The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Alcohol Use Disorder and Depressive Disorders
Open accessAbstract
Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance. The aim of this review is to characterize the prevalence, course, and treatment of co-occurring AUD and depressive disorders. Studies have indicated that the co-occurrence of AUD and depressive disorders is associated with greater severity and worse prognosis for both disorders. Both pharmacologic and behavioral treatments have demonstrated efficacy for this population. However, treatment response is somewhat modest, particularly for drinking outcomes, highlighting the importance of further research on the etiology and treatment of co-occurring AUD and depressive disorders. Key future directions include studies to understand the heterogeneity of both AUD and depressive disorders, research on novel treatment approaches to enhance outcomes, and better understanding of sex and gender differences.
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“Similarly, abstinence from or a reduction in SUD behaviors often accompanies similar reductions in mood, anxiety and other comorbid symptoms (241, 242).”
From The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines (2023) · cites this paper as [242]
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Cites
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“Several potential developmental pathways have been proposed to explain the high rate of co-occurring AUD and depressive disorders, including: (1) depressive disorders increase risk for AUD, (2) AUD increases risk for depressive disorders, and (3) both conditions share pathophysiology or have common risk factors.”
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Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
Remes, O., Mendes, J. F., & Templeton, P. (2021) · Brain Sciences · doi:10.3390/brainsci11121633 · Cited by 482
Charles, N. E., Strong, S. J., Burns, L. C., Bullerjahn, M. R., & Serafine, K. M. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113706 · Cited by 459
Dobrowolski, P., Prejbisz, A., Kuryłowicz, A., Baska, A., Burchardt, P., Chlebus, K., Dzida, G. J., Jankowski, P., Jaroszewicz, J., Jaworski, P., et al. (2022) · Archives of Medical Science · doi:10.5114/aoms/152921 · Cited by 236
“It is also recommended to administer depression and anxiety screening to patients who confirm using alcohol [16].”
BackgroundPuddephatt, J., Irizar, P., Jones, A., Gage, S. H., & Goodwin, L. (2021) · Addiction · doi:10.1111/add.15735 · Cited by 229
Tsermpini, E. E., Ilješ, A. P., & Dolžan, V. (2022) · Antioxidants · doi:10.3390/antiox11071374 · Cited by 212
Metadata
- Authors
- McHugh, R.
- Affiliations
- Harvard University (US)
- Corresponding author
- McHugh, RK
- ORCID
- McHugh, RK
- Venue
- Alcohol Research: Current Reviews
- Published
- 2019
- Volume
- 40
- Issue
- 1
- ISSN
- 2168-3492 (ISSN-L)
- 2169-4796
- PMC
- PMC6799954
- OpenAlex
- W2972722553
- Cited by
- 517
- References
- 64
- Citations by year
- 2026: 38 · 2025: 125 · 2024: 104 · 2023: 93 · 2022: 93 · 2021: 48 · 2020: 16
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- public-domain
- Locations
- Alcohol research (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Charles Engelhard Foundation
- National Institute on Drug Abuse (K24DA022288, K23DA035297)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- alcoholism, depressive disorders, comorbidities, prevalence, clinical course, treatment response, pharmacotherapy, behavior therapy, prognosis, sex and gender differences
- MeSH terms
- Alcoholism, Depressive Disorder, Humans, Prognosis, Comorbidity, Prevalence
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