Mesenchymal stem cell infusion therapy in a carbon tetrachloride‐induced liver fibrosis model affects matrix metalloproteinase expression
Abstract
In order to investigate the effects of bone marrow‐derived MSCs (mesenchymal stem cells) in reversing liver fibrosis and to determine their possible mechanism of action, mouse MSCs were infused into the tail vein of a CCl 4 injection mouse chronic model. MSCs caused a decrease in liver fibrosis histopathologically, 4 weeks after transplantation. The reduction in liver collagen was confirmed by quantitative analysis. Moreover, lipid peroxidation in the CCl 4/MSC group decreased significantly. Quantitative RT (reverse transcription)‐PCR analysis showed administration of MSCs has a significant antifibrotic effect as evidenced by the decrease in expression of liver collagen and increase in MMP13 (matrix metalloproteinase 13) in the CCl 4/MSC group when compared with the CCl 4 group, 4 weeks after transplantation. The expression of αSMA (smooth muscle actin) and TIMP1 was also down‐regulated in the CCl 4/MSC group. Additionally, the expression of MMP9 was significantly up‐regulated in the CCl 4‐treated group; however, there was no significant change after MSC injection. Few engrafted cells in the recipient liver and were able to differentiate into albumin‐positive cells. In conclusion, MSCs can enhance recovery of a CCl 4‐injured mouse liver through their influence in reducing collagen deposition by possibly affecting expression of MMPs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MSCs modulate fibrosis by enhancing expression of MMPs and downregulating TIMPs, resulting in regression of liver fibrosis.
“Moreover, MSCs can modulate fibrosis by enhancing the expression of matrix metalloproteinases (MMPs) and downregulating the expression of tissue inhibitors of MMPs, resulting in the regression of liver fibrosis [202], [203].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [202]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992 · see citing works
Liver fibrosis – from bench to bedside
Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780 · see citing works
Glycosyltransferase activity of Fringe modulates Notch–Delta interactions
Brückner, K., Perez, L., Clausen, H., & Cohen, S. (2000) · Nature · doi:10.1038/35019075 · Cited by 694 · see citing works
Sato, Y., Araki, H., Kato, J., Nakamura, K., Kawano, Y., Kobune, M., Sato, T., Miyanishi, K., Takayama, T., Takahashi, M., et al. (2005) · Blood · doi:10.1182/blood-2005-02-0572 · Cited by 610 · see citing works
Stem Cells and Liver Regeneration
Duncan, A. W., Dorrell, C., & Grompe, M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.044 · Cited by 547 · see citing works
van Poll, D., Parekkadan, B., Cho, C. H., Berthiaume, F., Nahmias, Y., Tilles, A. W., & Yarmush, M. L. (2008) · Hepatology · doi:10.1002/hep.22236 · Cited by 501 · see citing works
The Bone Marrow Functionally Contributes to Liver Fibrosis
Russo, F. P., Alison, M. R., Bigger, B., Amofah, E., Florou, A., Amin, F., Bou–Gharios, G., Jeffery, R. E., Iredale, J. P., & Forbes, S. J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.036 · Cited by 483 · see citing works
Fallowfield, J. A., Mizuno, M., Kendall, T. J., Constandinou, C. M., Benyon, R. C., Duffield, J. S., & Iredale, J. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5288 · Cited by 479 · see citing works
Kuo, T. K., Hung, S., Chuang, C., Chen, C., Shih, Y. V., Fang, S. Y., Yang, V. W., & Lee, O. K. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.015 · Cited by 466 · see citing works
Banaś-Ząbczyk, A., Teratani, T., Yamamoto, Y., Tokuhara, M., Takeshita, F., Osaki, M., Kawamata, M., Kato, T., Okochi, H., & Ochiya, T. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0034 · Cited by 306 · see citing works
Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
Oyagi, S., Hirose, M., Kojima, M., Okuyama, M., Kawase, M., Nakamura, T., Ohgushi, H., & Yagi, K. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.026 · Cited by 299 · see citing works
Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis
Aziz, M. T. A., Atta, H. M., Mahfouz, S., Fouad, H. H., Roshdy, N. K., Ahmed, H., Rashed, L. A., Sabry, D., Hassouna, A. A., & Hasan, N. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.04.017 · Cited by 292 · see citing works
di Bonzo, L. V., Ferrero, I., Cravanzola, C., Mareschi, K., Rustichell, D., Novo, E., Sanavio, F., Cannito, S., Zamara, E., Bertero, M. T., et al. (2007) · Gut · doi:10.1136/gut.2006.111617 · Cited by 290 · see citing works
Banaś-Ząbczyk, A., Teratani, T., Yamamoto, Y., Tokuhara, M., Takeshita, F., Osaki, M., Kato, T., Okochi, H., & Ochiya, T. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05496.x · Cited by 263 · see citing works
Tsai, P.-C., Fu, T.-W., Chen, Y. A., Ko, T.-L., Chen, T.-H., Shih, Y., Hung, S., & Fu, Y.-S. (2009) · Liver Transplantation · doi:10.1002/lt.21715 · Cited by 206 · see citing works
Carvalho, A. B., Quintanilha, L. F., Dias, J. V., Paredes, B. D., Mannheimer, E. G., de Carvalho, F. G., Asensi, K. D., Gutfilen, B., da Fonseca, L. M. B., Resende, C. M. C., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0941 · Cited by 162 · see citing works
Bone Marrow–Derived Mesenchymal Stem Cells Improve Islet Graft Function in Diabetic Rats
Figliuzzi, M., Cornolti, R., Perico, N., Rota, C., Morigi, M., Remuzzi, G., Remuzzi, A., & Benigni, A. (2009) · Transplantation Proceedings · doi:10.1016/j.transproceed.2008.11.015 · Cited by 135 · see citing works
Inhibition of hepatic fibrogenesis by matrix metalloproteinase‐9 mutants in mice
Roderfeld, M., Weiskirchen, R., Wagner, S., Berres, M., Henkel, C., Grötzinger, J., Gressner, A. M., Matern, S., & Roeb, E. (2006) · The FASEB Journal · doi:10.1096/fj.05-4828com · Cited by 134 · see citing works
Murine mesenchymal stem cells isolated by low density primary culture system
Eslaminejad, M. B., Nikmahzar, A., Taghiyar, L., Nadri, S., & Massumi, M. (2006) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2006.00874.x · Cited by 133 · see citing works
Zhou, X., Hovell, C. J., Pawley, S., Hutchings, M. I., Arthur, M. J. P., Iredale, J. P., & Benyon, R. C. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.0946.x · Cited by 104 · see citing works
Effect of human umbilical cord blood‐derived mesenchymal stem cells in a cirrhotic rat model
Jung, K. H., Shin, H. P., Lee, S., Lim, Y. J., Hwang, S. H., Han, H. J., Park, H. K., Chung, J., & Yim, S. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02031.x · Cited by 93 · see citing works
Snykers, S., Henkens, T., Rop, E. D., Vinken, M., Fraczek, J., Kock, J. D., Prins, E. D., Geerts, A. E., Rogiers, V., & Vanhaecke, T. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.009 · Cited by 74 · see citing works
Wang, L., Potter, J. J., Rennie-Tankersley, L., Novitskiy, G., Sipes, J., & Mezey, E. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.08.009 · Cited by 70 · see citing works
Janakat, S. M., & Al-Merie, H. (2002) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(03)00019-4 · Cited by 56 · see citing works
Liang, L., Ma, T., Chen, W., Hu, J., Bai, X., Li, J., & Liang, T. (2009) · Hepatology Research · doi:10.1111/j.1872-034x.2009.00506.x · Cited by 51 · see citing works
Inagaki, Y., Higashiyama, R., & Okazaki, I. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00267.x · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Paracrine Mechanisms of Mesenchymal Stem Cells in Tissue Repair
