The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophrenia
Open accessAbstract
Background: Antiviral therapy for chronic infection with HCV is associated with significant neuropsychiatric side effects. Research indicates that patients with mental illness are less likely to receive antiviral therapy, despite limited data regarding the influence of antiviral therapy on psychiatric symptoms in patients with specific psychiatric disorders. The aim of this study was to determine whether antiviral therapy is associated with higher rates of psychiatric symptoms in patients with schizophrenia (SCHZ). Methods: A regional Veterans Healthcare Administration database was used to identify veterans meeting criteria for this retrospective chart review. Patients confirmed to have SCHZ and to have received antiviral therapy for HCV between 1998 and 2006 ( n=30) were compared with a control group of demographically matched (age, race and gender) patients with SCHZ who did not receive antiviral therapy ( n=30). Clinicians blinded to antiviral therapy status used chart notes to evaluate whether patients exhibited prominent symptoms of SCHZ, depression or mania during a 6 month pre-treatment period, the treatment period and a 6 month post-treatment period (or during equivalent periods for the control group). Results: Groups did not significantly differ in rates of symptoms of SCHZ, depression or mania during any study period. During the treatment period, groups did not significantly differ in rates of emergency room visits or inpatient hospitalizations. Conclusions: Our retrospective chart review suggests that patients with SCHZ experience similar rates of psychiatric symptoms on and off antiviral therapy. Despite limitations and constraints of the methods, our data suggest that SCHZ is not a contraindication to antiviral therapy for HCV.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Today, respiratory diseases are still more prevalent in people with SMI.
“Today, respiratory diseases are still more prevalent in people with SMI (8,(410)(411)(412)(413)(414)(415)(416)(417).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [412]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness
(2001) · American Journal of Public Health · doi:10.2105/ajph.91.1.31 · Cited by 589 · see citing works
Elevated prevalence of hepatitis C infection in users of United States veterans medical centers
Dominitz, J. A., Boyko, E. J., Koepsell, T. D., Heagerty, P. J., Maynard, C. C., & Sporleder, J. L. (2005) · Hepatology · doi:10.1002/hep.20502 · Cited by 209 · see citing works
Appendix: The National Institutes of Health Consensus Development Conference
Seeff, L. B., & Hoofnagle, J. H. (2003) · Clinics in Liver Disease · doi:10.1016/s1089-3261(02)00078-8 · Cited by 174 · see citing works
Rate and predictors of treatment prescription for hepatitis C
Butt, A. A., Justice, A. C., Skanderson, M., Rigsby, M. O., Good, C. B., & Kwoh, C. K. (2006) · Gut · doi:10.1136/gut.2006.099150 · Cited by 151 · see citing works
Ho, S. B., Nguyen, H. A., Tetrick, L. L., Opitz, G., Basara, M. L., & Dieperink, E. W. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03468.x · Cited by 103 · see citing works
Psychiatric and Substance Use Disorders in Individuals with Hepatitis C: Epidemiology and Management
Loftis, J. M., Matthews, A. M., & Hauser, P. (2006) · Drugs · doi:10.2165/00003495-200666020-00003 · Cited by 86 · see citing works
Self-citationOsher, F. C., Goldberg, R. W., McNary, S. W., Swartz, M. S., Essock, S. M., Butterfield, M. I., & Rosenberg, S. D. (2003) · Psychiatric Services · doi:10.1176/appi.ps.54.6.842 · Cited by 67 · see citing works
Rowan, P. J., Tavakoli–Tabasi, S., Abdul-latif, M., Kunik, M. E., & El‐Serag, H. B. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000123203.36471.70 · Cited by 65 · see citing works
The STIRR Model of Best Practices for Blood-Borne Diseases Among Clients With Serious Mental Illness
Rosenberg, S., Brunette, M., Oxman, T., Marsh, B., Dietrich, A., Mueser, K., Drake, R., Torrey, W., & Vidaver, R. (2004) · Psychiatric Services · doi:10.1176/appi.ps.55.6.660 · Cited by 41 · see citing works
Hepatitis C Treatment for People With Severe Mental Illness
Mistler, L. A., Brunette, M. F., Marsh, B. J., Vidaver, R. M., Luckoor, R., & Rosenberg, S. D. (2006) · Psychosomatics · doi:10.1176/appi.psy.47.2.93 · Cited by 39 · see citing works
Management of Hepatitis C Disease Among VA Patients With Schizophrenia and Substance Use Disorders
Huckans, M. S., Blackwell, A. D., Harms, T. A., & Hauser, P. (2006) · Psychiatric Services · doi:10.1176/appi.ps.57.3.403 · Cited by 35 · see citing works
Self-citationChainuvati, S. P., Khalid, S., Kancir, S., Shea, M. C., Edwards, J. W., Sernyak, M. J., Wongcharatrawee, S., & García–Tsao, G. (2005) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00681.x · Cited by 33 · see citing works
Huckans, M. S., Mitchell, A., Ruimy, S., Loftis, J. M., & Hauser, P. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn065 · Cited by 27 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [9]Diagnostic and statistical manual of mental disorders 2000 American Psychiatric Association Arlington, VA Fourth Edition, Text Revision ed.
