Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs
Abstract
Hepatotoxic adverse drug reactions have contributed to the decline of many promising therapies, even among mainstream medication classes (bromfenac and troglitazone are recent examples). The spectrum of nonsteroidal anti-inflammatory drug-related liver toxicity continues to expand, with reports in children, interactive toxicity in persons with hepatitis C, and recognition of the toxicity of both the preferential and selective cyclooxygenase-2 inhibitors. Of the antihypertensive agents, methyldopa is now rarely prescribed and adverse effects are reported infrequently, whereas cases of liver injury associated with the angiotensin receptor and converting enzyme inhibitors are increasingly reported. Of the antidiabetic agents, acarbose, gliclazide, metformin, and human insulin have been implicated in causing liver injury. To date, the newer thiazolidinediones do not appear to share the hepatotoxic potential of troglitazone, although a few reports of acute hepatitis have accrued. Although liver injury has been associated with the "statins," the frequency of such toxicity is lower than that of the background population and the value of biochemical monitoring remains unproved. Newer concepts in anticonvulsant hepatotoxicity have been the recognition of the reactive metabolite syndrome, delineation of the risk factors for valproic acid toxicity, the potential role of carnitine in preventing valproic acid hepatotoxicity, and the toxicity of second-line antiepileptic drugs. Liver injury associated with newer psychotropic agents, particularly the selective serotonin reuptake inhibitors, is also discussed. The focus of the review is the hepatotoxicity of commonly used drugs with particular reference to recent and novel reports of toxicity. Well-known causes of liver injury such as chlorpromazine, phenytoin, and methyldopa are not discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gliclazide has significant hepatic metabolism.
“Gliclazide has signi fi cant hepatic metabolism.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [467]
Hepatotoxicity has been reported for glibenclamide and is rarely seen with gliclazide.
“Hepatotoxicity has also been reported for glibenclamide and is rarely seen with gliclazide.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [467]
Cited by
Sorted by citations
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Lee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594 · see citing works
Squires, R. H., Shneider, B. L., Bucuvalas, J. C., Alonso, E. M., Sokol, R. J., Narkewicz, M. R., Dhawan, A. K., Rosenthal, P. J., Rodriguez‐Baez, N., Murray, K. F., et al. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.12.051 · Cited by 866 · see citing works
Andrade, R. J., Chalasani, N., Bjornsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H. C., Merz, M., Lucena, M. I., Kaplowitz, N., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0105-0 · Cited by 907 · see citing works
Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs
Zhou, S., Chan, S. Y., Goh, B. C., Chan, E., Duan, W., Huang, M., & McLeod, H. L. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544030-00005 · Cited by 512 · see citing works
Liver transplantation for acute liver failure from drug induced liver injury in the United States
Russo, M. W., Galanko, J. A., Shrestha, R., Fried, M. W., & Watkins, P. B. (2004) · Liver Transplantation · doi:10.1002/lt.20204 · Cited by 473 · see citing works
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 510 · see citing works
Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
Chalasani, N., Aljadhey, H., Kesterson, J., Murray, M. D., & Hall, S. D. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.015 · Cited by 441 · see citing works
Zhang, H., Wei, J., Xue, R., Wu, J.-D., Zhao, W., Wang, Z., Wang, S., Zhou, Z.-X., Song, D., Wang, Y., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.07.029 · Cited by 442 · see citing works
“With the adverse effect reports for the thiazolidinediones (TZDs) [12,13], hypoglycemic drugs with new targets are highly desirable.”
BackgroundPadda, M. S., Sanchez, M. J., Akhtar, A. J., & Boyer, J. L. (2011) · Hepatology · doi:10.1002/hep.24229 · Cited by 393 · see citing works
Lang, C., Meier, Y., Stieger, B., Beuers, U. H., Lang, T., Kerb, R., Kullak-Ublick, G. A., Meier, P. J., & Pauli‐Magnus, C. (2007) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000230418.28091.76 · Cited by 337 · see citing works
Peroxisome Proliferator–Activated Receptors as Transcriptional Nodal Points and Therapeutic Targets
Brown, J. D., & Plutzky, J. (2007) · Circulation · doi:10.1161/circulationaha.104.475673 · Cited by 338 · see citing works
Labbe, G., Pessayre, D., & Fromenty, B. (2008) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00608.x · Cited by 317 · see citing works
Hepatobiliary transporters and drug‐induced cholestasis†
Pauli‐Magnus, C., & Meier, P. J. (2006) · Hepatology · doi:10.1002/hep.21359 · Cited by 283 · see citing works
Review article: drug hepatotoxicity
Chang, C., & Schiano, T. D. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03307.x · Cited by 264 · see citing works
Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance
Zhou, S., Chan, E., Duan, W., Huang, M., & Chen, Y. (2005) · Drug Metabolism Reviews · doi:10.1081/dmr-200028812 · Cited by 273 · see citing works
“…ta th io n e; N A C , N -a ce ty lL -c y te in e; G S T , g lu ta th io n eS -t ra n sf er as e. e S L E , S y te m ic lu p u s er y th em at o su s. drug-protein adduct formation and degradation, affected proteins and organs, and pathological conditions of the patients (Chitturi and George, 2002).”
