Nitrite and nitrate: cardiovascular risk–benefit and metabolic effect
Abstract
PURPOSE OF REVIEW: To review the most recent published literature on the biological effects of nitrite and nitrate in order to establish the context for potential health benefits vs. potential risks or adverse effects. Nitrite and nitrate are indigenous to our diet and are formed naturally within our body from the oxidation of nitric oxide. Emerging health benefits from dietary sources of nitrite and nitrate contradict decades of epidemiological research that have suggested an association of nitrite and nitrate in foods, primarily cured and processed meat, with certain cancers. RECENT FINDINGS: The major source of exposure of nitrite and nitrate comes from the consumption of nitrate-enriched vegetables. The preponderance of epidemiological studies shows a very weak association with consumption of meats and certain cancers, which contain very little nitrite and nitrate. Nitrite and nitrate in certain foods and diets can be metabolized to nitric oxide and promote cardiovascular benefits and cytoprotection. SUMMARY: The cardiovascular benefits of nitrite and nitrate are beginning to be translated in humans by the increasing number of clinical trials using nitrite and nitrate. The collective body of evidence suggests that foods enriched in nitrite and nitrate provide significant health benefits with very little risk.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dietary supplementation of nitrites can cause methemoglobinemia and interfere with oxygenation of the blood.
“Dietary supplementation of nitrites can cause methemoglobinemia and interfere with oxygenation of the blood.”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [18]
Diet is an important source of nitrite, largely via secondary reduction from nitrate.
“the diet is an important source of nitrite (largely via secondary reduction from nitrate)”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [118]
Diet has the potential to contribute significantly to nitrite-dependent responses.
“several studies have shown that it has the potential to contribute significantly to nitrite-dependent responses [84, 86-89, 118-121]”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [118]
Cites
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078 · see citing works
Food sources of nitrates and nitrites: The physiologic context for potential health benefits
Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069 · see citing works
Self-citationNitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739 · see citing works
Carter, P., Gray, L. J., Troughton, J., Khunti, K., & Davies, M. J. (2010) · BMJ · doi:10.1136/bmj.c4229 · Cited by 728 · see citing works
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · see citing works
Inorganic nitrate is a possible source for systemic generation of nitric oxide
Lundberg, J. O., & Govoni, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.027 · Cited by 657 · see citing works
Effects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works
Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO
Kapil, V., Milsom, A. B., Okorie, M., Maleki-Toyserkani, S., Akram, F., Rehman, F., Arghandawi, S., Pearl, V., Benjamin, N., Loukogeorgakis, S., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153536 · Cited by 621 · see citing works
Nitrate and nitrite in biology, nutrition and therapeutics
Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.260 · Cited by 617 · see citing works
Self-citationWebb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · see citing works
Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596 · see citing works
Effects of Dietary Nitrate on Blood Pressure in Healthy Volunteers
Larsen, F. J., Ekblom, B., Sahlin, K., Lundberg, J. O., & Weitzberg, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmc062800 · Cited by 587 · see citing works
Govoni, M., Jansson, E. Å., Weitzberg, E., & Lundberg, J. O. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.003 · Cited by 585 · see citing works
Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works
Cross, A. J., Ferrucci, L. M., Risch, A., Graubard, B. I., Ward, M. H., Park, Y., Hollenbeck, A. R., Schatzkin, A., & Sinha, R. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3929 · Cited by 469 · see citing works
Carlström, M., Larsen, F. J., Nyström, T., Hezel, M., Borniquel, S., Weitzberg, E., & Lundberg, J. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008872107 · Cited by 382 · see citing works
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347 · see citing works
Self-citationDejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334 · see citing works
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.006 · Cited by 320 · see citing works
When Does Nitrate Become a Risk for Humans?
