Cited by 425Angiogenesis and VEGF in CancerFibroblast Growth Factor ResearchPregnancy and preeclampsia studies

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

The discovery of placenta growth factor and its biological activity

Open access

De Falco, Sandro·2012·Experimental and Molecular Medicine

DOI 10.3858/emm.2012.44.1.025PMC PMC3277892

Open this paper in CoChat — free account Open PDF

Abstract

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis, diabetic retinopathy and age-related macular degeneration. Among the several molecular players involved in angiogenesis, some members of VEGF family, VEGF-A, VEGF-B and placenta growth factor (PlGF), and the related receptors VEGF receptor 1 (VEGFR-1, also known as Flt-1) and VEGF receptor 2 (VEGFR-2, also known as Flk-1 in mice and KDR in human) have a decisive role. In this review, we describe the discovery and molecular characteristics of PlGF, and discuss the biological role of this growth factor in physiological and pathological conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3858/emm.2012.44.1.025

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,090
The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
de Vries, C. J. M., Escobedo, J. A., Ueno, H., Houck, K. A., Ferrara, N., & Williams, L. T. (1992) · Science · doi:10.1126/science.1312256 · Cited by 2,019
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · cited 1×
“The main effectors of hypoxic stimulus are the transcriptional factors known as hypoxia inducible factors (HIFs) (Semenza, 1999).”
Background
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) · Nature Medicine · doi:10.1038/nm1101-1194 · Cited by 1,860
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., Mol, M. D., Wu, Y., Bono, F., Devy, L., Beck, H., et al. (2001) · Nature Medicine · doi:10.1038/87904 · Cited by 1,708
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D. S., Armellino, D. C., Gospodarowicz, D., & Böhlen, P. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90483-2 · Cited by 1,519
Macrophages, innate immunity and cancer: balance, tolerance, and diversity
Mantovani, A., & Sica, A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.009 · Cited by 1,484
Cardiac Hypertrophy: The Good, the Bad, and the Ugly
Frey, N., & Olson, E. N. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142243 · Cited by 1,480
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,194
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,186
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.
Park, J. E., Chen, H. H., Winer, J., Houck, K. A., & Ferrara, N. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47298-5 · Cited by 1,112
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Luttun, A., Tjwa, M., Moons, L., Wu, Y. L., Angelillo‐Scherrer, A., Liao, F., Nagy, J. A., Hooper, A. T., Priller, J., Klerck, B. D., et al. (2002) · Nature Medicine · doi:10.1038/nm731 · Cited by 1,076
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.
Maglione, D., Guerriero, V., Viglietto, G., Bovi, P. D., & Persico, M. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9267 · Cited by 998
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
Takahashi, H., & Shibuya, M. (2005) · Clinical Science · doi:10.1042/cs20040370 · Cited by 990
Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.
Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H. T., Donnini, S., Granger, H. J., & Bicknell, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119451 · Cited by 909
Signaling Pathways for Cardiac Hypertrophy and Failure
Hunter, J. J., & Chien, K. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910213411706 · Cited by 867
The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities
Clauss, M. A., Weich, H. A., Breier, G., Knies, U. E., Röckl, W., Waltenberger, J. L., & Risau, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17629 · Cited by 834
Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels
Fischer, C., Jonckx, B., Mazzone, M., Zacchigna, S., Loges, S., Pattarini, L., Chorianopoulos, E., Liesenborghs, L., Koch, M., Mol, M. D., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.038 · Cited by 780
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Autiero, M., Waltenberger, J. L., Communi, D., Kranz, A., Moons, L., Lambrechts, D., Krøll, J., Plaisance, S., Mol, M. D., Bono, F., et al. (2003) · Nature Medicine · doi:10.1038/nm884 · Cited by 775
HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF
Rolny, C., Mazzone, M., Tugues, S., Laoui, D., Johansson, I., Coulon, C., Squadrito, M. L., Segura, I., Li, X., Knevels, E., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.11.009 · Cited by 695