BackgroundChalasani, N. (2005) · Hepatology · doi:10.1002/hep.20671 · Cited by 264 · see citing works
Statin Safety: An Overview and Assessment of the Data—2005
Bays, H. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.12.006 · Cited by 264 · see citing works
Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?
Bessone, F. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i45.5651 · Cited by 249 · see citing works
Review article: prescribing medications in patients with cirrhosis – a practical guide
Lewis, J. H., & Stine, J. G. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12324 · Cited by 210 · see citing works
Sheng, X., Zhang, Y., Gong, Z., Huang, C., & Zang, Y. Q. (2008) · PPAR Research · doi:10.1155/2008/581348 · Cited by 203 · see citing works
“However, these agonists can also produce moderate to serious side effects such as edema, weight gain, congestive heart failure, and hepatotoxicity [9, 10].”
BackgroundGoldkind, L., & Laine, L. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1207 · Cited by 180 · see citing works
Lipid-lowering agents that cause drug-induced hepatotoxicity.
Bhardwaj, S. S., & Chalasani, N. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.06.010 · Cited by 173 · see citing works
Lluis, J. M., Colell, A., García‐Ruiz, C., Kaplowitz, N., & Fernández-Checa, J. C. (2003) · Gastroenterology · doi:10.1053/gast.2003.50089 · Cited by 172 · see citing works
Hepatotoxicity related to antirheumatic drugs
Aithal, G. P. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.214 · Cited by 170 · see citing works
“Serious liver injury has been described with several NSAIDs, either in isolated reports or case series”
BackgroundNonsteroidal Anti-Inflammatory Drug–Induced Hepatotoxicity
Aithal, G. P., & Day, C. P. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.06.004 · Cited by 163 · see citing works
Medication‐induced mitochondrial damage and disease
Neustadt, J. O., & Pieczenik, S. R. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700075 · Cited by 158 · see citing works
Silva, F. S. G., Oliveira, P. J., & Duarte, M. F. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b06021 · Cited by 156 · see citing works
Drug‐induced liver injury at an Asian center: a prospective study
Wai, C. T., Tan, B., Chan, C., Sutedja, D. S., Lee, Y.-M., Khor, C. J. L., & Lim, S. G. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01461.x · Cited by 151 · see citing works
“Other adulterants, namely phenylbutazone, metformin, and glibenclamide, are known causative agents of DILI (10).”
BackgroundLigueros‐Saylan, M., Foley, J. E., Schweizer, A., Couturier, A., & Kothny, W. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01214.x · Cited by 145 · see citing works
“These include drug-induced liver injury (DILI) resulting from high background rate of non-alcoholic fatty liver disease (NAFLD) [1,2] and the association with hepatitis C infection [3,4], pancreatitis [5,6], and a broad spectrum of cardiovascular disease [7,8].”
BackgroundInfluentialMasubuchi, Y., Bourdi, M., Reilly, T. P., Graf, M. L. M., George, J. W., & Pohl, L. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00572-2 · Cited by 145 · see citing works
Self-citationDrug‐related Hepatotoxicity and Acute Liver Failure
Murray, K. F., Hadžić, N., Wirth, S., Bassett, M. D., & Kelly, D. A. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181709464 · Cited by 143 · see citing works
“phenobarbital, phenytoin, carbamazepine, oxcarbazepine, lamotrigine, vigabatrin, felbamate, and valproic acid (Table 1), although for most of these drugs serious hepatotoxicity is uncommon (90,91).”
BackgroundDiabetes and Hepatitis C: A Two-Way Association
Hammerstad, S. S., Grock, S., Lee, H. J., Hasham, A., Sundaram, N. K., & Tomer, Y. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00134 · Cited by 142 · see citing works
“(209)], and therefore, it should be used with caution.”
