Risk factors for development of coronary artery disease in women with systemic lupus erythematosus

GOLDBERG, ROBERT J.; UROWITZ, MURRAY B.; IBAÑEZ, DOMINIQUE; NIKPOUR, MANDANA; GLADMAN, DAFNA D.

doi:10.3899/jrheum.090011

Cited by 78Systemic Lupus Erythematosus ResearchCardiovascular Function and Risk FactorsLipoproteins and Cardiovascular Health

Risk factors for development of coronary artery disease in women with systemic lupus erythematosus

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GOLDBERG, ROBERT J., UROWITZ, MURRAY B., IBAÑEZ, DOMINIQUE, NIKPOUR, MANDANA, GLADMAN, DAFNA D.·2009·The Journal of Rheumatology

DOI 10.3899/jrheum.090011

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Abstract

Objective.: To ascertain coronary artery disease (CAD) outcomes and predictive factors in a prospective study of patients with systemic lupus erythematosus (SLE) and matched healthy controls. Methods.: SLE patients and non-SLE age-matched controls without a history of CAD were recruited into a prospective study between 1997 and 1999. CAD events were assessed at clinic visit for SLE patients and through telephone interview and chart review for controls. All events were verified with patient medical records. Results.: Followup information was available on 237 controls and 241 SLE patients. The mean followup time was 7.2 years. Univariate analyses identified age and postmenopausal status as predictors of CAD in both the groups. Sedentary lifestyle, hypertension, the presence of metabolic syndrome, and the number of Framingham risk factors were predictive in the control group only. The 10-year risk of CAD score was predictive in both groups but was not as marked in the SLE group as in the controls. None of the lipid subfractions were predictive for CAD in the SLE group, whereas in the controls, a high triglyceride level ≥ 2.8 was predictive. Time-to-event multivariate analysis for CAD in all subjects revealed SLE itself, older age, and triglycerides ≥ 2.8 to be highly predictive for CAD. Conclusion.: In a prospective study of patients with SLE and matched controls followed over a median of 8 years, patients with SLE developed significantly more CAD events than controls. Accounting for demographic variability, CAD risk factors, and lipid factors, SLE is an independent risk factor for the development of CAD.

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Autoimmune diseases including rheumatoid arthritis, SLE, psoriasis, and anti-phospholipid syndrome are characterized by enhanced atherosclerosis and higher CV morbidity and mortality compared with the general population.
“Autoimmune diseases, including rheumatoid arthritis, SLE, psoriasis and anti-phospholipid syndrome, are characterized by enhanced atherosclerosis and consequently higher CV morbidity and mortality rates compared with the general population. 383-385”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [383]