Gnecchi, M., Danieli, P., Malpasso, G., & Ciuffreda, M. C. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3584-0_7 · Cited by 456 · see citing works
Shi, M., Zhang, Z., Xu, R., Lin, H., Fu, J., Zou, Z., Zhang, A., Shi, J., Chen, L., Lv, S., et al. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0034 · Cited by 374 · see citing works
Zhang, Z., Lin, H., Shi, M., Xu, R., Fu, J., Lv, J., Chen, L., Lv, S., Li, Y., Yu, S., et al. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.07024.x · Cited by 372 · see citing works
Suk, K. T., Yoon, J., Kim, M. Y., Kim, C. W., Kim, J. K., Park, H., Hwang, S. G., Kim, D. J., Lee, B. S., Lee, S. H., et al. (2016) · Hepatology · doi:10.1002/hep.28693 · Cited by 303 · see citing works
Mesenchymal stem cell therapy for liver fibrosis
Eom, Y. W., Shim, K. Y., & Baik, S. K. (2015) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2015.30.5.580 · Cited by 226 · see citing works
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 205 · see citing works
Management of Fibrosis: The Mesenchymal Stromal Cells Breakthrough
Usunier, B., Benderitter, M., Tamarat, R., & Chapel, A. (2014) · Stem Cells International · doi:10.1155/2014/340257 · Cited by 167 · see citing works
Shi, M., Li, Y.-Y., Xu, R.-N., Meng, F.-P., Yu, S.-J., Fu, J.-L., Hu, J.-H., Li, J.-X., Wang, L.-F., Jin, L., et al. (2021) · Hepatology International · doi:10.1007/s12072-021-10199-2 · Cited by 151 · see citing works
Use of mesenchymal stem cells to treat liver fibrosis: Current situation and future prospects
Berardis, S., Sattwika, P. D., Najimi, M., & Sokal, E. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i3.742 · Cited by 140 · see citing works
Cao, H., Yang, J., Yu, J., Pan, Q., Li, ., Zhou, P., Li, Y., Pan, X., Li, ., Wang, Y., et al. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-56 · Cited by 130 · see citing works
Mardpour, S., Hassani, S., Mardpour, S., Sayahpour, F. A., Vosough, M., Ai, J., Aghdami, N., Hamidieh, A. A., & Baharvand, H. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26413 · Cited by 110 · see citing works
Self-citationWang, Y., Lian, F., Li, J., Fan, W., Xu, H., Yang, X., Liang, L., Chen, W., & Yang, J. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-133 · Cited by 98 · see citing works
Zhang, L., Ma, X.-J.-N., Fei, Y.-Y., Han, H., Xu, J., Cheng, L., & Li, X. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108004 · Cited by 93 · see citing works
Du, Z., Wei, C., Cheng, K., Han, B., Yan, J., Zhang, M., Peng, C., & Liu, Y. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.02.009 · Cited by 91 · see citing works
Mesenchymal stem cells attenuate liver fibrosis by suppressing Th17 cells - an experimental study
Milosavljević, N., Gazdic, M., Marković, B. S., Arsenijević, A., Nurković, J., Dolicanin, Z. C., Jovicic, N. U., Jeftic, I. D., Djonov, V., Arsenijević, N., et al. (2017) · Transplant International · doi:10.1111/tri.13023 · Cited by 87 · see citing works
Mesenchymal stromal cells and liver fibrosis: a complicated relationship
Haldar, D., Henderson, N. C., Hirschfield, G. M., & Newsome, P. N. (2016) · The FASEB Journal · doi:10.1096/fj.201600433r · Cited by 81 · see citing works
Mesenchymal Stem Cell-Dependent Modulation of Liver Diseases
Gazdic, M., Arsenijević, A., Marković, B. S., Volarevic, A., Dimova, I., Djonov, V., Arsenijević, N., Stojković, M., & Volarević, V. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.20240 · Cited by 80 · see citing works
Fiore, E. J., Bayo, J., García, M. G., Malvicini, M., Lloyd, R., Piccioni, F., Rizzo, M., Peixoto, E., Sola, M. B., Atorrasagasti, C., et al. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0174 · Cited by 79 · see citing works