BackgroundDavid, S., & Hamilton, J. P. (2010) · PubMed · Cited by 235 · see citing works
Yogeeswari, P., Sriram, D., Thirumurugan, R., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050283b · Cited by 137 · see citing works
Biochemical mechanisms in drug-induced liver injury: Certainties and doubts
Grattagliano, I., Bonfrate, L., Diogo, C. V., Wang, H. H., Wang, D. Q. ‐., & Portincasa, P. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.4865 · Cited by 136 · see citing works
Drug-induced liver injury: Is it somehow foreseeable?
Tarantino, G., Minno, M. N. D. D., & Capone, D. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.2817 · Cited by 137 · see citing works
Rostom, A., Goldkind, L., & Laine, L. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00777-3 · Cited by 134 · see citing works
Vuppalanchi, R., Chalasani, N., & Teal, E. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200502000-00002 · Cited by 133 · see citing works
Ursolic acid derivatives for pharmaceutical use: a patent review (2012-2016)
Hussain, H., Green, I. R., Ali, I., Khan, I. A., Ali, Z., Al-Sadi, A. M., & Ahmed, I. (2017) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1344219 · Cited by 130 · see citing works
Drug- and chemical-induced cholestasis
Mohi-Ud-Din, R., & Lewis, J. H. (2004) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00124-7 · Cited by 118 · see citing works
Rana, A., Siddiqui, N., Khan, S. A., et al. (2007) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2007.07.008 · Cited by 120 · see citing works
The road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118 · see citing works
Talpur, N. A., Echard, B. W., Ingram, C., Bagchi, D., & Preuss, H. G. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00386.x · Cited by 103 · see citing works
Metformin and metabolic diseases: a focus on hepatic aspects
Zheng, J., Woo, S., Hu, X., Botchlett, R. E., Chen, L., Huo, Y., & Wu, C. (2015) · Frontiers of Medicine · doi:10.1007/s11684-015-0384-0 · Cited by 99 · see citing works
“Patients with cirrhosis, particularly those with encephalopathy, may have arterial hypoxemia, which increases the risk of developing lactic acidosis [149,151].”
BackgroundDrug-Induced Hepatotoxicity: A Review
Pandit, A., Sachdeva, T., & Bafna, P. A. (2012) · Cited by 97 · see citing works
Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy
Pauli‐Magnus, C., Meier, P. J., & Stieger, B. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1253224 · Cited by 93 · see citing works
“It occurs with many drugs through a variety of mechanisms, which might differ in their clinical presentations ranging from asymptomatic mild biochemical abnormalities to an acute illness with jaundice that resembles viral hepatitis.(124) Although good epidemiologic data exist on the entire spectrum of drug-induced liv…”
BackgroundStatins and its hepatic effects: Newer data, implications, and changing recommendations
José, J. (2015) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.171699 · Cited by 93 · see citing works
“[33] These elevations do not always recur if the patient resumes the statin.”
Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo
Craft, J. M., Watterson, D. M., Frautschy, S. A., & Eldik, L. J. V. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.006 · Cited by 91 · see citing works
Hargreaves, I. P., Duncan, A. J., Heales, S. J. R., & Land, J. M. (2005) · Drug Safety · doi:10.2165/00002018-200528080-00002 · Cited by 91 · see citing works
Prabhu, S. I., Vinodhini, S., Elanchezhiyan, C., & Rajeswari, V. D. (2017) · Journal of Diabetes · doi:10.1111/1753-0407.12554 · Cited by 88 · see citing works
“The standard drug glibenclamide, which was used in the present study, has been reported to cause serious irreversible liver damage.(50) However, the mechanism underlying the hepatotoxicity of glibenclamide is unknown.”
BackgroundRetractedFDA drug prescribing warnings: is the black box half empty or half full?
Wagner, A. K., Chan, K. A., Dashevsky, I., Raebel, M. A., Andrade, S. E., Lafata, J. E., Davis, R. L., Gurwitz, J. H., Soumerai, S. B., & Platt, R. G. (2005) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1193 · Cited by 87 · see citing works
Yin, F., Bruemmer, D., Blaschke, F., Hsueh, W. A., Law, R. E., & Herle, A. J. V. (2004) · Oncogene · doi:10.1038/sj.onc.1207598 · Cited by 89 · see citing works
“Although TRO was removed from the market because of hepatotoxity, two other TZDs, rosiglitazone and pioglitazone are currently in widespread clinical usage (Kostrubsky et al., 2000; Chitturi and George, 2002; Otto et al., 2002).”
