersz, G. A., McKenzie, I. F. C., & Cheers, C. (2002) · Vaccine · doi:10.1016/s0264-410x(01)00456-x · Cited by 34 · see citing works

Novel Adjuvant Strategies for Experimental Malaria and AIDS Vaccines

Alving, C. R., Detrick, B., Richards, R. L., Lewis, M. G., Avigdor Shafferman, C., & Eddy, G. A. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb44015.x · Cited by 34 · see citing works

Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells

Zom, G. G., Willems, M. M. J. H. P., Meeuwenoord, N. J., Reintjens, N. R. M., Tondini, E., Khan, S., Overkleeft, H. S., van der Marel, G. A., Codée, J. D. C., OSSENDORP, F. A., et al. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00087 · Cited by 34 · see citing works

Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system

Nevagi, R. J., Dai, W., Khalil, Z. G., Hussein, W. M., Capon, R. J., Skwarczyński, M., & Tóth, I. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.05.033 · Cited by 34 · see citing works

Glycans as Vaccine Antigens and Adjuvants: Immunological Considerations

Zimmermann, S., & Lepenies, B. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2874-3_2 · Cited by 33 · see citing works

Recent Advances in Vaccine Delivery

Cordeiro, A. S., & Alonso, M. J. (2015) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.15.38 · Cited by 32 · see citing works

Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN

Gao, H., Gonçalves, C., Gallego, T., François‐Heude, M., Malard, V., Mateo, V., Lemoine, F. M., Cendret, V., Djedaïni‐Pilard, F., Moreau, V., et al. (2019) · Carbohydrate Research · doi:10.1016/j.carres.2019.107877 · Cited by 32 · see citing works

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Giddam, A. K., Reiman, J. M., Zaman, M., Skwarczyński, M., Tóth, I., & Good, M. F. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.08.020 · Cited by 31 · see citing works

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Lehner, T., & Anton, P. A. (2002) · AIDS · doi:10.1097/00002030-200216004-00017 · Cited by 30 · see citing works

Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system

Nevagi, R. J., Dai, W., Khalil, Z. G., Hussein, W. M., Capon, R. J., Skwarczyński, M., & Tóth, I. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.047 · Cited by 30 · see citing works

Regulation of antigen transport into the cytosol for cross-presentation by ubiquitination of the mannose receptor

Zehner, M., & Burgdorf, S. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.10.010 · Cited by 29 · see citing works

Phase I study of a Neisseria meningitidis liposomal vaccine containing purified outer membrane proteins and detoxified lipooligosaccharide

Zollinger, W. D., Babcock, J., Moran, E. E., Brandt, B. L., Matyas, G. R., Wassef, N. M., & Alving, C. R. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.11.084 · Cited by 29 · see citing works

Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists

Smith, A. J., Miller, S. M., Buhl, C., Child, R., Whitacre, M., Schoener, R., Ettenger, G., Burkhart, D. J., Ryter, K. T., & Evans, J. T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00338 · Cited by 29 · see citing works

Is fucose the answer to the immunomodulatory paradox of Quillaja saponins?

Marciani, D. J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.10.028 · Cited by 28 · see citing works

Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease

Dedloff, M. R., Effler, C. S., Holban, A. M., & Gestal, M. C. (2019) · Materials · doi:10.3390/ma12152445 · Cited by 28 · see citing works

Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory

Wang, C., Liu, P., Zhuang, Y., Li, P., Jiang, B.-L., Pan, H., Liu, L., Cai, L., & Ma, Y. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.05.022 · Cited by 27 · see citing works

Monophosphoryl Lipid A‐Adjuvanted Virosomes with Ni‐Chelating Lipids for Attachment of Conserved Viral Proteins as Cross‐Protective Influenza Vaccine

Dong, W., Bhide, Y. C., Marsman, S., Holtrop, M. E., Meijerhof, T., de Vries-Idema, J. J., de Haan, A., & Huckriede, A. L. W. (2017) · Biotechnology Journal · doi:10.1002/biot.201700645 · Cited by 27 · see citing works

Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

Thakur, A., Rodríguez‐Rodríguez, C., Saatchi, K., Rose, F., Esposito, T., Nosrati, Z., Andersen, P. L., Christensen, D., Häfeli, U. O., & Foged, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02825 · Cited by 27 · see citing works

A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 ResponsesIn Vitro

Schülke, S., Vogel, L., Junker, A., Hanschmann, K.-M. O., Flaczyk, A., Vieths, S., & Scheurer, S. (2016) · Journal of Immunology Research · doi:10.1155/2016/4156456 · Cited by 26 · see citing works

Astragalus Saponins and Liposome Constitute an Efficacious Adjuvant Formulation for Cancer Vaccines

