Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti-inflammatory effects, and inhibition of the p38-MAPK mechanism
Open accessAbstract
Asiaticoside has potent pharmacological activity and broader pharmacological effects, including anti‑oxidant, antidepressant and hepatic protection effects, and the inhibition of tumor cell proliferation. However, the mechanism underlying the effects of asiaticoside on neurological pain in spinal cord injury (SCI) remain to be fully elucidated. Therefore, the present study investigated the specific mechanism underlying the beneficial action of asiaticoside in a SCI rat model. In the present study, Basso, Beattie and Bresnahan scores was determined to analyze the therapeutic effects of asiaticoside on the neurological function of the SCI rat model. The water content of the spinal cord was also determined to measure its effects on the SCI rats. Oxidative stress, levels of nitric oxide and inflammation were detected using commercial kits. Western blot analysis was used to measure the protein expression levels of p38‑mitogen‑activated protein kinase (MAPK) in the SCI rat. Asiaticoside effectively augmented the Basso, Beattie and Bresnahan scores of the SCI rats. Significant reductions in the water content of the spinal cord, the levels of inducible nitric oxide synthase (iNOS), and the activities of the nuclear factor‑κB p65 unit, tumor necrosis factor‑α, interleukin(IL)‑1β and IL‑6 were observed in the experimental animals. Furthermore, on examination of the oxidative stress‑associated parameters, increased production of malondialdehyde and decreased levels of superoxide dismutase, glutathione and glutathione peroxidase were detected in the SCI rat model. Asiaticoside also significantly suppressed the expression of p38‑MAPK, which indicated that the therapeutic effects of asiaticoside may be associated with the p38‑MAPK pathway. These data confirmed that asiaticoside attenuates SCI through antioxidant and anti‑inflammatory effects, and through inhibition of the p38‑MAPK mechanism.
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Asiaticoside attenuates spinal cord injury in rat models by preventing oxidative damage, nitric oxide activity and production of pro-inflammatory cytokines, and by inactivating the p38-MAPK signalling pathway.
“The results attested to the neuroprotective properties of asiaticoside in attenuating SCI which prevented oxidative damage, nitric oxide activity and the production of pro‐inflammatory cytokines. Furthermore, asiaticoside also inactivated the p38‐MAPK signalling pathway, which when expressed leads to the destruction of the blood–spinal cord barrier. 71”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [71]
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Wan, J., Gong, X., Jiang, R., Zhang, Z., & Zhang, L. (2013) · Phytotherapy Research · doi:10.1002/ptr.4838 · Cited by 75 · see citing works
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
He, Z., Hu, Y., Niu, Z., Zhong, K., Liu, T., Yang, M., Ji, L., & Hu, W. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115865 · Cited by 93 · see citing works
Song, D., Jiang, X., Liu, Y., Sun, Y., Cao, S., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00028 · Cited by 72 · see citing works
Self-citationEffects of Asiaticoside Treatment on the Survival of Random Skin Flaps in Rats
Feng, X., Huang, D., Lin, D., Zhu, L., Zhang, M., Chen, Y., & Wu, F. (2021) · Journal of Investigative Surgery · doi:10.1080/08941939.2019.1584255 · Cited by 23 · see citing works
Fan, L., Li, X., & Liu, T. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01601-z · Cited by 20 · see citing works
- Authors
- LUO, Y., FU, C., WANG, Z., ZHANG, Z., WANG, H., & LIU, Y.
- Affiliations
- First Hospital of Jilin University (CN)
- Chinese PLA General Hospital (CN)
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2012-10-09
- Volume
- 12
- Issue
- 6
- Pages
- 8294-8300
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- OpenAlex
- W1901507375
- Cited by
- 57
- References
- 1
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 13 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Medicine Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- asiaticoside, spinal cord injury, neuroprotection, oxidative stress, neuroinflammation, p38 MAPK signaling, antioxidant activity, anti-inflammatory activity, NF-κB, inducible nitric oxide synthase, neurological recovery, glutathione, superoxide dismutase, malondialdehyde
- MeSH terms
- Animals, Anti-Inflammatory Agents, Male, Nitric Oxide, Spinal Cord, Spinal Cord Injuries, Triterpenes, Water, Rats, Sprague-Dawley, Oxidative Stress, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Rats, Nitric Oxide Synthase Type II
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