Cited by 425Angiogenesis and VEGF in CancerFibroblast Growth Factor ResearchPregnancy and preeclampsia studies

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

The discovery of placenta growth factor and its biological activity

Open access

De Falco, Sandro·2012·Experimental and Molecular Medicine

DOI 10.3858/emm.2012.44.1.025PMC PMC3277892

Open this paper in CoChat — free account Open PDF

Abstract

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis, diabetic retinopathy and age-related macular degeneration. Among the several molecular players involved in angiogenesis, some members of VEGF family, VEGF-A, VEGF-B and placenta growth factor (PlGF), and the related receptors VEGF receptor 1 (VEGFR-1, also known as Flt-1) and VEGF receptor 2 (VEGFR-2, also known as Flk-1 in mice and KDR in human) have a decisive role. In this review, we describe the discovery and molecular characteristics of PlGF, and discuss the biological role of this growth factor in physiological and pathological conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3858/emm.2012.44.1.025

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Molecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,090
The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
de Vries, C. J. M., Escobedo, J. A., Ueno, H., Houck, K. A., Ferrara, N., & Williams, L. T. (1992) · Science · doi:10.1126/science.1312256 · Cited by 2,019
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · cited 1×
“The main effectors of hypoxic stimulus are the transcriptional factors known as hypoxia inducible factors (HIFs) (Semenza, 1999).”
Background
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) · Nature Medicine · doi:10.1038/nm1101-1194 · Cited by 1,860
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
Carmeliet, P., Moons, L., Luttun, A., Vincenti, V., Compernolle, V., Mol, M. D., Wu, Y., Bono, F., Devy, L., Beck, H., et al. (2001) · Nature Medicine · doi:10.1038/87904 · Cited by 1,708
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D. S., Armellino, D. C., Gospodarowicz, D., & Böhlen, P. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90483-2 · Cited by 1,519
Macrophages, innate immunity and cancer: balance, tolerance, and diversity
Mantovani, A., & Sica, A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.009 · Cited by 1,484

Show all 99 references

Research works printed but not linked: 5

Adini, 2002, Cancer Res, 62, 2749
Green, 2001, Cancer Res, 61, 2696
Maglione, 1993, Oncogene, 8, 925
Viglietto, 1995, Oncogene, 11, 1569
Ziche, 1997, Lab Invest, 76, 517