Mesenchymal Stem Cells for the Treatment of Liver Disease: Present and Perspectives
Kang, S. H., Kim, M. Y., Eom, Y. W., & Baik, S. K. (2020) · Gut and Liver · doi:10.5009/gnl18412 · Cited by 78 · see citing works
Immunopathogenesis and prognostic immune markers of chronic hepatitis B virus infection
Zhang, Z., Zhang, J.-Y., Wang, L.-F., & Wang, F.-S. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06940.x · Cited by 71 · see citing works
Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis
Kwak, K.-A., Cho, H., Yang, J.-Y., & Park, Y. (2018) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2018/4197857 · Cited by 70 · see citing works
Stem cell-based regenerative opportunities for the liver: State of the art and beyond
Tsolaki, E. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i43.12334 · Cited by 70 · see citing works
Du, Z., Wei, C., Yan, J., Han, B., Zhang, M., Peng, C., & Liu, Y. (2012) · Liver Transplantation · doi:10.1002/lt.23577 · Cited by 55 · see citing works
Hodge, A. D., Lourensz, D., Vaghjiani, V., Nguyen, H. T.-L., Tchongue, J., Wang, B., Murthi, P., Sievert, W., & Manuelpillai, U. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.01.005 · Cited by 54 · see citing works
Zhou, R., Li, Z., He, C., Li, R., Xia, H., Li, C., Xiao, J., & Chen, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104392 · Cited by 50 · see citing works
Recent Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis
Jangra, A., Kothari, A., Sarma, P., Medhi, B., Omar, B. J., & Kaushal, K. (2022) · Cells · doi:10.3390/cells11091500 · Cited by 48 · see citing works
Shao, C., Chen, S., Dong, T., Chai, H., Yu, Y. Y., Deng, L., Wang, Y., & Cheng, F. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.08.016 · Cited by 47 · see citing works
Najimi, M., Berardis, S., El‐Kehdy, H., Rosseels, V., Evraerts, J., Lombard, C. A., Taghdouini, A. E., Henriet, P., van Grunsven, L. A., & Sokal, E. M. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0575-5 · Cited by 47 · see citing works
Regenerative Potential of Mesenchymal Stem Cells’ (MSCs) Secretome for Liver Fibrosis Therapies
Ignat, S.-R., Gharbia, S., Hermenean, A. O., Dinescu, S., & Costache, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413292 · Cited by 46 · see citing works
Wang, W., Du, Z., Yan, J., Ma, D., Shi, M., Zhang, M., Peng, C., & Li, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112532 · Cited by 43 · see citing works
Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Liver Fibrosis in Rats
Kubo, K., Ohnishi, S., Hosono, H., Fukai, M., Kameya, A., Higashi, R., Yamada, T., Onishi, R., Yamahara, K., Takeda, H., et al. (2015) · Transplantation Direct · doi:10.1097/txd.0000000000000525 · Cited by 43 · see citing works
Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model
Winkler, S., Borkham‐Kamphorst, E., Stock, P., Brückner, S., Dollinger, M., Weiskirchen, R., & Christ, B. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.04.017 · Cited by 42 · see citing works
Mesenchymal stem cells and their relationship to pericytes
Meirelles, L. D. S. (2015) · Frontiers in bioscience · doi:10.2741/4380 · Cited by 41 · see citing works
Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice
Shams, S., Mohsin, S., Nasir, G. A., Khan, M., & Khan, S. N. (2015) · Stem Cells International · doi:10.1155/2015/747245 · Cited by 38 · see citing works
de Oliveira, S. A., Souza, B. S. D. F., Barreto, E. P. D. S., Kaneto, C. M., Neto, H. A., Azevedo, C. M., Guimarães, E. T., de Freitas, L. A. R., Ribeiro‐dos‐Santos, R., & Soares, M. B. P. (2011) · Cytotherapy · doi:10.3109/14653249.2011.637668 · Cited by 34 · see citing works
Will stem cells bring hope to pathological skin scar treatment?