Zhang, X., Li, Y., Luo, L., Liu, Y., Yang, L., Guo, C., Li, Z.-D., Xie, X., Song, H., Yang, L., et al. (2018) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2017.2369 · Cited by 26 · see citing works

N-Oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing: Synthesis of lipids, characterisation of mannan-coated nanoliposomes and in vitro stimulation of dendritic cells

Bartheldyová, E., Knötigová, P. T., Zachová, K., Mašek, J., Kulich, P., Effenberg, R., Zýka, D., Hubatka, F., Kotouček, J., Čelechovská, H., et al. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.10.121 · Cited by 26 · see citing works

Hyaluronic Acid Nanocapsules as a Platform for Needle-Free Vaccination

Bussio, J. I., Molina-Perea, C., & González-Aramúndiz, J. V. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11050246 · Cited by 26 · see citing works

Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Ghirardello, M., Ruiz‐de‐Angulo, A., Sacristán, N., Barriales, D., Jiménez‐Barbero, J., Poveda, A. M., Corzana, F., Anguíta, J., & Fernández‐Tejada, A. (2019) · Chemical Communications · doi:10.1039/c9cc07781b · Cited by 26 · see citing works

Lipo-Peptides/Saccharides for Peptide Vaccine Delivery

Skwarczyński, M., Zaman, M., & Tóth, I. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385095-9.00078-6 · Cited by 24 · see citing works

Combining Monophosphoryl Lipid A (MPL), CpG Oligodeoxynucleotide (ODN), and QS-21 Adjuvants Induces Strong and Persistent Functional Antibodies and T Cell Responses against Cell-Traversal Protein for Ookinetes and Sporozoites (CelTOS) of Plasmodium falciparum in BALB/c Mice

Pirahmadi, S., Zakeri, S., Mehrizi, A. A., Djadid, N. D., Raz, A., & Sani, J. J. (2019) · Infection and Immunity · doi:10.1128/iai.00911-18 · Cited by 24 · see citing works

Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant

Christensen, D., Christensen, J. P., Korsholm, K. S., Isling, L. K., Erneholm, K., Thomsen, A. R., & Andersen, P. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01928 · Cited by 23 · see citing works

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Sedaghat, B., Stephenson, R. J., & Tóth, I. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140826115552 · Cited by 21 · see citing works

Enhanced Immunogenicity and Protective Efficacy of a Campylobacter jejuni Conjugate Vaccine Coadministered with Liposomes Containing Monophosphoryl Lipid A and QS-21

Ramakrishnan, A., Schumack, N. M., Gariepy, C. L., Eggleston, H., Núñez, G., Espinoza, N., Nieto, M., Castillo, R., Rojas, J. D., McCoy, A. J., et al. (2019) · mSphere · doi:10.1128/msphere.00101-19 · Cited by 21 · see citing works

Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold

Bojarska, J., Mieczkowski, A., Ziora, Z. M., Skwarczyński, M., Tóth, I., Shalash, A. O., Parang, K., El-Mowafi, S. A., Mohammed, E. H. M., Elnagdy, S. M., et al. (2021) · Biomolecules · doi:10.3390/biom11101515 · Cited by 128 · see citing works

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Lu, L., Duong, V. T., Shalash, A. O., Skwarczyński, M., & Tóth, I. (2021) · Vaccines · doi:10.3390/vaccines9060563 · Cited by 105 · see citing works

Bioactive Lipids and Their Derivatives in Biomedical Applications

Park, J.-W., Choi, J., Kim, D., Lee, S., Lee, B., Lee, Y., Kim, S., Kwon, S., Noh, M., Lee, M., et al. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.107 · Cited by 79 · see citing works

Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review

Mallakpour, S. E., Azadi, E., & Hussain, C. M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.05.155 · Cited by 78 · see citing works

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Edo, G. I., Yousif, E. A., & Al-Mashhadani, M. H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133526 · Cited by 69 · see citing works

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Nahar, U. J., Tóth, I., & Skwarczyński, M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.038 · Cited by 64 · see citing works

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Chand, U., Priyambada, P., & Kushawaha, P. K. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127362 · Cited by 56 · see citing works

Cell-Penetrating Peptides-Based Liposomal Delivery System Enhanced Immunogenicity of Peptide-Based Vaccine against Group A Streptococcus

Yang, J., Firdaus, F. Z., Azuar, A., Khalil, Z. G., Marasini, N., Capon, R. J., Hussein, W. M., Tóth, I., & Skwarczyński, M. (2021) · Vaccines · doi:10.3390/vaccines9050499 · Cited by 35 · see citing works

Spatial, Temporal, and Demographic Patterns in the Prevalence of Hemorrhagic Septicemia in 41 Countries in 2005–2019: A Systematic Analysis with Special Focus on the Potential Development of a New-Generation Vaccine

