Resveratrol Protects against Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cell Apoptosis via Inhibition of Mitochondrial-Derived Oxidative Stress
Open accessAbstract
Resveratrol, a natural phytochemical found in grapes and red wine, has been found to possess protective effects against endothelial cell apoptosis and oxidative damage. Oxidized‑low density lipoprotein (ox‑LDL) can induce apoptosis of endothelial cells, which is an important initial event in several cardiovascular diseases. However, the effect of resveratrol on ox‑LDL‑induced apoptosis and oxidative damage, and the possible associated mechanisms remain to be elucidated. In the present study, following exposure to ox‑LDL, human umbilical vein endothelial cells (HUVECs) were treated with or without resveratrol. Cell viability was examined using Cell Counting Kit‑8 and 5‑bromo‑2'‑deoxyuridine uptake assays, respectively. Cell apoptosis was determined by flow cytometry. Apoptosis‑associated markers were detected using western blot analysis. Oxidative stress was analyzed using molecular and biochemical approaches. Resveratrol restored ox‑LDL‑induced HUVEC injury and apoptosis in a dose‑dependent manner. In addition, compared with the control group, ox‑LDL treatment decreased the B cell lymphoma‑2 (Bcl‑2)/Bcl‑2‑associated X protein ratio, mitochondrial membrane potential and activation of superoxide dismutase, and enhanced the release of mitochondrial cytochrome c into the cytoplasm, the activation of caspase and lipid peroxidation. All these alterations were significantly inhibited following treatment with resveratrol. The results demonstrated that resveratrol prevented HUVEC apoptosis through inhibiting mitochondria‑derived oxidative damage. These findings may provide a novel mechanism by which resveratrol prevents against endothelial cell apoptosis.
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As an antioxidant agent, RSV can scavenge free radicals and reduce ROS formation by inhibiting expression of NADPH and glycogen synthase kinase 3 beta proteins, and upregulating expression of antioxidant enzymes such as SOD2, CAT, GPx, and thioredoxin.
“As an antioxidant agent, RSV can scavenge free radicals and reduce ROS formation, by inhibiting the expression of NADPH and glycogen synthase kinase 3 beta proteins, and upregulating the expression of some antioxidant enzymes, such as SOD2, CAT, GPx, and thioredoxin [320,339,340].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [320]
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Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
Self-citationMitochondria and cell death: outer membrane permeabilization and beyond
Tait, S. W. G., & Green, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2952 · Cited by 2,593 · see citing works
The Vascular Endothelium and Human Diseases
Rajendran, P., Rengarajan, T., Thangavel, J., Nishigaki, Y., Sakthisekaran, D., Sethi, G., & Nishigaki, I. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.7502 · Cited by 1,473 · see citing works
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2014) · Circulation · doi:10.1161/01.cir.0000442015.53336.12 · Cited by 1,408 · see citing works
Mechanisms of caspase activation
Boatright, K. M., & Salvesen, G. S. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.009 · Cited by 1,374 · see citing works
Oxidative Stress and Cardiovascular Injury
Griendling, K. K., & FitzGerald, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000093660.86242.bb · Cited by 940 · see citing works
More than one way to die: apoptosis, necrosis and reactive oxygen damage
Fiers, W. C., Beyaert, R., Declercq, W., & Vandenabeele, P. (1999) · Oncogene · doi:10.1038/sj.onc.1203249 · Cited by 858 · see citing works
Vascular oxidative stress, nitric oxide and atherosclerosis
Li, H., Horke, S., & Förstermann, U. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.09.001 · Cited by 656 · see citing works
Reactive oxygen species are downstream mediators of p53-dependent apoptosis.
