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Cited by 25Bone Tissue Engineering MaterialsTissue Engineering and Regenerative MedicineWound Healing and Treatments

Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration

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Oh, Nuri, Hwang, Juyoung, Kang, Moon Sung, Yoo, Chung-Yul, Kwak, Minseok, Han, Dong-Wook·2025·Biomaterials Research
DOI 10.34133/bmr.0183PMC PMC11994882
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Abstract

Over the past decade, substantial focus has been placed on polydeoxyribonucleotide (PDRN) due to its promising pharmacological properties, making it a valuable candidate for tissue engineering applications. Accordingly, this paper aims to review and summarize the latest experimental research on PDRN in the context of tissue engineering and regeneration. The unique biochemical mechanisms of PDRN to promote cellular behavior and regeneration are summarized. We categorize commonly utilized PDRN-based tissue engineering fields as neuromuscular tissues, diabetic wound or skin, and bone regeneration. At the same time, we explore scaffold strategies for integrating PDRN into bioceramics, polymers, and cell/tissue-derived materials, along with its combination with photo/electromodulation techniques. Furthermore, we discuss potential opportunities and challenges in translating PDRN-based approaches into clinical practice. We expect future interdisciplinary research and clinical trials to evaluate the long-term efficacy and safety of PDRN while emphasizing standardization and quality control to ensure its consistency and effectiveness in regenerative applications.

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Cited by

Sorted by citations

Authors
Oh, N., Hwang, J., Kang, M. S., Yoo, C.-Y., Kwak, M., & Han, D.-W.
Affiliations
  • Korea Advanced Institute of Science and Technology (KR)
  • Ajou University (KR)
  • Pusan National University (KR)
  • Pukyong National University (KR)
Corresponding author
  • Kwak, Minseok
  • Han, Dong-Wook
ORCID
Venue
Biomaterials Research
Publisher
American Association for the Advancement of Science (AAAS)
Published
2025-01
Volume
29
Pages
0183-0183
ISSN
  • 1226-4601 (ISSN-L)
  • 2055-7124
DOI
10.34133/bmr.0183
PMC
PMC11994882
OpenAlex
W4409076323
Cited by
25
References
6
Citations by year
2026: 16 · 2025: 9
FWCI
2.01
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Biomaterials Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea (RS-2024-00406152, RS-2023-00281553)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
polydeoxyribonucleotide, tissue engineering, tissue regeneration, diabetic wound healing, skin regeneration, bone regeneration, bioceramics, polymers, photomodulation, electromodulation, clinical translation, quality control

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