Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

Yamakawa, Midori; Liu, Louis X.; Date, Taro; Belanger, Adam J.; Vincent, Karen A.; Akita, Geoffrey Y.; Kuriyama, Takayuki; Cheng, Seng H.; Gregory, Richard J.; Jiang, Canwen

doi:10.1161/01.res.0000093984.48643.d7

Cited by 327Angiogenesis and VEGF in CancerCancer, Hypoxia, and MetabolismLymphatic System and Diseases

Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

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Yamakawa, Midori, Liu, Louis X., Date, Taro, Belanger, Adam J., Vincent, Karen A., Akita, Geoffrey Y., Kuriyama, Takayuki, Cheng, Seng H. +2 more·2003·Circulation Research

DOI 10.1161/01.res.0000093984.48643.d7

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Abstract

Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial growth factor (VEGF) and other hypoxia-responsive genes. Transgenic expression of a constitutively stable HIF-1alpha mutant increases the number of vascular vessels without vascular leakage, tissue edema, or inflammation. This study aimed to investigate the molecular basis by which HIF-1 mediates the angiogenic response to hypoxia. In primary human endothelial cells, hypoxia, desferrioxamine, or infection with Ad2/HIF-1alpha/VP16, an adenoviral vector encoding a constitutively stable hybrid form of HIF-1alpha, increased the mRNA and protein levels of VEGF, angiopoietin-2 (Ang-2), and angiopoietin-4 (Ang-4). Infection with Ad2/CMVEV (a control vector expressing no transgene) had no effect. Angiopoietin-1 (Ang-1) expression was not detected in human endothelial cells. Ang-4 was also induced by hypoxia or Ad2/HIF-1alpha/VP16 in human cardiac cells, whereas Ang-1 expression remained unchanged. Recombinant Ang-4 protein protected endothelial cells against serum starvation-induced apoptosis and increased cultured endothelial cell migration and tube formation. Ad2/HIF-1alpha/VP16 stimulated endothelial cell proliferation and tube formation. Hypoxia- or Ad2/HIF-1alpha/VP16-induced tube formation was significantly reduced by a Tie-2 inhibitor. These results suggest that HIF-1 mediates the angiogenic response to hypoxia by upregulating the expression of multiple angiogenic factors. Ang-4 can function similarly as Ang-1 and substitute for Ang-1 to participate in hypoxia-induced angiogenesis. Activation of the angiopoietin/Tie-2 system may play a role in the ability of HIF-1 to induce hypervascularity without excessive permeability.

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Activation of HIF-1α and formation of the HIF complex induce angiogenic growth factor genes including VEGF and SDF-1/CXCL12.
“The activation of HIF-1α and the formation of the HIF complex induce several angiogenic growth factor genes, including VEGF and stromal cell-derived factor-1 (SDF-1)/C-X-C motif chemokine 12 (CXCL12) [82,83,84].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [84]

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Authors: Yamakawa, M., Liu, L. X., Date, T., Belanger, A. J., Vincent, K. A., Akita, G. Y., Kuriyama, T., Cheng, S. H., Gregory, R. J., & Jiang, C.
Affiliations: Chiba University (JP)
ORCID: Vincent, Karen A.
Gregory, Richard J.
Jiang, Canwen
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-10-03
Volume: 93
Issue: 7
Pages: 664-673
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000093984.48643.d7
OpenAlex: W2171354819
Cited by: 327
References: 48
Citations by year: 2026: 7 · 2025: 13 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 13 · 2016: 21 · 2015: 15 · 2014: 12 · 2013: 17 · 2012: 15
FWCI: 6.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: HIF-1, HIF-1α, angiogenesis, hypoxia, vascular endothelial cells, vascular endothelial growth factor, angiopoietin-2, angiopoietin-4, angiopoietin-1, Tie2, endothelial cell migration, tube formation, endothelial cell proliferation, apoptosis, deferoxamine, hypervascularity, vascular permeability
MeSH terms: Placenta Growth Factor, Blood Vessels, Cell Division, Cell Membrane Permeability, Cell Movement, Cells, Cultured, Deferoxamine, DNA-Binding Proteins, Endothelium, Vascular, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Genetic Vectors, Humans, Lymphokines, Nuclear Proteins, Platelet-Derived Growth Factor, Pregnancy Proteins, RNA, Messenger, Transcription Factors, Cell Hypoxia, Endothelial Growth Factors, Apoptosis, Caspases, Receptor Protein-Tyrosine Kinases, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiopoietins, Angiopoietin-2, Receptor, TIE-2, Angiogenesis Inducing Agents, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Caspase 3

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Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

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