Powlson, D. S., Addiscott, T. M., Benjamin, N., Cassman, K. G., de Kok, T. M., van Grinsven, H., L'hirondel, J., Avery, A. A., & van Kessel, C. (2008) · Journal of Environmental Quality · doi:10.2134/jeq2007.0177 · Cited by 313 · see citing works
van Duijnhoven, F. J. B., Bueno-de-Mesquita, H. B., Ferrari, P., Jenab, M., Boshuizen, H. C., Ros, M. M., Casagrande, C., Tjønneland, A. M., Olsen, A., Overvad, K., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27120 · Cited by 300 · see citing works
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281 · see citing works
Pluta, R. M. (2005) · JAMA · doi:10.1001/jama.293.12.1477 · Cited by 261 · see citing works
Jung, K.-H., Chu, K., Ko, S.-Y., Lee, S.-T., Sinn, D.-I., Park, D.-K., Kim, J.-M., Song, E.-C., Kim, M., & Roh, J.-K. (2006) · Stroke · doi:10.1161/01.str.0000245116.40163.1c · Cited by 253 · see citing works
Petersson, J., Carlström, M., Schreiber, O., Phillipson, M., Christoffersson, G., Jägare, A., Roos, S., Jansson, E. Å., Persson, A. E. G., Lundberg, J. O., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.011 · Cited by 235 · see citing works
Tripatara, P., Patel, N. S. A., Webb, A., Rathod, K., Lecomte, F. M. J., Mazzon, E., Cuzzocrea, S., Yaqoob, M. M., Ahluwalia, A., & Thiemermann, C. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050450 · Cited by 226 · see citing works
Tissue Processing of Nitrite in Hypoxia
Feelisch, M., Fernandez, B. O., Bryan, N. S., Garcia-Saura, M. F., Bauer, S., Whitlock, D. R., Ford, P. C., Janero, D. R., Rodriguez, J., & Ashrafian, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806654200 · Cited by 218 · see citing works
Self-citationEichholzer, M., & Gutzwiller, F. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb01721.x · Cited by 205 · see citing works
Zuckerbraun, B. S., Shiva, S., Ifedigbo, E., Mathier, M. A., Mollen, K. P., Rao, J., Bauer, P. M., Choi, J. J. W., Curtis, E., Choi, A. M. K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.891077 · Cited by 192 · see citing works
Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis
Kumar, D., Branch, B. G., Pattillo, C. B., Hood, J., Thoma, S., Simpson, S., Illum, S., Arora, N., Chidlow, J. H., Langston, W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711480105 · Cited by 187 · see citing works
Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers
Sobko, T., Marcus, C., Govoni, M., & Kamiya, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.007 · Cited by 185 · see citing works
Cardioprotective effects of vegetables: is nitrate the answer?
Lundberg, J. O., Feelisch, M., Björne, H., Jansson, E. Å., & Weitzberg, E. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.013 · Cited by 185 · see citing works
Sinha, R., Park, Y., Graubard, B. I., Leitzmann, M. F., Hollenbeck, A., Schatzkin, A., & Cross, A. J. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp280 · Cited by 181 · see citing works
Dezfulian, C., Shiva, S., Alekseyenko, A., Pendyal, A., Beiser, D. G., Munasinghe, J. P., Anderson, S. A., Chesley, C. F., Vanden Hoek, T. L., & Gladwin, M. T. (2009) · Circulation · doi:10.1161/circulationaha.109.853267 · Cited by 174 · see citing works
Stokes, K. Y., Dugas, T. R., Tang, Y., Garg, H., Guidry, E., & Bryan, N. S. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2008 · Cited by 171 · see citing works
Self-citationBryan, N. S., Calvert, J. W., Gundewar, S., & Lefer, D. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.040 · Cited by 161 · see citing works
Self-citationDietary nitrate increases gastric mucosal blood flow and mucosal defense
Petersson, J., Phillipson, M., Jansson, E. Å., Patzak, A., Lundberg, J. O., & Holm, L. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00435.2006 · Cited by 161 · see citing works
Rocha, B. S., Gago, B., Barbosa, R. M., & Laranjinha, J. (2009) · Toxicology · doi:10.1016/j.tox.2009.09.008 · Cited by 142 · see citing works
Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide
Elrod, J. W., Calvert, J. W., Gundewar, S., Bryan, N. S., & Lefer, D. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800700105 · Cited by 137 · see citing works
Self-citationEisenbrand, G., Spiegelhalder, B., & Preußmann, R. (2009) · Oncology · doi:10.1159/000225441 · Cited by 127 · see citing works
Nitrite is an alternative source of NO in vivo
Tsuchiya, K., Kanematsu, Y., Yoshizumi, M., Ohnishi, H., Kirima, K., Izawa, Y., Shikishima, M., Ishida, T., Kondo, S., Kagami, S., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2004 · Cited by 127 · see citing works