Johnson, T. M., Yu, Z., Ferrans, V. J., Lowenstein, R. A., & Finkel, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11848 · Cited by 596 · see citing works
Alcohol and Mortality in Middle-Aged Men from Eastern France
Renaud, S., Gueguen, R., Schenker, J., & d'Houtaud, A. (1998) · Epidemiology · doi:10.1097/00001648-199803000-00014 · Cited by 427 · see citing works
Tricot, O., Mallat, Z., Heymes, C., Belmin, J., Lesèche, G., & Tedgui, A. (2000) · Circulation · doi:10.1161/01.cir.101.21.2450 · Cited by 401 · see citing works
Cardiovascular effects and molecular targets of resveratrol
Li, H., Xia, N., & Förstermann, U. (2012) · Nitric Oxide · doi:10.1016/j.niox.2011.12.006 · Cited by 294 · see citing works
Evidence of a Novel Event during Neuronal Death
Deshmukh, M., & Johnson, E. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80587-5 · Cited by 281 · see citing works
Endothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols
Pérez‐Vizcaíno, F., Duarte, J., & Andriantsitohaina, R. (2006) · Free Radical Research · doi:10.1080/10715760600823128 · Cited by 218 · see citing works
Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease
Rossi, L. C., Mazzitelli, S., Arciello, M., Capo, C. R., & Rotilio, G. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9696-7 · Cited by 216 · see citing works
Oxidized Low-Density Lipoprotein and Atherosclerosis Implications in Antioxidant Therapy
Mitra, S., Deshmukh, A. J., Sachdeva, R., Lü, J., & Mehta, J. L. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318224a147 · Cited by 197 · see citing works
Resveratrol: Potential as Anticancer Agent
Aluyen, J. K., Ton, Q. N., Tran, T., Yang, A. E., Gottlieb, H. B., & Bellanger, R. A. (2012) · Journal of Dietary Supplements · doi:10.3109/19390211.2011.650842 · Cited by 184 · see citing works
Recent Advances in the Study on Resveratrol
Nakata, R., Takahashi, S., & Inoue, H. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.273 · Cited by 168 · see citing works
Oxidative Stress and Lectin-Like Ox-LDL-Receptor LOX-1 in Atherogenesis and Tumorigenesis
Lü, J., Mitra, S., Wang, X., Khaidakov, M., & Mehta, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3792 · Cited by 167 · see citing works
New dimension in therapeutic targeting of BCL-2 family proteins
Besbes, S., Mirshahi, M., Pocard, M. D., & Billard, C. (2015) · Oncotarget · doi:10.18632/oncotarget.3868 · Cited by 101 · see citing works
Endothelial microparticles as conveyors of information in atherosclerotic disease
Schiro, A., Wilkinson, F. L., Weston, R., Smyth, J. V., Serracino‐Inglott, F., & Alexander, M. Y. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.03.019 · Cited by 96 · see citing works
Park, Y. S., Kim, J., Misonou, Y., Takamiya, R., Takahashi, M., Freeman, M. R., & Taniguchi, N. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.132837 · Cited by 93 · see citing works
Resveratrol in cardiovascular disease: what is known from current research?
Wang, H., Yang, Y., Qian, H., Zhang, Q., Xu, H., & Li, J. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9260-4 · Cited by 92 · see citing works
Self-citationLin, Y., Chang, H.-C., Chen, T.-L., Chang, J.-H., Chiu, W., Lin, J., & Chen, R. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123505 · Cited by 86 · see citing works
Intracellular Signaling of LOX-1 in Endothelial Cell Apoptosis
Li, D., & Mehta, J. L. (2009) · Circulation Research · doi:10.1161/circresaha.109.194209 · Cited by 86 · see citing works
From French Paradox to Cancer Treatment: Anti-cancer Activities and Mechanisms of Resveratrol
Yang, X., Li, X., & Ren, J. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520614666140521121722 · Cited by 72 · see citing works
Effect of resveratrol on endothelial cell function: Molecular mechanisms
Schmitt, C. A., Heiß, E. H., & Dirsch, V. M. (2010) · BioFactors · doi:10.1002/biof.109 · Cited by 68 · see citing works
Fukao, H., Ijiri, Y., Miura, M., Hashimoto, M., Yamashita, T., Fukunaga, C., Oiwa, K., Kawai, Y., Suwa, M., & Yamamoto, J. (2004) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-200408000-00001 · Cited by 68 · see citing works
Effect of resveratrol on some activities of isolated and in whole blood human neutrophils
Cavallaro, A., Ainis, T., Bottari, C. O., & Fimiani, V. (2003) · Physiological Research · doi:10.33549/physiolres.930364 · Cited by 63 · see citing works
