The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer
Open accessAbstract
Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become one major obstacle for improving the clinical outcome of patients with metastatic and advanced‑stage non‑small cell lung cancer (NSCLC). While cell behavior can be modulated by long non‑coding RNAs (lncRNAs), the contributions of lncRNAs within extracellular vesicles (exosomes) are largely unknown. To this end, the involvement and regulatory functions of lncRNA H19 wrapped by exosomes during formation of gefitinib resistance in human NSCLC were investigated. Gefitinib‑resistant cell lines were built by continuously grafting HCC827 and HCC4006 cells into gefitinib‑contained culture medium. RT‑qPCR assays indicated that H19 was increased in gefitinib‑resistant cells when compared to sensitive parent cells. Functional experiments revealed that silencing of H19 potently promoted gefitinib‑induced cell cytotoxicity. H19 was secreted by packaging into exosomes and this packaging process was specifically mediated by hnRNPA2B1. H19 wrapped in exosomes could be transferred to non‑resistant cells, thus inducing gefitinib resistance. Moreover, treatment‑sensitive cells with exosomes highly‑expressing H19 induced gefitinib resistance, while knockdown of H19 abrogated this effect. In conclusion, H19 promoted gefitinib resistance of NSCLC cells by packaging into exosomes. Therefore, exosomal H19 may be a promising therapeutic target for EGFR+ NSCLC patients.
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Cites
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RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
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Cited by
Emran, T. B., Shahriar, A., Mahmud, A. R., Rahman, T., Abir, M. H., Siddiquee, M. F. R., Ahmed, H., Rahman, N., Nainu, F., Wahyudin, E., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.891652 · Cited by 606
The biology, function, and applications of exosomes in cancer
Liu, J., Ren, L., Li, S., Li, W., Zheng, X., Yang, Y., Fu, W., Yi, J., Wang, J., & Du, G. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.001 · Cited by 561
Self-citationLong non-coding RNA in lung cancer
Chen, Z., Lei, T., Chen, X., Gu, J., Huang, J., Lu, B., & Wang, Z. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.11.031 · Cited by 65
Ansari, M. A., Thiruvengadam, M., Venkidasamy, B., Alomary, M. N., Salawi, A., Chung, I.-M., Shariati, M. A., & Rebezov, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.04.005 · Cited by 63
Metadata
- Authors
- Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., & Li, W.
- Venue
- Oncology Reports
- Publisher
- Spandidos Publications
- Published
- 2018-10-03
- Volume
- 40
- Issue
- 6
- Pages
- 3438-3446
- ISSN
- 1021-335X (ISSN-L)
- 1791-2431
- OpenAlex
- W2894774189
- Cited by
- 165
- References
- 6
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
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- Lei, Y., Guo, W., Chen, B., Chen, L., Gong, J., & Li, W. (2018). Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer. Oncology Reports. https://doi.org/10.3892/or.2018.6762
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