Methemoglobinemia in young infants
Cornblath, M., & Hartmann, A. F. (1948) · The Journal of Pediatrics · doi:10.1016/s0022-3476(48)80200-3 · Cited by 124 · see citing works
Milkowski, A., Garg, H. K., Coughlin, J. R., & Bryan, N. S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.08.004 · Cited by 123 · see citing works
Self-citationJansson, E. Å., Petersson, J., Reinders, C., Sobko, T., Björne, H., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.018 · Cited by 106 · see citing works
Meat and components of meat and the risk of bladder cancer in the NIH-AARP diet and health study
Ferrucci, L. M., Sinha, R., Ward, M. H., Graubard, B. I., Hollenbeck, A. R., Kilfoy, B. A., Schatzkin, A., Michaud, D. S., & Cross, A. J. (2010) · Cancer · doi:10.1002/cncr.25463 · Cited by 103 · see citing works
Bioavailability of sodium nitrite from an aqueous solution in healthy adults
Hunault, C. C., van Velzen, A. G., Sips, A. J. A. M., Schothorst, R. C., & Meulenbelt, J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.06.865 · Cited by 102 · see citing works
(2005) · PubMed · Cited by 88 · see citing works
Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study
Mack, A. K., McGowan II, V. R., Tremonti, C. K., Ackah, D., Barnett, C., Machado, R. F., Gladwin, M. T., & Kato, G. J. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07259.x · Cited by 64 · see citing works
Impact of Exposure Measurement Error in Nutritional Epidemiology
Kipnis, V., & Freedman, L. S. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn408 · Cited by 46 · see citing works
Nitric oxide bioactivity of traditional Chinese medicines used for cardiovascular indications
Tang, Y., Garg, H. K., Geng, Y., & Bryan, N. S. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.024 · Cited by 32 · see citing works
Self-citationOrally administered nitrite attenuates cardiac allograft rejection in rats
Zhan, J., Nakao, A., Sugimoto, R., Dhupar, R., Wang, Y., Wang, Z., Billiar, T. R., & McCurry, K. R. (2009) · Surgery · doi:10.1016/j.surg.2009.05.002 · Cited by 19 · see citing works
Inhibition of Cancer Cell Replication by Inorganic Nitrite
Morcos, E., Carlsson, S., Weitzberg, E., Wiklund, N. P., & Lundberg, J. O. (2010) · Nutrition and Cancer · doi:10.1080/01635580903441170 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Graves, D. B. (2012) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,512 · see citing works
Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance
LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388 · see citing works
Nitrate Supplementation’s Improvement of 10-km Time-Trial Performance in Trained Cyclists
Cermak, N. M., Gibala, M. J., & van Loon, L. J. C. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.1.64 · Cited by 326 · see citing works
Etemadi, A., Sinha, R., Ward, M. H., Graubard, B. I., Inoue-Choi, M., Dawsey, S. M., & Abnet, C. C. (2017) · BMJ · doi:10.1136/bmj.j1957 · Cited by 296 · see citing works
Moreno‐Luna, R., Múñoz‐Hernández, R., Miranda, M. L., Costa, A. F., Jiménez-Jiménez, L., Vallejo‐Vaz, A. J., Muriana, F. J. G., Villar, J. R., & Stiefel, P. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.128 · Cited by 243 · see citing works
Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits
Machha, A., & Schechter, A. N. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0192-5 · Cited by 146 · see citing works
No Improvement in Endurance Performance after a Single Dose of Beetroot Juice
Cermak, N. M., Res, P., Stinkens, R., Lundberg, J. O., Gibala, M. J., & van Loon, L. J. C. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.6.470 · Cited by 144 · see citing works
Chazelas, E., Pierre, F., Druesne-Pecollo, N., Esseddik, Y., Szabo de Edelenyi, F., Agaesse, C., De Sa, A., Lutchia, R., Gigandet, S., Srour, B., et al. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyac046 · Cited by 135 · see citing works
NITRATE IN LEAFY GREEN VEGETABLES AND ESTIMATED INTAKE
Brkić, D., Bošnir, J., Bevardi, M., Bošković, A. G., Miloš, S., Lasić, D., Krivohlavek, A., Racz, A., Ćuić, A. M., & Uršulin-Trstenjak, N. (2017) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v14i3.4 · Cited by 103 · see citing works
Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly
Ashley C, T., Mayank, A., & Nathan S, B. (2012) · Journal of Geriatric Cardiology · doi:10.3724/sp.j.1263.2011.00230 · Cited by 101 · see citing works
Self-citationIs Grassfed Meat and Dairy Better for Human and Environmental Health?
