Cited by 337Probiotics and Fermented FoodsInflammatory Bowel DiseaseGut microbiota and health

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Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives

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Roy, Supriya, Dhaneshwar, Suneela·2023·World Journal of Gastroenterology

DOI 10.3748/wjg.v29.i14.2078PMC PMC10130969

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Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal (GI) tract with dysregulated mucosal immune functions and disturbed commensal ecosystem of the intestinal lumen.IBD is categorized into two major subsets: Crohn's disease (CD) and ulcerative colitis (UC).Though advent of biologics has shifted the treatment with relatively longer remission compared to small molecule pharmaceuticals, patients still suffer from long-term complications.Since gutmicrobiome is now accepted as another human organ holding potential for long-lasting human health, probiotics, and its engineering hold great promises to treat several previously untreatable chronic inflammatory conditions including IBD.Several emerging biological engineering tools have unlimited potential to manipulate probiotic bacterial system.These can produce useful therapeutic biologics with a goal to either ameliorate and/or treat previously untreatable chronic inflammatory conditions.As gut-microbiome is diverse and vary in different ethnic, geographic, and cultural human population, it will be important to develop vision for personalized probiotic treatment and develop the technology thereof to make personalized probiotic options a reality.The aim of this review paper is to present an overview of the current knowledge on both pharmacological and nonpharmacological IBD treatment modalities with a special emphasis on probiotic strains that are developed through the probiotic engineering.These engineered probiotics contain the most anti-inflammatory cytokines found within the human immune response and are currently being used to treat the intestinal inflammation in IBD for the IBD treatment.

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Figure 1 Comparison between normal microbiome and dysbiosis.CC BY-NC · PubMed Central

Figure 2 Role of dysbiosis in inflammatory bowel disease pathophysiology. SCFA: Short chain fatty acids; Tregs: Regulatory T cells; ROS: Reactive oxygen species.CC BY-NC · PubMed Central

Figure 3 Dysbiosis in inflammatory bowel disease and its pathological outcomes. IBD: Inflammatory bowel disease; SCFA: Short chain fatty acids.CC BY-NC · PubMed Central

Figure 4 Various actions of probiotics. IL-10: Interleukin-10; TGF-β: Transforming growth factor-β; TNF-α: Tumor necrosis factor-alpha.CC BY-NC · PubMed Central

Figure 5 The mechanism of actions of probiotics in combating inflammatory bowel disease symptoms. IBD: Inflammatory bowel disease.CC BY-NC · PubMed Central

Figure 6 Mechanisms of action of probiotics, prebiotics, and synbiotics. SCFA: Short chain fatty acids; IBD: Inflammatory bowel disease.CC BY-NC · PubMed Central

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10.21203/rs.3.rs-1742266/v1 · DOI

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See all 337

Authors: Roy, S., & Dhaneshwar, S.
Affiliations: Amity University (IN)
Amity University Mumbai (IN)
ORCID: Roy, Supriya
Dhaneshwar, Suneela
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2023-04-14
Volume: 29
Issue: 14
Pages: 2078-2100
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v29.i14.2078
PMC: PMC10130969
OpenAlex: W4365152756
Cited by: 334
References: 100
Citations by year: 2026: 91 · 2025: 125 · 2024: 95 · 2023: 23
FWCI: 7.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, probiotics, prebiotics, synbiotics, gut microbiota, probiotic engineering, engineered probiotics, anti-inflammatory cytokines, intestinal inflammation, mucosal immunity
MeSH terms: Humans, Inflammation, Inflammatory Bowel Diseases, Probiotics, Prebiotics, Synbiotics, Microbiota

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Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives

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