BackgroundCoulson, S., Butt, H., Vecchio, P. C., Gramotnev, H., & Vitetta, L. (2012) · Inflammopharmacology · doi:10.1007/s10787-012-0146-4 · Cited by 86 · see citing works
“These patients, however, were taking a number of medications for hyperlipidaemia, hypertension, diabetes, gastric reflux and depression/anxiety that are known to elevate liver enzymes (Gillett and Norrell 2011; Chitturi and George 2002).”
BackgroundDo Preclinical Testing Strategies Help Predict Human Hepatotoxic Potentials?
Peters, T. S. (2005) · Toxicologic Pathology · doi:10.1080/01926230590522121 · Cited by 86 · see citing works
Efficacy and Tolerability of Meloxicam, a COX-2 Preferential Nonsteroidal Anti-Inflammatory Drug
Tacca, M. D., Colucci, R., Fornai, M., et al. (2002) · Clinical Drug Investigation · doi:10.2165/00044011-200222120-00001 · Cited by 85 · see citing works
Atasoy, N., Erdoğan, A., Yaluğ, İ., Öztürk, Ü. A., Konuk, N., Atik, L., & Üstündağ, Y. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.05.005 · Cited by 82 · see citing works
Gotto, A. M. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.6.657 · Cited by 75 · see citing works
Hepatotoxicity associated with non-steroidal anti-inflammatory drugs
Teoh, N., & Farrell, G. C. (2003) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00022-9 · Cited by 71 · see citing works
Ozer, J. S., Chetty, R., Kenna, J. G., Palandra, J., Zhang, Y., Lanevschi, A., Koppiker, N., Souberbielle, B. E., & Ramaiah, S. K. (2009) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2009.11.001 · Cited by 69 · see citing works
“Of par- ticular concern was the late onset of idiosyncratic DILI after start of troglitazone dosing (average of four months) and progression of liver injury despite discontinuation of drug (Chitturi and George, 2002).”
BackgroundInfluentialMolecular targets of statins and their potential side effects: Not all the glitter is gold
Patel, K. K., Sehgal, V. S., & Kashfi, K. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174906 · Cited by 73 · see citing works
Risk of acute liver injury associated with the use of drugs: a multicentre population survey
Sabaté, M., Ibáñez, L., Pérez, E., Vidal, X., Buti, M., Xiol, X., Mas, A., Guarner, C., Forné, M., Sola, R. L., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03338.x · Cited by 66 · see citing works
Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4
Zhou, S.-F., Chan, E., Li, X., & Huang, M. (2005) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.1.1.3.53600 · Cited by 67 · see citing works
“The formation of drug-CYP3A adducts may thus be either nontoxic, or rarely fatal, depending on the drugs, the kinetics of adduct formation and degradation, other affected target proteins and organs, and the pathological conditions of the patients (Chitturi and George 2002).”
Metabolic Syndrome and Bipolar Disorder: What Should Psychiatrists Know?
de Almeida, K. M., Moreira, C. L. R. L., & Lafer, B. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2011.00240.x · Cited by 64 · see citing works
“However, caution is warranted regarding liver toxicity resulting from concurrent use of medications that have been occasionally implicated in liver injury, that is, some antidiabetics, antihypertensives, statins, and anticonvulsants commonly used in the treatment of BD [90].”
BackgroundSpecificity of transaminase activities in the prediction of drug-induced hepatotoxicity
Kobayashi, A., Suzuki, Y., & Sugai, S. (2020) · The Journal of Toxicological Sciences · doi:10.2131/jts.45.515 · Cited by 68 · see citing works
Mechanisms of the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes
Abdoli, N., Heidari, R., Azarmi, Y., & Eghbal, M. A. (2013) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21485 · Cited by 65 · see citing works
Quinazolino–benzothiazoles: Fused pharmacophores as anticonvulsant agents
Ugale, V. G., Patel, H., Wadodkar, S. G., et al. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.03.045 · Cited by 61 · see citing works
Ramos‐Casals, M., Sánchez-Tapias, J. M., Parés, A. R., et al. (2006) · PubMed · Cited by 59 · see citing works
Difficulty with diagnosis of malignant pancreatic neoplasms coexisting with chronic pancreatitis
Leung, T.-K. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i32.4931 · Cited by 59 · see citing works
“Although TGZ has been withdrawn from the marked increase because of its severe hepatotoxicity[ 30 ], it is still currently used in animal models or in cell culture systems, to establish a ‘proof of concept’ that may be expanded to other drugs of the same class, such as rosiglitazone or pioglitazone[31,32].”
