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Cited by 27MicroRNA in disease regulationCancer-related molecular mechanisms researchGastric Cancer Management and Outcomes

MicroRNA‑23a/27a/24‑2 cluster promotes gastric cancer cell proliferation synergistically

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Hua, Kate, Chen, Yu‑Ting, Chen, Chian‑Feng, Tang, Ya‑Syuan, Huang, Tzu‑Ting, Lin, Yu‑Cheng, Yeh, Tien‑Shun, Huang, Kuo‑Hung +6 more·2018·Oncology Letters
DOI 10.3892/ol.2018.8924PMC PMC6036456
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Abstract

Previous studies have indicated that certain microRNAs (miRNAs/miRs) function as either tumor suppressors or oncogenes in human cancer. The present study identified the miR‑23a/27a/24‑2 cluster, containing miR‑23, miR‑27a and miR‑24, as an oncogene in gastric cancer. The expression of the miR‑23a/27a/24‑2 cluster was upregulated in clinical gastric cancer tissues. Transfection with inhibitors of miR‑23a, miR‑27a, or miR‑24, either independently or together, repressed in vitro colony formation and in vivo tumor formation. The miR23a/27a/24‑2 cluster inhibitors repressed the growth of gastric cancer cells in a synergistic manner. In addition, treatment with lower doses of the miRNA inhibitor mixture induced the formation of apoptotic bodies. According to computational predictions using TargetScan, suppressor of cytokine‑induced signaling 6 (SOCS6) was identified as one of the downstream target genes of the miR‑23a/27a/24‑2 cluster. The expression of SOCS6 was significantly lower in tumor tissues than in matched normal tissues (P<0.01) and was associated with poor survival (P<0.00001). Taken together, these results strongly suggested that the miR‑23a/27a/24‑2 cluster may mediate the progression of gastric cancer through the suppression of SOCS6 expression. The present study also provides a novel molecular target for the development of an anti‑gastric cancer agent.

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  • miR-23 expression is upregulated in colorectal cancer and gastric cancer patients, including in serum exosomes, blood tissues, and gastric cancer tissues.

    “upregulation of miR-23 expression has been detected in both colorectal cancer and gastric cancer patients, such as in serum exosomes, blood tissues, and gastric cancer tissues [[78], [79], [80]].”

    From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [80]

    The Results (page not provided) report upregulated miR-23a in gastric cancer tissues compared with paired non-neoplastic tissues. The Discussion says studies of colorectal cancer found miR-23a downregulated, not upregulated. The supplied passages do not support the serum-exosome or blood-tissue parts of the claim. (LLM, conf=0.88)

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Authors
Hua, K., Chen, Y., Chen, C., Tang, Y., Huang, T., Lin, Y., Yeh, T., Huang, K., Lee, H., Hsu, M., Chi, C., Wu, C., Lin, C., & Ping, Y.
Affiliations
  • National Yang Ming University (TW)
  • Department and Institute of Pharmacology, School of Medicine, National Yang‑Ming University, Taipei 11221, Taiwan, R.O.C.
  • Taipei Veterans General Hospital (TW)
Corresponding author
Ping, Yueh‑Hsin
ORCID
Venue
Oncology Letters
Publisher
Spandidos Publications
Published
2018-06-07
Volume
16
Issue
2
Pages
2319-2325
ISSN
  • 1792-1074 (ISSN-L)
  • 1792-1082
DOI
10.3892/ol.2018.8924
PMC
PMC6036456
OpenAlex
W2806530454
Cited by
27
References
47
Citations by year
2025: 1 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 1
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Oncology Letters (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Ministry of Science and Technology, Taiwan (MOST 105-, MOST105-2319-B010-001)
  • National Yang-Ming University
  • Yen Tjing Ling Medical Foundation
  • Taipei Veterans General Hospital (DOH102-TD-C-111-007, MOHW103-TD-B-111-02, DOH101-TD-C-111-007)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
Keywords
gastric cancer, oncogenic microRNA, SOCS6, cell proliferation, apoptosis, tumor suppressor gene downregulation, prognostic factors, anti-cancer therapeutic target

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