Sorted by citations

Untitled work
Rana (2019) · doi:10.1161/circresaha.118.313276 · Cited by 2,095
Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity
Lee, W. S., Yang, H., Chon, H. J., & Kim, C. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00500-y · Cited by 727
Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor
Zhao, Y., & Adjei, A. A. (2015) · The Oncologist · doi:10.1634/theoncologist.2014-0465 · Cited by 573
Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing
Martino, M. M., Briquez, P. S., Güç, E., Tortelli, F., Kilarski, W. W., Metzger, S., Rice, J. J., Kuhn, G. A., Müller, R., Swartz, M. A., et al. (2014) · Science · doi:10.1126/science.1247663 · Cited by 507
Angiogenesis in the atherosclerotic plaque
Camaré, C., Pucelle, M., Nègre-Salvayre, A., & Salvayre, R. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.007 · Cited by 401
Tracking placental development in health and disease
Aplin, J., Myers, J., Timms, K., & Westwood, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0372-6 · Cited by 394
Redefining Preeclampsia Using Placenta-Derived Biomarkers
Staff, A. C., Benton, S. J., von Dadelszen, P., Roberts, J. M., Taylor, R. N., Powers, R. W., Jones, D. S., & Redman, C. W. G. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00250 · Cited by 383
VEGFR1 signaling in retinal angiogenesis and microinflammation
Uemura, A., Fruttiger, M., D'Amore, P. A., Falco, S. D., Joussen, A. M., Sennlaub, F., Brunck, L. R., Johnson, K. T. M., Lambrou, G. N., Rittenhouse, K. D., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100954 · Cited by 360
Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?
McElwain, C. J., Tuboly, E., McCarthy, F. P., & McCarthy, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00655 · Cited by 236
Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy
Gacche, R. N., & Meshram, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.05.002 · Cited by 203
Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches
Armaly, Z., Jadaon, J. E., Jabbour, A. R., & Abassi, Z. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00973 · Cited by 217
Newly Identified Regulators of Ovarian Folliculogenesis and Ovulation
Gershon, E., & Dekel, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124565 · Cited by 181
Vascular Endothelial Growth Factor-B in Physiology and Disease
Bry, M., Kivelä, R., Leppänen, V., & Alitalo, K. K. (2014) · Physiological Reviews · doi:10.1152/physrev.00028.2013 · Cited by 175
A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy
Kong, D.-H., Kim, M., Jang, J., Na, H.-J., & Lee, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081786 · Cited by 161
A molecular signature for anastasis, recovery from the brink of apoptotic cell death
Sun, G., Guzman, E., Balasanyan, V., Conner, C. M., Wong, K., Zhou, H. R., Kosik, K. S., & Montell, D. J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201706134 · Cited by 151
Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension
Spradley, F. T., Tan, A. Y., Joo, W. S., Daniels, G., Kussie, P. H., Karumanchi, S. A., & Granger, J. P. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06783 · Cited by 149
Physiological and tumor-associated angiogenesis: Key factors and therapy targeting VEGF/VEGFR pathway
Lorenc, P., Sikorska, A., Molenda, S., Guzniczak, N., Dams‐Kozlowska, H., & Florczak, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117585 · Cited by 142
miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma
Jin, Y., Hu, Y., Wu, X., Wu, Y., Ye, Y., Li, H.-F., Liu, Y., Jiang, L., Liu, F.-T., Zhang, Y., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0258-2 · Cited by 122
The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease
Gbotosho, O. T., Kapetanaki, M. G., & Kato, G. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.561917 · Cited by 118
Placental growth factor and its potential role in diabetic retinopathy and other ocular neovascular diseases
Nguyen, Q. D., Falco, S. D., Béhar‐Cohen, F., Lam, W., Li, X., Reichhart, N., Ricci, F., Pluim, J. L., & Li, W. W. (2016) · Acta Ophthalmologica · doi:10.1111/aos.13325 · Cited by 97
Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients
Tsai, T., Kuehn, S., Tsiampalis, N., Vu, M.-K., Kakkassery, V., Stute, G., Dick, H. B., & Joachim, S. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194603 · Cited by 93
The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight
Armistead, B., Kadam, L., Drewlo, S., & Kohan‐Ghadr, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051775 · Cited by 89
Tyrosine Kinase Inhibitor–Induced Thyroid Disorders: A Review and Hypothesis
Makita, N., & Iiri, T. (2013) · Thyroid · doi:10.1089/thy.2012.0456 · Cited by 89