Provenza, F. D., Kronberg, S. L., & Gregorini, P. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00026 · Cited by 102 · see citing works
Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate
Norouzirad, R., González‐Muniesa, P., & Ghasemi, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5350267 · Cited by 96 · see citing works
Bahadoran, Z., Mirmiran, P., Ghasemi, A., Kabir, A., Azizi, F., & Hadaegh, F. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.04.002 · Cited by 95 · see citing works
Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications
Bahadoran, Z., Ghasemi, A., Mirmiran, P., Azizi, F., & Hadaegh, F. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0013-6 · Cited by 82 · see citing works
Plasmonic nanoparticles for colorimetric detection of nitrite and nitrate
Sepahvand, M., Ghasemi, F., & Hosseini, H. M. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112025 · Cited by 66 · see citing works
Chirinos, J. A., & Zamani, P. L. (2016) · Current Heart Failure Reports · doi:10.1007/s11897-016-0277-9 · Cited by 65 · see citing works
Rassaf, T., Ferdinandy, P., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12291 · Cited by 62 · see citing works
Vitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59 · see citing works
Toxicological issues associated with production and processing of meat
Püssa, T. (2013) · Meat Science · doi:10.1016/j.meatsci.2013.04.032 · Cited by 57 · see citing works
Machha, A., & Schechter, A. N. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00477.x · Cited by 51 · see citing works
Susic, D., & Frohlich, E. D. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834d9c52 · Cited by 49 · see citing works
Public Health Risk-benefit Assessment Associated with Food Consumption–A Review
Boué, G., Guillou, S., Antignac, J., Bizec, B. L., & Membré, J. (2014) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2015/12285 · Cited by 48 · see citing works
Xanthopoulos, A. V., Triposkiadis, F. K., & Starling, R. C. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.01.001 · Cited by 45 · see citing works
Bahadoran, Z., Mirmiran, P., Ghasemi, A., Carlström, M., Azizi, F., & Hadaegh, F. (2016) · Nutrients · doi:10.3390/nu8120811 · Cited by 41 · see citing works
Exposure to perchlorate, nitrate and thiocyanate, and prevalence of diabetes mellitus
Liu, G., Zong, G., Dhana, K., Hu, Y., Blount, B. C., Morel-Espinosa, M., & Sun, Q. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyx188 · Cited by 39 · see citing works
Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy
Oliveira‐Paula, G. H., & Tanus-Santos, J. E. (2018) · Current Drug Targets · doi:10.2174/1389450119666180816120816 · Cited by 33 · see citing works
Does inorganic nitrate say NO to obesity by browning white adipose tissue?
