Cited by 517Substance Abuse Treatment and OutcomesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

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Alcohol Use Disorder and Depressive Disorders

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McHugh, RK·2019·Alcohol Research: Current Reviews

DOI 10.35946/arcr.v40.1.01PMC PMC6799954

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Abstract

Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance. The aim of this review is to characterize the prevalence, course, and treatment of co-occurring AUD and depressive disorders. Studies have indicated that the co-occurrence of AUD and depressive disorders is associated with greater severity and worse prognosis for both disorders. Both pharmacologic and behavioral treatments have demonstrated efficacy for this population. However, treatment response is somewhat modest, particularly for drinking outcomes, highlighting the importance of further research on the etiology and treatment of co-occurring AUD and depressive disorders. Key future directions include studies to understand the heterogeneity of both AUD and depressive disorders, research on novel treatment approaches to enhance outcomes, and better understanding of sex and gender differences.

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von Zimmermann, C., Hübner, M., Mühle, C., Müller, C. P., Weinland, C., Kornhuber, J., & Lenz, B. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01567-0 · Cited by 19
“Substance abuse frequently co-occurs with Major Depressive Disorder (MDD) [21–23].”
Background
Lavender essential oil alleviates depressive-like behavior in alcohol-withdrawn rats: Insights from gut metabolites and hippocampal transcriptome analysis
Li, X., Xiao, D., Li, C., Wu, T., Li, L., Li, T., Pan, X., Liu, Q., Chi, M., Li, R., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116835 · Cited by 20
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“These studies’ findings shed light on both the complexity and high degree of variability of the course of co-occurring AUD and depression (McHugh and Weiss, 2019).”
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“Alcohol has been studied in connection with cancers, cardiovascular diseases and mental health (Bell et al., 2017; Conner, 2019; IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010; McHugh, 2019).”
Background
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“The clinical variable regarding current alcohol drinking was included as alcohol consumption might contribute to any underlying condition of sadness/melancholy in MDD subjects with a comorbid condition of alcoholism [44,45].”
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Mednova, I. A., Levchuk, L. A., Boiko, A. S., Roschina, O. V., Simutkin, G. G., Bokhan, N. A., LOONEN, A. J. M., & Ivanova, S. А. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2095439 · Cited by 16
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Beas, R., Riva-Moscoso, A., Ribaudo, I., Chambergo‐Michilot, D., Norwood, D. A., Karkash, A., Izquierdo-Veraza, D., Montrose, J. A., Rojas, M. R., & Montalvan-Sanchez, E. E. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102115 · Cited by 16
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Mashayekhi‐Sardoo, H., Razazpour, F., Hakemi, Z., Hedayati‐Moghadam, M., & Baghcheghi, Y. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01569-7 · Cited by 17
“Inpatient populations with severe AUD often present with “secondary depression,” characterized by melancholic features such as diurnal mood variation and non-reactive affect, which resolve partially with sustained abstinence (McHugh and Weiss 2019).”
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“…in the Diagnostic and Statistical Manual of mental disorders (DSM-IV), whereas, in DSM-V, they are integrated into one broader category of alcohol use disorder (AUD) which includes sub-classifications, depending on the severity of the symptoms (Kathryn Mchugh and Weiss, 2019; Nutt et al., 2021).”
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Problematic substance use in depressed adolescents: Prevalence and clinical correlates
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“…disorder), as well as alterations to brain development in regions that control higher order cognitive functioning and inhibitory control (Clayborne et al., 2019; Esmaeelzadeh et al., 2018; Fergusson et al., 2009; Gray & Squeglia, 2018; McHugh & Weiss, 2019; Pedrelli et al., 2016; Spear, 2018).”
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The Prevalence of Mild Cognitive Impairment in a Convenience Sample of 202 Gulf War Veterans
Chao, L. L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197158 · Cited by 16
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Bauer, E. E., Shoeman, A., Buhr, T. J., Daniels, K. M., Lyte, M., & Clark, P. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14592 · Cited by 15
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“The higher cut-off in AUD patients could be due to overlapping MDD and withdrawal symptoms such as insomnia and psychomotor agitation (Barral et al., 2016; McHugh and Weiss, 2019; Weiss et al., 2006).”
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“Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) are highly prevalent mental health conditions, and they tend to co-occur more frequently than one would expect by chance [1].”
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“47,48 With recent advances in internet services, the availability of alcohol and drugs may have become higher owing to content and postings on social media.”
Background
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“52 Prior studies have shown a relationship between depression and increased alcohol use, 53 decreased physical activity, 54 and worse NAFLD ‐ related histologic findings.”
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Depressive symptoms and associated factors among pregnant women attending antenatal care at Comprehensive Specialized Hospitals in Northwest Ethiopia, 2022: an institution-based cross-sectional study
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“The possible reason for this association might be that the presence of mental disorders may contribute to the use of alcohol or vice versa (70).”
Background
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Authors: McHugh, R.
Affiliations: Harvard University (US)
Corresponding author: McHugh, RK
ORCID: McHugh, RK
Venue: Alcohol Research: Current Reviews
Publisher: National Institute on Alcohol Abuse and Alcoholism
Published: 2019
Volume: 40
Issue: 1
ISSN: 2168-3492 (ISSN-L)
2169-4796
DOI: 10.35946/arcr.v40.1.01
PMC: PMC6799954
OpenAlex: W2972722553
Cited by: 517
References: 64
Citations by year: 2026: 38 · 2025: 125 · 2024: 104 · 2023: 93 · 2022: 93 · 2021: 48 · 2020: 16
FWCI: 5.72
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: public-domain
Locations: Alcohol research (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: Charles Engelhard Foundation
National Institute on Drug Abuse (K24DA022288, K23DA035297)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: alcoholism, depressive disorders, comorbidities, prevalence, clinical course, treatment response, pharmacotherapy, behavior therapy, prognosis, sex and gender differences
MeSH terms: Alcoholism, Depressive Disorder, Humans, Prognosis, Comorbidity, Prevalence

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