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The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519 · see citing works
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
Systemic Lupus Erythematosus
Tsokos, G. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37754-6.50094-4 · Cited by 3,990 · see citing works
SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY INDEX
Gladman, D. D., Ibañez, D., & Urowitz, M. B. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-04434-9.50060-9 · Cited by 2,928 · see citing works
Self-citation
Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents.
Tunstall-Pedoe, H., Kuulasmaa, K., Amouyel, P., Arveiler, D., Rajakangas, A.-M., & Pająk, A. (1994) · Circulation · doi:10.1161/01.cir.90.1.583 · Cited by 2,260 · see citing works
Age-specific Incidence Rates of Myocardial Infarction and Angina in Women with Systemic Lupus Erythematosus: Comparison with the Framingham Study
Manzi, S., Meilahn, E. N., Rairie, J. E., Conte, C. G., Medsger, T. A., Jansen-McWilliams, L., D’Agostino, R. B., & Kuller, L. H. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009122 · Cited by 1,831 · see citing works
Systemic Lupus Erythematosus Disease Activity Index
National Cancer Institute (2020) · Definitions · doi:10.32388/n5g0vc · Cited by 1,029 · see citing works
The bimodal mortality pattern of systemic lupus erythematosus
Urowitz, M. B., BOOKMAN, A. A. M., Koehler, B. E., Gordon, D. A., SMYTHE, H. A., & Ogryzlo, M. A. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90431-9 · Cited by 999 · see citing works
Self-citation
Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus
Asanuma, Y., Oeser, A. M., Shintani, A., Turner, E. L., Olsen, N. J., Fazio, S., Linton, M. F., Raggi, P., & Stein, C. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035611 · Cited by 890 · see citing works
Some health benefits of physical activity. The Framingham Study
Kannel, W. B. (1979) · Archives of Internal Medicine · doi:10.1001/archinte.139.8.857 · Cited by 783 · see citing works
Hypertriglyceridemia: its etiology, effects and treatment
Yuan, G., Al-Shali, K. Z., & Hegele, R. A. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.060963 · Cited by 624 · see citing works
Risk factors for coronary artery disease in patients with systemic lupus erythematosus
Petri, M., Perez‐Gutthann, S., Spence, D., & Hochberg, M. C. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90578-y · Cited by 623 · see citing works
Risk Factors for Cardiovascular Disease in Systemic Lupus Erythematosus
Svenungsson, E., Jensen‐Urstad, K., Heimbürger, M., Silveira, A. M. V., Hamsten, A., Fairé, U. D., Witztum, J. L., & Frostegård, J. (2001) · Circulation · doi:10.1161/hc4101.097518 · Cited by 500 · see citing works
Risk factors for coronary heart disease in women with systemic lupus erythematosus: The Toronto Risk Factor Study
Bruce, I. N., Urowitz, M. B., Gladman, D. D., Ibañez, D., & Steiner, G. A. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11296 · Cited by 393 · see citing works
Self-citation
Systemic lupus erythematosus in a multiethnic US cohort (LUMINA): XXIII. Baseline predictors of vascular events
Toloza, S., Uribe, A. G., McGwin, G., Alarcón, G. S., Fessler, B. J., Bastian, H. M., Vilá, L. M., Wu, R., Shoenfeld, Y., Roseman, J. M., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20622 · Cited by 319 · see citing works
Dyslipoproteinemias in systemic lupus erythematosus: influence of disease, activity, and anticardiolipin antibodies
Borba, E. F., & Bonfá, E. (1997) · Lupus · doi:10.1177/096120339700600610 · Cited by 289 · see citing works
PREMATURE ATHEROSCLEROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Bruce, I. N., Gladman, D. D., & Urowitz, M. B. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70138-1 · Cited by 241 · see citing works
Self-citation
Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus
Selzer, F., Sutton‐Tyrrell, K., Fitzgerald, S. G., Pratt, J. E., Tracy, R. P., Kuller, L. H., & Manzi, S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11418 · Cited by 228 · see citing works
Systemic Lupus Erythematosus
Lee, P., Urowitz, M. B., Bookman, A. A., Koehler, B. E., SMYTHE, H. A., Gordon, D. A., & Ogryzlo, M. A. (1977) · QJM · doi:10.1093/oxfordjournals.qjmed.a067490 · Cited by 204 · see citing works
Self-citation
Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus
Bessant, R. (2004) · British journal of rheumatology · doi:10.1093/rheumatology/keh213 · Cited by 182 · see citing works
Dyslipoproteinemia in pediatric systemic lupus erythematosus
Ilowite, N. T., Samuel, P., Ginzler, E. M., & Jacobson, M. S. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310706 · Cited by 165 · see citing works