Almoheer, R., Wahid, M. E. A., Zakaria, H. A., Jonet, M. A., Al-shaibani, M. M., Al-Gheethi, A. A. S., & Addis, S. (2022) · Vaccines · doi:10.3390/vaccines10020315 · Cited by 35 · see citing works

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Kalita, P., & Tripathi, T. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.03.004 · Cited by 36 · see citing works

Novel Vaccine Adjuvants as Key Tools for Improving Pandemic Preparedness

Pogostin, B. H., & McHugh, K. J. (2021) · Bioengineering · doi:10.3390/bioengineering8110155 · Cited by 28 · see citing works

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Fan, J., Tóth, I., & Stephenson, R. J. (2024) · Vaccines · doi:10.3390/vaccines12030272 · Cited by 29 · see citing works

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He, Z., Li, F., Liu, M., Liao, J., & Guo, C. (2025) · Vaccines · doi:10.3390/vaccines13030260 · Cited by 29 · see citing works

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Vassilakopoulou, V., Karachaliou, C., Evangelou, A., Zikos, C. C., & Livaniou, E. (2021) · Vaccines · doi:10.3390/vaccines9111278 · Cited by 26 · see citing works

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Zhang, X., Zhang, Z., Xia, N., & Zhao, Q. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1939688 · Cited by 20 · see citing works

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De Masi, R., & Orlando, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137373 · Cited by 20 · see citing works

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Pogostin, B. H., Saenz, G., Cole, C. C., Euliano, E. M., Hartgerink, J. D., & McHugh, K. J. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.2c00461 · Cited by 18 · see citing works

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Hulbert, S. W., Desai, P., Jewett, M. C., DeLisa, M. P., & Williams, A. J. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108234 · Cited by 17 · see citing works

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Mu, R., Dong, L., & Wang, C. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.08.006 · Cited by 16 · see citing works

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Orosco, F. L., & Espiritu, L. (2024) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2024v16i1.49563 · Cited by 15 · see citing works

Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements

Aroffu, M., Manca, M. L., Pedraz, J. L., & Manconi, M. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2288856 · Cited by 14 · see citing works

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Adegbite, A., & McCarthy, P. C. (2021) · Vaccines · doi:10.3390/vaccines9091021 · Cited by 13 · see citing works

Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors

Colaço, M., Cruz, M. T., de Almeida, L. P., & Borges, O. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16101308 · Cited by 12 · see citing works

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Spacova, I., Patusco, R., Lebeer, S., & Jensen, M. G. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.01.001 · Cited by 12 · see citing works

Staphylococcus aureus derived hyaluronic acid and bacillus Calmette-Guérin purified proteins as immune enhancers to rabies vaccine and related immuno-histopathological alterations

Shebl, R. I., Amer, M. E., Abu-Amara, T. M. M., Matar, E. R., Ahmed, H. F., Gomah, T. A., EI-Moselhy, L. E., Abu‐Elghait, M., & Mohamed, A. F. (2021) · Clinical and Experimental Vaccine Research · doi:10.7774/cevr.2021.10.3.229 · Cited by 12 · see citing works

Hookworm infection: Toward development of safe and effective peptide vaccines

Shalash, A. O., Hussein, W. M., Skwarczyński, M., & Tóth, I. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.013 · Cited by 13 · see citing works

Limitations and potential strategies of immune checkpoint blockade in age-related neurodegenerative disorders

Lasheen, N. N., Allam, S., Elgarawany, A., Aswa, D. W., Mansour, R., & Farouk, Z. E. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-024-00933-4 · Cited by 11 · see citing works

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Makavana, A., & Dudhat, K. R. (2025) · Journal of Nanoparticle Research · doi:10.1007/s11051-025-06336-9 · Cited by 9 · see citing works

The Development of Surface-Modified Liposomes as an Intranasal Delivery System for Group A Streptococcus Vaccines

Yang, J., Boer, J. C., Khongkow, M., Phunpee, S., Khalil, Z. G., Bashiri, S., Deceneux, C., Goodchild, G., Hussein, W. M., Capon, R. J., et al. (2023) · Vaccines · doi:10.3390/vaccines11020305 · Cited by 9 · see citing works

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de Moura, I. A., Silva, A. J. D., de Macêdo, L. S., de Melo, K. M. T. B., Leal, L. R. S., Espinoza, B. C. F., Invenção, M. D. C. V., de Pinho, S. S., & de Freitas, A. C. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17050640 · Cited by 8 · see citing works

Self-assembled monovalent lipidated mannose ligand as a standalone nanoadjuvant

Nahar, U. J., Wang, J., Shalash, A. O., Lu, L., Islam, M. T., Alharbi, N., Koirala, P., Khalil, Z. G., Capon, R. J., Hussein, W. M., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.06.027 · Cited by 6 · see citing works

