Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double‐blinded, placebo‐controlled multicenter trial
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BACKGROUND AND AIM: We conducted a randomized, double-blinded, placebo-controlled trial to investigate the efficacy of Bifidobacterium longum 536 (BB536) supplementation for induction of remission in Japanese patients with active ulcerative colitis (UC). METHODS: Fifty-six patients with mild to moderate UC were enrolled. Three patients had pancolitis, 36 had left-sided colitis, and 17 had proctitis. Patients were randomly treated with 2-3 × 10(11) freeze-dried viable BB536 (28 patients) or placebo (28 patients) for 8 weeks. RESULTS: In total, 63% of patients receiving BB536 showed clinical remission (UC disease activity index [UCDAI] ≤2) at week 8 compared to 52% of those receiving placebo (P = 0.395). We observed a significant decrease of UCDAI scores (3.8 ± 0.4 at baseline to 2.6 ± 0.4 at week 8) in the BB536 group (P < 0.01), whereas there was no significant decrease in the placebo group (P = 0.88). There was also a significant decrease in the Rachmilewitz endoscopic index (EI) and the Mayo subscore at week 8 in the BB536 group, whereas there was no significant decrease in the placebo group. A single patient in the BB536 group complained of a mild side-effect, but no other adverse effects were observed. CONCLUSION: Supplementation with BB536 was well tolerated and reduced UCDAI scores, EI and Mayo subscores after 8 weeks in Japanese patients with mild to moderately active UC.
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B. longum 536 alleviates the symptoms of patients with mild to moderately active UC.
“B. longum 536 alleviates the symptoms of patients with mild to moderately active UC (139).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [139]
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- Authors
- Tamaki, H., Nakase, H., Inoue, S., Kawanami, C., Itani, T., Ohana, M., Kusaka, T., Uose, S., Hisatsune, H., Tojo, M., Noda, T., Arasawa, S., Izuta, M., Kubo, A., Ogawa, C., Matsunaka, T., & Shibatouge, M.
- Affiliations
- Takamatsu Red Cross Hospital (JP)
- Kyoto University (JP)
- Kobe Medical Center (JP)
- Tenri Hospital (JP)
- Kyoto Katsura Hospital (JP)
- Kansai Electric Power Hospital (JP)
- Saiseikai Noe Hospital (JP)
- Otsu Red Cross Hospital (JP)
- Department of Gastroenterology Takamatsu Red Cross Hospital Takamatsu Japan
- Corresponding author
- Tamaki, Hiroyuki
- Venue
- Digestive Endoscopy
- Publisher
- Wiley
- Published
- 2015-11-02
- Volume
- 28
- Issue
- 1
- Pages
- 67-74
- ISSN
- 0915-5635 (ISSN-L)
- 1443-1661
- OpenAlex
- W1903258410
- Cited by
- 214
- References
- 22
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 34 · 2023: 36 · 2022: 29 · 2021: 21 · 2020: 20 · 2019: 17 · 2018: 15 · 2017: 9 · 2016: 4
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Digestive Endoscopy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26893122, 90941, 26460967, 25860532)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, ulcerative colitis, remission induction, Japanese patients, probiotic supplementation
- MeSH terms
- Administration, Oral, Adult, Bifidobacterium, Colitis, Ulcerative, Colonoscopy, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Remission Induction, Retrospective Studies, Time Factors, Treatment Outcome, Probiotics
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