Li, Q., Zhang, C., & Fu, X. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.05.008 · Cited by 33 · see citing works
Mohammadian, M., Boskabady, M. H., Kashani, I. R., Jahromi, G. P., Omidi, A., Nejad, A. K., Khamse, S., & Sadeghipour, H. R. (2016) · Europe PMC (PubMed Central) · Cited by 32 · see citing works
Yan, W., Li, D., Chen, T., Tian, G., Zhou, P., & Ju, X. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00777 · Cited by 32 · see citing works
Vainshtein, J. M., Kabarriti, R., Mehta, K., Roy‐Chowdhury, J., & Guha, C. (2014) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2014.02.017 · Cited by 31 · see citing works
Wang, R., Shen, Z., Liu, Y., Yin, M.-L., Zheng, W., Wu, B., Liu, T., & Song, H. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3121 · Cited by 27 · see citing works
Mesenchymal stem cells to treat liver diseases
Eom, Y. W., Kang, S. H., Kim, M. Y., Lee, J. I., & Baik, S. K. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.163 · Cited by 26 · see citing works
Lopes‐Pacheco, M., Ventura, T. G., de Oliveira, H. D., Monção-Ribeiro, L. C., Gutfilen, B., de Souza, S. A. L., Rocco, P. R. M., Borojević, R., Morales, M. M., & Takiya, C. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109982 · Cited by 26 · see citing works
Chiabotto, G., Pasquino, C., Camussi, G., & Bruno, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594794 · Cited by 27 · see citing works
A nondenatured, noncrosslinked collagen matrix to deliver stem cells to the heart
Kouris, N. A., Squirrell, J. M., Jung, J. P., Pehlke, C. A., Hacker, T. A., Eliceiri, K. W., & Ogle, B. M. (2011) · Regenerative Medicine · doi:10.2217/rme.11.48 · Cited by 26 · see citing works
Stem cells for liver regeneration
Than, N. N., & Newsome, P. N. (2014) · QJM · doi:10.1093/qjmed/hcu013 · Cited by 25 · see citing works
Zhang, L., Zhou, D., Li, J., Yan, X., Zhu, J., Xiao, P., Chen, T., & Xie, X. (2019) · Medical Science Monitor · doi:10.12659/msm.916428 · Cited by 26 · see citing works
Miryounesi, M., Piryaei, A., Pournasr, B., Aghdami, N., & Baharvand, H. (2013) · Cell Biology International · doi:10.1002/cbin.10048 · Cited by 25 · see citing works
Self-citationDong, S., & Su, S.-B. (2014) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(14)60022-4 · Cited by 25 · see citing works
Antler stem cells as a novel stem cell source for reducing liver fibrosis
Rong, X., Yang, Y., Zhang, G., Zhang, H., Li, C., & Wang, Y. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03081-z · Cited by 24 · see citing works
Scheers, I. (2011) · The Open Tissue Engineering and Regenerative Medicine Journal · doi:10.2174/1875043501104010048 · Cited by 22 · see citing works
Kim, J. K., Kim, S., Kim, Y., Chung, Y. E., Park, Y. N., Kim, H. O., Kim, J. S., Park, M., Sakaida, I., Kim, D. Y., et al. (2017) · Cell Transplantation · doi:10.3727/096368917x694778 · Cited by 22 · see citing works
Perspective on Stem Cell Therapy in Organ Fibrosis: Animal Models and Human Studies
Wiśniewska, J., Sadowska, A., Wójtowicz, A., Słyszewska, M., & Szóstek-Mioduchowska, A. (2021) · Life · doi:10.3390/life11101068 · Cited by 17 · see citing works
Mesenchymal stem cells-based therapy in liver diseases
Han, H., Jin, W., & Li, X. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00088-x · Cited by 22 · see citing works
Cell-based therapies for the preterm infant