Bioconjugated materials in the development of subunit vaccines

Fan, J., Tóth, I., & Stephenson, R. J. (2023) · Comprehensive analytical chemistry · doi:10.1016/bs.coac.2023.02.005 · Cited by 5 · see citing works

Immune cell receptor-specific nanoparticles as a potent adjuvant for nasal split influenza vaccine delivery

Li, X., Xiu, X., Su, R., Ma, S., Li, Z., Zhang, L., Wang, Z., Zhu, Y., & Ma, F. (2023) · Nanotechnology · doi:10.1088/1361-6528/ad1644 · Cited by 4 · see citing works

N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2

Weiss, C. M., Liu, H., Ball, E. E., Hoover, A. R., Wong, T. S., Wong, C. F., Lam, S. S. K., Hode, T., Keel, M. K., Levenson, R. M., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289139 · Cited by 3 · see citing works

A narrative review of strategies to improve childhood vaccination coverage in Low- and Middle-Income Countries

Otaigbe, I. I. (2023) · Babcock University Medical Journal · doi:10.38029/babcockuniv.med.j..v6i2.323 · Cited by 3 · see citing works

Recent Advancement in Self Emulsifing Drug Delivery System

Bist, V. L., & Faruk, A. (2023) · Journal for Research in Applied Sciences and Biotechnology · doi:10.55544/jrasb.2.2.14 · Cited by 3 · see citing works

Strategic development of a self-adjuvanting SARS-CoV-2 RBD vaccine: From adjuvant screening to enhanced immunogenicity with a modified TLR7 agonist

Meng, X., Xu, Y. C., Yang, J., Meng, S., Ding, N., Sun, T., & Zong, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111909 · Cited by 2 · see citing works

VETERINARY VACCINES: WHERE ARE THEY NOW?

(2022) · International Journal of Veterinary Science · doi:10.47278/book.ahp/2022.53

Mannans: Obtaining from the cell walls of Saccharomyces cerevisiae yeast and assessing their adjuvant properties in a subunit vaccine model

Esina, T. I., Volosnikova, E. A., Щербаков, Д. Н., Волкова, Н. В., Zaykovskaya, A. V., Шимина, Г. Г., & Даниленко, Е. Д. (2024) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2024-9.4.24

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Velázquez-Dodge, B. I., & Salinas-Marín, R. (2025) · Revista Digital Universitaria · doi:10.22201/ceide.16076079e.2025.26.2.6

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Barrera-Rosales, A., Mata‐Espinosa, D., Villegas-Ruiz, V., Silva‐Miranda, M., Zenteno, E., Sánchez, S., Hernández‐Pando, R., Rodrı́guez-Sanoja, R., & Moreno-Mendieta, S. A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0327718

Glycosylated Carbonated Apatite Particles for Macrophage‐Targeted Delivery of CpG Oligodeoxynucleotides From Streptococcus thermophilus Enhance Immune Activation

Chowdhury, M. R., Goto, M., Islam, A., & Shimosato, T. (2026) · Animal Science Journal · doi:10.1111/asj.70209

Carbohydrate polymer-based nanoplatforms for cancer theragnostic: advancements in drug delivery, immunotherapy, and precision oncology

Kadam, Y., Desai, S. A., Parkhe, V., & Patel, V. P. (2026) · Biomaterials and Living Medicine for Pharmaceutics · doi:10.1016/j.bioliv.2026.100008

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Afkhamian, A., Natanzi, A. S., Jafaridarabjerdi, M., Aghaei, S., Haghjou, A., Shafiei, M., Bashkandi, A. H., Shahraki, S., Reiter, R. J., Kashani, H. H., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03067-9

Study Progress on Pseudomonas plecoglossicida—Virulence Factors, Prevention and Control Methods, and Interaction with Host

Chen, L., Wang, J., Ma, X., Yanling, Y., 林位琅, Qian, H., & Zhuang, Z. (2026) · Toxins · doi:10.3390/toxins18110463

Carbohydrates as putative pattern recognition receptor agonists in vaccine development

Mu, R., Dong, L., & Wang, C. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.08.006 · Cited by 16 · see citing works

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García-Vello, P., Speciale, I., Chiodo, F., Molinaro, A., & Castro, C. D. (2020) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2020.09.005 · Cited by 34 · see citing works

Glycans as Vaccine Antigens and Adjuvants: Immunological Considerations

Zimmermann, S., & Lepenies, B. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2874-3_2 · Cited by 33 · see citing works

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Stefanetti, G., Borriello, F., Richichi, B., Zanoni, I., & Lay, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.808005 · Cited by 43 · see citing works

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