Elevated triglycerides and low levels of high‐density lipoprotein as markers of disease activity in association with up‐regulation of the tumor necrosis factor α/tumor necrosis factor receptor system in systemic lupus erythematosus
Svenungsson, E., Gunnarsson, I., Fei, G., Lundberg, I. E., Klareskog, L., & Frostegård, J. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11264 · Cited by 164 · see citing works
Summarizing disease features over time: I. Adjusted mean SLEDAI derivation and application to an index of disease activity in lupus.
Ibañez, D., Urowitz, M. B., & Gladman, D. D. (2003) · PubMed · Cited by 161 · see citing works
Self-citation
Hypertriglyceridemia and cardiovascular risk reduction
Jacobson, T. A., Miller, M. J., & Schaefer, E. J. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.05.002 · Cited by 148 · see citing works
Atherosclerotic vascular events in a single large lupus cohort: prevalence and risk factors.
Urowitz, M. B., Ibañez, D., & Gladman, D. D. (2007) · PubMed · Cited by 140 · see citing works
Self-citation
Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus
Feldt, J. M. V., Scalzi, L. V., Cucchiara, A. J., Morthala, S., Kealey, C., Flagg, S. D., Genin, A., Dyke, A. L. V., Nackos, E., Chander, A., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21967 · Cited by 130 · see citing works
Prevalence of conventional and lupus‐specific risk factors for cardiovascular disease in patients with systemic lupus erythematosus: A case–control study
Bessant, R., Duncan, R., Ambler, G., Swanton, J., Isenberg, D. A., Gordon, C., & Rahman, A. (2006) · Arthritis Care & Research · doi:10.1002/art.22343 · Cited by 106 · see citing works
Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort
Urowitz, M. B., Gladman, D. D., Ibañez, D., Fortin, P. R., Sánchez‐Guerrero, J., Bae, S., Clarke, A. E., Bernatsky, S., Gordon, C., Hanly, J. G., et al. (2007) · Lupus · doi:10.1177/0961203307081113 · Cited by 104 · see citing works
Self-citation
Systemic lupus erythematosus and “lupus dyslipoproteinemia”
de Carvalho, J. F., Bonfá, E., & Borba, E. F. (2007) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.11.016 · Cited by 99 · see citing works
Accumulation of coronary artery disease risk factors over three years: Data from an international inception cohort
Urowitz, M. B., Gladman, D. D., Ibañez, D., Fortin, P. R., Sánchez‐Guerrero, J., Bae, S., Clarke, A. E., Bernatsky, S., Gordon, C., Hanly, J. G., et al. (2008) · Arthritis Care & Research · doi:10.1002/art.23353 · Cited by 99 · see citing works
Self-citation
Differences Between Men and Women in Terms of Clinical Features of ST-Segment Elevation Acute Myocardial Infarction
Kosuge, M., Kimura, K., Ishikawa, T., Ebina, T., Hibi, K., Tsukahara, K., Kanna, M., Iwahashi, N., Okuda, J., Nozawa, N., et al. (2006) · Circulation Journal · doi:10.1253/circj.70.222 · Cited by 99 · see citing works
Premature Atherosclerosis in Systemic Lupus Erythematosus
Nikpour, M., Urowitz, M. B., & Gladman, D. D. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2005.01.001 · Cited by 89 · see citing works
Self-citation
Coronary calcium in systemic lupus erythematosus is associated with traditional cardiovascular risk factors, but not with disease activity.
Kiani, A. N., Magder, L. S., & Petri, M. (2008) · PubMed · Cited by 82 · see citing works
Atherosclerosis is accelerated in patients with long-term well-controlled Systemic Lupus Erythematosus (SLE)
Sato, H., Miida, T., Wada, Y., Maruyama, M., Murakami, S., Hasegawa, H., Kuroda, T., Narita, I., Nakano, M., & Gejyo, F. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.04.023 · Cited by 46 · see citing works
Carotid atherosclerotic alterations in systemic lupus erythematosus patients treated at a Brazilian university setting
Telles, R. W., Lanna, C., Ferreira, G. A., Souza, A., Navarro, T. P., & Ribeiro, A. L. P. (2008) · Lupus · doi:10.1177/0961203307085312 · Cited by 32 · see citing works
The complex nature of the interaction between disease activity and therapy on the lipid profile in patients with pediatric systemic lupus erythematosus
Sarkissian, T., Beyenne, J., Feldman, B. M., Adeli, K., & Silverman, E. D. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21748 · Cited by 31 · see citing works
Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies
Ho (2001) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200110)44:10 · Cited by 3 · see citing works
OE-295 Regression of Coronary Atherosclerotic Plaques by Pioglitazone in Patients with Diabetes Mellitus or Impaired Glucose Tolerance : A Randomized Prospective Study(Cardiovascular pharmacology, basic/clinical-1 (H) OE50,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Soeki, T., Fukuda, Y., Koshiba, K., Yamaguchi, K., Kawano, T., Yamada, H., Wakatsuki, T., Nomura, M., Kangawa, K., & Itoh, S. (2006) · Japanese Circulation Journal-english Edition · Cited by 1 · see citing works