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment
Hattori, K., Heissig, B., Wu, Y. L., Dias, S., Tejada, R., Ferris, B., Hicklin, D. J., Zhu, Z., Böhlen, P., Witte, L., et al. (2002) · Nature Medicine · doi:10.1038/nm740 · Cited by 636
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
Kelly, B. D., Hackett, S. F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P. A., & Semenza, G. L. (2003) · Circulation Research · doi:10.1161/01.res.0000102937.50486.1b · Cited by 611
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
Fischer, C., Mazzone, M., Jonckx, B., & Carmeliet, P. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2524 · Cited by 582
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
Olofsson, B., Korpelainen, E., Pepper, M. S., Mandriota, S. J., Aase, K., Kumar, V., Gunji, Y., Jeltsch, M., Shibuya, M., Alitalo, K. K., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11709 · Cited by 559
Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors
Keyt, B. A., Nguyen, H. V., Berleau, L. T., Duarte, C. M., Park, J., Chen, H., & Ferrara, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5638 · Cited by 504
Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor
Wiesmann, C., Fuh, G., Christinger, H. W., Eigenbrot, C. W., Wells, J. A., & de Vos, A. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80456-0 · Cited by 494
Persico MG.Isolation of a human placenta cDNA coding for a potein related to the vascular premeability factor
Maglione, D. (1991) · Medical Entomology and Zoology · Cited by 352
Neuropilin-1 Is a Placenta Growth Factor-2 Receptor
Migdal, M., Huppertz, B., Tessler, S., Comforti, A., Shibuya, M., Reich, R., Baumann, H., & Neufeld, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22272 · Cited by 351
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
Yamakawa, M., Liu, L. X., Date, T., Belanger, A. J., Vincent, K. A., Akita, G. Y., Kuriyama, T., Cheng, S. H., Gregory, R. J., & Jiang, C. (2003) · Circulation Research · doi:10.1161/01.res.0000093984.48643.d7 · Cited by 327
Placental Growth Factor, a Member of the VEGF Family, Contributes to the Development of Choroidal Neovascularization
Rakic, J., Lambert, V., Devy, L., Luttun, A., Carmeliet, P., Claes, C., Nguyen, L., Foidart, J., Noël, A., & Munaut, C. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1092 · Cited by 321
VEGFR-1–Selective VEGF Homologue PlGF Is Arteriogenic
Pipp, F. C., Heil, M., Issbrücker, K., Ziegelhoeffer, T., Martin, S. M., van den Heuvel, J., Weich, H. A., Fernández, B., Golomb, G., Carmeliet, P., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000057997.77714.72 · Cited by 315
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.
Maglione, D., Guerriero, V., Viglietto, G., Ferraro, M. G., Aprelikova, O. N., Alitalo, K. K., Vecchio, S. D., Lei, K. J., Chou, J. Y., & Persico, M. G. (1993) · PubMed · Cited by 313
Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
Cao, Y. (2009) · Science Signaling · doi:10.1126/scisignal.259re1 · Cited by 296
Purification and Characterization of a Naturally Occurring Vascular Endothelial Growth Factor · Placenta Growth Factor Heterodimer
DiSalvo, J., BAYNE, M. L., Conn, G., Kwok, P., Trivedi, P. G., Soderman, D. D., Palisi, T. M., Sullivan, K. A., & Thomas, K. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7717 · Cited by 295
Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic.
Ziche, M., Maglione, D., Ribatti, D., Morbidelli, L., Lago, C. T., Battisti, M., Paoletti, I., Barra, A., Tucci, M., Parise, G., et al. (1997) · PubMed · Cited by 277
Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor
Selvaraj, S. K., Giri, R. K., Perelman, N., Johnson, C. S., Malik, P., & Kalra, V. K. (2003) · Blood · doi:10.1182/blood-2002-11-3423 · Cited by 268
Neuropilin-1 Binds Vascular Endothelial Growth Factor 165, Placenta Growth Factor-2, and Heparin via Its b1b2 Domain
Mamluk, R., Gechtman, Z., Kutcher, M., Gasiunas, N., Gallagher, J. T., & Klagsbrun, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200730200 · Cited by 261
Placenta Growth Factor
Persico, M. G. (2001) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-0213-4_16 · Cited by 260
Expression of Vascular Endothelial Growth Factor and Placenta Growth Factor in Human Placenta1
Vuorela, P., Hatva, E., Lymboussaki, A., Kaipainen, A., Joukov, V., Persico, M. G., Alitalo, K. K., & Halmesmäki, E. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.2.489 · Cited by 260
Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease
de Veire, S. V., Stalmans, I., Heindryckx, F., Oura, H., Tijeras‐Raballand, A., Schmidt, T., Loges, S., Albrecht, I., Jonckx, B., Vinckier, S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.039 · Cited by 255
A Heparin-Binding Form of Placenta Growth Factor (PlGF-2) is Expressed in Human Umbilical Vein Endothelial Cells and in Placenta
Hauser, S., & Weich, H. A. (1993) · Growth Factors · doi:10.3109/08977199308991586 · Cited by 245
The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 Å resolution: multiple copy flexibility and receptor binding
Muller, Y. A., Christinger, H. W., Keyt, B. A., & de Vos, A. M. (1997) · Structure · doi:10.1016/s0969-2126(97)00284-0 · Cited by 244
Placental growth factor is a survival factor for tumor endothelial cells and macrophages.
Adini, A., Kornaga, T., Firoozbakht, F., & Benjamin, L. E. (2002) · PubMed · Cited by 212
Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines.
Viglietto, G., Maglione, D., Rambaldi, A., Cerutti, J. M., Romano, A., Trapasso, F., Fedele, M., Ippolito, P., Chiappetta, G., & Botti, G. (1995) · PubMed · Cited by 208
Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability
Odorisio, T., Schietroma, C., Zaccaria, M. L., Cianfarani, F., Tiveron, C., Tatangelo, L., Failla, C. M., & Zambruno, G. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.12.2559 · Cited by 203
Modulation of Angiogenesis during Adipose Tissue Development in Murine Models of Obesity
Vörös, G., Maquoi, E., Demeulemeester, D., Clerx, N., Collen, D., & LIJNEN, H. R. (2005) · Endocrinology · doi:10.1210/en.2005-0532 · Cited by 203
Localisation of Placenta Growth Factor (PlGF) in Human Term Placenta
Khaliq, A., Li, X. F., Shams, M., Sisi, P., Acevedo, C. A., Whittle, M. J., Weigh, H., & Ahmed, A. (1996) · Growth Factors · doi:10.3109/08977199609003225 · Cited by 201
Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PlGF)
Persico, M. G., Vincenti, V., & DiPalma, T. (1999) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59953-8_2 · Cited by 199
Placenta Growth Factor: Identification and Characterization of a Novel Isoform Generated by RNA Alternative Splicing
Cao, Y., Ji, W.-R., Pang, Q., Rosin, Å., & Cao, Y. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6813 · Cited by 199
Placenta Growth Factor and Vascular Endothelial Growth Factor B and C Expression in Microvascular Endothelial Cells and Pericytes
Yonekura, H., Sakurai, S., Liu, X., Migita, H., Wang, H., Yamagishi, S., Nomura, M., Abedin, M. J., Unoki‐Kubota, H., Yamamoto, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35172 · Cited by 192
Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1.
Green, C. J., Lichtlen, P., Huynh, N., Yanovsky, M., Laderoute, K. R., Schaffner, W., & Murphy, B. J. (2001) · PubMed · Cited by 179
A critical role of placental growth factor in the induction of inflammation and edema formation
Oura, H., Bertoncini, J., Velasco, P., Brown, L. F., Carmeliet, P., & Detmar, M. J. (2002) · Blood · doi:10.1182/blood-2002-05-1516 · Cited by 175
Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
Maes, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26772 · Cited by 172
The Crystal Structure of Placental Growth Factor in Complex with Domain 2 of Vascular Endothelial Growth Factor Receptor-1
Christinger, H. W., Fuh, G., de Vos, A. M., & Wiesmann, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313237200 · Cited by 163
PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth
Bais, C., Wu, X., Yao, J. J., Yang, S., Crawford, Y., McCutcheon, K. M., Tan, C., Kolumam, G. A., Vernes, J.-M., Eastham‐Anderson, J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.033 · Cited by 159
Placental growth factor-1 and epithelial haemato–retinal barrier breakdown: potential implication in the pathogenesis of diabetic retinopathy
Miyamoto, N., de Kozak, Y., Jeanny, J., Glotin, A., Mascarelli, F., Massin, P., BenEzra, D., & Béhar‐Cohen, F. (2006) · Diabetologia · doi:10.1007/s00125-006-0539-2 · Cited by 152
Role of Class 3 Semaphorins and Their Receptors in Tumor Growth and Angiogenesis
Gaur, P., Bielenberg, D. R., Samuel, S., Bose, D., Zhou, Y., Gray, M. J., Dallas, N. A., Fan, F., Xia, L., Lu, J., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1810 · Cited by 151
TIMPs and cardiac remodeling: ‘Embracing the MMP-independent-side of the family’
Vanhoutte, D., & Heymans, S. R. B. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.09.013 · Cited by 150
Angiogenic Factors Reconstitute Hematopoiesis by Recruiting Stem Cells from Bone Marrow Microenvironment
