Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis
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AIMTo perform a systematic review and meta-analysis on proton pump inhibitors (PPIs) therapy and the risk of Clostridium difficile infection (CDI). METHODSWe conducted a systematic search of MEDLINE/ PubMed and seven other databases through January 1990 to March 2017 for published studies that evaluated the association between PPIs and CDI.Adult case-control and cohort studies providing information on the association between PPI therapy and the development of CDI were included.Pooled odds ratios (ORs) estimates with 95% confidence intervals (CIs) were calculated using the random effect.Heterogeneity was assessed by I 2 test and Cochran's Q statistic.
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PPIs can influence the onset of enteric infections, resulting in an increased risk of Clostridium difficile infection (CDI), as well as Salmonella, Campylobacter and diarrheagenic Escherichia coli.
“PPIs can influence the onset of enteric infections, resulting in an increased risk of Clostridium difficile infection (CDI), as well as Salmonella, Campylobacter and diarrheagenic Escherichia coli (E. coli)[110-113].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [111]
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Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
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Macke, L., Schulz, C., Koletzko, L., & Malfertheiner, P. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15604 · Cited by 118 · see citing works
Dumitru, C. N., Dumitru, A. O., Goroftei, L., Niculet, E., Ignat, M. D., Baroiu, L., Nechita, A., & Balan, G. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060651 · Cited by 4 · see citing works
- Authors
- Trifan, A., Stanciu, C., Girleanu, I., Stoica, O. C., Singeap, A. M., Maxim, R., Chiriac, S. A., Ciobica, A., & Boiculese, L.
- Affiliations
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi (RO)
- Alexandru Ioan Cuza University (RO)
- ORCID
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2017-09-21
- Volume
- 23
- Issue
- 35
- Pages
- 6500-6515
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC5643276
- OpenAlex
- W2759589333
- Cited by
- 286
- References
- 148
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 44 · 2023: 27 · 2022: 33 · 2021: 30 · 2020: 56 · 2019: 35 · 2018: 10 · 2017: 1
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- proton pump inhibitors, Clostridium difficile infection, drug-induced infection risk, gastric acid suppression, antibiotic-associated diarrhea
- MeSH terms
- Adult, Clostridium Infections, Gastrointestinal Diseases, Humans, Prospective Studies, Risk Factors, Incidence, Clostridioides difficile, Proton Pump Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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