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2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162 · see citing works
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582 · see citing works
Systemic lupus erythematosus
Kaul, A., Gordon, C., Crow, M. K., Touma, Z., Urowitz, M. B., van Vollenhoven, R., Ruiz‐Irastorza, G., & Hughes, G. R. V. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.39 · Cited by 1,450 · see citing works
Self-citation
ESC/EAS Guidelines for the management of dyslipidaemias
Catapano, A. L., Reiner, Ž., De Backer, G., Graham, I., Taskinen, M.-R., Wiklund, O., Agewall, S., Alegria, E., Chapman, M. J., Durrington, P., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.028 · Cited by 706 · see citing works
EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome
Drosos, G. C., Vedder, D., Houben, E., Boekel, L., Atzeni, F., Badreh, S., Boumpas, D. T., Brodin, N., Bruce, I. N., González-Gay, M. Á., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-221733 · Cited by 426 · see citing works
The epidemiology of atherosclerotic cardiovascular disease among patients with SLE: A systematic review
Schoenfeld, S. R., Kasturi, S., & Costenbader, K. H. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2012.12.002 · Cited by 370 · see citing works
Dyslipidemia in systemic lupus erythematosus: just another comorbidity?
Tselios, K., Koumaras, C., Gladman, D. D., & Urowitz, M. B. (2015) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2015.10.010 · Cited by 124 · see citing works
Self-citation
Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study
Bengtsson, C., Öhman, M.-L., Nived, O., & Rantapää‐Dahlqvist, S. (2011) · Lupus · doi:10.1177/0961203311425524 · Cited by 124 · see citing works
Cardiovascular Disease in Systemic Lupus Erythematosus: Recent Data on Epidemiology, Risk Factors and Prevention
Kostopoulou, M., Nikolopoulos, D., Parodis, I., & Bertsias, G. K. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161118666191227101636 · Cited by 114 · see citing works
Modified Framingham Risk Factor Score for Systemic Lupus Erythematosus
Urowitz, M. B., Ibañez, D., Su, J., & Gladman, D. D. (2016) · The Journal of Rheumatology · doi:10.3899/jrheum.150983 · Cited by 96 · see citing works
Self-citation
The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis.
Murad, M. H., Hazem, A., Coto-Yglesias, F., Dzyubak, S., Gupta, S., Bancos, I., Lane, M. A., Erwin, P. J., Berglund, L., Elraiyah, T., et al. (2012) · BMC Endocrine Disorders · doi:10.1186/1472-6823-12-2 · Cited by 87 · see citing works
Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study
Nikpour, M., Urowitz, M. B., Ibañez, D., Harvey, P., & Gladman, D. D. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3473 · Cited by 86 · see citing works
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Optimal Monitoring For Coronary Heart Disease Risk in Patients with Systemic Lupus Erythematosus: A Systematic Review
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Increased Arterial Stiffness in Systemic Lupus Erythematosus (SLE) Patients at Low Risk for Cardiovascular Disease: A Cross-Sectional Controlled Study
Sacré, K., Escoubet, B., Pasquet, B., Chauveheid, M., Zennaro, M., Tubach, F., & Papo, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094511 · Cited by 75 · see citing works
Evolution of Risk Factors for Atherosclerotic Cardiovascular Events in Systemic Lupus Erythematosus: A Longterm Prospective Study
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Self-citation
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Predictive Utility of Cardiovascular Risk Prediction Algorithms in Inflammatory Rheumatic Diseases: A Systematic Review
Colaco, K., Ocampo, V., Ayala, A. P., Harvey, P., Gladman, D. D., Piguet, V., & Eder, L. (2019) · The Journal of Rheumatology · doi:10.3899/jrheum.190261 · Cited by 63 · see citing works
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Bogdanovic, G., Stojanovich, L., Djoković, A., & Stanisavljević, N. (2015) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.237.193 · Cited by 62 · see citing works
Definitions of and contributions to cardiovascular disease in systemic lupus erythematosus
Gustafsson, J. T., & Svenungsson, E. (2013) · Autoimmunity · doi:10.3109/08916934.2013.856005 · Cited by 59 · see citing works