Rafii, S., Avecilla, S. T., Shmelkov, S. V., Shido, K., Tejada, R., Moore, M. A. S., Heissig, B., & Hattori, K. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03232.x · Cited by 145
Placenta growth factor is over-expressed and has prognostic value in human breast cancer
Parr, C., Watkins, G., Boulton, M. E., Cai, J., & Jiang, W. G. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.07.022 · Cited by 137
Structure and Function of Placental Growth Factor
Falco, S. D. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(02)00168-8 · Cited by 135
Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.
Arrick, B. A., Lee, A. L., Grendell, R. L., & Derynck, R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.9.4306 · Cited by 131
Placenta growth factor expression is correlated with survival of patients with colorectal cancer
Wei, S.-C. (2005) · Gut · doi:10.1136/gut.2004.050831 · Cited by 111
The Crystal Structure of Human Placenta Growth Factor-1 (PlGF-1), an Angiogenic Protein, at 2.0 Å Resolution
Iyer, S., Leonidas, D. D., Swaminathan, G. J., Maglione, D., Battisti, M., Tucci, M., Persico, M. G., & Acharya, K. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008055200 · Cited by 110
Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells
Yang, W., Ahn, H., Hinrichs, M., Torry, R. J., & Torry, D. S. (2003) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(03)00082-2 · Cited by 102
Measurement of Phosphorylated Extracellular Signal–Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology
Hay, D. L. (2009) · Science Signaling · doi:10.1126/scisignal.262tr1 · Cited by 101
Impaired Adipose Tissue Development in Mice With Inactivation of Placental Growth Factor Function
LIJNEN, H. R., Christiaens, V., Scroyen, I., Vörös, G., Tjwa, M., Carmeliet, P., & Collen, D. (2006) · Diabetes · doi:10.2337/db06-0526 · Cited by 100
Tumor Necrosis Factor-α–Converting Enzyme Is a Key Regulator of Agonist-Induced Cardiac Hypertrophy and Fibrosis
Wang, X., Oka, T., Chow, F. L., Cooper, S., Odenbach, J., Lopaschuk, G. D., Kassiri, Z., & Fernández-Patrón, C. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127670 · Cited by 96
Role of placenta growth factor and its receptor flt‐1 in rheumatoid inflammation: A link between angiogenesis and inflammation
Yoo, S., Yoon, H.-J., Kim, H., Chae, C., Falco, S. D., Cho, C., & Kim, W. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24289 · Cited by 95
The inflammatory side of human chondrocytes unveiled by antibody microarrays
Ceuninck, F. D., Dassencourt, L., & Anract, P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.184 · Cited by 87
Placenta Growth Factor and Vascular Endothelial Growth Factor are Co-Expressed During Early Embryonic Development
Achen, M. G., Gad, J. M., Stacker, S. A., & Wilks, A. F. (1997) · Growth Factors · doi:10.3109/08977199709002113 · Cited by 84
NF-κB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells
Cramer, M., Nagy, I., Murphy, B. J., Gassmann, M., Hottiger, M. O., Georgiev, O., & Schaffner, W. (2005) · Biological Chemistry · doi:10.1515/bc.2005.101 · Cited by 81
Intracellular pathways triggered by the selective FLT‐1‐agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia
Bellik, L., Vinci, M. C., Filippi, S., Ledda, F., & Parenti, A. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706347 · Cited by 80
The placenta growth factor in skin angiogenesis
Odorisio, T., Cianfarani, F., Failla, C. M., & Zambruno, G. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.08.008 · Cited by 79
cis-Acting Translational Effects of the 5′ Noncoding Region of c-myc mRNA
Parkin, N. T., Darveau, A., Nicholson, R., & Sonenberg, N. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.7.2875 · Cited by 75
Mapping the Charged Residues in the Second Immunoglobulin-like Domain of the Vascular Endothelial Growth Factor/Placenta Growth Factor Receptor Flt-1 Required for Binding and Structural Stability
Davis-Smyth, T., Presta, L. G., & Ferrara, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3216 · Cited by 73
The placenta growth factor gene of the mouse
DiPalma, T., Tucci, M., Russo, G., Maglione, D., Lago, C. T., Romano, A., Saccone, S., Valle, G. D., Gregorio, L. D., Dragani, T. A., et al. (1996) · Mammalian Genome · doi:10.1007/s003359900003 · Cited by 72
Placental Growth Factor Regulates Cardiac Inflammation Through the Tissue Inhibitor of Metalloproteinases-3/Tumor Necrosis Factor-α–Converting Enzyme Axis
Carnevale, D., Cifelli, G., Mascio, G., Madonna, M., Sbroggió, M., Perrino, C., Persico, M. G., Frati, G., & Lembo, G. (2011) · Circulation · doi:10.1161/circulationaha.111.050500 · Cited by 65