Zhu, D., Wallace, E. M., & Lim, R. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.06.004 · Cited by 21 · see citing works
Fu, X., Jiang, B., Zheng, B., Yan, Y., Wang, J., Duan, Y., Li, S., Yan, L., Wang, H., Chen, B., et al. (2018) · PeerJ · doi:10.7717/peerj.4336 · Cited by 21 · see citing works
Chen, B., Wang, Y., Qian, J., Wu, D., Chen, E., & Tang, H. (2018) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001156 · Cited by 21 · see citing works
Papanikolaou, I. G., Katselis, C., Apostolou, K. G., Feretis, T., Lymperi, M., Konstadoulakis, M. M., Papalois, A. E., & Zografos, G. (2017) · Stem Cells International · doi:10.1155/2017/7567958 · Cited by 20 · see citing works
Stem Cell and Tissue Engineering Research in the Islamic Republic of Iran
Gheisari, Y., Baharvand, H., Nayernia, K., & Vasei, M. (2012) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9343-6 · Cited by 20 · see citing works
Self-citationZHANG, L.-T., Fang, X.-Q., Chen, Q., Chen, H., Xiao, P., Peng, X., ZHANG, S.-X., LI, J.-F., & Mao, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4362 · Cited by 17 · see citing works
Goradel, N. H., Darabi, M., Shamsasenjan, K., Ejtehadifar, M., & Zahedi, S. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.041 · Cited by 17 · see citing works
Ryu, H. S., Abueva, C. D. G., Padalhin, A., Park, S. Y., Yoo, S. H., Seo, H. H., Chung, P., & Woo, S. H. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03694-4 · Cited by 16 · see citing works
Effect of mesenchymal stem cell in liver regeneration and clinical applications
Lee, S. M., Lee, S. D., Wang, S. Z., Sarkar, D., Lee, H. M., Khan, A. A., Bhati, C. S., Sharma, A., Kumaran, V., Bruno, D. A., et al. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2021.07 · Cited by 17 · see citing works
The Effects of Programmed Cell Death of Mesenchymal Stem Cells on the Development of Liver Fibrosis
Wu, H., Chen, H.-D., Chen, Y., Mao, X., Feng, Y., Li, S.-W., & Zhou, X.-B. (2023) · Stem Cells International · doi:10.1155/2023/4586398 · Cited by 15 · see citing works
Zhang, F., Liu, H., Liu, F., Peng, Y., Chen, M., Liu, Y., & Chen, G. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.03.036 · Cited by 15 · see citing works
Garg, A., Khan, S., Luu, N., Nicholas, D. J., Day, V. P., King, A., Fear, J., Lalor, P. F., & Newsome, P. N. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17698 · Cited by 15 · see citing works
Bone marrow contributions to fibrosis
MacKinnon, A. C., & Forbes, S. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.01.022 · Cited by 15 · see citing works
Barcena, A. J. R., Owens, T. C., Melancon, S., Workeneh, I., Cao, H. S. T., Vauthey, J., & Huang, S. Y. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10719-1 · Cited by 14 · see citing works
Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease
Yi, S., Cong, Q., Zhu, Y., & Xu, Q. (2023) · Stem Cells International · doi:10.1155/2023/3919002 · Cited by 15 · see citing works
Furuta, T., Furuya, K., Zheng, Y., & Oda, T. (2020) · World Journal of Transplantation · doi:10.5500/wjt.v10.i3.64 · Cited by 14 · see citing works
Rafiq, H. M. U., Ayaz, M., Khan, H. A., Iqbal, M., Quraish, S., Afridi, S. G., Khan, A., Khan, B., Sher, A., Siraj, F., et al. (2022) · Brazilian Journal of Biology · doi:10.1590/1519-6984.253061 · Cited by 13 · see citing works
Feng, Y., Wang, A.-T., Jia, H., Zhao, M., & Yu, H. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200101124317 · Cited by 13 · see citing works