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Physical activity and sedentary behavior in patients with systemic lupus erythematosus and rheumatoid arthritis
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Prevalence and risk of metabolic syndrome in patients with systemic lupus erythematosus: A meta‐analysis
Sun, C., Qin, W., Zhang, Y., Wu, Y., Li, Q., Liu, M., & He, C. (2017) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13153 · Cited by 47 · see citing works
Primary prevention of cardiovascular disease in patients with systemic lupus erythematosus: case series and literature review
Fasano, S., Margiotta, D. P. E., Navarini, L., Pierro, L., Pantano, I., Riccardi, A., Afeltra, A., & Valentini, G. (2017) · Lupus · doi:10.1177/0961203317722847 · Cited by 47 · see citing works
Understanding Accelerated Atherosclerosis in Systemic Lupus Erythematosus: Toward Better Treatment and Prevention
Reiss, A. B., Jacob, B., Ahmed, S., Carsons, S. E., & DeLeon, J. R. (2021) · Inflammation · doi:10.1007/s10753-021-01455-6 · Cited by 47 · see citing works
Implications of immunosuppressive agents in cardiovascular risks and carotid intima media thickness among lupus nephritis patients
Shaharir, S. S., Shahrir, M. M., Kong, N. C. T., Tan, H., Basri, H., & Azmi, M. (2011) · Lupus · doi:10.1177/0961203311411347 · Cited by 44 · see citing works
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I. M., Backer, G. D., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Kardiologia Polska · doi:10.5603/kp.2016.0157 · Cited by 41 · see citing works
Circulating FABP4 is a marker of metabolic and cardiovascular risk in SLE patients
Parra, S., Cabré, A., Marimón, F., Ferré, R., Ribalta, J., Gonzàlez, M., Heras, M., Castro, A., & Masana, L. (2014) · Lupus · doi:10.1177/0961203313517405 · Cited by 34 · see citing works
Cardiovascular Risk Factors and Atherosclerotic Cardiovascular Events Among Incident Cases of Systemic Sclerosis: Results From a Population-Based Cohort (1980-2016)
Kurmann, R., Sandhu, A. S., Crowson, C. S., Matteson, E. L., Osborn, T. G., Warrington, K. J., Mankad, R., & Makol, A. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.12.015 · Cited by 34 · see citing works
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Chuang, Y., Yu, M., Lin, C., Yu, T., Shu, K., & Kao, C. (2015) · Medicine · doi:10.1097/md.0000000000002121 · Cited by 29 · see citing works
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Self-citation
Ability of non-fasting and fasting triglycerides to predict coronary artery disease in lupus patients
Touma, Z., Gladman, D., Ibañez, D., & Urowitz, M. B. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/ker339 · Cited by 27 · see citing works
Self-citation
Executive summary of the Hellenic Atherosclerosis Society guidelines for the diagnosis and treatment of dyslipidemias - 2023
Katsiki, N., Filippatos, T. D., Vlachopoulos, C. V., Panagiotakos, D. B., Milionis, H. J., Tselepis, A. D., Garoufi, A., Rallidis, L. S., Richter, D. J., Nomikos, T., et al. (2024) · Atherosclerosis Plus · doi:10.1016/j.athplu.2024.01.004 · Cited by 27 · see citing works
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Sacré, K., Escoubet, B., Zennaro, M., Chauveheid, M., Gayat, É., & Papo, T. (2015) · Medicine · doi:10.1097/md.0000000000002177 · Cited by 25 · see citing works
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Eder, L., Gladman, D., Ibañez, D., & Urowitz, M. B. (2014) · Lupus · doi:10.1177/0961203314537696 · Cited by 25 · see citing works
Self-citation
Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013
Ungprasert, P., Matteson, E. L., & Crowson, C. S. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.09.015 · Cited by 25 · see citing works
Cardiovascular risk factors, burden of disease and preventive strategies in patients with systemic lupus erythematosus: a literature review
Benvenuti, F., Gatto, M., Larosa, M., Iaccarino, L., Punzi, L., & Doria, A. (2015) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2015.1073259 · Cited by 24 · see citing works
Novel cardiovascular risk prediction models in patients with systemic lupus erythematosus
Kawai, V. K., Solus, J. F., Oeser, A. M., Rho, Y., Raggi, P., Bian, A., Gebretsadik, T. S., Shintani, A., & Stein, C. M. (2011) · Lupus · doi:10.1177/0961203311420317 · Cited by 21 · see citing works