A Placental Growth Factor Variant Unable to Recognize Vascular Endothelial Growth Factor (VEGF) Receptor-1 Inhibits VEGF-Dependent Tumor Angiogenesis via Heterodimerization
Tarallo, V., Vesci, L., Capasso, O., Esposito, M. T., Riccioni, T., Pastore, L., Orlandi, A., Pisano, C., & Falco, S. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2609 · Cited by 59
Structural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1D2
Iyer, S., Darley, P. I., & Acharya, K. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.130658 · Cited by 58
Identification of Placenta Growth Factor Determinants for Binding and Activation of Flt-1 Receptor
Errico, M., Riccioni, T., Iyer, S., Pisano, C., Acharya, K. R., Persico, M. G., & Falco, S. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401418200 · Cited by 57
Bone marrow transplantation abolishes inhibition of arteriogenesis in placenta growth factor (PlGF) –/– mice
Scholz, D. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(02)00304-8 · Cited by 57
Transcriptional Activation of Placental Growth Factor by the Forkhead/Winged Helix Transcription Factor FoxD1
Zhang, H., Palmer, R., Gao, X., Kreidberg, J. A., Gerald, W. L., Hsiao, L., Jensen, R. V., Gullans, S. R., & Haber, D. A. (2003) · Current Biology · doi:10.1016/j.cub.2003.08.054 · Cited by 55
Plgf−/−eNos−/−mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia
Gigante, B., Morlino, G., Gentile, M. T., Persico, M. G., & Falco, S. D. (2006) · The FASEB Journal · doi:10.1096/fj.05-4481fje · Cited by 52
Monoclonal Antibody TB-403: A First-in-Human, Phase I, Double-Blind, Dose Escalation Study Directed Against Placental Growth Factor in Healthy Male Subjects
Niskanen, T. M., Riisbro, R., Larsson, L., Winstedt, L., Stenberg, Y., Pakola, S., Stassen, J., & Glazer, S. (2011) · Clinical Therapeutics · doi:10.1016/j.clinthera.2011.08.007 · Cited by 51
Human retinal epithelium produces and responds to placenta growth factor
Hollborn, M., Tenckhoff, S., Seifert, M., Köhler, S., Wiedemann, P., Bringmann, A., & Kohen, L. (2005) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-005-0154-9 · Cited by 46
Modulation of the angiogenesis response through Ha‐ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis
Larcher, F., Franco, M., Bolontrade, M. F., Rodríguez‐Puebla, M. L., Casanova, M., Navarro, M., Yancopoulos, G. D., Jorcano, J. L., & Conti, C. J. (2003) · Molecular Carcinogenesis · doi:10.1002/mc.10126 · Cited by 44
Placenta growth factor is not required for exercise-induced angiogenesis
Gigante, B., Tarsitano, M., Cimini, V., Falco, S. D., & Persico, M. G. (2004) · Angiogenesis · doi:10.1007/s10456-004-4179-1 · Cited by 42
Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor 1
Ponticelli, S., Marasco, D., Tarallo, V., Albuquerque, R., Mitola, S. M. F., Takeda, A., Stassen, J.-M., Presta, M., Ambati, J., Ruvo, M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806607200 · Cited by 42
Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release
Mohammed, K. A., Nasreen, N., Tepper, R. S., & Antony, V. B. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00075.2006 · Cited by 38
Upregulation of placental growth factor by vascular endothelial growth factor via a post‐transcriptional mechanism
Yao, Y., Yang, H. S., Cao, Z., Danielsson, J. A., & Duh, E. J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.01.017 · Cited by 37
The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.
Muller, A. J., & Witte, O. N. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5234 · Cited by 30
NFAT1 Mediates Placental Growth Factor-Induced Myelomonocytic Cell Recruitment via the Induction of TNF - α
Ding, Y., Huang, Y., Song, N., Gao, X., Yuan, S., Wang, X., Cai, H., Fu, Y., & Luo, Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902378 · Cited by 28
Translation of the Placenta Growth Factor mRNA is Severely Affected by a Small Open Reading Frame Localized in the 5′ Untranslated Region
Maglione, D., Guerriero, V., Rambaldi, M., Russo, G., & Persico, M. G. (1993) · Growth Factors · doi:10.3109/08977199309046934 · Cited by 27
cis-Acting Translational Effects of the 5′ Noncoding Region of c-myc mRNA
Parkin, N. T., Darveau, A., Nicholson, R., & Sonenberg, N. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.7.2875-2883.1988 · Cited by 23
The 5′ Noncoding Region of the Human Leukemia-Associated Oncogene BCR/ABL Is a Potent Inhibitor of In Vitro Translation
Muller, A. J., & Witte, O. N. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5234-5238.1989 · Cited by 11

