Cited by 20Spinal Cord Injury ResearchNerve injury and regenerationTraumatic Brain Injury and Neurovascular Disturbances

Asiaticoside Inhibits Neuronal Apoptosis and Promotes Functional Recovery After Spinal Cord Injury in Rats

Fan, Lei, Li, Xiaobin, Liu, Tao·2020·Journal of Molecular Neuroscience

Abstract

Spinal cord injury is a critical traumatic injury. This study aimed to investigate the possible protective effects of asiaticoside on neuronal injury in a rat model of spinal cord injury and to clarify the possible molecular mechanisms underlying these protective effects. Rats were randomly divided into the following four groups: naïve, sham, spinal cord injury (moderate mechanical compression injury model), and spinal cord injury + asiaticoside. Time to spontaneous urination after spinal cord injury was measured. The Basso-Beattie-Bresnahan scoring method, inclined plate grasp experiments, and footprint experiments were used to evaluate motor function. Neuritin and TNF-α levels in the spinal cord were detected via ELISA, and caspase-3 level was detected via Western blotting. Spinal cord morphology was assessed via hematoxylin-eosin staining. Apoptosis in the spinal cord was assessed using Fluoro-Jade B staining. Recovery times for spontaneous urination and motor function were shorter in the spinal cord injury + asiaticoside group than in the spinal cord injury group. The neuritin level was increased and TNF-α and caspase-3 levels were decreased in the spinal cord injury + asiaticoside group. Morphological integrity of neurons was better in the spinal cord injury + asiaticoside group than in the spinal cord injury group. It can thus be said that asiaticoside decreased apoptosis of spinal cord neurons. Asiaticoside exerts protective effects against spinal cord injury in rats,…

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Crossref · 10.1007/s12031-020-01601-z

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  • Asiaticoside treatment significantly reduces expression of the pro-inflammatory marker TNF-α in spinal cord tissue and serum of SCI-induced rats, blocks apoptosis of spinal cord neurons and enhances neuronal survival, promoting recovery.

    “Asiaticoside treatment has proven to significantly reduce the expression of the pro‐inflammatory marker TNF‐α in spinal cord tissue, as revealed by low TNF‐α levels in the serum of SCI‐induced rats in a reported study. Moreover, the triterpene functioned by blocking the apoptosis of spinal cord neurons and enhancing neuronal survival, thereby promoting recovery. 70”

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Authors
Fan, L., Li, X., & Liu, T.
Affiliations
Zhengzhou University (CN)
Corresponding author
Liu, Tao
Venue
Journal of Molecular Neuroscience
Published
2020-06-11
Volume
70
Issue
12
Pages
1988-1996
ISSN
  • 0895-8696 (ISSN-L)
  • 1559-1166
OpenAlex
W3034714285
Cited by
20
References
32
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 1
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Molecular Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
asiaticoside, spinal cord injury, neuronal apoptosis, functional recovery, neuritin, TNF-α, caspase-3, anti-inflammatory activity, neuroprotection, motor function, bladder function
MeSH terms
Animals, Male, Motor Activity, Neurons, Neuropeptides, Spinal Cord, Spinal Cord Injuries, Triterpenes, Tumor Necrosis Factor-alpha, Rats, Sprague-Dawley, Apoptosis, Neuroprotective Agents, Rats, Caspase 3, GPI-Linked Proteins

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