Chen, T.-G., Chen, T.-L., Chang, H., Tai, Y., Cherng, Y., Chang, Y.-T., & Chen, R. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.11.031 · Cited by 51 · see citing works
Resveratrol: A Multifunctional Compound Improving Endothelial Function
Li, H., & Förstermann, U. (2009) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-009-6209-0 · Cited by 49 · see citing works
Ladurner, A., Schachner, D., Schueller, K., Pignitter, M., Heiß, E. H., Somoza, V., & Dirsch, V. M. (2014) · Molecules · doi:10.3390/molecules191016724 · Cited by 34 · see citing works
Huang, E., Xue, S.-J., Li, X., Xu, S., Cheng, J.-D., Zheng, J., Shi, H., Lv, G., Li, Z., Li, Y., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.127 · Cited by 8 · see citing works
Self-citationPeng, H., Zhong, W., Zhao, H., Chen, L., Zhou, X. Q., Li, F., Zhu, W., & Li, G. (2015) · PubMed Central · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1
Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403 · see citing works
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
Resveratrol and endothelial function: A literature review
Parsamanesh, N., Asghari, A., Sardari, S., Tasbandi, A., Jamialahmadi, T., Xu, S., & Sahebkar, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105725 · Cited by 210 · see citing works
Litak, J., Mazurek, M., Kulesza, B., Szmygin, P., Litak, J., Kamieniak, P., & Grochowski, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249729 · Cited by 187 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results
Gál, R., Deres, L., Tóth, K., Halmosi, R., & Habon, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810152 · Cited by 116 · see citing works
Shaito, A. A., Al‐Mansoob, M., Ahmad, S. M. S., Haider, M. Z., Eid, A. H., Posadino, A. M., Pintus, G., & Giordo, R. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666221012122855 · Cited by 84 · see citing works
Abdollahi, S., Salehi‐Abargouei, A., Toupchian, O., Sheikhha, M. H., Fallahzadeh, H., Rahmanian, M., Tabatabaie, M., & Mozaffari–Khosravi, H. (2019) · Phytotherapy Research · doi:10.1002/ptr.6487 · Cited by 57 · see citing works
Zhou, Y., Jin, Y., Yu, H., Shan, A., Shen, J., Zhou, C., Zhao, Y., Fang, H., Wang, X., Wang, J., et al. (2019) · Toxicon · doi:10.1016/j.toxicon.2019.03.022 · Cited by 53 · see citing works
Therapeutic and Nutraceutical Effects of Polyphenolics from Natural Sources
Sahiner, M., Yilmaz, A. S., Güngör, B., Ayoubi, Y., & Şahiner, N. (2022) · Molecules · doi:10.3390/molecules27196225 · Cited by 52 · see citing works
Gál, R., Halmosi, R., Gallyas, F., Tschida, M., Mutirangura, P., Tóth, K., Alexy, T., & Czopf, L. (2023) · Biomedicines · doi:10.3390/biomedicines11112888 · Cited by 53 · see citing works
Li, J., Long, Q., Ding, H., Wang, Y., Luo, D., Li, Z., & Zhang, W. (2024) · Advanced Science · doi:10.1002/advs.202308677 · Cited by 47 · see citing works
Self-citationResveratrol and Reproductive Health
Novaković, R., Rajković, J., Gostimirović, M., Gojković‐Bukarica, L., & Radunović, N. V. (2022) · Life · doi:10.3390/life12020294 · Cited by 47 · see citing works
Zhao, H., Song, A., Zhang, Y., Shu, L., Song, G., & Ma, H. (2018) · Obesity · doi:10.1002/oby.22348 · Cited by 36 · see citing works
Xi, X., Yang, Y., Ma, J., Chen, Q., Zeng, Y., Li, J., Chen, L., & Li, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109924 · Cited by 34 · see citing works
Self-citationResveratrol protects Leydig cells from nicotine‐induced oxidative damage through enhanced autophagy
Liu, S., Sun, Y., & Li, Z. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12895 · Cited by 31 · see citing works
New insights into vascular aging: Emerging role of mitochondria function
Li, Y., Jin, X., Li, D. X., Lu, J. Z., Zhang, X., Yang, S., Zhao, Y., & Wu, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113954 · Cited by 30 · see citing works
Li, Y., Yang, S., Jin, X., Li, D. X., Lu, J., Wang, X., & Wu, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1082817 · Cited by 26 · see citing works
Huang, Y., Xu, M., Li, J., Chen, K., Xia, L., Wang, W., Ren, P., & Huang, X. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130323 · Cited by 19 · see citing works
Self-citationXue, C. Y., Zhou, M., Zheng, Q., Cheng, W.-T., Bai, X., Bai, X., Zhou, F., Wu, A. M., Nie, B., Liu, W. J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1043406 · Cited by 17 · see citing works