Flagged first, then by citations

Research works printed but not linked: 5

Adini, 2002, Cancer Res, 62, 2749
Green, 2001, Cancer Res, 61, 2696
Maglione, 1993, Oncogene, 8, 925
Viglietto, 1995, Oncogene, 11, 1569
Ziche, 1997, Lab Invest, 76, 517

Sorted by citations

Untitled work
Rana (2019) · doi:10.1161/circresaha.118.313276 · Cited by 2,095
Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity
Lee, W. S., Yang, H., Chon, H. J., & Kim, C. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00500-y · Cited by 727
Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor
Zhao, Y., & Adjei, A. A. (2015) · The Oncologist · doi:10.1634/theoncologist.2014-0465 · Cited by 573
Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing
Martino, M. M., Briquez, P. S., Güç, E., Tortelli, F., Kilarski, W. W., Metzger, S., Rice, J. J., Kuhn, G. A., Müller, R., Swartz, M. A., et al. (2014) · Science · doi:10.1126/science.1247663 · Cited by 507

See all 425

Authors: De Falco, S.
Affiliations: Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics, 'Adriano Buzzati-Traverso' - CNR - Via Pietro Castellino, 111, 80131 Napoli, Italy.
Venue: Experimental and Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2012
Volume: 44
Issue: 1
Pages: 1
ISSN: 1226-3613 (ISSN-L)
2092-6413
DOI: 10.3858/emm.2012.44.1.025
PMC: PMC3277892
OpenAlex: W2097881605
Cited by: 425
References: 99
Citations by year: 2026: 10 · 2025: 33 · 2024: 34 · 2023: 39 · 2022: 35 · 2021: 28 · 2020: 38 · 2019: 44 · 2018: 35 · 2017: 32 · 2016: 22 · 2015: 23 · 2014: 35 · 2013: 14 · 2012: 2
FWCI: 2.16
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Experimental & Molecular Medicine (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Associazione Italiana per la Ricerca sul Cancro
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: placental growth factor, angiogenesis, VEGF family, VEGF receptor 1, VEGF receptor 2, Flt-1, Flk-1, KDR, VEGF-A, VEGF-B, biological activity, pathogenesis
MeSH terms: Placenta Growth Factor, Animals, Female, Humans, Neovascularization, Pathologic, Nitric Oxide, Placenta, Pregnancy, Pregnancy Proteins, Mice, Knockout, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Endothelial Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The discovery of placenta growth factor and its biological activity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks