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Cited by 101Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionAntioxidant Activity and Oxidative Stress

Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly

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Ashley C, Torregrossa, Mayank, Aranke, Nathan S, Bryan·2012·Journal of Geriatric Cardiology
DOI 10.3724/sp.j.1263.2011.00230PMC PMC3390088
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Abstract

The nation's aging population is growing rapidly. By 2030, the number of adults age 65 and older will nearly double to 70 million. Americans are living longer and older adults can now live for many years with multiple chronic illnesses but with a substantial cost to health care. Twenty percent of the Medicare population has at least five chronic conditions i.e., hypertension, diabetes, arthritis, etc. Studies in experimental models and even humans reveal that constitutive production of nitric oxide (NO) is reduced with aging and this circumstance may be relevant to a number of diseases that plague the aging population. NO is a multifunctional signaling molecule, intricately involved with maintaining a host of physiological processes including, but not limited to, host defense, neuronal communication and the regulation of vascular tone. NO is one of the most important signaling molecules in our body, and loss of NO function is one of the earliest indicators or markers of disease. Clinical studies provide evidence that insufficient NO production is associated with all major cardiovascular risk factors, such as hyperlipidemia, diabetes, hypertension, smoking and severity of atherosclerosis, and also has a profound predictive value for disease progression including cardiovascular and Alzheimers disease. Thirty plus years after its discovery and over 13 years since a Nobel Prize was awarded for its discovery, there have been no hallmark therapeutic breakthroughs or even NO based diagnostics. We will review the current state of the science surrounding NO in the etiology of a number of different diseases in the geriatric patient. From these observations, it can be concluded that enzymatic production of NO declines steadily with increasing age in healthy human subjects. Implementing strategies to diagnose and treat NO insufficiency may provide enormous benefit to the geriatric patient.

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  • Improvements in endothelial function and arterial stiffness suggest a role for dietary nitrate in both primary and secondary prevention in ageing populations.

    “Improvements in endothelial function and arterial stiffness–key predictors of cardiovascular risk–suggest a role in both primary and secondary prevention [145,159,160,161].”

    From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [159]

    The Nitric oxide production pathways section says dietary nitrate and nitrite may protect against NO insufficiency, and the Conclusions propose restoring NO availability to delay or prevent age-related disease. But the paper does not report that dietary nitrate improves both endothelial function and arterial stiffness, nor does it specifically establish a role in both primary and secondary prevention. Its mention of vascular stiffness concerns L-arginine treatment, which did not improve that measure. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • In ageing populations, the benefits of dietary nitrate extend beyond reducing blood pressure.

    “In ageing populations, the benefits of dietary nitrate extend beyond reducing blood pressure.”

    From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [159]

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Authors
Ashley C, T., Mayank, A., & Nathan S, B.
Venue
Journal of Geriatric Cardiology
Publisher
Tsinghua University Press
Published
2012-01-13
Volume
8
Issue
4
Pages
230-242
ISSN
1671-5411 (ISSN-L)
DOI
10.3724/sp.j.1263.2011.00230
PMC
PMC3390088
OpenAlex
W1613874005
Cited by
101
References
26
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 17 · 2020: 11 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 3
FWCI
2.79
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • 老年心脏病学杂志：英文版 (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
nitric oxide, aging, older adults, cardiovascular risk factors, atherosclerosis, hypertension, diabetes mellitus, Alzheimer's disease, polypharmacy

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