Zhang, Q., Zhang, X., Yang, B., Li, Y., Sun, X., Li, X., Sui, P., Wang, Y., Tian, S., & Wang, C. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14460 · Cited by 15 · see citing works
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H2O2
Zhou, N., Tian, Y., Wu, H., Cao, Y., Li, R., Zou, K., Xu, W., & Lizhi, L. (2022) · Molecules · doi:10.3390/molecules27113542 · Cited by 14 · see citing works
Liu, Y., Guo, F.-M., Qiu, W.-J., Gao, Y.-P., Han, X., & Shen, B. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12100384 · Cited by 12 · see citing works
Self-citationShi, X., Xu, L., Zhang, J., Mo, J., Zhuang, P., & Zheng, L. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105371 · Cited by 12 · see citing works
Zhou, Y., Zhang, J., Li, W., Zhang, D., Wang, Z., Zhai, Y., Yu, H., & Li, Z. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13344 · Cited by 11 · see citing works
Soliman, A. Y., Elguindy, N. M., Saleh, A. M., & Balbaa, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-11156-x · Cited by 10 · see citing works
Zhang, H., Liu, Y., Zheng, H., Xu, Q., Zhang, N., Wang, J., Zheng, X., Ding, Y., Yin, Z., & Zhang, X. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1065001 · Cited by 10 · see citing works
Self-citationAgeing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants
Santos, A. L., & Sinha, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_15 · Cited by 8 · see citing works
Karagül, P., & Uğraş, H. İ. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146352 · Cited by 7 · see citing works
Assessment of Biocompatibility of 3D‐Printed Cardiovascular Stent
Veerubhotla, K., McGraw, H. F., & Lee, C. H. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202200292 · Cited by 6 · see citing works
Mitochondrial dysfunction in hypertension: mechanistic pathways and therapeutic implications
Tian, J., Yi, L., Lu, Y., Kou, Y., Zhang, L., Jin, P., Wang, X., Wu, T., Yang, X., Wang, Y., et al. (2026) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01813-9 · Cited by 5 · see citing works
Bonneville, J., Rondeau, P., Veeren, B., Faccini, J., Gonthier, M., Meilhac, O., & Vindis, C. (2021) · Antioxidants · doi:10.3390/antiox11010034 · Cited by 4 · see citing works
Escobedo-Moratilla, A., Patiño-Rodríguez, O., Arzola‐Paniagua, A., Herrera, J. L., Senosiain, J. P., & Pérez‐Urizar, J. (2025) · Applied Sciences · doi:10.3390/app15179533 · Cited by 1 · see citing works
Reduction of Cardiovascular Disease Risks with Dietary Antioxidant Supplements
Liu, L., Li, Y., Dong, L., Zhang, Y., Wu, Z., & Xiao, J. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839166112-00040 · Cited by 1 · see citing works
Srisook, K. (2018) · Warasan Witthayasat Mahawitthayalai Naresuan
Xue, C., Zhou, M., Zheng, Q., Cheng, W., Bai, X., Zhang, J., Zhou, F., Wu, A., Nie, B., Liu, W., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1567213/v1
Demirel, G., Yirün, A., Güneş, B. Ş., Selvi, S., & Erkekoğlu, P. (2026) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1616268
Simental‐Mendía, L. E., Arce‐Quiñones, M., & Sahebkar, A. (2026) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2026.104866
Ren, Y., He, J., Zheng, L., Yue, L., 何聪芬, Huang, D., & Zhang, F. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209109
- Authors
- Liu, Y., Chen, X., & Li, J.
- Affiliations
- Baoji City Central Hospital (CN)
- Sun Yat-sen University (CN)
- Corresponding author
- Li, Jie
- ORCID
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2017-03-09
- Volume
- 15
- Issue
- 5
- Pages
- 2457-2464
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- PMC
- PMC5428741
- OpenAlex
- W2593733916
- Cited by
- 39
- References
- 36
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 1 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Molecular Medicine Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Guangdong Province (S2012040008068, 2012B091100454, S2013010014514)
- Fundamental Research Funds for the Central Universities
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, oxidized LDL, endothelial cell apoptosis, human umbilical vein endothelial cells, mitochondrial oxidative stress, Bcl-2/Bax ratio, mitochondrial membrane potential, cytochrome c release, caspase activation, lipid peroxidation, superoxide dismutase, cardiovascular disease
- MeSH terms
- Resveratrol, Humans, Lipoproteins, LDL, Mitochondria, Stilbenes, Apoptosis, Oxidative Stress, Human Umbilical Vein Endothelial Cells
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