BackgroundCastellino, S. M., Muir, A. J., Shah, A. J., et al. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22265 · Cited by 58 · see citing works
“[61–64] Standard behavioral recommendations include abstinence from alcohol use and immunization against hepatitis A and B if immunity is not established.”
MethodClarifying metformin's role and risks in liver dysfunction
Brackett, C. C. (2010) · Journal of the American Pharmacists Association · doi:10.1331/japha.2010.08090 · Cited by 58 · see citing works
Sirolimus-Associated Hepatotoxicity in Liver Transplantation
Neff, G. W., Ruiz, P., Madariaga, J. R., et al. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1e165 · Cited by 57 · see citing works
Yamamoto, T., Kikkawa, R., Yamada, H., et al. (2006) · The Journal of Toxicological Sciences · doi:10.2131/jts.31.49 · Cited by 56 · see citing works
The treatment of diabetes mellitus of patients with chronic liver disease
García‐Compeán, D., González, J. A., Lavalle-Gonzalez, F. J., González-Moreno, E. I., Maldonado-Garza, H. J., & Villarreal‐Pérez, J. Z. (2015) · Annals of Hepatology · doi:10.5604/16652681.1171746 · Cited by 56 · see citing works
Ibuprofen-induced hypersensitivity syndrome
Nanau, R. M., & Neuman, M. G. (2010) · Translational research · doi:10.1016/j.trsl.2010.01.005 · Cited by 55 · see citing works
Separation and detection methods for covalent drug–protein adducts
Zhou, S. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00399-4 · Cited by 52 · see citing works
Wen, B., & Zhou, M. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.05.014 · Cited by 52 · see citing works
Nadanaciva, S., Aleo, M. D., Strock, C. J., Stedman, D. B., Wang, H., & Will, Y. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.06.019 · Cited by 52 · see citing works
The Effect of Antiepileptic Drugs on Mitochondrial Activity: A Pilot Study
Berger, I., Segal, I., Shmueli, D., & Saada, A. (2010) · Journal of Child Neurology · doi:10.1177/0883073809352888 · Cited by 51 · see citing works
Weisberg, S. P., Leibel, R. L., & Tortoriello, D. V. (2016) · Nutrition and Diabetes · doi:10.1038/nutd.2016.13 · Cited by 48 · see citing works
Kristiansen, M., Leandro, C., Ordway, D. J., Martins, M., Viveiros, M., Pacheco, T., Molnar, J. A., Kristiansen, J. E., & Amaral, L. (2006) · PubMed · Cited by 51 · see citing works
Leone, A. M., Nie, A. Y., Parker, J. B., Sawant, S. P., Piechta, L.-A., Kelley, M. F., Kao, L. M., Proctor, S. J., Verheyen, G. R., Johnson, M. D., et al. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.01.017 · Cited by 50 · see citing works
Lü, W., Cheng, F., Jiang, J., Zhang, C., Deng, X., Xu, Z., Zou, S., Shen, X., Tang, Y., & Huang, J. Y. (2015) · Scientific Reports · doi:10.1038/srep08114 · Cited by 46 · see citing works
Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model
Geyikoğlu, F., Yilmaz, E. G., Erol, H. S., Koç, K., Çeriğ, S., Özek, N. Ş., & Aysin, F. (2018) · Annals of Hepatology · doi:10.5604/01.3001.0012.7198 · Cited by 45 · see citing works
Singh, R., Elipe, M. V. S., Pearson, P. G., et al. (2003) · Chemical Research in Toxicology · doi:10.1021/tx025635l · Cited by 43 · see citing works
Gonzalez–Heydrich, J., Raches, D., Wilens, T. E., Leichtner, A. M., & Mezzacappa, E. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200310000-00014 · Cited by 43 · see citing works
Monitoring drug–protein interaction
Yang, X.-X., Hu, Z., Chan, S. Y., & Zhou, S.-F. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.08.021 · Cited by 43 · see citing works
Kamp, H., Fabian, E. J., Groeters, S., Herold, M. J., Krennrich, G., Looser, R., Mattes, W. B., Mellert, W., Prokoudine, A., Ruiz-Noppinger, P., et al. (2012) · Bioanalysis · doi:10.4155/bio.12.214 · Cited by 42 · see citing works
Safety of Anti-Tumor Necrosis Factor Therapies in Arthritis Patients