Roberts, L. D. (2015) · Adipocyte · doi:10.1080/21623945.2015.1005525 · Cited by 29 · see citing works
Derosa, G., & Maffioli, P. (2016) · Vascular Health and Risk Management · doi:10.2147/vhrm.s64460 · Cited by 28 · see citing works
The role of probiotics in improving food safety; detoxification of heavy metals and chemicals
Ansari, F., Lee, C., Rashidimehr, A., Eskandari, S., Ashaolu, T. J., Mirzakhani, E., Pourjafar, H., & Jafari, S. M. (2023) · Toxin Reviews · doi:10.1080/15569543.2023.2283768 · Cited by 29 · see citing works
Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making
Mian, A. I., Aranke, M., & Bryan, N. S. (2013) · The Open Biochemistry Journal · doi:10.2174/1874091x01307010024 · Cited by 26 · see citing works
Self-citationDietary N‐Nitroso Compounds and Risk of Hepatocellular Carcinoma: A USA‐Based Study
Zheng, J., Daniel, C. R., Hatia, R. I., Stuff, J. E., Abdelhakeem, A. A. F., Rashid, A., Chun, Y. S., Jalal, P. K., Kaseb, A. O., Li, D., et al. (2021) · Hepatology · doi:10.1002/hep.32046 · Cited by 23 · see citing works
PROTECTIVE EFFECT OF VANILLIC ACID ON OVARIECTOMY-INDUCED OSTEOPOROSIS IN RATS
Wang, Y. G., Jiang, L. B., & Gou, B. (2017) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v14i4.4 · Cited by 22 · see citing works
Benefit-risk analysis for foods (BRAFO): Evaluation of exposure to dietary nitrates
Wikoff, D. S., Thompson, C. M., Rager, J. E., Chappell, G. A., Fitch, S., & Doepker, C. L. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.08.031 · Cited by 21 · see citing works
NO Signaling in the Cardiovascular System and Exercise
Fernandes, T. M., Gomes‐Gatto, C. D. V., Pereira, N. P., Alayafi, Y. R., das Neves, V. J., & de Oliveira, E. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4304-8_13 · Cited by 20 · see citing works
Hidaka, M., Gotoh, A., Shimizu, T., Minamisawa, K., Imamura, H., & Uchida, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.687632 · Cited by 20 · see citing works
Dietary nitrate, nitric oxide, and restenosis
Cooke, J. P., & Ghebremariam, Y. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57193 · Cited by 19 · see citing works
Nitrate supplementation and human exercise performance
POORTMANS, J. R., Gualano, B., & Carpentier, A. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000222 · Cited by 19 · see citing works
Application of a Nitric Oxide Sensor in Biomedicine
Saldanha, C., Almeida, J. P., & Silva-Herdade, A. S. (2014) · Biosensors · doi:10.3390/bios4010001 · Cited by 18 · see citing works
Potential role for age as a modulator of oral nitrate reductase activity
Ahmed, K. A., Kim, K., Ricart, K. C., Pol, W. V. D., Qi, X., Bamman, M. M., Behrens, C. E., Fisher, G., Boulton, M. E., Morrow, C. D., et al. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.12.001 · Cited by 18 · see citing works
Roth, I., Casas, R. M., Ribó-Coll, M., & Estruch, R. (2019) · Nutrients · doi:10.3390/nu11061266 · Cited by 15 · see citing works
Determination of Nitrate and Nitrite Content of Dietary Supplements Using Ion Chromatography
Petróczi, A. (2014) · Journal of Analytical & Bioanalytical Techniques · doi:10.4172/2155-9872.s12-003 · Cited by 14 · see citing works
Gholami, F., Rahmani, L., Amirnezhad, F., & Cheraghi, K. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0816 · Cited by 13 · see citing works
An, J., Sun, L., Liu, M., Dai, R., Si, Q., Ge, G., Wang, Z., & Jia, Y. (2024) · Fermentation · doi:10.3390/fermentation10020092 · Cited by 13 · see citing works
Nitrate Supplementation, Exercise, and Kidney Function
CARPENTIER, A., Stragier, S., Bréjeon, C., & POORTMANS, J. R. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000548 · Cited by 12 · see citing works
Yu, H., Chaimbault, P., Clarot, I., Chen, Z., & Leroy, P. (2018) · Talanta · doi:10.1016/j.talanta.2018.09.011 · Cited by 12 · see citing works
Bahadoran, Z., Carlström, M., Ghasemi, A., Mirmiran, P., Azizi, F., & Hadaegh, F. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0254-2 · Cited by 10 · see citing works
