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Cited by 226Mesenchymal stem cell researchLiver physiology and pathologyLiver Disease and Transplantation

Mesenchymal stem cell therapy for liver fibrosis

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Eom, Young Woo, Shim, Kwang Yong, Baik, Soon Koo·2015·The Korean Journal of Internal Medicine
DOI 10.3904/kjim.2015.30.5.580PMC PMC4578027
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Abstract

Currently, the most effective treatment for end-stage liver fibrosis is liver transplantation; however, transplantation is limited by a shortage of donor organs, surgical complications, immunological rejection, and high medical costs. Recently, mesenchymal stem cell (MSC) therapy has been suggested as an effective alternate approach for the treatment of hepatic diseases. MSCs have the potential to differentiate into hepatocytes, and therapeutic value exists in their immune-modulatory properties and secretion of trophic factors, such as growth factors and cytokines. In addition, MSCs can suppress inflammatory responses, reduce hepatocyte apoptosis, increase hepatocyte regeneration, regress liver fibrosis and enhance liver functionality. Despite these advantages, issues remain; MSCs also have fibrogenic potential and the capacity to promote tumor cell growth and oncogenicity. This paper summarizes the properties of MSCs for regenerative medicine and their therapeutic mechanisms and clinical application in the treatment of liver fibrosis. We also present several outstanding risks, including their fibrogenic potential and their capacity to promote pre-existing tumor cell growth and oncogenicity.

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Authors
Eom, Y. W., Shim, K. Y., & Baik, S. K.
Affiliations
Yonsei University (KR)
Corresponding author
Baik, Soon Koo
ORCID
Venue
The Korean Journal of Internal Medicine
Publisher
Korean Association of Internal Medicine
Published
2015-08-27
Volume
30
Issue
5
Pages
580-589
ISSN
  • 1226-3303 (ISSN-L)
  • 2005-6648
DOI
10.3904/kjim.2015.30.5.580
PMC
PMC4578027
OpenAlex
W1794770698
Cited by
226
References
4
Citations by year
2026: 4 · 2025: 13 · 2024: 20 · 2023: 19 · 2022: 19 · 2021: 56 · 2020: 23 · 2019: 21 · 2018: 20 · 2017: 18 · 2016: 12 · 2015: 1
FWCI
2.39
Type
journal article
Language
en
Open access
Licence
Locations
  • The Korean Journal of Internal Medicine (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Yonsei University Future-leading Research Initiative
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
mesenchymal stem cells, liver fibrosis, regenerative medicine, hepatocyte differentiation, immunomodulation, hepatocyte regeneration, tumor promotion, oncogenicity, liver transplantation alternatives, clinical application
MeSH terms
Animals, Cell Differentiation, Humans, Liver, Liver Cirrhosis, Liver Regeneration, Phenotype, Risk Factors, Signal Transduction, Treatment Outcome, Hepatocytes, Regenerative Medicine, Mesenchymal Stem Cell Transplantation, Cell Proliferation, Mesenchymal Stem Cells

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