Nanau, R. M., & Neuman, M. G. (2014) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3wp4f · Cited by 41 · see citing works
Application of mechanism-based CYP inhibition for predicting drug–drug interactions
Zhou, Z.-W., & Zhou, S.-F. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250902926099 · Cited by 43 · see citing works
Bellmann, R., Feistritzer, C., Zoller, H., Graziadei, I. W., Schwaighofer, H., Propst, A., Wiedermann, C. J., & Joannidis, M. (2004) · ASAIO Journal · doi:10.1097/01.mat.0000132552.58214.00 · Cited by 41 · see citing works
Risperidone and liver function tests in children and adolescents: A short-term prospective study
Erdoğan, A., Atasoy, N., Akkurt, H., Ozturk, D., Karaahmet, E., Yaluğ, İ., Yaluğ, K., Ankaralı, H. Ç., & Balcıoğlu, İ. C. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.12.032 · Cited by 38 · see citing works
Pharmacokinetic Changes of Psychotropic Drugs in Patients with Liver Disease
Schlatter, C., Egger, S. S., Tchambaz, L., & Krähenbühl, S. (2009) · Drug Safety · doi:10.2165/00002018-200932070-00003 · Cited by 38 · see citing works
Martín-Castillo, A. M., Castells, M. T., Adánez, G., et al. (2009) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2009.06.003 · Cited by 37 · see citing works
Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities
McLaren, K., & Marangell, L. B. (2004) · Annals of General Hospital Psychiatry · doi:10.1186/1475-2832-3-7 · Cited by 36 · see citing works
Gura, K. M., Strijbosch, R., Arnold, S., McPherson, C. C., & Puder, M. (2007) · Nutrition in Clinical Practice · doi:10.1177/0115426507022006664 · Cited by 32 · see citing works
A Case of Drug-induced Hepatic Injury Associated with Sitagliptin
Toyoda-Akui, M., Yokomori, H., Kaneko, F., et al. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.5057 · Cited by 32 · see citing works
“Patients with type II diabetes mellitus have a high incidence of nonalcoholic fatty liver disease, and several antidiabetic agents such as acarbose, gliclazide, and metformin have been associated with drug-induced liver injury (12).”
BackgroundSaadi, T., Baruch, Waterman, & Yassin, H. (2013) · International Journal of General Medicine · doi:10.2147/ijgm.s49657 · Cited by 31 · see citing works
Ritschel, T., Hermans, S. M. A., Schreurs, M., van den Heuvel, J. J. M. W., Koenderink, J. B., Greupink, R., & Rüssel, F. G. M. (2014) · Chemical Research in Toxicology · doi:10.1021/tx5000393 · Cited by 30 · see citing works
Die PRISCUS-Liste im klinischen Test
Siebert, S., Elkeles, B., Hempel, G., Kruse, J., & Smollich, M. (2012) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-012-0324-4 · Cited by 32 · see citing works
“Dies erscheint zweifelhaft, da die bei geriatrischen Patienten häufige Nieren- oder Leberinsuffizienz eine Kontraindikation für sämtliche NSAR darstellt [5, 11].”
Background
- Authors
- Chitturi, S., & George, J.
- Affiliations
- The University of Sydney (AU)
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 2002-05-16
- Volume
- 22
- Issue
- 02
- Pages
- 169-184
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W1996604226
- Cited by
- 216
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 14 · 2014: 8 · 2013: 10 · 2012: 10
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- drug-induced liver injury, hepatotoxicity, adverse drug reactions, nonsteroidal anti-inflammatory drugs, COX-2 inhibitors, antihypertensive drugs, angiotensin receptor blockers, ACE inhibitors, methyldopa, antidiabetic drugs, thiazolidinediones, troglitazone, statins, antiepileptic drugs, L-carnitine, selective serotonin reuptake inhibitors, psychotropic drugs, hepatitis C
- MeSH terms
- Adult, Anti-Inflammatory Agents, Non-Steroidal, Anticonvulsants, Antihypertensive Agents, Hypolipidemic Agents, Child, Cholestasis, Humans, Hypoglycemic Agents, Liver, Psychotropic Drugs, Liver Failure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