Conversion to Aflibercept After Prior Anti-VEGF Therapy for Persistent Diabetic Macular Edema
Rahimy, E., Shahlaee, A., Ma, K., Ying, G., Maguire, J. I., Ho, A. C., Regillo, C. D., & Hsu, J. (2015) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2015.12.030 · Cited by 90
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex
Gerrits, E., Giannini, L. A. A., Brouwer, N., Melhem, S., Seilhean, D., Le Ber, I., The Brainbank Neuro-CEB Neuropathology Network, Kamermans, A., Kooij, G., de Vries, H. E., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01124-3 · Cited by 88
Recent advances in anti-angiogenic nanomedicines for cancer therapy
Bhattarai, P., Hameed, S., & Dai, Z. (2018) · Nanoscale · doi:10.1039/c7nr09612g · Cited by 89
Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia
Ward, J., Strawbridge, R. J., Bailey, M. E. S., Graham, N., Ferguson, A., Lyall, D. M., Cullen, B., Pidgeon, L. M., Cavanagh, J., Mackay, D., et al. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0012-7 · Cited by 89
Synthesis, structural investigation, computational study, antimicrobial activity and molecular docking studies of novel synthesized (E)-4-((pyridine-4-ylmethylene)amino)-N-(pyrimidin-2-yl)benzenesulfonamide from pyridine-4-carboxaldehyde and sulfadiazine
Elangovan, N., Sowrirajan, S., Manoj, K. P., & Kumar, A. M. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.130544 · Cited by 86
Research Progress and Applications of Multivalent, Multispecific and Modified Nanobodies for Disease Treatment
Wang, J., Kang, G., Yuan, H.-X., Cao, X.-C., Huang, H., & de Marco, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.838082 · Cited by 79
Platelet lysate coating on scaffolds directly and indirectly enhances cell migration, improving bone and blood vessel formation
Léotot, J., Coquelin, L., Bodivit, G., Bierling, P., Hernigou, P., Rouard, H., & Chevallier, N. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.02.003 · Cited by 86
Genomic signatures of high-altitude adaptation in Ethiopian sheep populations
Edea, Z., Dadi, H., Dessie, T., & Kim, K. (2019) · Genes & Genomics · doi:10.1007/s13258-019-00820-y · Cited by 90
Role and mechanisms of the NF-ĸB signaling pathway in various developmental processes
Liu, P., Li, Y., Wang, W., Bai, Y., Jia, H., Yuan, Z., & Zhonghua, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113513 · Cited by 92
Vascular Endothelial Growth Factor B and Its Signaling
Lal, N., Puri, K., & Rodrigues, B. B. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00039 · Cited by 88
Computational Investigation on Structural and Reactive Sites (HOMO-LUMO, MEP, NBO, NPA, ELF, LOL, RDG) Identification, Pharmacokinetic (ADME) Properties and Molecular Docking Investigation of (E)-4-((4-chlorobenzylidene) amino) Benzene Sulfonamide Compound
Elangovan, N., Sangeetha, R., Sowrirajan, S., Sarala, S., & Muthu, S. (2022) · Analytical Chemistry Letters · doi:10.1080/22297928.2021.1933588 · Cited by 81
Relationship between VEGFA polymorphisms and serum VEGF protein levels and recurrent spontaneous miscarriage
Almawi, W. Y., Saldanha, F. L., Mahmood, N. A., Al-Zaman, I., Sater, M. S., & Mustafa, F. E. (2013) · Human Reproduction · doi:10.1093/humrep/det308 · Cited by 82
Synthesis, single crystal (XRD), Hirshfeld surface analysis, computational study (DFT) and molecular docking studies of (E)-4-((2-hydroxy-3,5-diiodobenzylidene)amino)-N-(pyrimidine)-2-yl) benzenesulfonamide
Elangovan, N., & Sowrirajan, S. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07724 · Cited by 80
Placental growth factor in cancer
Dewerchin, M. A., & Carmeliet, P. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.948420 · Cited by 82
Role of angiogenesis in melanoma progression: Update on key angiogenic mechanisms and other associated components
Cho, W. C., Jour, G., & Aung, P. P. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.015 · Cited by 83
Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns
Portelli, M., & Baron, B. (2018) · Journal of Pregnancy · doi:10.1155/2018/2632637 · Cited by 84
Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment
Chen, W., Shen, L., Jiang, J., Zhang, L., Zhang, Z., Pan, J., Ni, C., & Chen, Z. (2021) · Biomarker Research · doi:10.1186/s40364-021-00312-w · Cited by 75
Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings
Weckman, A. M., McDonald, C. R., Baxter, J. B., Fawzi, W. W., Conroy, A. L., & Kain, K. C. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz015 · Cited by 74
ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses
Azimi, I., Milevskiy, M. J. G., Chalmers, S. B., Yapa, K. T. D. S., Robitaille, M., Henry, C., Baillie, G. J., Thompson, E. W., Roberts‐Thomson, S. J., & Monteith, G. R. (2019) · Cancers · doi:10.3390/cancers11020208 · Cited by 72
Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors
Kang, Y., Li, H., Liu, Y., & Li, Z. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05714-5 · Cited by 73
Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy
Benschop, L. H., Schalekamp–Timmermans, S., Broere-Brown, Z. A., van Lennep, J. E. R., Jaddoe, V. W. V., Roos‐Hesselink, J. W., Ikram, M. K., Steegers, E. A. P., Roberts, J. M., & Gandley, R. E. (2019) · Circulation · doi:10.1161/circulationaha.118.036632 · Cited by 70
Antiangiogenesis therapy: an update after the first decade
Falco, S. D. (2014) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2014.29.1.1 · Cited by 72
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
Pinto, M. P., Sotomayor, P. C., Carrasco-Aviño, G., Corvalán, A. H., & Owen, G. I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091489 · Cited by 67
Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion
Ishii, T., Miyazawa, M., Takanashi, Y., Tanigawa, M., Yasuda, K., Onouchi, H., Kawabe, N., Mitsushita, J., Hartman, P. S., & Ishii, N. (2014) · Redox Biology · doi:10.1016/j.redox.2014.05.001 · Cited by 66
PlGF–MMP9-engineered iPS cells supported on a PEG–fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium
Bearzi, C., Gargioli, C., Baci, D., Fortunato, O., Shapira‐Schweitzer, K., Kossover, O., Latronico, M. V. G., Seliktar, D., Condorelli, G., & Rizzi, R. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.12 · Cited by 65
Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment
Xu, X. H., Zhao, C., Peng, Q., Xie, P., & Liu, Q. H. (2017) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20165396 · Cited by 65
VEGF Receptor Tyrosine Kinases
Álvarez-Aznar, A., Muhl, L., & Gaengel, K. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.10.001 · Cited by 66
Vascular endothelial growth factors and placenta growth factor in retinal vasculopathies: Current research and future perspectives
Mesquita, J., Sousa, J. P. C., Vaz-Pereira, S., Neves, A., Passarinha, L. A., & Tomaz, C. T. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.11.005 · Cited by 65
Predictive value of the sFlt‑1/PlGF ratio in women with suspected preeclampsia: An update (Review)
Velegrakis, A., Kouvidi, E., Fragkiadaki, P., & Sifakis, S. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5292 · Cited by 85
Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis Bypass in Malignant Tumors
Bokhari, S. M. Z., & Hamar, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713317 · Cited by 58
The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands
Anisimov, A., Leppänen, V., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., Kaijalainen, S., & Alitalo, K. K. (2013) · Science Signaling · doi:10.1126/scisignal.2003905 · Cited by 58
Placental growth factor regulates the generation of TH17 cells to link angiogenesis with autoimmunity
Yoo, S., Kim, M., Kang, M., Kong, J., Kim, K., Lee, S., Hong, B.-K., Jeong, G. H., Lee, J., Shin, M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0456-4 · Cited by 57
Synthesis, experimental antimicrobial activity, theoretical vibrational analysis, quantum chemical modeling and molecular docking studies of (E)-4-(benzylideneamino)benzenesulfonamide
Muthukumar, R., Karnan, M., Elangovan, N., Karunanidhi, M., Sankarapandian, V., & Venkateswaran, K. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.133187 · Cited by 54
A distinct gene expression signature characterizes human neuroblastoma cancer stem cells
Ross, R. A., Walton, J. D., Han, D., Guo, H.-F., & Cheung, N. V. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.08.008 · Cited by 53
VEGF/VEGFR axis and its signaling in melanoma: Current knowledge toward therapeutic targeting agents and future perspectives
Malekan, M., Haass, N. K., Rokni, G. R., Gholizadeh, N., Ebrahimzadeh, M. A., & Kazeminejad, A. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122563 · Cited by 53
Angiogenesis-related non-coding RNAs and gastrointestinal cancer
Razavi, Z. S., Asgarpour, K., Mahjoubin‐Tehran, M., Rasouli, S., Khan, H. Z., Shahrzad, M. K., Hamblin, M. R., & Mirzaei, H. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.04.002 · Cited by 51
Tracking nutrient transfer at the human maternofetal interface from 4 weeks to term
Jones, C. J. P., Choudhury, R., & Aplin, J. D. (2015) · Placenta · doi:10.1016/j.placenta.2015.01.002 · Cited by 50
The role of angiogenic factors in the management of preeclampsia
Flint, E. J., Cerdeira, A. S., Redman, C. W. G., & Vatish, M. (2019) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13540 · Cited by 52