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Haasken, S., Auger, J. L., & Binstadt, B. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000967 · Cited by 21 · see citing works
Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Cutaneous Lupus Erythematosus: A Population‐Based Cohort Study
Singh, A. G., Crowson, C. S., Singh, S., Denis, M., Davis, P. C., Kremers, H. M., Matteson, E. L., & CHOWDHARY, V. R. (2016) · Arthritis Care & Research · doi:10.1002/acr.22892 · Cited by 21 · see citing works
Metabolic syndrome in patients with systemic lupus erythematosus: Association with disease activity, disease damage and age
Mobini, M., Niksolat, F., Mohammadpour, R. A., Dargahloo, S. D., & Marzban, D. (2018) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13276 · Cited by 20 · see citing works
Disease Damage Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Systemic Lupus Erythematosus
Quevedo-Abeledo, J. C., Rúa‐Figueroa, Í., Sánchez‐Pérez, H., Segura, B. T., de Vera-González, A., Delgado, A. G., Llorca, J., González-Gay, M. Á., & Ferraz‐Amaro, I. (2019) · The Journal of Rheumatology · doi:10.3899/jrheum.180881 · Cited by 20 · see citing works
Association of Lupus Nephritis With Coronary Artery Disease by ISN/RPS Classification: Results From a Large Real‐world Lupus Population
Sun, E. Y., Álvarez, C., & Sheikh, S. Z. (2019) · ACR Open Rheumatology · doi:10.1002/acr2.1035 · Cited by 20 · see citing works
Cardiovascular risk stratification and appropriate use of statins in patients with systemic lupus erythematosus according to different strategies
Masson, W. M., Rossi, E., Mora-Crespo, L. M., Cornejo-Peña, G., Pessio, C., Gago, M. P., Alvarado, R. N., & Scolnik, M. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04856-z · Cited by 18 · see citing works
Athérosclérose au cours du lupus érythémateux systémique
Tazi, Z. M., Harmouche, H., Ammouri, W., Maamar, M., Adnaoui, M., & Cacoub, P. (2014) · La Presse Médicale · doi:10.1016/j.lpm.2014.01.021 · Cited by 18 · see citing works
The pleiotropic role of HDL in autoimmune diseases
Parra, S., Castro, A., & Masana, L. (2014) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2014.09.002 · Cited by 15 · see citing works
Assessment of Arterial Stiffness and Biochemical Markers in Systemic Lupus Erythematosus in the Diagnosis of Subclinical Atherosclerosis
Blachut, D., Przywara-Chowaniec, B., Mazurkiewicz, M., & Tomasik, A. R. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14030289 · Cited by 12 · see citing works
QRISK3 relation to carotid plaque is higer than that of score in patients with systemic lupus erythematosus
Quevedo-Abeledo, J. C., Cáceres, L., Palazuelos, C., Llorca, J., González-Gay, M. Á., & Ferraz‐Amaro, I. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab531 · Cited by 12 · see citing works
Atherosclerosis in Systemic Lupus Erythematosus – Epidemiology, Risk Factors, Subclinical Assessment and Future Study
Sheane, B. J. (2013) · Rheumatology Current Research · doi:10.4172/2161-1149.s5-004 · Cited by 11 · see citing works
Atherosclerosis and Lupus: What We Know and What We Should Know
Doria, A. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.090999 · Cited by 11 · see citing works
Predictors of thickened carotid intima media thickness among well controlled lupus nephritis patients in a Malaysian tertiary centre
Shaharir, S. S., Said, M. S. M., & Kong, N. C. T. (2012) · Reumatismo · doi:10.4081/reumatismo.2012.341 · Cited by 10 · see citing works
Do adverse pregnancy outcomes contribute to accelerated cardiovascular events seen in young women with systemic lupus erythematosus?
Soh, M. C., Nelson‐Piercy, C., Westgren, M., McCowan, L. M. E., & Pasupathy, D. (2017) · Lupus · doi:10.1177/0961203317719146 · Cited by 11 · see citing works
Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus
Baharfard, N., Shiroodi, M. K., Fotoohi, F., Samangooie, S., Asli, I. N., Eghtesadi-Araghi, P., Javadi, H. R., Semnani, S., Amini, A. S., & Assadi, M. (2010) · Perfusion · doi:10.1177/0267659110389844 · Cited by 9 · see citing works
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Weinstein, P. K., Amirkhosravi, A., Angelopoulos, T. J., Bushy, A., Covelli, M. M., & Dennis, K. E. (2013) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e31827f0d53 · Cited by 9 · see citing works
Thickened carotid intima media thickness and carotid atherosclerosis among lupus nephritis patients: the role of traditional and lupus-specific factors