Hu, C., Zhao, L., & Li, L. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02031-5 · Cited by 13 · see citing works
Pan, C., Wu, F., Wang, X., Tang, J., Gao, W., Ge, J., & Chen, F. (2014) · Cell Biology International · doi:10.1002/cbin.10287 · Cited by 12 · see citing works
Gabriel, N., Samuel, R., & Jayandharan, G. R. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2034 · Cited by 11 · see citing works
Brückner, S., Zipprich, A., Hempel, M., Thonig, A., Schwill, F., Roderfeld, M., Roeb, E., & Christ, B. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.09.006 · Cited by 11 · see citing works
Stem Cell Therapy: Current Applications and Potential for Urology
Wiafe, B., Metcalfe, P., & Adesida, A. B. (2015) · Current Urology Reports · doi:10.1007/s11934-015-0551-5 · Cited by 10 · see citing works
Removal from adherent culture contributes to apoptosis in human bone marrow mesenchymal stem cells
Deng, B., Jiang, H., Zeng, K., Liang, Y., Wu, Y., & Yang, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6440 · Cited by 10 · see citing works
Aithal, A. P., Bairy, L. K., Seetharam, R. N., & Rao, M. K. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28573 · Cited by 8 · see citing works
Khalifa, J., François, S., Rancoule, C., Riccobono, D., Magné, N., Drouet, M., & Chargari, C. (2019) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2019.06.002 · Cited by 8 · see citing works
Mesenchymal stem cell applications on the chronic liver disease
Kotb, E. Z., Montaser, L., & El-Azab, D. (2020) · Menoufia Medical Journal · doi:10.4103/mmj.mmj_301_18 · Cited by 7 · see citing works
Deng, B., Deng, W., Xiao, P., Zeng, K., Zhang, S., Zhang, H., Deng, D. Y. B., & Yang, Y. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2457 · Cited by 7 · see citing works
Mohammadian, M., Sadeghipour, H. R., Jahromi, G. P., Jafari, M., Nejad, A. K., Khamse, S., & Boskabady, M. H. (2018) · Cytokine · doi:10.1016/j.cyto.2018.06.016 · Cited by 6 · see citing works
Liu, W.-H., Liu, Z.-C., You, N., Zhang, N., Wang, T., Gong, Z.-B., Liu, H.-B., & Dou, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047346 · Cited by 5 · see citing works
HARAGUCHI, T., Kenji, T. A. N. I., TAKAGISHI, R., Yasutaka, O. D. A., ITAMOTO, K., Yamamoto, N., Terai, S., Sakaida, I., Nakazawa, H., & TAURA, Y. (2011) · Journal of Veterinary Medical Science · doi:10.1292/jvms.11-0505 · Cited by 5 · see citing works
Bone Marrow Stem Cell Therapy for Liver Disease
King, A., & Newsome, P. N. (2014) · Digestive Diseases · doi:10.1159/000360491 · Cited by 5 · see citing works
Effect of stem cell transplantation on amiodarone-induced hepatic changes in adult male albino rats
Attia, M. M., Eldien, A. A. S., Haiba, D. A., & Mohamed, S. M. (2015) · The Egyptian Journal of Histology · doi:10.1097/01.ehx.0000464780.75492.5e · Cited by 5 · see citing works
Liu, D., Liu, L., Wang, L., Duan, S., Song, Y., Qu, M., Gao, N., Wu, J., Zhang, H., Wu, H., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8096 · Cited by 5 · see citing works
Mahmoud, E. A., Baghdadi, H., Hassan, R., & Ghazy, S. (2023) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2023.105674 · Cited by 4 · see citing works
Prospective application of stem cells to prevent post‐operative skeletal fibrosis
Li, X., Chen, S., Yan, L., Wang, J., & Pei, M. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24266 · Cited by 4 · see citing works