The Role of VEGF Receptors as Molecular Target in Nuclear Medicine for Cancer Diagnosis and Combination Therapy
Masłowska, K., Halik, P. K., Tymecka, D., Misicka, A., & Gniazdowska, E. (2021) · Cancers · doi:10.3390/cancers13051072 · Cited by 53
Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy
Dang, B.-T. N., Kwon, T. K., Lee, S., Jeong, J., & Yook, S. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.007 · Cited by 51
Association of VEGF Genetic Polymorphisms with Recurrent Spontaneous Abortion Risk: A Systematic Review and Meta-Analysis
Xu, X., Du, C., Li, H., Du, J., Yan, X., Peng, L., Li, G., & Chen, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123696 · Cited by 49
Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta
Laakkonen, J. P., Lähteenvuo, J., Jauhiainen, S., Heikura, T., & Ylä‐Herttuala, S. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.10.005 · Cited by 49
MMP-12 activates protease-activated receptor-1, upregulates placenta growth factor, and leads to pulmonary emphysema
Hou, H., Wang, H., Cheng, S.-L., Chen, Y., Lu, K.-Z., & Yu, C. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00216.2017 · Cited by 48
The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery
Mansour, S. G., Zhang, W. R., Moledina, D. G., Coca, S. G., Jia, Y., Thiessen‐Philbrook, H., McArthur, E., Inoue, K., Koyner, J. L., Shlipak, M. G., et al. (2019) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2019.01.028 · Cited by 48
Placental Growth Factor Is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles
Bender, H. R., Trau, H. A., & Duffy, D. M. (2017) · Endocrinology · doi:10.1210/en.2017-00739 · Cited by 47
The vascular endothelial growth factors and receptors family: Up to now the only target for anti-angiogenesis therapy
Tarallo, V., & Falco, S. D. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.04.008 · Cited by 47
Gene and protein therapies utilizing VEGF for ALS
Keifer, O. P., O'Connor, D. M., & Boulis, N. M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.009 · Cited by 46
Research progress in tumor angiogenesis and drug resistance in breast cancer
Mou, J., Li, C., Zheng, Q., Meng, X., & Tang, H. (2024) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0515 · Cited by 48
Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor
Wang, X., Mendelsohn, L. G., Rogers, H. M., Leitman, S. F., Raghavachari, N., Yang, Y., Yau, Y. Y., Tallack, M. R., Perkins, A. C., Taylor, J. G., et al. (2014) · Blood · doi:10.1182/blood-2013-11-539718 · Cited by 45
Epigenetic control of hypoxia inducible factor-1α-dependent expression of placental growth factor in hypoxic conditions
Tudisco, L., Ragione, F. D., Tarallo, V., Apicella, I., D’Esposito, M., Matarazzo, M. R., & Falco, S. D. (2014) · Epigenetics · doi:10.4161/epi.27835 · Cited by 47
Human chorionic gonadotropin and risk of pre‐eclampsia: prospective population‐based cohort study
Barjaktarovic, M., Korevaar, T. I. M., Jaddoe, V. W. V., de Rijke, Y. B., Peeters, R. P., & Steegers, E. A. P. (2019) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20256 · Cited by 45
PlGF Immunological Impact during Pregnancy
Albonici, L., Benvenuto, M., Focaccetti, C., Cifaldi, L., Miele, M. T., Limana, F., Manzari, V., & Bei, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228714 · Cited by 47
Vitreous levels of placental growth factor correlate with activity of proliferative diabetic retinopathy and are not influenced by bevacizumab treatment
Kahtani, E. A., Xu, Z., Rashaed, S. A., Wu, L., Mahale, A., Tian, J., Abboud, E. B., Ghazi, N. G., Kozak, I., Gupta, V., et al. (2016) · Eye · doi:10.1038/eye.2016.246 · Cited by 44
Comparison of 12-month therapeutic effect of conbercept and ranibizumab for diabetic macular edema: a real-life clinical practice study
Xu, Y., Rong, A., Xu, W., Niu, Y., & Wang, Z. (2017) · BMC Ophthalmology · doi:10.1186/s12886-017-0554-8 · Cited by 44
Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies
Hoeller, A., Ehrlich, L. C., Golić, M., Herse, F., Perschel, F. H., Siwetz, M., Henrich, W., Dechend, R., Huppertz, B., & Verlohren, S. (2017) · Hypertension in Pregnancy · doi:10.1080/10641955.2016.1273363 · Cited by 43
Transcriptomic profiling reveals differential cellular response to copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta
Chortarea, S., Gupta, G. S., Saarimäki, L. A., Netkueakul, W., Manser, P., Aengenheister, L., Wichser, A., Fortino, V., Wick, P., Greco, D., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108015 · Cited by 44
Cell and molecular targeted therapies for diabetic retinopathy
Reddy, S. K., Devi, V., Seetharaman, A. T. M., Shailaja, S., Bhat, K. M. R., Gangaraju, R., & Upadhya, D. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1416668 · Cited by 47
