Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection
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AIM: To address to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. METHODS: The ability of the liver to regenerate is remarkable on both clinical and biological grounds. Basic mechanisms underlying this process have been intensively investigated. However, it is still debated to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. We addressed this issue using a genetically tagged system. We were able to follow the fate of single transplanted hepatocytes during the regenerative response elicited by 2/3 partial surgical hepatectomy (PH) in rats. Clusters of transplanted cells were 3D reconstructed and their size distribution was evaluated over time after PH. RESULTS: = 0.11). A sizeable fraction of the remnant hepatocyte population does not participate actively in tissue mass restoration. CONCLUSION: Hyperplasia stands as the major mechanism contributing to liver mass restoration after PH, with hypertrophy playing a transient role in the process.
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Hepatocyte hyperplasia is generally accepted as the dominant mechanism restoring liver mass after partial hepatectomy, with hypertrophy playing a supportive or transient role.
“However, hepatocyte hyperplasia is generally accepted as the dominant mechanism restoring liver mass after PH, with hypertrophy playing a supportive or transient role[8].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [8]
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- Authors
- Marongiu, F., Marongiu, M., Contini, A., Serra, M., Cadoni, E., Murgia, R., & Laconi, E.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Marongiu, Fabio
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2017
- Volume
- 23
- Issue
- 10
- Pages
- 1764
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC5352916
- OpenAlex
- W2596020506
- Cited by
- 24
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 1 · 2018: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
- Funders
- Università degli Studi di Cagliari
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, hepatocyte hyperplasia, hepatocyte hypertrophy, partial hepatectomy, hepatocyte transplantation, cell size distribution
- MeSH terms
- Animals, Cell Cycle, Hepatectomy, Hyperplasia, Hypertrophy, Liver, Liver Regeneration, Rats, Inbred F344, Hepatocytes, Models, Animal, Cell Size, Rats
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