Stem cells harvested from different sources ameliorate liver fibrosis: comparative study
Ali, I. S., Abdel-Wahab, N. D., & Nabil, A. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04707-6 · Cited by 3 · see citing works
Hsu, L., Nakano, T., Huang, K., Chen, C., Chen, K., Lai, C., Yang, S., Lin, C., Wang, C., Cheng, Y., et al. (2014) · Hepatology Research · doi:10.1111/hepr.12413 · Cited by 3 · see citing works
Tamai, R., & Katsuda, T. (2014) · Cited by 3 · see citing works
Application of stem cells in the precise diagnosis and treatment of liver diseases
Wang, Y.-X., Ren, Y.-N., Zhang, S.-S., Sun, S., Xu, M.-Y., Wei, T., & Zhang, L.-S. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i46.114415 · Cited by 2 · see citing works
Zaki, M. M., Atta, H. M., Shenouda, H. D., Yousef, M. M., & Ahmed, N. E. (2011) · The Egyptian Journal of Histology · doi:10.1097/01.ehx.0000407697.17485.f6 · Cited by 2 · see citing works
Huang, X., Wang, X., Li, J., Zheng, L., Zhao, H.-Z., Liang, P., & Dai, J. (2011) · Surgery Today · doi:10.1007/s00595-011-0107-3 · Cited by 2 · see citing works
Adult Stem Cell Therapy in Chronic Liver Diseases
Eom, Y. W., & Baik, S. K. (2015) · Hanyang Medical Reviews · doi:10.7599/hmr.2015.35.4.236 · Cited by 2 · see citing works
Effect of stem cell and vitamin E for the reduction of liver fibrosis
Shams, S., Khan, S. F., Ayaz, M., Khan, H. A., & Hassan, H. (2018) · eCommons - AKU (Aga Khan University) · Cited by 2 · see citing works
Clinical Application of Stem Cells in Liver Diseases: From Bench to Bedside
Xu, Y., & Zhang, Q. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812301-0.00015-3 · Cited by 1 · see citing works
The Role of Mesenchymal Stem Cells in Liver Regeneration
Gunardi, H. (2023) · Jurnal Gastrohepatologi Anak Indonesia/Archives of Pediatric Gastroenterology, Hepatology, and Nutrition · doi:10.58427/apghn.2.3.2023.39-51 · Cited by 1 · see citing works
Adel, A. (2019) · Al-Azhar Journal of Pharmaceutical Sciences/Al-Azhar Journal of Pharmaceutical Sciences · doi:10.21608/ajps.2019.64106 · Cited by 1 · see citing works
- Authors
- Rabani, V., Shahsavani, M., Gharavi, M., Piryaei, A., Azhdari, Z., & Baharvand, H.
- Affiliations
- Royan Institute (IR)
- Iranian Legal Medicine Organization (IR)
- University of Science and Culture (IR)
- Corresponding author
- Baharvand, Hossein
- Venue
- Cell Biology International
- Publisher
- Wiley
- Published
- 2010-06
- Volume
- 34
- Issue
- 6
- Pages
- 601-605
- ISSN
- 1065-6995 (ISSN-L)
- 1095-8355
- OpenAlex
- W2040041350
- Cited by
- 112
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 5 · 2015: 14 · 2014: 16 · 2013: 6 · 2012: 7
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Biology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- mesenchymal stem cells, liver fibrosis, carbon tetrachloride, matrix metalloproteinases, MMP-13, MMP-9, collagen deposition, lipid peroxidation, alpha-smooth muscle actin, TIMP-1, stem cell engraftment, antifibrotic therapy, bone marrow-derived stem cells
- MeSH terms
- Actins, Animals, Bone Marrow Cells, Carbon Tetrachloride, Collagen, Disease Models, Animal, Female, Liver Cirrhosis, Down-Regulation, Up-Regulation, Tissue Inhibitor of Metalloproteinase-1, Matrix Metalloproteinase 9, Mesenchymal Stem Cell Transplantation, Mice, Matrix Metalloproteinase 13, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
