The effects of prolonged handling, scopolamine, and physostigmine on the activity of isolated and socially reared rats
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In adolescent rodents, even brief isolation (e.g., 24 h) can cause increased anxiety, hyperactivity, heightened sensitivity to social rewards, and increased seeking of food or drug rewards, making them prone to addictions.
“On a behavioural level, even a brief duration (eg, 24 h) of isolation in adolescent rodents can cause increased anxiety,40 hyperactivity,41 and heightened sensitivity to social rewards,42 which extends to the seeking of food or drug rewards, making these animals particularly prone to developing addictions.43”
From The effects of social deprivation on adolescent development and mental health (2020) · cites this paper as [41]
Citation 41 is attached to the hyperactivity claim. The Discussion reports significantly higher locomotor activity in isolation-reared rats than in socially reared rats. However, the Rearing Conditions and subsequent discussion indicate 53 days of differential rearing before testing at 75 days of age, not an effect of 24 hours of isolation in adolescent rodents. (LLM, conf=0.90)
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- Authors
- Morley, B. J., & Worsham, E.
- Affiliations
- University of Alabama (US)
- Rutgers, The State University of New Jersey (US)
- ORCID
- Morley, Barbara J.
- Venue
- Physiological Psychology
- Published
- 1978-03
- Volume
- 6
- Issue
- 1
- Pages
- 83-88
- ISSN
- 0090-5046 (ISSN-L)
- OpenAlex
- W2045285107
- Cited by
- 13
- References
- 24
- Citations by year
- 2026: 1 · 2021: 2 · 2020: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Physiological Psychology (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social isolation, rearing density, tactile stimulation, handling, scopolamine, physostigmine, locomotor activity, social environment, rats
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