Cited by
Sorted by citations
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488 · see citing works
Individualisation of antiviral therapy for chronic hepatitis C
Teoh, N., Farrell, G. C., & Chan, H. L. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06392.x · Cited by 20 · see citing works
Hauser, P. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i15.1921 · Cited by 18 · see citing works
Self-citationInfluence of Healthcare-Associated Factors on the Efficacy of Hepatitis C Therapy
Daw, M. A., Dau, A. A., & Agnan, M. M. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/580216 · Cited by 17 · see citing works
Barriers to receiving hepatitis C treatment for people who inject drugs: Myths and evidence.
Higgs, P., Sacks‐Davis, R., Gold, J., & Hellard, M. E. (2011) · Europe PMC (PubMed Central) · Cited by 17 · see citing works
Wu, J. Y. J., Shadbolt, B., Teoh, N., Blunn, A., To, C., Rodriguez‐Morales, I., Chitturi, S., Kaye, G., Rodrigo, K., & Farrell, G. C. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12515 · Cited by 14 · see citing works
Depression and pegylated interferon-based hepatitis C treatment
Papafragkakis, H., Rao, M. S., Moehlen, M., Dhillon, S., & Martin, P. (2012) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s28901 · Cited by 10 · see citing works
Determining rates of hepatitis C in a clozapine treated cohort
Sockalingam, S., Shammi, C., Powell, V., Barker, L. C., & Remington, G. J. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.06.005 · Cited by 11 · see citing works
Hepatitis C–associated late-onset schizophrenia: a nationwide, population-based cohort study
Cheng, J., Hu, J., Chang, M., Lin, M., Ku, H., Chien, R., & Chang, M. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.200154 · Cited by 10 · see citing works
Kosikowska, U., Biernasiuk, A., Korona‐Głowniak, I., Kiciak, S., Tomasiewicz, K., & Malm, A. (2016) · Medical Science Monitor · doi:10.12659/msm.895544 · Cited by 7 · see citing works
The efficacy and safety of treating hepatitis C in patients with a diagnosis of schizophrenia
Mustafa, M. Z., Schofield, J., Mills, P. R., Priest, M., Fox, R., Datta, S., Morris, J., Forrest, E. H., Gillespie, R., Stanley, A. J., et al. (2014) · Journal of Viral Hepatitis · doi:10.1111/jvh.12234 · Cited by 6 · see citing works
Vats, A., Nair, A. R., Bandhu, A. K., Koirala, D., Pallapothu, M. R., Mariñez, M. G. Q., Chakkera, M., Ravi, N., Ramaraju, R., & Francini, A. (2023) · Cureus · doi:10.7759/cureus.34234 · Cited by 5 · see citing works
Utilizing genomic polymorphisms to personalize hepatitis C therapies
Rifai, M. A., & Sabouni, M. A. (2012) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e328351093b · Cited by 5 · see citing works
Self-citationSaitou, Y., Aonuma, H., Ichihashi, T., Kawamoto, F., Shimoyama, T., Kimura, A., Oku, K., Kawaguchi, S., Saitou, S., & Saitou, J. (2013) · Kanzo · doi:10.2957/kanzo.54.214 · Cited by 1 · see citing works
Management of Comorbid Medical Conditions in Schizophrenia
Rado, J. T. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0656-7_10
Maj, M., Ïðåçèäåíò, È., Tasman, A., & Herrman, H. (2011)
Wang, M. Y.-H., Tang, C., Tsai, S., Liu, C., & Wu, C. (2017) · Journal of Psychology and Psychiatry · doi:10.15761/jpp.1000102
Medical social factors affecting the effectiveness of the treatment of viral hepatitis patients
Raduto, O. I. (2014) · Epidemiology and Infectious Diseases · doi:10.17816/eid40836
- Authors
- Huckans, M., Mitchell, A., Pavawalla, S., Morasco, B. J., Ruimy, S., Loftis, J. M., Rifai, M. A., & Hauser, P.
- Affiliations
- Oregon Health & Science University (US)
- Portland VA Medical Center (US)
- Lehigh Valley Hospital (US)
- Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, OR, USA
- Corresponding author
- Huckans, Marilyn
- Venue
- Antiviral Therapy
- Publisher
- SAGE Publications
- Published
- 2010-01
- Volume
- 15
- Issue
- 1
- Pages
- 111-119
- ISSN
- 1359-6535 (ISSN-L)
- 2040-2058
- PMC
- PMC2998439
- OpenAlex
- W2072091903
- Cited by
- 18
- References
- 12
- Citations by year
- 2023: 1 · 2021: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antiviral Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K23DA023467)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- hepatitis C, schizophrenia, psychiatric symptoms, neuropsychiatric adverse effects, depression, mania, veterans
- MeSH terms
- Adult, Antiviral Agents, Bipolar Disorder, Depression, Female, Hospitalization, Humans, Male, Middle Aged, Retrospective Studies, Schizophrenia, Hepacivirus, Treatment Refusal, Outcome Assessment, Health Care, Hepatitis C, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
