The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
Open accessAbstract
Protein phosphorylation is an impo-rtant cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosph-atases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors.
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Cites
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Cited by
Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
Alquezar, C., Arya, S., & Kao, A. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.595532 · Cited by 367
Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy.
Tarantino, G., Citro, V., & Capone, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010015 · Cited by 134
Song, Y., Zhao, M., Zhang, H., & Yu, B. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107966 · Cited by 125
Qin, W., Myers, S. A., Carey, D. K., Carr, S. A., & Ting, A. Y. (2021) · Nature Communications · doi:10.1038/s41467-021-25259-2 · Cited by 84
Metadata
- Authors
- Ardito, F., Giuliani, M., Perrone, D., Troiano, G., & Muzio, L. L.
- Venue
- International Journal of Molecular Medicine
- Publisher
- Spandidos Publications
- Published
- 2017-06-22
- Volume
- 40
- Issue
- 2
- Pages
- 271-280
- ISSN
- 1107-3756 (ISSN-L)
- 1791-244X
- OpenAlex
- W2635415917
- Cited by
- 1,336
- References
- 20
- FWCI
- 23.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ardito, F., Giuliani, M., Perrone, D., Troiano, G., & Muzio, L. L. (2017). The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review). International Journal of Molecular Medicine. https://doi.org/10.3892/ijmm.2017.3036
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