Blood Pressure and Angiogenic Markers in Pregnancy
Birukov, A., Herse, F., Nielsen, J. H., Kyhl, H. B., Golić, M., Kräker, K., Haase, N., Busjahn, A., Bruun, S., Jensen, B. L., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.13966 · Cited by 41
Anastasis: Return Journey from Cell Death
Zaitceva, V., Kopeina, G. S., & Zhivotovsky, B. (2021) · Cancers · doi:10.3390/cancers13153671 · Cited by 41
Vascular Endothelial Growth Factor 165-Binding Heparan Sulfate Promotes Functional Recovery From Cerebral Ischemia
Chan, S. J., Esposito, E., Hayakawa, K., Mandaville, E., Smith, R. A. A., Guo, S., Niu, W., Wong, P. T. ‐., Cool, S. M., Lo, E. H., et al. (2020) · Stroke · doi:10.1161/strokeaha.119.025304 · Cited by 41
Anti-angiogenic therapy in ovarian cancer: Current understandings and prospects of precision medicine
Mei, C., Gong, W., Wang, X., Lv, Y., Zhang, Y., Wu, S., & Zhu, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1147717 · Cited by 41
Placental growth factor enhances angiogenesis in human intestinal microvascular endothelial cells via PI3K/Akt pathway: Potential implications of inflammation bowel disease
Zhou, Y., Tu, C., Zhao, Y., Liu, H., & Zhang, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.073 · Cited by 39
Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels
Wickremasinghe, N. C., Kumar, V., Shi, S., & Hartgerink, J. D. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00210 · Cited by 39
Human mesenchymal stromal cells and derived extracellular vesicles: Translational strategies to increase their proangiogenic potential for the treatment of cardiovascular disease
Nazari‐Shafti, T. Z., Neuber, S., Duran, A. G., Xu, Z.-Y., Beltsios, E. T., Seifert, M., Falk, V., & Stamm, C. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0432 · Cited by 39
Basal and apical regulation of VEGF-A and placenta growth factor in the RPE/choroid and primary RPE.
Klettner, A., Kaya, L., Flach, J., Lassen, J. F., Treumer, F., & Roider, J. B. (2015) · Europe PMC (PubMed Central) · Cited by 39
Endocrinology of Human Pregnancy and Fetal-Placental Neuroendocrine Development
Mesiano, S. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00011-1 · Cited by 42
Elastase induces lung epithelial cell autophagy through placental growth factor
Hou, H., Cheng, S.-L., Chung, K., Kuo, M. Y., Yeh, C., Chang, B., Lu, H., Wang, H., & Yu, C. (2014) · Autophagy · doi:10.4161/auto.29190 · Cited by 38
Comparison of the effectiveness of conbercept and ranibizumab treatment for retinopathy of prematurity
Cheng, Y., Zhu, X., Linghu, D., & Liang, J. (2020) · Acta Ophthalmologica · doi:10.1111/aos.14460 · Cited by 38
Placental protein levels in maternal serum are associated with adverse pregnancy outcomes in nulliparous patients
Parry, S. I., Carper, B. A., Grobman, W. A., Wapner, R. J., Chung, J. M., Haas, D. M., Mercer, B. M., Silver, R. M., Simhan, H. N., Saade, G. R., et al. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.03.064 · Cited by 37
A role of placental growth factor in hair growth
Yoon, S., Yoon, J.-S., Jo, S. J., Shin, C. Y., Shin, J.-Y., Kim, J., Kwon, O., & Kim, K. H. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.01.011 · Cited by 37
Elastase induced lung epithelial cell apoptosis and emphysema through placenta growth factor
Hou, H.-H., Cheng, S.-L., Liu, H.-T., Yang, F.-Z., Wang, H.-C., & Yu, C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.329 · Cited by 37
Impact of placental growth factor deficiency on early mouse implant site angiogenesis
Rätsep, M. T., Carmeliet, P., Adams, M. A., & Croy, B. A. (2014) · Placenta · doi:10.1016/j.placenta.2014.07.006 · Cited by 35
Maternal Serum Placental Growth Factor (PlGF) Isoforms 1 and 2 at 11-13 Weeks' Gestation in Normal and Pathological Pregnancies
Nucci, M., Poon, L. C., Demirdjian, G., Darbouret, B., & Nicolaides, K. H. (2014) · Fetal Diagnosis and Therapy · doi:10.1159/000357842 · Cited by 35
Intravitreal Aflibercept for Patients With Diabetic Macular Edema Refractory to Bevacizumab or Ranibizumab: Analysis of Response to Aflibercept
Chen, Y.-Y., Chang, P.-Y., & Wang, J.-K. (2017) · Asia-Pacific Journal of Ophthalmology · doi:10.22608/apo.2016186 · Cited by 35
Characterisation of the inflammatory cytokine and growth factor profile in a rabbit model of proliferative vitreoretinopathy
Wong, C. W., Cheung, N., Ho, C. E. H., Barathi, V. A., Storm, G., & Wong, T. T. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-51633-8 · Cited by 35
The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications
Ceci, C., Lacal, P. M., Barbaccia, M. L., Mercuri, N. B., Graziani, G., & Ledonne, A. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107101 · Cited by 36