Shaharir, S. S., SHAHRIR, M. S. M., Kong, N. C. T., Tan, H. J., Basri, H., & Tamil, A. M. (2011) · International Journal of Rheumatic Diseases · doi:10.1111/j.1756-185x.2011.01638.x · Cited by 7 · see citing works
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Rezaieyazdi, Z., Sedighi, S., Salari, M., FARD, M. H., Azarpazhooh, M. R., Tabrizi, P. S., Afshari, J. T., & Masoud, S. (2019) · Current Rheumatology Reviews · doi:10.2174/1573397116666191217122030 · Cited by 5 · see citing works
Development of High Fat Diet-Induced Hyperinsulinemia in Mice Is Enhanced by Co-treatment With a TLR7 Agonist
Kakalij, R. M., Dsouza, D. L., & Boesen, E. I. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.930353 · Cited by 5 · see citing works
The association of cardiovascular disease risk with coronary artery calcification and thoracic aortic dilation: a study in idiopathic inflammatory myopathies and systemic lupus erythematosus
Yang, T., Qiu, Y., Zhang, Y., Hu, W., Li, M., Dai, Y., Zhou, Y., & Yin, Y. (2024) · Clinical Rheumatology · doi:10.1007/s10067-024-07115-y · Cited by 4 · see citing works
Riesgo cardiovascular en el lupus eritematoso sistémico: factores implicados y métodos para su valoración
Checa, C. M., Salvatierra, J., Rosales-Alexander, J. L., & Álvarez, E. R. (2012) · Seminarios de la Fundación Española de Reumatología · doi:10.1016/j.semreu.2012.06.004 · Cited by 3 · see citing works
University of Toronto Lupus Clinic Turns 40
Gladman, D. D., & Urowitz, M. B. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.111581 · Cited by 3 · see citing works
Self-citation
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Tselios, K., & Urowitz, M. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803267-1.00010-7 · Cited by 3 · see citing works
Self-citation
Risk Factors and Modifiers for Cardiovascular Disease Assessment of Patients with Heterozygous Familial Hypercholesterolaemia
Malone, R., Savage, S., Crowley, V., Hennessy, M., O’Connor, P. A., & Kennedy, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082270 · Cited by 2 · see citing works
Rural–urban disparities in hospitalisation for myocardial infarction in systemic lupus erythematosus in the USA
Singh, J. A., & Chandrupatla, S. R. (2025) · Lupus Science & Medicine · doi:10.1136/lupus-2025-001516 · Cited by 2 · see citing works
Prevalence of metabolic syndrome in low-income childhood-onset systemic lupus erythematosus patients
Iannini, N. G., & Rodrigues, C. E. M. (2025) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-025-00464-5 · Cited by 1 · see citing works
Evaluation of Ischemia Modified Albumin Levels and Carotid Intima Media Thickness in Patients with Systemic Lupus Eythematosus
Toker, A., Küçükşen, S., Küçük, A., Salbaş, E., Uçar, R., Kayrak, M., & Tunç, R. (2014) · European Journal of Basic Medical Sciences · doi:10.15197/sabad.2.4.14 · Cited by 1 · see citing works
Studies on cardiovascular risk factors in Systemic Lupus Erythematosus
Gustafsson, J. T. (2012) · Figshare · Cited by 1 · see citing works
The Role of MRI for Diagnosis in Women with Angina and Open Arteries
Thomson, L. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4838-8_21
Serological Biomarkers in Systemic Lupus Erythematosus
Chan, M. T.-L. (2013) · The University of Bath Online Publications Store (The University of Bath)
Immunity and Tolerance in the K/BxN Model of Spontaneous Arthritis and Endocarditis
Haasken, S. (2013) · University of Minnesota Digital Conservancy (University of Minnesota)
Srce i krvni Sudovi
Beleslin, B., Deljanin, M., Kanjuh, V., Parapid, B. J., Giga, V. L., Prostran, M. S., Angelkov, L., Balinovac, J., Bikicki, M., Ambrosio, G., et al. (2013)
Cardiovascular Risk in Rheumatic Disease
Gabriel, S. E., & Symmons, D. P. M. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1738-9.00036-0
Causal relationship between systemic lupus erythematosus and coronary artery disease: Insights from a meta-analysis and Mendelian randomization
Yuan, P., Fu, L., Ge, M., & Fan, Y. (2026) · Medicine · doi:10.1097/md.0000000000048748
Global prevalence and associated factors of metabolic syndrome in patients with systemic lupus erythematosus: A systematic review and meta-analysis
Nayak, S. S., Ghodous, S., Keetha, N. R., Gurram, A., Letafatkar, N., Ahlawat, P., Habibi, A., Boora, S. R., Hashemi, S. M., Cheetirala, S., et al. (2026) · Lupus · doi:10.1177/09612033261477274

Risk factors for coronary artery disease in patients with systemic lupus erythematosus
Petri, M., Perez‐Gutthann, S., Spence, D., & Hochberg, M. C. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90578-y · Cited by 623 · see citing works
Lupus an independent risk factor for coronary artery disease
Staff, R. (2010)
POS0724 RISK FACTORS FOR CORONARY ARTERY DISEASE IN CHINESE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A MULTI-CENTER, RETROSPECTIVE, COHORT STUDY
Ci, W., Zhao, J., Wang, Y., Pan, L., & Li, M. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2022-eular.51
Contribution of traditional risk factors to coronary artery disease in patients with systemic lupus erythematosus.
Rahman, P., Mb, U., Gladman, D. D., Bruce, I. N., & Genest, J. J. (1999) · PubMed · Cited by 117 · see citing works
Self-citation
Characteristics and risk factors of severe coronary artery disease in systemic lupus erythematosus: A multicenter, Chinese Rheumatism Date Center database study
Ci, W., Zhao, J., Qi, W., Gao, N., Qian, J., Zhang, G., Wang, Y., Pan, L., & Li, M. (2022) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.14402 · Cited by 9 · see citing works

Authors: GOLDBERG, R. J., UROWITZ, M. B., IBAÑEZ, D., NIKPOUR, M., & GLADMAN, D. D.
Affiliations: University of Toronto (CA)
Corresponding author: GLADMAN, DAFNA D.
ORCID: UROWITZ, MURRAY B.
IBAÑEZ, DOMINIQUE
NIKPOUR, MANDANA
GLADMAN, DAFNA D.
Venue: The Journal of Rheumatology
Publisher: The Journal of Rheumatology
Published: 2009-10-15
Volume: 36
Issue: 11
Pages: 2454-2461
ISSN: 0315-162X (ISSN-L)
1499-2752
DOI: 10.3899/jrheum.090011
OpenAlex: W2099413757
Cited by: 78
References: 39
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 6
FWCI: 3.77
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Rheumatology (publishedVersion)
PubMed (publishedVersion)
Funders: Heart and Stroke Foundation of Canada
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords: systemic lupus erythematosus, coronary artery disease, cardiovascular risk factors, triglycerides, metabolic syndrome, hypertension, sedentary lifestyle, Framingham risk score, postmenopausal status, age, lipid subfractions, women
MeSH terms: Adult, Coronary Artery Disease, Female, Humans, Lupus Erythematosus, Systemic, Middle Aged, Prospective Studies, Risk Factors, Multivariate Analysis, Young Adult

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Risk factors for development of coronary artery disease in women with systemic lupus erythematosus

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