Towards nitric oxide based diagnostics: call to action
Aranke, M., Bryan, N. S., & Mian, A. I. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.07.006 · Cited by 6 · see citing works
Self-citationAli, D. M., & Abdelzaher, W. (2017) · International Journal of Clinical Pharmacology & Toxicology · doi:10.19070/2167-910x-1700044 · Cited by 5 · see citing works
Evaluation of produced water quality by using water quality indices in Heglig area, Sudan
Zooalnoon, M. O., & Musa, A. (2019) · AQUA - Water Infrastructure Ecosystems and Society · doi:10.2166/aqua.2019.088 · Cited by 4 · see citing works
EVALUATION OF PHYTOCHEMICALS AND ANTI-NUTRITIONAL PROFILE IN UNDERUTILISED GREEN LEAFY VEGETABLES
Kundub, P., Sethia, N., Guptab, P., & Bhattic, J. S. (2021) · European Journal of Molecular & Clinical Medicine · Cited by 3 · see citing works
Nitric Oxide Signalling in Vascular Control and Cardiovascular Risk
Schmidt, A. (2012) · InTech eBooks · doi:10.5772/34801 · Cited by 2 · see citing works
Raj, V., Charles, S., Goenka, L., Ramamoorthy, T., Marimuthu, C., Emmanuel, C., Mala, K., Kumarasamy, S., & George, M. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20190409 · Cited by 1 · see citing works
Khoshui, S. K., Ravandi, S. A. H., Karimi, M. B., & Talebi, Z. (2023) · Journal of Applied Polymer Science · doi:10.1002/app.54627 · Cited by 1 · see citing works
Tang, Z., Wu, X., Zhang, J., Zhong, H., Wan, X., Yan, T., Li, Z., Lu, Z., Liu, C., Zhi, Q., et al. (2025) · BMC Public Health · doi:10.1186/s12889-024-20929-4 · Cited by 1 · see citing works
In vivo effect of N-ethylmaleimide (NEM) on the measurement of nitrate in plasma
Mansoor, M. A., & Andersen, D. O. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.07.006 · Cited by 1 · see citing works
Testing Pharmacological Profiles with Biomarkers Relevant to Cardiovascular Profiles
Derosa, G., & Maffioli, P. (2015) · Springer eBooks · doi:10.1007/978-94-007-7741-5_27-1 · Cited by 1 · see citing works
Beneficial Effects of Inorganic Nitrate/Nitrite on Vascular Function and Blood Pressure in Diabetes
Bahadoran, Z., Mirmiran, P., & Ghasemi, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_23 · Cited by 1 · see citing works
THE EFFECT OF ACUTE BEETROOT JUICE SUPPLEMENTATION ON MUSCLE FATIGUE IN KNEE EXTENSOR EXERCISE
Lee, S. (2013) · UKnowledge (University of Kentucky)
INORGANIC AND ORGANIC NITRATES AS SOURCES OF NITRIC OXIDE
Govoni, M. (2012) · Figshare · doi:10.13140/rg.2.2.17705.85607
Estudo de mecanismos anti-hipertensivos do nitrito de sódio na hipertensão renovascular experimental
Pinheiro, L. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-18032015-230532
Enxaguante bucal inibe os efeitos anti-hipertensivos da Larginina em modelo de hipertensão 2R1C
Batista, R. I. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2019.tde-16102019-110724
Control of nitrate in vegetable products
Klyap, N., Krachkovska, O., Maslyuk, A., Мостіпан, К. С., & Yakubchak, O. M. (2020) · VETERINARY SCIENCE TECHNOLOGIES OF ANIMAL HUSBANDRY AND NATURE MANAGEMENT · doi:10.31890/vttp.2020.05.11
Testing Pharmacological Profiles with Biomarkers Relevant to Cardiovascular Profiles
Derosa, G., & Maffioli, P. (2016) · Springer eBooks · doi:10.1007/978-94-007-7678-4_27
Davarpanah, M., Bahadoran, Z., Javadi, M., Mirmiran, P., & Azizi, F. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.07.010
- Authors
- Tang, Y., Jiang, H., & Bryan, N. S.
- Affiliations
- Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
- Corresponding author
- Bryan, Nathan S
- Venue
- Current Opinion in Lipidology
- Published
- 2011-02
- Volume
- 22
- Issue
- 1
- Pages
- 11-15
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2066945371
- Cited by
- 69
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 8
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- nitrite, nitrate, nitric oxide, dietary nitrate, cancer risk, cytoprotection, metabolic effects, clinical trials
- MeSH terms
- Cardiovascular Diseases, Humans, Nitrates, Nitrites
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