Authors: De Falco, S.
Affiliations: Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics, 'Adriano Buzzati-Traverso' - CNR - Via Pietro Castellino, 111, 80131 Napoli, Italy.
Venue: Experimental and Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2012
Volume: 44
Issue: 1
Pages: 1
ISSN: 1226-3613 (ISSN-L)
2092-6413
DOI: 10.3858/emm.2012.44.1.025
PMC: PMC3277892
OpenAlex: W2097881605
Cited by: 425
References: 99
Citations by year: 2026: 10 · 2025: 33 · 2024: 34 · 2023: 39 · 2022: 35 · 2021: 28 · 2020: 38 · 2019: 44 · 2018: 35 · 2017: 32 · 2016: 22 · 2015: 23 · 2014: 35 · 2013: 14 · 2012: 2
FWCI: 2.16
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Experimental & Molecular Medicine (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Associazione Italiana per la Ricerca sul Cancro
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: placental growth factor, angiogenesis, VEGF family, VEGF receptor 1, VEGF receptor 2, Flt-1, Flk-1, KDR, VEGF-A, VEGF-B, biological activity, pathogenesis
MeSH terms: Placenta Growth Factor, Animals, Female, Humans, Neovascularization, Pathologic, Nitric Oxide, Placenta, Pregnancy, Pregnancy Proteins, Mice, Knockout, Gene Expression Regulation, Developmental, Neovascularization, Physiologic, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A, Endothelial Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The discovery of placenta growth factor and its biological activity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks